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Heart Disease and Stroke
Photo credit: Unsplash
Heart Disease and Stroke are leading causes of death and disability in the United States and worldwide. Numerous primary and secondary faculty used rigorous epidemiologic methods to improve our understanding of heart disease and stroke conducting research both nationally and internationally. For example, in the Department of Chronic Disease Epidemiology, the availability of access to large administrative medical claims databases enables researchers to investigate long term trends, patterns of care, and outcomes among elderly patients with heart disease and stroke.
Our research areas include:
- disease trends
- the role of traditional risk factors
- genetics
- biomarkers
- patterns of care
- biological, social, and environmental factors that influence the presentation and outcomes of young women with heart disease
- effect of community-based characteristics on disease rates and outcomes.
Recent Publications
- Epigenetic Changes in Cerebrospinal Fluid and Blood of People with Neurosyphilis.Mostaghimi D, Mehta S, Yoon J, Kosana P, Marra CM, Corley MJ, Farhadian SF. J Infect Dis. 2024 Oct 2; 2024 Oct 2. PMID: 39356164.
- Long-term exposure to wildland fire smoke PM(2.5) and mortality in the contiguous United States.Ma Y, Zang E, Liu Y, Wei J, Lu Y, Krumholz HM, Bell ML, Chen K. Proc Natl Acad Sci U S A. 2024 Oct; 2024 Sep 24. PMID: 39316057.
- Current out of pocket care costs among HIV and hypertension co-morbid patients in urban and peri-urban Uganda.Cameron DB, Morrell LC, Kagoya F, Kiggundu JB, Hutchinson B, Twine R, Schwartz JI, Muddu M, Mutungi G, Kayima J, Katahoire AR, Longenecker CT, Nugent R, Loya DC, Semitala FC. PLOS Glob Public Health. 2024; 2024 Sep 25. PMID: 39321165.
- Incorporating Social Determinants of Health in Infectious Disease Models: A Systematic Review of Guidelines.Ali S, Li Z, Moqueet N, Moghadas SM, Galvani AP, Cooper LA, Stranges S, Haworth-Brockman M, Pinto AD, Asaria M, Champredon D, Hamilton D, Moulin M, John-Baptiste AA. Med Decis Making. 2024 Sep 21; 2024 Sep 21. PMID: 39305116.
- Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study.Friligkou E, Løkhammer S, Cabrera-Mendoza B, Shen J, He J, Deiana G, Zanoaga MD, Asgel Z, Pilcher A, Di Lascio L, Makharashvili A, Koller D, Tylee DS, Pathak GA, Polimanti R. Nat Genet. 2024 Sep 18; 2024 Sep 18. PMID: 39294497.
- Genome-wide association study between SARS-CoV-2 single nucleotide polymorphisms and virus copies during infections.Li K, Chaguza C, Stamp J, Chew YT, Chen NFG, Ferguson D, Pandya S, Kerantzas N, Schulz W, Hahn AM, Ogbunugafor CB, Pitzer VE, Crawford L, Weinberger DM, Grubaugh ND. PLoS Comput Biol. 2024 Sep; 2024 Sep 17. PMID: 39288189.
- Design and implementation of a Type-2 hybrid, prospective randomized trial of opioid agonist therapies integration into primary care clinics in Ukraine.Machavariani E, Dumchev K, Pykalo I, Filippovych M, Ivasiy R, Esserman D, Madden LM, Bromberg DJ, Haddad M, Morozova O, Ahmad B, Gómez DO, Farnum SO, Dvoriak S, Altice FL. Contemp Clin Trials. 2024 Sep 14; 2024 Sep 14. PMID: 39265780.
- Antecedent and persistent symptoms in COVID-19 and other respiratory illnesses: Insights from prospectively collected data in the BRACE trial.McDon Ald E, Pittet LF, Barry SE, Bonten M, Campbell J, Croda J, Croda MG, Dalcolmo MP, Davidson A, de Almeida E Val FF, Dos Santos G, Gardiner K, Gell G, Gwee A, Krastev A, Lacerda MVG, Lucas M, Lynn DJ, Manning L, McPhate N, Perrett KP, Post JJ, Prat-Aymerich C, Quinn LE, Richmond PC, Wood NJ, Messina NL, Curtis N. J Infect. 2024 Sep 6; 2024 Sep 6. PMID: 39245151.
- Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases.Kalizang'oma A, Richard D, Kwambana-Adams B, Coelho J, Broughton K, Pichon B, Hopkins KL, Chalker V, Beleza S, Bentley SD, Chaguza C, Heyderman RS. Nat Commun. 2024 Sep 6; 2024 Sep 6. PMID: 39242612.
- Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.Ding E, Deng F, Fang J, Liu J, Yan W, Yao Q, Miao K, Wang Y, Sun P, Li C, Liu Y, Dong H, Dong L, Zhang X, Lu Y, Lin X, Ding C, Li T, Shi Y, Cai Y, Liu X, Godri Pollitt KJ, Ji JS, Tong S, Tang S, Shi X. Environ Health Perspect. 2024 Sep; 2024 Sep 6. PMID: 39240788.
- Genomic Landscape of Osteosarcoma of Bone in an Older-Aged Patient Population and Analysis of Possible Etiologies Based on Molecular Signature.Kaseb H, Tan C, Townsend JP, Costa J, Laskin WB. Genet Test Mol Biomarkers. 2024 Sep; 2024 Jul 25. PMID: 39052504.
- Multimodal fusion learning for long QT syndrome pathogenic genotypes in a racially diverse population.Jiang J, Thi Vy HM, Charney A, Kovatch P, Reddy V, Jayaraman P, Do R, Khera R, Chugh S, Bhatt DL, Vaid A, Lampert J, Nadkarni GN. NPJ Digit Med. 2024 Aug 24; 2024 Aug 24. PMID: 39181999.
- Vaccination to Prevent Lyme Disease: A Movement Towards Anti-Tick Approaches.Johnson EE, Hart TM, Fikrig E. J Infect Dis. 2024 Aug 14. PMID: 39140718.
- The amalgam of naive CD4(+) T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response.Even Z, Meli AP, Tyagi A, Vidyarthi A, Briggs N, de Kouchkovsky DA, Kong Y, Wang Y, Waizman DA, Rice TA, De Kumar B, Wang X, Palm NW, Craft J, Basu MK, Ghosh S, Rothlin CV. Immunity. 2024 Aug 13; 2024 Aug 2. PMID: 39096910.
- WHO global research priorities for antimicrobial resistance in human health.Bertagnolio S, Dobreva Z, Centner CM, Olaru ID, Donà D, Burzo S, Huttner BD, Chaillon A, Gebreselassie N, Wi T, Hasso-Agopsowicz M, Allegranzi B, Sati H, Ivanovska V, Kothari KU, Balkhy HH, Cassini A, Hamers RL, Weezenbeek KV. Lancet Microbe. 2024 Aug 12; 2024 Aug 12. PMID: 39146948.
- Disruption of outdoor activities caused by wildfires increases disease circulation.Arregui-Garcıa B, Ascione C, Pera A, Wang B, Stocco D, Carlson CJ, Bansal S, Valdano E, Pullano G. medRxiv. 2024 Aug 9; 2024 Aug 9. PMID: 39148844.
- Upper respiratory Streptococcus pneumoniae colonization among working-age adults with prevalent exposure to overcrowding.Parker AM, Jackson N, Awasthi S, Kim H, Alwan T, Wyllie AL, Kogut K, Holland N, Mora AM, Eskenazi B, Riley LW, Lewnard JA. Microbiol Spectr. 2024 Aug 6; 2024 Jul 16. PMID: 39012111.
- SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity.Peña-Hernández MA, Alfajaro MM, Filler RB, Moriyama M, Keeler EL, Ranglin ZE, Kong Y, Mao T, Menasche BL, Mankowski MC, Zhao Z, Vogels CBF, Hahn AM, Kalinich CC, Zhang S, Huston N, Wan H, Araujo-Tavares R, Lindenbach BD, Homer R, Pyle AM, Martinez DR, Grubaugh ND, Israelow B, Iwasaki A, Wilen CB. Nat Microbiol. 2024 Aug; 2024 Jul 29. PMID: 39075235.
- Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study.Dyson ZA, Ashton PM, Khanam F, Chunga Chirambo A, Shakya M, Meiring JE, Tonks S, Karkey A, Msefula C, Clemens JD, Dunstan SJ, Baker S, Dougan G, Pitzer VE, Basnyat B, Qadri F, Heyderman RS, Gordon MA, Pollard AJ, Holt KE. Lancet Microbe. 2024 Aug; 2024 Jul 9. PMID: 38996496.
- Liver epigenomic signature associated with chronic oxidative stress in a mouse model of glutathione deficiency.Hong SH, Yu X, Zhu Y, Chen Y. Chem Biol Interact. 2024 Aug 1; 2024 Jun 1. PMID: 38830566.
- An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms.Hart TM, Sonnert ND, Tang X, Chaurasia R, Allen PE, Hunt JR, Read CB, Johnson EE, Arora G, Dai Y, Cui Y, Chuang YM, Yu Q, Rahman MS, Mendes MT, Rolandelli A, Singh P, Tripathi AK, Ben Mamoun C, Caimano MJ, Radolf JD, Lin YP, Fingerle V, Margos G, Pal U, Johnson RM, Pedra JHF, Azad AF, Salje J, Dimopoulos G, Vinetz JM, Carlyon JA, Palm NW, Fikrig E, Ring AM. Cell. 2024 Jul 25; 2024 Jun 13. PMID: 38876107.
- Cost per episode of diarrhea and respiratory syncytial virus (RSV) in 128 low- and middle-income countries: how well do disease-specific and WHO-CHOICE estimates align?Li X, Bilcke J, Asare EO, Wenger C, Kwon J, Bont L, Beutels P, Pitzer VE. medRxiv. 2024 Jul 17; 2024 Jul 17. PMID: 39072019.
- Two decades of molecular surveillance in Senegal reveal rapid changes in known drug resistance mutations over time.Ndiaye YD, Wong W, Thwing J, Schaffner SF, Brenneman KV, Tine A, Diallo MA, Deme AB, Sy M, Bei AK, Thiaw AB, Daniels R, Ndiaye T, Gaye A, Ndiaye IM, Toure M, Gadiaga N, Sene A, Sow D, Garba MN, Yade MS, Dieye B, Diongue K, Zoumarou D, Ndiaye A, Gomis JF, Fall FB, Ndiop M, Diallo I, Sene D, Macinnis B, Seck MC, Ndiaye M, Ngom B, Diedhiou Y, Mbaye AM, Ndiaye L, Sy N, Badiane AS, Hartl DL, Wirth DF, Volkman SK, Ndiaye D. Malar J. 2024 Jul 9; 2024 Jul 9. PMID: 38982475.
- Interactions between respiratory syncytial virus and Streptococcus pneumoniae in the pathogenesis of childhood respiratory infections: a systematic review.Besteman SB, Bogaert D, Bont L, Mejias A, Ramilo O, Weinberger DM, Dagan R. Lancet Respir Med. 2024 Jul 8; 2024 Jul 8. PMID: 38991585.
- Efficient deep learning-based automated diagnosis from echocardiography with contrastive self-supervised learning.Holste G, Oikonomou EK, Mortazavi BJ, Wang Z, Khera R. Commun Med (Lond). 2024 Jul 6; 2024 Jul 6. PMID: 38971887.
- e3SIM: epidemiological-ecological-evolutionary simulation framework for genomic epidemiology.Xu P, Liang S, Hahn A, Zhao V, Lo WT', Haller BC, Sobkowiak B, Chitwood MH, Colijn C, Cohen T, Rhee KY, Messer PW, Wells MT, Clark AG, Kim J. bioRxiv. 2024 Jul 2; 2024 Jul 2. PMID: 39005464.
- Beyond "business as usual": lessons from FIFA for fair benefit-sharing in global health.Wahl B, Butin G, Gombe S, Demiray A, Schwalbe N. Health Aff Sch. 2024 Jul; 2024 May 15. PMID: 39050554.
- SHEA position statement on pandemic preparedness for policymakers: introduction and overview.Hsu VP, Haessler S, Banach DB, Batshon LJ, Branch-Elliman W, Dumyati G, Jump RLP, Malani AN, Mathew TA, Murthy RK, Pergam SA, Shenoy ES, Weber DJ. Infect Control Hosp Epidemiol. 2024 Jul; 2024 Jun 5. PMID: 38835222.
- DNA methylation-based telomere length is associated with HIV infection, physical frailty, cancer, and all-cause mortality.Liang X, Aouizerat BE, So-Armah K, Cohen MH, Marconi VC, Xu K, Justice AC. Aging Cell. 2024 Jul; 2024 Apr 17. PMID: 38629454.
- Performance of contemporary cardiovascular risk stratification scores in Brazil: an evaluation in the ELSA-Brasil study.Pedroso Camargos A, Barreto S, Brant L, Ribeiro ALP, Dhingra LS, Aminorroaya A, Bittencourt M, Figueiredo RC, Khera R. Open Heart. 2024 Jun 11; 2024 Jun 11. PMID: 38862252.
- Generating the evidence to support the establishment of a Respiratory Syncytial Virus surveillance system in Cameroon: A study protocol.Njuma Libwea J, Esso L, Njoh AA, Ngwa CH, Ngomba Armelle V, Bilounga Ndongo C, Etoundi Mballa GA, Nwaru BI, Weinberger D, Njouom R, Koulla-Shiro S. PLoS One. 2024; 2024 Jun 11. PMID: 38861519.
- Long-term exposure to wildland fire smoke PM(2.5) and mortality in the contiguous United States.Ma Y, Zang E, Liu Y, Wei J, Lu Y, Krumholz HM, Bell ML, Chen K. medRxiv. 2024 Jun 11; 2024 Jun 11. PMID: 36778437.
- Evolutionary druggability for low-dimensional fitness landscapes toward new metrics for antimicrobial applications.Guerrero RF, Dorji T, Harris RM, Shoulders MD, Ogbunugafor CB. Elife. 2024 Jun 4; 2024 Jun 4. PMID: 38833384.
- Study Protocol for the Artificial Intelligence-Driven Evaluation of Structural Heart Diseases Using Wearable Electrocardiogram (ID-SHD).Aminorroaya A, Dhingra LS, Camargos AP, Shankar SV, Khunte A, Sangha V, Sen S, McNamara RL, Haynes N, Oikonomou EK, Khera R. medRxiv. 2024 Jun 3; 2024 Jun 3. PMID: 38562867.
- Acute Cardiac Events in Hospitalized Older Adults With Respiratory Syncytial Virus Infection.Woodruff RC, Melgar M, Pham H, Sperling LS, Loustalot F, Kirley PD, Austin E, Yousey-Hindes K, Openo KP, Ryan P, Brown C, Lynfield R, Davis SS, Barney G, Tesini B, Sutton M, Talbot HK, Zahid H, Kim L, Havers FP. JAMA Intern Med. 2024 Jun 1. PMID: 38619857.
- Trajectories of Purpose in Life Across Diagnosis of Alzheimer's Disease or Related Dementias in Older Adulthood.Mroz EL, Collette T, Keefe K, Gil H, Monin J, Sharma S. J Aging Health. 2024 May 30; 2024 May 30. PMID: 38816276.
- Catastrophic Floods in Rio Grande do Sul, Brazil: The Need for Public Health Responses to Potential Infectious Disease Outbreaks.Martins-Filho PR, Croda J, Araújo AAS, Correia D, Quintans-Júnior LJ. Rev Soc Bras Med Trop. 2024; 2024 May 27. PMID: 38808800.
