Modeling Complex Data

Yale Biostatistics faculty and researchers develop cutting edge statistical methodology to handle complex data in public health, biology and medicine. In recent years, a few areas have been a focus of advanced modeling efforts. Statistical genetics has evolved into multi-omics, a field including data on genetics, genomics, proteomics and metabolomics. Methodological and data science advances in the field have enabled precision medicine tools and a deeper understanding of biological processes. Spatial data continue to be relevant for addressing infectious diseases, climate change and air pollution and the geographic determinants of health, with methods evolving to meet these challenges. And analyzing networks is crucial to understanding populations at the social and biological levels, providing modern challenges to traditional statistical methods. YSPH is at the forefront of interdisciplinary public health modeling, providing policy makers and care delivery organizations the data and analyses they need to make decisions.

2022 Neyman Memorial Lecture Video: “Genes, Brain, and Us”

Heping Zhang, the Susan Dwight Bliss Professor of Biostatistics at the Yale School of Public Health, gives the prestigious 2022 Neyman Memorial Lecture by the Institute of Mathematical Statistics (IMS) at its annual meeting in London, June 27-30, 2022. Given every three years, this is one of the highest honors in statistical societies. The Neyman Lecture highlights innovative work at the intersection of statistical theory and scientific research. The honor carries with it a hefty bit of prestige: Named after groundbreaking Polish statistician Jerzy Neyman, a founder of modern statistical inference, the lecture has been given by just over a dozen of the top researchers in the field. The IMS, a leading statistical society, also invited Zhang to contribute an article related to his lecture to its publications.

IMS Neyman Lecture: "Genes, Brain, and Us"

by Heping Zhang - June 29, 2022

Faculty of Interest

Heather Allore, PhD
Professor of Medicine (Geriatrics) and of Biostatistics; Leader, Data Management and Statistics Core, Yale Alzheimer's Disease Research Center, Internal Medicine; Associate Director of Gerontologic Biostatistical Methods, Internal Medicine: Geriatrics; Senior Biostatistician and Epidemiologist, Internal Medicine: Rheumatology; Co-Director of Biostatistical Core, Internal Medicine: Geriatrics
Research Interests
Mathematical Concepts
Statistics as Topic
Aging
Biostatistics
Epidemiologic Methods
Frail Elderly
Geriatrics
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Elizabeth Claus, PhD, MD
Professor of Biostatistics; Director of Medical Research, School of Public Health
Research Interests
Glioma
Epidemiology
Breast Neoplasms
Central Nervous System Neoplasms
Astrocytoma
Oligodendroglioma
Neurosurgery
Meningioma
Statistics as Topic
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Laura Forastiere, PhD
Associate Professor of Biostatistics; Affiliated Faculty, Yale Institute for Global Health
Research Interests
HIV
Global Health
Health Plan Implementation
Behavioral Sciences
Biostatistics
Causality
Clinical Trial
Social Networking
Observational Study
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Leying Guan
Assistant Professor of Biostatistics (Biostatistics)
Research Interests
Computational Biology
Epigenomics
Gene Regulatory Networks
Genetics
Neurosciences
Immune System Diseases
Machine Learning
Statistics
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Yuan Huang, PhD
Assistant Professor of Biostatistics (Biostatistics)
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Lee Kennedy-Shaffer, PhD
Assistant Professor of Biostatistics
Research Interests
Biostatistics
Communicable Diseases
Data Science
Drug Evaluation
Epidemiologic Methods
Models, Statistical
Regression Analysis
Vaccine-Preventable Diseases
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Shuangge Steven Ma, PhD
Department Chair and Professor of Biostatistics; Affiliated Faculty, Yale Institute for Global Health; Director, Biostatistics and Bioinformatics Shared Resource
Research Interests
Economics
Biostatistics
Neoplasms
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Jeffrey Townsend, PhD
Elihu Professor of Biostatistics and Professor of Ecology and Evolutionary Biology; Co-Leader, Genomics, Genetics, & Epigenetics Research Program
Research Interests
Organisms
Nonlinear Dynamics
Mycoses
Nature
Neoplasm Metastasis
Neoplasms
Molecular Epidemiology
Models, Genetic
Models, Statistical
Models, Theoretical
Microarray Analysis
Microbiological Phenomena
Likelihood Functions
Logistic Models
Mathematical Concepts
Sequence Analysis, DNA
Sequence Analysis, Protein
Phenomena and Processes
Phylogeny
Polymerase Chain Reaction
Public Health Informatics
Host-Pathogen Interactions
Fungi
Gene Expression Profiling
Gene Transfer Techniques
Genetic Engineering
Genetic Phenomena
Genetic Speciation
Evolution, Molecular
Bread
Biological Evolution
Algorithms
Bacteria
Bacterial Infections and Mycoses
Beer
Cell Transformation, Neoplastic
Coccidioidomycosis
Computing Methodologies
Crops, Agricultural
Viruses
Wine
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Zuoheng Anita Wang, PhD
Associate Professor of Biostatistics; Associate Professor, Biomedical Informatics & Data Science
Research Interests
Single-Cell Analysis
Psychiatry
Public Health
Informatics
Mental Health
Machine Learning
Longitudinal Studies
Multiomics
Neurosciences
Data Science
Computational Biology
Biostatistics
Electronic Health Records
Genetics
Genomics
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Joshua Warren, PhD
Associate Professor of Biostatistics
Research Interests
Algorithms
Biostatistics
Disorders of Environmental Origin
Eye Diseases
Pregnancy Complications
Probability
Statistical Distributions
Statistics as Topic
Stochastic Processes
Virus Diseases
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Heping Zhang, PhD
Susan Dwight Bliss Professor of Biostatistics, Professor in the Child Study Center and Professor of Statistics and Data Science, Professor of Obstetrics, Gynecology, and Reproductive Sciences; Affiliated Faculty, Yale Institute for Global Health
Research Interests
Epidemiology
Infertility
Mental Health
Pregnancy
Psychiatry
Computational Biology
Statistics
Genomics
Biostatistics
Child Psychiatry
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Hongyu Zhao, PhD
Ira V. Hiscock Professor of Biostatistics, Professor of Genetics and Professor of Statistics and Data Science
Research Interests
Wearable Electronic Devices
Genetics
Public Health
Computational Biology
Statistics
Genomics
Proteomics
Biostatistics
Single-Cell Analysis
Microbiota
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Yize Zhao, PhD
Associate Professor of Biostatistics
Research Interests
Mental Health
Neuroimaging
Neurodegenerative Diseases
Psychiatry
Electronic Health Records
Genetics
Biomedical Research
Biostatistics
Aging
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Xin Zhou, PhD
Assistant Professor of Biostatistics
Research Interests
Epidemiologic Methods
Research Design
Clinical Trial
Randomized Controlled Trial
Biostatistics
Precision Medicine
Dimensional Measurement Accuracy
Implementation Science
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Centers and other resources

