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Developmental origin of health and disease

The Developmental Origins of Health and Disease (DOHaD) theory hypothesized that environmental exposures during early life (particularly the in-utero period) can permanently influence health and vulnerability to disease in later life. Obesity, diabetes, cardiovascular disease, and certain cancers are just some examples of adult-onset conditions that may be linked to early life nutritional status and/or exposures to environmental chemicals, drugs, infections, lifestyles, or stress.

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Faculty and Research Topics
  • Caroline Johnson
    • Dr. Johnson’s lab is investigating how hormones regulate metabolism in women and can effect the internal processing of exposure chemicals. Within this context, and in collaboration with investigators at Yale Center for Perinatal, Pediatric and Environmental Epidemiology (CPPEE), the lab is identifying metabolic biomarkers for pregnancy outcomes such as “preterm birth” and “large for gestational age” during various stages of pregnancy.
  • Brian Leaderer
  • Zeyan Liew
    • Dr. Liew’s research investigate adverse health effects from fetal exposures to persistent organic pollutants, pesticides, air-pollutants, and medications. The outcomes of interests include fetal loss, adverse birth outcomes, neurodevelopmental disorders, asthma and obesity. He also contributes to methodological research specifically in causal inference and bias analyses. He works are integrated in the Yale Center for Perinatal, Pediatric and Environmental Epidemiology (CPPEE).
  • Vasilis Vasiliou
    • Dr. Vasiliou’s laboratory investigates the roles of genetic and environmental factors (exposome) in the developmental origins of health and disease. One investigation utilizes state-of-the art omics technologies to study the role of redox homeostasis in regulating eye development and microphthalmia. Another project elucidates how prenatal exposure to common maternal analgesics may lead to adverse effects on fetal neurodevelopment through neuronal progenitor cell and induced pluripotent stem cell models by assessing transcriptomic, proteomic and metabolomic changes after chronic low-dose exposures to analgesics. Dr. Vasiliou is also an associate editor of the Journal of Developmental Origins of Health and Disease.
  • Catherine Yeckel
  • Yong Zhu

Secondary Faculty: