4,4’-Methylene diphenyl diisocyanate exposure induces expression of alternatively activated macrophage-associated markers and chemokines partially through Krüppel-like factor 4 mediated signaling in macrophages
Lin C, Law B, Hettick J. 4,4’-Methylene diphenyl diisocyanate exposure induces expression of alternatively activated macrophage-associated markers and chemokines partially through Krüppel-like factor 4 mediated signaling in macrophages. Xenobiotica 2023, 53: 653-669. PMID: 38014489, DOI: 10.1080/00498254.2023.2284867.Peer-Reviewed Original ResearchConceptsMacrophage-associated markersBronchoalveolar lavage cellsOccupational asthmaAllergic airway responsesPathogenesis of asthmaKrüppel-like factor 4Induction of KLF4Airway responsesMDI exposureLavage cellsOccupational exposureT cellsAlveolar macrophagesKLF4 knockdownWestern blotChemokinesMacrophagesTranscription factorsRT-qPCRInduces expressionCCL17Factor 4AsthmaMarkersChemotactic ability