- Factors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil.de Oliveira D, Khalil H, Almerinda G Palma F, Santana R, Nery N Jr, C Quintero-Vélez J, Zeppelini CG, Almeida do Sacramento G, Cruz JS, Lustosa R, Santana Ferreira I, Carvalho-Pereira T, Diggle PJ, Wunder EA Jr, I Ko A, Alzate Lopez Y, Begon M, G Reis M, Costa F. PLoS Negl Trop Dis. 2024 May; 2024 May 17. PMID: 38758957.
- An update on clinical presentation and responses to therapy of patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH).Zhu Z, Bo-Ran Ho B, Chen A, Amrhein J, Apetrei A, Carpenter TO, Lazaretti-Castro M, Colazo JM, McCrystal Dahir K, Geßner M, Gurevich E, Heier CA, Simmons JH, Hunley TE, Hoppe B, Jacobsen C, Kouri A, Ma N, Majumdar S, Molin A, Nokoff N, Ott SM, Peña HG, Santos F, Tebben P, Topor LS, Deng Y, Bergwitz C. Kidney Int. 2024 May; 2024 Feb 15. PMID: 38364990.
- High prevalence of impaired glucose metabolism among children and adolescents living with HIV in Ghana.Ayanful-Torgby R, Shabanova V, Essuman AA, Boafo E, Aboagye F, Al-Mahroof Y, Amponsah J, Tetteh JKA, Amoah LE, Paintsil E. HIV Med. 2024 May; 2024 Jan 19. PMID: 38240173.
- The full value of immunisation against respiratory syncytial virus for infants younger than 1 year: effects beyond prevention of acute respiratory illness.Feikin DR, Karron RA, Saha SK, Sparrow E, Srikantiah P, Weinberger DM, Zar HJ. Lancet Infect Dis. 2024 May; 2023 Nov 21. PMID: 38000374.
- IgG Isotypes Targeting a Recombinant Chimeric Protein of Trypanosoma cruzi in Different Clinical Presentations of Chronic Chagas Disease.Serrano IM, Ribeiro G, Santos RS, Cruz JS, Lanza FC, Santos EFD, Almeida MC, Soares JFS, Luquetti AO, Celedon PAF, Zanchin NIT, Santos FLN, Reis MGD. Am J Trop Med Hyg. 2024 Apr 3; 2024 Feb 27. PMID: 38412539.
- Biometric contrastive learning for data-efficient deep learning from electrocardiographic images.Sangha V, Khunte A, Holste G, Mortazavi BJ, Wang Z, Oikonomou EK, Khera R. J Am Med Inform Assoc. 2024 Apr 3. PMID: 38269618.
- Statistical methods for assessing the effects of de novo variants on birth defects.Xie Y, Wu R, Li H, Dong W, Zhou G, Zhao H. Hum Genomics. 2024 Mar 14; 2024 Mar 14. PMID: 38486307.
- CRB1-associated retinal degeneration is dependent on bacterial translocation from the gut.Peng S, Li JJ, Song W, Li Y, Zeng L, Liang Q, Wen X, Shang H, Liu K, Peng P, Xue W, Zou B, Yang L, Liang J, Zhang Z, Guo S, Chen T, Li W, Jin M, Xing XB, Wan P, Liu C, Lin H, Wei H, Lee RWJ, Zhang F, Wei L. Cell. 2024 Mar 14; 2024 Feb 26. PMID: 38412859.
- Computationally inferred cell-type specific epigenome-wide DNA methylation analysis unveils distinct methylation patterns among immune cells for HIV infection in three cohorts.Zhang X, Hu Y, Vandenhoudt RE, Yan C, Marconi VC, Cohen MH, Wang Z, Justice AC, Aouizerat BE, Xu K. PLoS Pathog. 2024 Mar; 2024 Mar 11. PMID: 38466776.
- Sex and HIV Differences in Preserved Ratio Impaired Spirometry (PRISm) Among Ugandans Postpneumonia.Abelman RA, Fitzpatrick J, Byanova KL, Zawedde J, Sanyu I, Byanyima P, Musisi E, Hsieh J, Zhang M, Branchini J, Sessolo A, Hunt PW, Lalitha R, Davis JL, Crothers K, Worodria W, Huang L. Open Forum Infect Dis. 2024 Mar; 2024 Jan 22. PMID: 38456193.
- Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan.Gaffey AE, Spatz ES. Curr Atheroscler Rep. 2024 Mar; 2024 Jan 19. PMID: 38240928.
- The role of viral interference in shaping RSV epidemics following the 2009 H1N1 influenza pandemic.Li K, Thindwa D, Weinberger DM, Pitzer VE. medRxiv. 2024 Feb 27; 2024 Feb 27. PMID: 38464193.
- Enduring Injustice: Infectious Disease Outbreaks in Carceral Settings.Andrews JR, Liu YE, Croda J. J Infect Dis. 2024 Feb 14. PMID: 37493282.
- Contribution of climate change to the spatial expansion of West Nile virus in Europe.Erazo D, Grant L, Ghisbain G, Marini G, Colón-González FJ, Wint W, Rizzoli A, Van Bortel W, Vogels CBF, Grubaugh ND, Mengel M, Frieler K, Thiery W, Dellicour S. Nat Commun. 2024 Feb 8; 2024 Feb 8. PMID: 38331945.
- Assessing heterogeneity of patient and health system delay among TB in a population with internal migrants in China.Sun R, Wu Z, Zhang H, Huang J, Liu Y, Chen M, Lv Y, Zhao F, Zhang Y, Li M, Yan J, Jiang H, Zhan Y, Xu J, Xu Y, Yuan J, Zhao Y, Shen X, Yang C. Front Public Health. 2024; 2024 Feb 2. PMID: 38371243.
- Modelling counterfactual incidence during the transition towards culture-independent diagnostic testing.Healy JM, Ray L, Tack DM, Eikmeier D, Tobin-D'Angelo M, Wilson E, Hurd S, Lathrop S, McGuire SM, Bruce BB. Int J Epidemiol. 2024 Feb 1. PMID: 37820050.
- When Direct Oral Anticoagulants Should Not Be Standard Treatment: JACC State-of-the-Art Review.Bejjani A, Khairani CD, Assi A, Piazza G, Sadeghipour P, Talasaz AH, Fanikos J, Connors JM, Siegal DM, Barnes GD, Martin KA, Angiolillo DJ, Kleindorfer D, Monreal M, Jimenez D, Middeldorp S, Elkind MSV, Ruff CT, Goldhaber SZ, Krumholz HM, Mehran R, Cushman M, Eikelboom JW, Lip GYH, Weitz JI, Lopes RD, Bikdeli B. J Am Coll Cardiol. 2024 Jan 23. PMID: 38233019.
- Eco-epidemiological study of seropositivity against Rickettsia and Leptospira agents in rural areas of Urabá, Colombia.Torres-Bustamante M, Cantillo-Barraza O, Ko AI, Wunder EA, Quintero-Vélez JC. Res Sq. 2024 Jan 4; 2024 Jan 4. PMID: 38260656.
- Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer.Jiang T, Zheng J, Li N, Li X, He J, Zhou J, Sun B, Chi Q. Curr Gene Ther. 2024. PMID: 38682449.
- Immune Control in Repeated Babesia microti Infection in a Patient With B-Cell Deficiency.Little JS, Oakley MS, Thorner AR, Johnston D, Majam V, Liakos AD, Novack LA, Zheng H, Meredith S, Chou CK, Newton BR, Soiffer RJ, Krause PJ, Baden LR, Kumar S. Open Forum Infect Dis. 2024 Jan; 2023 Nov 13. PMID: 38213635.
- Seasonality of endemic COVID-19.Townsend JP, Hassler HB, Lamb AD, Sah P, Alvarez Nishio A, Nguyen C, Tew AD, Galvani AP, Dornburg A. mBio. 2023 Dec 19; 2023 Nov 8. PMID: 37937979.
- Typhoid fever.Meiring JE, Khanam F, Basnyat B, Charles RC, Crump JA, Debellut F, Holt KE, Kariuki S, Mugisha E, Neuzil KM, Parry CM, Pitzer VE, Pollard AJ, Qadri F, Gordon MA. Nat Rev Dis Primers. 2023 Dec 14; 2023 Dec 14. PMID: 38097589.
- The population-level impact of Enterococcus faecalis genetics on intestinal colonization and extraintestinal infection.Chaguza C, Pöntinen AK, Top J, Arredondo-Alonso S, Freitas AR, Novais C, Torres C, Bentley SD, Peixe L, Coque TM, Willems RJL, Corander J. Microbiol Spectr. 2023 Dec 12; 2023 Oct 9. PMID: 37811975.
- Self-care and healthcare seeking practices among patients with hypertension and diabetes in rural Uganda.Tusubira AK, Ssinabulya I, Kalyesubula R, Nalwadda CK, Akiteng AR, Ngaruiya C, Rabin TL, Katahoire A, Armstrong-Hough M, Hsieh E, Hawley NL, Schwartz JI. PLOS Glob Public Health. 2023; 2023 Dec 11. PMID: 38079386.
- Leptospirosis seroprevalence and risk factors among slaughterhouse workers in Burkina Faso.Zida S, Ouédraogo HG, Compaoré TR, Sagna T, Soubeiga ST, Banhoro BY, Zouré AA, Kambiré D, Dicko A, Wunder EA Jr, Kouanda S. IJID Reg. 2023 Dec; 2023 Oct 30. PMID: 38074946.
- Lysinoalanine cross-linking is a conserved post-translational modification in the spirochete flagellar hook.Lynch MJ, Deshpande M, Kurniyati K, Zhang K, James M, Miller M, Zhang S, Passalia FJ, Wunder EA Jr, Charon NW, Li C, Crane BR. PNAS Nexus. 2023 Dec; 2023 Oct 26. PMID: 38047041.
- Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations.Zhao S, Mekbib KY, van der Ent MA, Allington G, Prendergast A, Chau JE, Smith H, Shohfi J, Ocken J, Duran D, Furey CG, Hao LT, Duy PQ, Reeves BC, Zhang J, Nelson-Williams C, Chen D, Li B, Nottoli T, Bai S, Rolle M, Zeng X, Dong W, Fu PY, Wang YC, Mane S, Piwowarczyk P, Fehnel KP, See AP, Iskandar BJ, Aagaard-Kienitz B, Moyer QJ, Dennis E, Kiziltug E, Kundishora AJ, DeSpenza T Jr, Greenberg ABW, Kidanemariam SM, Hale AT, Johnston JM, Jackson EM, Storm PB, Lang SS, Butler WE, Carter BS, Chapman P, Stapleton CJ, Patel AB, Rodesch G, Smajda S, Berenstein A, Barak T, Erson-Omay EZ, Zhao H, Moreno-De-Luca A, Proctor MR, Smith ER, Orbach DB, Alper SL, Nicoli S, Boggon TJ, Lifton RP, Gunel M, King PD, Jin SC, Kahle KT. Nat Commun. 2023 Nov 17; 2023 Nov 17. PMID: 37978175.
