2025
Examining socioeconomic differences in sepsis risk and mediation by modifiable factors: a Mendelian randomization study
Stensrud V, Rogne T, Flatby H, Mohus R, Gustad L, Nilsen T. Examining socioeconomic differences in sepsis risk and mediation by modifiable factors: a Mendelian randomization study. BMC Infectious Diseases 2025, 25: 739. PMID: 40410669, PMCID: PMC12103053, DOI: 10.1186/s12879-025-11130-y.Peer-Reviewed Original ResearchConceptsSummary-level dataSocioeconomic differencesGenome-wide association studiesGenetic instrumentsEducational attainmentMendelian randomizationMR analysisStandard deviation increaseBias due to population stratificationOdds ratioPreventive factorsMR-Egger regressionExamined socioeconomic differencesMultivariable MR analysisEffect of smoking initiationAssociation studiesMendelian randomization studiesEffects of educational attainmentDeviation increaseYears of educationBody mass indexBackgroundEducational attainmentDynastic effectsMedian OREgger regressionA sibling study of the prenatal and perinatal risks for cerebral palsy
Zhuo H, Rogne T, Liew Z. A sibling study of the prenatal and perinatal risks for cerebral palsy. Pediatric Research 2025, 1-8. PMID: 40316681, DOI: 10.1038/s41390-025-04055-4.Peer-Reviewed Original ResearchSibling comparison designCerebral palsyLow Apgar scoreMaternal pregnancy complicationsSibling designPerinatal factorsAssociated with CPApgar scoreComparison designPregnancy complicationsOdds ratioPreterm birthAttenuated to nullConfidence intervalsPre-pregnancy overweightLifestyle-related factorsCP riskSibling comparison studiesSibling-comparison designGestational ageMaternal cigarette smokingSingleton birthsCP etiologyInterpretation of findingsPre-pregnancyLong-term drought and risk of infant mortality in Africa: A cross-sectional study
Wang P, Rogne T, Warren J, Asare E, Akum R, Toure N, Ross J, Chen K. Long-term drought and risk of infant mortality in Africa: A cross-sectional study. PLOS Medicine 2025, 22: e1004516. PMID: 39888958, PMCID: PMC11785314, DOI: 10.1371/journal.pmed.1004516.Peer-Reviewed Original ResearchConceptsRisk of infant mortalityInfant mortality riskCross-sectional studyInfant mortalityMortality riskIncreased risk of infant mortalityIncreased risk of neonatal mortalityIncreased riskRisk of neonatal mortalityHealth Surveys ProgramPost-neonatal mortalityCox regression modelsStatistically significant associationChild healthGlobal burdenNon-casesNeonatal mortalitySignificant associationImpact mortalityNon-exposureSurvival periodRegression modelsPregnancyMortalityHealthAdverse Pregnancy Outcomes and Coronary Artery Disease Risk: A Negative Control Mendelian Randomization Study
Rogne T, Gill D. Adverse Pregnancy Outcomes and Coronary Artery Disease Risk: A Negative Control Mendelian Randomization Study. Circulation 2025, 151: 193-195. PMID: 39804903, PMCID: PMC11740089, DOI: 10.1161/circulationaha.124.070509.Peer-Reviewed Original ResearchUromodulin and Risk of Upper Urinary Tract Infections: A Mendelian Randomization Study
Liyanarachi K, Flatby H, Hallan S, Åsvold B, Damås J, Rogne T. Uromodulin and Risk of Upper Urinary Tract Infections: A Mendelian Randomization Study. American Journal Of Kidney Diseases 2025, 85: 570-576.e1. PMID: 39805364, DOI: 10.1053/j.ajkd.2024.11.007.Peer-Reviewed Original ResearchUpper urinary tract infectionGenome-wide association studiesUrinary tract infectionOdds ratioMendelian randomizationTwo-sample Mendelian randomization analysisTwo-sample MR studyEuropean ancestryMichigan Genomics InitiativeInverse variance-weightedAssociation studiesMendelian randomization analysisMendelian randomization studiesAssociated with elevated oddsConfounding factorsSerum uromodulin levelsReduced riskTract infectionsUromodulin levelsSex-specific analysesAbstractText Label="PLAIN-LANGUAGE SUMMARYGenetic instrumentsHealth StudyUK BiobankUrinary uromodulinAssociations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two‐Sample Mendelian Randomization Analysis
de La Harpe R, Rogne T, Nyberg M, Cronjé H, Burgess S, Karhunen V, Gill D. Associations of Genetically Predicted NPR3 and NPR2 Perturbation and Preeclampsia Risk: A Two‐Sample Mendelian Randomization Analysis. International Journal Of Hypertension 2025, 2025: 9972031. PMID: 40406480, PMCID: PMC12097871, DOI: 10.1155/ijhy/9972031.Peer-Reviewed Original ResearchGenome-wide association studiesMendelian randomizationTwo-sample Mendelian randomization analysisRisk of preeclampsiaTwo-sample MR analysisGenetic association estimatesGenetic instrumental variablesPreeclampsia riskMendelian randomization analysisFemale participantsC-type natriuretic peptideIndividual-level dataEffects of C-type natriuretic peptideGenetic instrumentsMR analysisUK BiobankRandomization analysisAssociation estimatesMR paradigmAssociation studiesGenetic variantsPregnancy complicationsProtective effects of C-type natriuretic peptideTwo-sampleInstrumental variables
2024
Autoimmune Diseases and Risk of Non‐Hodgkin Lymphoma: A Mendelian Randomisation Study
Shi X, Wallach J, Ma X, Rogne T. Autoimmune Diseases and Risk of Non‐Hodgkin Lymphoma: A Mendelian Randomisation Study. Cancer Medicine 2024, 13: e70327. PMID: 39506244, PMCID: PMC11540836, DOI: 10.1002/cam4.70327.Peer-Reviewed Original ResearchConceptsRisk of non-Hodgkin lymphomaNon-Hodgkin's lymphomaAutoimmune diseasesMendelian randomisationType 1 diabetesAssociated with risk of non-Hodgkin lymphomaWeak instrument biasNon-Hodgkin lymphoma subtypesTwo-sample MRNon-Hodgkin lymphoma riskRisk factorsSusceptibility to type 1 diabetesMendelian randomisation studiesCohorts of European ancestryAssociated with riskNo significant associationPotential pleiotropyPotential risk factorsUK BiobankFinnGen studyNon-HodgkinHaematological malignanciesRandomised studyEuropean ancestrySignificant associationEarly-life lower respiratory tract infection (LRTI) and risk of school-age asthma - A population-based cohort study
Myklebust Å, Døllner H, Pape K, Rogne T, Risnes K. Early-life lower respiratory tract infection (LRTI) and risk of school-age asthma - A population-based cohort study. 2024, pa3131. DOI: 10.1183/13993003.congress-2024.pa3131.Peer-Reviewed Original ResearchHigh ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study
Rogne T, Wang R, Wang P, Deziel N, Metayer C, Wiemels J, Chen K, Warren J, Ma X. High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. The Lancet Planetary Health 2024, 8: e506-e514. PMID: 38969477, PMCID: PMC11260908, DOI: 10.1016/s2542-5196(24)00121-9.Peer-Reviewed Original ResearchConceptsRisk of childhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaLatino childrenNon-Latino white childrenAssociated with risk of adverse pregnancy outcomesCalifornia Cancer RegistryRisk of acute lymphoblastic leukemiaCalifornia birth recordsRisk of adverse pregnancy outcomesPre-pregnancy periodAssociated with riskBayesian meta-regressionNational Institutes of HealthCancer RegistryCases of childhood acute lymphoblastic leukemiaNational Center for Advancing Translational SciencesAdverse pregnancy outcomesAcute lymphoblastic leukemia casesInstitutes of HealthInvestigation of mechanistic pathwaysBirth recordsGestational weeks 8Pre-pregnancyA Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections
Flatby H, Ravi A, Liyanarachi K, Afset J, Rasheed H, Brumpton B, Hveem K, Åsvold B, DeWan A, Solligård E, Damås J, Rogne T. A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections. The Journal Of Infectious Diseases 2024, 230: e1334-e1343. PMID: 38713594, PMCID: PMC11646603, DOI: 10.1093/infdis/jiae231.Peer-Reviewed Original ResearchGenome-wide association studiesMichigan Genomics InitiativeAssociation studiesUpper UTIMendelian randomizationMR analysisUpper urinary tract infectionRisk factorsPotential causal risk factorsCardiometabolic risk factorsModifiable risk factorsSex-stratified analysesCausal risk factorUrinary tract infectionGenome-wideFemale-only analysisGenetic lociPotential causal relationshipGenome InitiativeHealth StudyUK BiobankHLA-DQA2LociTract infectionsSmoking scoreChronic kidney disease and risk of bloodstream infections and sepsis: a 17-year follow-up of the population-based Trøndelag Health Study in Norway
Liyanarachi K, Mohus R, Rogne T, Gustad L, Åsvold B, Romundstad S, Solligård E, Hallan S, Damås J. Chronic kidney disease and risk of bloodstream infections and sepsis: a 17-year follow-up of the population-based Trøndelag Health Study in Norway. Infection 2024, 52: 1983-1993. PMID: 38679665, PMCID: PMC11499395, DOI: 10.1007/s15010-024-02265-2.Peer-Reviewed Original ResearchHazard ratioHazard ratio of deathChronic kidney diseaseCohort studyPopulation-based cohort studyNorwegian HUNT studyAlbumin-creatinine ratioTarget risk factorsAssociation of chronic kidney diseaseLoss of healthProspective cohort studyHUNT StudyHealth StudySystolic blood pressureSmoking statusKidney diseaseHospital admissionMedian follow-up timeGeneral populationRisk of bloodstream infectionImprove preventionFollow-up timeIncreased riskNormal albumin excretionRisk factorsPotential Selection Bias in Preterm Infant Mortality Study
Rogne T, Wu B, Hawley N. Potential Selection Bias in Preterm Infant Mortality Study. JAMA Pediatrics 2024, 178: 205-206. PMID: 38109083, DOI: 10.1001/jamapediatrics.2023.5582.Peer-Reviewed Original ResearchMediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes
Rogne T, Gill D, Liew Z, Shi X, Stensrud V, Nilsen T, Burgess S. Mediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes. JAMA Network Open 2024, 7: e2351166. PMID: 38206626, PMCID: PMC10784860, DOI: 10.1001/jamanetworkopen.2023.51166.Peer-Reviewed Original ResearchMeSH KeywordsBirth WeightCholesterolCohort StudiesDiabetes Mellitus, Type 2Educational StatusFemaleGenome-Wide Association StudyHumansHyperemesis GravidarumInfant, NewbornLipoproteins, HDLMediation AnalysisMendelian Randomization AnalysisPre-EclampsiaPregnancyPregnancy OutcomePregnancy, EctopicPremature BirthConceptsCardiometabolic risk factorsBody mass indexOffspring birth weightEducational attainmentMendelian randomizationHigh-density lipoprotein cholesterol levelsSystolic blood pressureInverse variance-weighted methodModifiable cardiometabolic risk factorsPregnancy outcomesCohort studyLipoprotein cholesterol levelsMR-Egger regressionMass indexUnivariable MR analysisEffects of educational attainmentAssociated with increased risk of adverse pregnancy outcomesPublic health interventionsMaternal education levelLower educational attainmentRisk factorsRisk of adverse pregnancy outcomesGenome-wide association studiesAssociated with increased riskBirth weight
2023
Influence of birth weight on later life cardiovascular structure, function and disease: unpacking influences from direct genetic effects versus intrauterine programming
Ardissino M, Slob E, Rayes B, Morley A, Raisi-Estabragh Z, De Marvao A, Williamson C, Rogne T, Burgess S, Ng F. Influence of birth weight on later life cardiovascular structure, function and disease: unpacking influences from direct genetic effects versus intrauterine programming. European Heart Journal 2023, 44: ehad655.2377. DOI: 10.1093/eurheartj/ehad655.2377.Peer-Reviewed Original ResearchCoronary artery diseaseFetal genetic effectsLow ejection fractionSystolic blood pressureBody mass indexBirth weightArtery diseaseAtrial fibrillationCardiovascular diseaseHigh riskMendelian randomisationEjection fractionBlood pressureMass indexRisk factorsGestational age-adjusted birth weightCardiac structureAge-adjusted birth weightHigher systolic blood pressureLater-life cardiovascular diseaseCardinal risk factorCardiometabolic risk factorsHigh birth weightLife cardiovascular diseaseBody surface areaPharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis
Lawler P, Manvelian G, Coppi A, Damask A, Cantor M, Ferreira M, Paulding C, Banerjee N, Li D, Jorgensen S, Attre R, Carey D, Krebs K, Milani L, Hveem K, Damås J, Solligård E, Stender S, Tybjærg-Hansen A, Nordestgaard B, Hernandez-Beeftink T, Rogne T, Flores C, Villar J, Walley K, Liu V, Fohner A, Lotta L, Kyratsous C, Sleeman M, Scemama M, DelGizzi R, Pordy R, Horowitz J, Baras A, Martin G, Steg P, Schwartz G, Szarek M, Goodman S. Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis. Critical Care Explorations 2023, 5: e0997. PMID: 37954898, PMCID: PMC10635596, DOI: 10.1097/cce.0000000000000997.Peer-Reviewed Original ResearchProprotein convertase subtilisin/kexin type 9Convertase subtilisin/kexin type 9Subtilisin/kexin type 9Human cohort studiesODYSSEY OUTCOMESCohort studyType 9Isotype-matched controlExperimental murine modelSepsis ratePCSK9 inhibitionPCSK9 inhibitorsSepsis complicationsSepsis mortalitySepsis outcomeImproved survivalBacterial sepsisClinical outcomesBloodstream clearanceSepsis modelClinical trialsOdds ratioCardiovascular diseasePretreatment settingSepsis diagnosisAssociation of Genetically Predicted Insomnia With Risk of Sepsis
Thorkildsen M, Gustad L, Mohus R, Burgess S, Nilsen T, Damås J, Rogne T. Association of Genetically Predicted Insomnia With Risk of Sepsis. JAMA Psychiatry 2023, 80: 1061-1065. PMID: 37556136, PMCID: PMC10413214, DOI: 10.1001/jamapsychiatry.2023.2717.Peer-Reviewed Original ResearchBirth weight influences cardiac structure, function, and disease risk: evidence of a causal association
Ardissino M, Morley A, Slob E, Schuermans A, Rayes B, Raisi-Estabragh Z, de Marvao A, Burgess S, Rogne T, Honigberg M, Ng F. Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association. European Heart Journal 2023, 45: 443-454. PMID: 37738114, PMCID: PMC10849320, DOI: 10.1093/eurheartj/ehad631.Peer-Reviewed Original ResearchLow birth weightAdverse intrauterine environmentCoronary artery diseaseBirth weightIntrauterine environmentCardiac structureArtery diseaseFoetal effectsCardiovascular disease prevention strategiesDisease riskAdverse cardiac structureCardiovascular disease riskCommon pregnancy complicationLower stroke volumeDisease prevention strategiesMendelian randomization studyBenjamini-Hochberg correctionPregnancy complicationsIschemic strokeHeart failureAtrial fibrillationCardiometabolic diseasesIntrauterine influencesStroke volumeCardiovascular diseaseGestational age at birth and hospitalisations for infections among individuals aged 0–50 years in Norway: a longitudinal, register-based, cohort study
Nilsen S, Valand J, Rogne T, Asheim A, Yin W, Metsälä J, Opdahl S, Døllner H, Damås J, Kajantie E, Solligård E, Sandin S, Risnes K. Gestational age at birth and hospitalisations for infections among individuals aged 0–50 years in Norway: a longitudinal, register-based, cohort study. EClinicalMedicine 2023, 62: 102108. PMID: 37538542, PMCID: PMC10393616, DOI: 10.1016/j.eclinm.2023.102108.Peer-Reviewed Original ResearchInfectious Diseases GroupRespiratory tract infectionsLower gestational age groupGestational age groupsGestational ageDisease groupCohort studyUniversity HospitalRate ratioAge groupsInfectious diseasesHigher hospitalisation risksHospitalisation rate ratiosNationwide hospital dataRisk of hospitalisationSt. Olavs University HospitalSigrid Jusélius FoundationYear of birthHospitalisation riskLate pretermPreterm birthSecondary outcomesTract infectionsPrimary outcomeChildhood infectionsRole of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort
Grønseth S, Rogne T, Heggelund L, Åsvold B, Afset J, Damås J. Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort. International Journal Of Infectious Diseases 2023, 134: 177-186. PMID: 37339716, DOI: 10.1016/j.ijid.2023.06.013.Peer-Reviewed Original ResearchConceptsCharlson Comorbidity IndexHIV-negative patientsPneumocystis pneumoniaRisk stratificationFungal burdenMulticenter cohortPolymerase chain reactionAbnormal leukocyte countComorbid cardiovascular diseaseLow serum albuminBronchoalveolar lavage fluidC-reactive proteinChain reactionHigher fungal burdenReal-time polymerase chain reactionProbable Pneumocystis pneumoniaCycle threshold valuesComorbidity indexCorticosteroid useLavage fluidSemiquantitative real-time polymerase chain reactionLeukocyte countImmunological disordersCardiovascular diseaseRetrospective analysisMendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia
Rogne T, DeWan A, Metayer C, Wiemels J, Ma X. Mendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101058. PMID: 37330008, DOI: 10.1016/j.ajogmf.2023.101058.Peer-Reviewed Original Research
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