Center for Infectious Disease Modeling and Analytics (CIDMA)CIDMA aims to optimize the effectiveness and cost-effectiveness of vaccination strategies and other health interventions by quantitatively evaluating and informing public health policies.
Center for Interdisciplinary Research on AIDS (CIRA)CIRA provides HIV-related resources, skills, services, training, and professional networking opportunities to HIV researchers and practitioners who can contribute to advances in HIV prevention and treatment.
Center for Methods in Implementation and Prevention Science (CMIPS)CMIPS develops and disseminates innovative methodologic approaches to address implementation gaps and improve public health worldwide.
Center for Outcomes Research & Evaluation (CORE)
Center for Perinatal, Pediatric and Environmental Epidemiology (CPPEE)CPPEE aims, through epidemiologic studies, to investigate the impact of environmental, genetic, and clinical factors on pregnancy, birth, and childhood.
The Center for Precision Pulmonary Medicine (P2MED)The Center for Precision Pulmonary Medicine (P2MED) aims to facilitate the application of precision medicine approaches to pulmonary, critical and sleep medicine.
Center of Excellence in Regulatory Science and Innovation (CERSI)
Ted Cohen LabTed Cohen Lab conducts research that contributes to the global effort to control two infectious diseases of public health importance: tuberculosis (TB) and HIV.
Collaborative Center for Statistics in Science (C²S²)C²S² fosters collaborations involving statistical methods and technology in scientific research, for understanding disease etiologies and developing treatment and prevention strategies.
Family Accommodation Obsessive-Compulsive DisorderFAOCD refers to family members' or significant others’ participation in or facilitation of patients’ rituals and/or avoidance.
Hongyu Zhao Lab - Center for Statistical Genomics and Proteomics
Institution for Social and Policy Studies (ISPS)
Transmission Dynamics of Enteric DiseasesOur research focuses on mathematical modeling of infectious diseases, with a special emphasis on the transmission dynamics of enteric diseases.
Weinberger LabOur research focuses on the mechanisms driving the observed epidemiological patterns of respiratory infections, particularly pneumococcal disease and RSV.
Public Health Modeling UnitMembers of the YSPH Public Health Modeling Unit use mathematical representations of disease spread, healthcare processes, and human behavior to make better public health decisions and predictions.
Yale Center for Analytical Sciences (YCAS)YCAS collaborative team provides expertise in the design, conduct, and analysis of health and health care studies, methodological development, and education and training.
Yale Alzheimer’s Disease Research CenterThe Yale Alzheimer’s Disease Research Center (ADRC) seeks to advance our understanding of Alzheimer’s disease at a cell biological level with the eventual goal of translating laboratory discoveries into novel effective clinical therapies.
Yale Claude D. Pepper Older Americans Independence Center Biostatistics CoreThe primary objective of the Biostatistics Core is to provide state-of-the-art design and analytical services to investigators conducting studies that advance the Yale OAIC theme of multifactorial geriatric conditions.