- Introduction of the ectoparasite Rhipicephalus pulchellus (Ixodida: Ixodidae) into Connecticut with a human traveler from Tanzania, and a review of its importation records into the United States.Stafford KC 3rd, Molaei G, Williams SC, Mertins JW. J Med Entomol. 2023 Nov 14. PMID: 37963278.
- Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis.Lawler PR, Manvelian G, Coppi A, Damask A, Cantor MN, Ferreira MAR, Paulding C, Banerjee N, Li D, Jorgensen S, Attre R, Carey DJ, Krebs K, Milani L, Hveem K, Damås JK, Solligård E, Stender S, Tybjærg-Hansen A, Nordestgaard BG, Hernandez-Beeftink T, Rogne T, Flores C, Villar J, Walley KR, Liu VX, Fohner AE, Lotta LA, Kyratsous CA, Sleeman MW, Scemama M, DelGizzi R, Pordy R, Horowitz JE, Baras A, Martin GS, Steg PG, Schwartz GG, Szarek M, Goodman SG. Crit Care Explor. 2023 Nov; 2023 Nov 8. PMID: 37954898.
- Machine learning-based cluster analysis of immune cell subtypes and breast cancer survival.Wang Z, Katsaros D, Wang J, Biglio N, Hernandez BY, Fei P, Lu L, Risch H, Yu H. Sci Rep. 2023 Nov 3; 2023 Nov 3. PMID: 37923775.
- Distinguishing features of long COVID identified through immune profiling.Klein J, Wood J, Jaycox JR, Dhodapkar RM, Lu P, Gehlhausen JR, Tabachnikova A, Greene K, Tabacof L, Malik AA, Silva Monteiro V, Silva J, Kamath K, Zhang M, Dhal A, Ott IM, Valle G, Peña-Hernández M, Mao T, Bhattacharjee B, Takahashi T, Lucas C, Song E, McCarthy D, Breyman E, Tosto-Mancuso J, Dai Y, Perotti E, Akduman K, Tzeng TJ, Xu L, Geraghty AC, Monje M, Yildirim I, Shon J, Medzhitov R, Lutchmansingh D, Possick JD, Kaminski N, Omer SB, Krumholz HM, Guan L, Dela Cruz CS, van Dijk D, Ring AM, Putrino D, Iwasaki A. Nature. 2023 Nov; 2023 Sep 25. PMID: 37748514.
- Daily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM 2.5 Oxidative Potential on Observed Associations Across Canada.Weichenthal S, Lavigne E, You H, Pollitt K, Shin T, Kulka R, Stieb DM, Hatzopoulou M, Evans G, Burnett RT. Epidemiology. 2023 Nov 1; 2023 Sep 26. PMID: 37732880.
- Comparison of acarological risk metrics derived from active and passive surveillance and their concordance with tick-borne disease incidence.Holcomb KM, Khalil N, Cozens DW, Cantoni JL, Brackney DE, Linske MA, Williams SC, Molaei G, Eisen RJ. Ticks Tick Borne Dis. 2023 Nov; 2023 Aug 21. PMID: 37611506.
- Environmental Biofilms from an Urban Community in Salvador, Brazil, Shelter Previously Uncharacterized Saprophytic Leptospira.Dos Santos Ribeiro P, Carvalho NB, Aburjaile F, Sousa T, Veríssimo G, Gomes T, Neves F, Blanco L, Lima JA, de Oliveira D, Jaiswal AK, Brenig B, Soares S, Ramos R, Matiuzzi M, Góes-Neto A, Figueira CP, Costa F, Ristow P, Azevedo V. Microb Ecol. 2023 Nov; 2023 Jun 16. PMID: 37326636.
- Transfusion-transmitted Babesia spp.: a changing landscape of epidemiology, regulation, and risk mitigation.Drews SJ, Kjemtrup AM, Krause PJ, Lambert G, Leiby DA, Lewin A, O'Brien SF, Renaud C, Tonnetti L, Bloch EM. J Clin Microbiol. 2023 Oct 24; 2023 Sep 26. PMID: 37750699.
- A ticking time bomb hidden in plain sight.Narasimhan S, Fish D, Pedra JHF, Pal U, Fikrig E. Sci Transl Med. 2023 Oct 18; 2023 Oct 18. PMID: 37851823.
- Leishmania major-derived lipophosphoglycan influences the host's early immune response by inducing platelet activation and DKK1 production via TLR1/2.Ihedioha OC, Sivakoses A, Beverley SM, McMahon-Pratt D, Bothwell ALM. Front Immunol. 2023; 2023 Oct 11. PMID: 37885890.
- The potential of saliva as an accessible and sensitive sample type for the detection of respiratory pathogens and host immunity.Laxton CS, Peno C, Hahn AM, Allicock OM, Perniciaro S, Wyllie AL. Lancet Microbe. 2023 Oct; 2023 Jul 26. PMID: 37516121.
- Biometric Contrastive Learning for Data-Efficient Deep Learning from Electrocardiographic Images.Sangha V, Khunte A, Holste G, Mortazavi BJ, Wang Z, Oikonomou EK, Khera R. medRxiv. 2023 Sep 14; 2023 Sep 14. PMID: 37745527.
- Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications.Guerrero RF, Dorji T, Harris RM, Shoulders MD, Ogbunugafor CB. bioRxiv. 2023 Sep 6; 2023 Sep 6. PMID: 37066376.
- Respiratory pandemic preparedness learnings from the June 2020 COVID-19 outbreak at San Quentin California State Prison.Kwan A, Sklar R, Cameron DB, Schell RC, Bertozzi SM, McCoy SI, Williams B, Sears DA. Int J Prison Health. 2023 Sep 5; 2022 Jun 10. PMID: 35678718.
- Use of Smart Devices to Track Cardiovascular Health Goals in the United States.Aminorroaya A, Dhingra LS, Nargesi AA, Oikonomou EK, Krumholz HM, Khera R. JACC Adv. 2023 Sep; 2023 Aug 8. PMID: 38094515.
- Race, Healthcare, and Health Disparities: A Critical Review and Recommendations for Advancing Health Equity.Macias-Konstantopoulos WL, Collins KA, Diaz R, Duber HC, Edwards CD, Hsu AP, Ranney ML, Riviello RJ, Wettstein ZS, Sachs CJ. West J Emerg Med. 2023 Sep. PMID: 37788031.
- Microbiota in disease-transmitting vectors.Wang J, Gao L, Aksoy S. Nat Rev Microbiol. 2023 Sep; 2023 May 22. PMID: 37217793.
- Erectile Dysfunction in a U.S. National Sample of Male Military Veterans.Way BM, Griffin KR, Kraus SW, Tsai J, Pietrzak RH. Mil Med. 2023 Aug 29. PMID: 35792506.
- Gestational age at birth and hospitalisations for infections among individuals aged 0-50 years in Norway: a longitudinal, register-based, cohort study.Nilsen SM, Valand J, Rogne T, Asheim A, Yin W, Metsälä J, Opdahl S, Døllner H, Damås JK, Kajantie E, Solligård E, Sandin S, Risnes K. EClinicalMedicine. 2023 Aug; 2023 Jul 20. PMID: 37538542.
- MPL36, a major plasminogen (PLG) receptor in pathogenic Leptospira, has an essential role during infection.Zhu W, Passalia FJ, Hamond C, Abe CM, Ko AI, Barbosa AS, Wunder EA Jr. PLoS Pathog. 2023 Jul; 2023 Jul 24. PMID: 37486929.
- Epidemiological connectivity between humans and animals across an urban landscape.Hassell JM, Muloi DM, VanderWaal KL, Ward MJ, Bettridge J, Gitahi N, Ouko T, Imboma T, Akoko J, Karani M, Muinde P, Nakamura Y, Alumasa L, Furmaga E, Kaitho T, Amanya F, Ogendo A, Fava F, Wee BA, Phan H, Kiiru J, Kang'ethe E, Kariuki S, Robinson T, Begon M, Woolhouse MEJ, Fèvre EM. Proc Natl Acad Sci U S A. 2023 Jul 18; 2023 Jul 14. PMID: 37450494.
- Dog ownership may promote cardiometabolic health in U.S. military veterans.Woodward SH, Baldassarri SR, Pietrzak RH. Sci Rep. 2023 Jul 8; 2023 Jul 8. PMID: 37422586.
- Meteorological associations of Vibrio vulnificus clinical infections in tropical settings: Correlations with air pressure, wind speed, and temperature.Ayala AJ, Kabengele K, Almagro-Moreno S, Ogbunugafor CB. PLoS Negl Trop Dis. 2023 Jul; 2023 Jul 6. PMID: 37410780.
- EVIDENCE OF PROTOZOAN AND BACTERIAL INFECTION AND CO-INFECTION AND PARTIAL BLOOD FEEDING IN THE INVASIVE TICK HAEMAPHYSALIS LONGICORNIS IN PENNSYLVANIA.Price KJ, Khalil N, Witmier BJ, Coder BL, Boyer CN, Foster E, Eisen RJ, Molaei G. J Parasitol. 2023 Jul 1. PMID: 37436911.
- Evolution and assembly of Anopheles aquasalis's immune genes: primary malaria vector of coastal Central and South America and the Caribbean Islands.Prado Sepulveda CC, Alencar RM, Santana RA, Belém de Souza I, D'Elia GMA, Godoy RSM, Duarte AP, Lopes SCP, de Lacerda MVG, Monteiro WM, Nacif-Pimenta R, Secundino NFC, Koerich LB, Pimenta PFP. Open Biol. 2023 Jul; 2023 Jul 12. PMID: 37433331.
- The Sordariomycetes: an expanding resource with Big Data for mining in evolutionary genomics and transcriptomics.Wang Z, Kim W, Wang YW, Yakubovich E, Dong C, Trail F, Townsend JP, Yarden O. Front Fungal Biol. 2023; 2023 Jun 30. PMID: 37746130.
- Association of Beta-Blocker Therapy With Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease.Godoy LC, Farkouh ME, Austin PC, Shah BR, Qiu F, Jackevicius CA, Wijeysundera HC, Krumholz HM, Ko DT. J Am Coll Cardiol. 2023 Jun 20. PMID: 37316110.
- Development of an amplicon-based sequencing approach in response to the global emergence of mpox.Chen NFG, Chaguza C, Gagne L, Doucette M, Smole S, Buzby E, Hall J, Ash S, Harrington R, Cofsky S, Clancy S, Kapsak CJ, Sevinsky J, Libuit K, Park DJ, Hemarajata P, Garrigues JM, Green NM, Sierra-Patev S, Carpenter-Azevedo K, Huard RC, Pearson C, Incekara K, Nishimura C, Huang JP, Gagnon E, Reever E, Razeq J, Muyombwe A, Borges V, Ferreira R, Sobral D, Duarte S, Santos D, Vieira L, Gomes JP, Aquino C, Savino IM, Felton K, Bajwa M, Hayward N, Miller H, Naumann A, Allman R, Greer N, Fall A, Mostafa HH, McHugh MP, Maloney DM, Dewar R, Kenicer J, Parker A, Mathers K, Wild J, Cotton S, Templeton KE, Churchwell G, Lee PA, Pedrosa M, McGruder B, Schmedes S, Plumb MR, Wang X, Barcellos RB, Godinho FMS, Salvato RS, Ceniseros A, Breban MI, Grubaugh ND, Gallagher GR, Vogels CBF. PLoS Biol. 2023 Jun; 2023 Jun 13. PMID: 37310918.
- Quantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients.Kwan JM, Arbune A, Henry ML, Hu R, Wei W, Nguyen V, Lee S, Lopez-Mattei J, Guha A, Huber S, Bader AS, Meadows J, Sinusas A, Mojibian H, Peters D, Lustberg M, Hull S, Baldassarre LA. PLoS One. 2023; 2023 May 30. PMID: 37252927.
- Excess Mortality and Years of Potential Life Lost Among the Black Population in the US, 1999-2020.Caraballo C, Massey DS, Ndumele CD, Haywood T, Kaleem S, King T, Liu Y, Lu Y, Nunez-Smith M, Taylor HA, Watson KE, Herrin J, Yancy CW, Faust JS, Krumholz HM. JAMA. 2023 May 16. PMID: 37191702.
- Adaptation of Nontypeable Haemophilus influenzae in Human Airways in COPD: Genome Rearrangements and Modulation of Expression of HMW1 and HMW2.Murphy TF, Kirkham C, D'Mello A, Sethi S, Pettigrew MM, Tettelin H. mBio. 2023 Apr 25; 2023 Mar 16. PMID: 36927061.
- Factors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil.de Oliveira D, Khalil H, Palma FAG, Santana R, Nery N Jr, Quintero-Vélez JC, Zeppelini CG, do Sacramento GA, Cruz J, Lustosa R, Ferreira IS, Carvalho-Pereira T, Diggle PJ, Wunder EA Jr, Ko AI, Lopez YA, Begon M, Reis MG, Costa F. medRxiv. 2023 Apr 11; 2023 Apr 11. PMID: 37090569.
- Human Borrelia miyamotoi Infection in North America.Burde J, Bloch EM, Kelly JR, Krause PJ. Pathogens. 2023 Apr 3; 2023 Apr 3. PMID: 37111439.
- Association of Upper Respiratory Streptococcus pneumoniae Colonization With Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Adults.Parker AM, Jackson N, Awasthi S, Kim H, Alwan T, Wyllie AL, Baldwin AB, Brennick NB, Moehle EA, Giannikopoulos P, Kogut K, Holland N, Mora-Wyrobek A, Eskenazi B, Riley LW, Lewnard JA. Clin Infect Dis. 2023 Apr 3. PMID: 36401872.
- The COVID-19 pandemic as an opportunity for unravelling the causative association between respiratory viruses and pneumococcus-associated disease in young children: a prospective study.Dagan R, van der Beek BA, Ben-Shimol S, Greenberg D, Shemer-Avni Y, Weinberger DM, Danino D. EBioMedicine. 2023 Apr; 2023 Feb 28. PMID: 36857965.
- Transmission modeling to infer tuberculosis incidence prevalence and mortality in settings with generalized HIV epidemics.Dodd PJ, Shaweno D, Ku CC, Glaziou P, Pretorius C, Hayes RJ, MacPherson P, Cohen T, Ayles H. Nat Commun. 2023 Mar 24; 2023 Mar 24. PMID: 36964130.
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Centers and other resources
- Becoming Breastfeeding Friendly (BBF): A Guide to Global Scale UpThis evidence-informed initiative is designed to help countries identify the strength of their breastfeeding-friendly environment and to improve breastfeeding policies and programs.
- Center for Neuroepidemiology and Clinical Neurological Research (CNE2)CNE2 is comprised of researchers across Yale schools who have common and complementary research and methodological interests in clinical neurological research.
- Community Alliance for Research and Engagement (CARE)CARE promotes the prevention of chronic diseases by focusing on social, environmental, and behavioral risk factors.
- Samoan Obesity, lifestyle and Genetic Adaptations Study Group (OLAGA)OLAGA study group aims to understand the origins of obesity among Samoans and other Pacific Islanders to develop relevant interventions to reduce obesity and obesity-related conditions.
- Yale Cancer Center (YCC)The Center provides the best approaches for the prevention, detection, diagnosis, and treatment of cancer.
- Yale-Griffin Prevention Research Center (PRC)The PRC works with community partners to develop and implement community-based approaches to prevent and control chronic diseases such as heart disease, diabetes, and cancer.
- Yale Institute for Global Health (YIGH)YIGH serves as the focal point for research, education, and engagement with global partners to improve the health of individuals and populations worldwide.