Chen Lin
About
Research
Publications
2024
MicroRNA-mediated Krüppel-like factor 4 upregulation induces alternatively activated macrophage-associated marker and chemokine transcription in 4,4’-methylene diphenyl diisocyanate exposed macrophages
Lin C, Law B, Hettick J. MicroRNA-mediated Krüppel-like factor 4 upregulation induces alternatively activated macrophage-associated marker and chemokine transcription in 4,4’-methylene diphenyl diisocyanate exposed macrophages. Xenobiotica 2024, ahead-of-print: 1-19. PMID: 38568505, DOI: 10.1080/00498254.2024.2334329.Peer-Reviewed Original ResearchSPINT2 mutations in the Kunitz domain 2 found in SCSD patients inactivate HAI-2 as prostasin inhibitor via abnormal protein folding and N-glycosylation
Huang N, Wang Q, Bernard R, Chen C, Hu J, Wang J, Chan K, Johnson M, Lin C. SPINT2 mutations in the Kunitz domain 2 found in SCSD patients inactivate HAI-2 as prostasin inhibitor via abnormal protein folding and N-glycosylation. Human Molecular Genetics 2024, 33: 752-767. PMID: 38271183, PMCID: PMC11031362, DOI: 10.1093/hmg/ddae005.Peer-Reviewed Original ResearchSubcellular targeting signalsAbnormal protein foldingHAI-2Protein foldingN-glycosylationMissense mutationsComplex-type N-glycansDomain 2Glycosylated mature formSyndromic congenital sodium diarrheaTarget signalKunitz domain 1Disulfide-linked oligomersDoxycycline-inducible expressionN-glycosylation mutationsAnti-protease activityN-glycansGlycosylation defectsKunitz domainProtease inhibitory activityHuman colorectal adenocarcinoma cellsGlycosylation statusMature formDomain 1Mutants
2023
4,4’-Methylene diphenyl diisocyanate exposure induces expression of alternatively activated macrophage-associated markers and chemokines partially through Krüppel-like factor 4 mediated signaling in macrophages
Lin C, Law B, Hettick J. 4,4’-Methylene diphenyl diisocyanate exposure induces expression of alternatively activated macrophage-associated markers and chemokines partially through Krüppel-like factor 4 mediated signaling in macrophages. Xenobiotica 2023, 53: 653-669. PMID: 38014489, DOI: 10.1080/00498254.2023.2284867.Peer-Reviewed Original ResearchConceptsMacrophage-associated markersBronchoalveolar lavage cellsOccupational asthmaAllergic airway responsesPathogenesis of asthmaKrüppel-like factor 4Induction of KLF4Airway responsesMDI exposureLavage cellsOccupational exposureT cellsAlveolar macrophagesKLF4 knockdownWestern blotChemokinesMacrophagesTranscription factorsRT-qPCRInduces expressionCCL17Factor 4AsthmaMarkersChemotactic abilityA statistical framework to identify cell types whose genetically regulated proportions are associated with complex diseases
Liu W, Deng W, Chen M, Dong Z, Zhu B, Yu Z, Tang D, Sauler M, Lin C, Wain L, Cho M, Kaminski N, Zhao H. A statistical framework to identify cell types whose genetically regulated proportions are associated with complex diseases. PLOS Genetics 2023, 19: e1010825. PMID: 37523391, PMCID: PMC10414598, DOI: 10.1371/journal.pgen.1010825.Peer-Reviewed Original ResearchConceptsCell typesDisease-associated tissuesWide association studyComplex diseasesCell type proportionsDisease-relevant tissuesReal GWAS dataFunctional genesTranscriptomic dataGWAS dataGenetic dataAssociation studiesNovel statistical frameworkChronic obstructive pulmonary diseaseStatistical frameworkObstructive pulmonary diseaseIdiopathic pulmonary fibrosisBreast cancer riskType proportionsBlood CD8Pulmonary diseasePulmonary fibrosisPredictive biomarkersLung tissueBreast cancerRobustness of quantifying mediating effects of genetically regulated expression on complex traits with mediated expression score regression
Chen Lin, Wei Liu, Wei Jiang, Hongyu Zhao, Robustness of quantifying mediating effects of genetically regulated expression on complex traits with mediated expression score regression, Biology Methods and Protocols, Volume 8, Issue 1, 2023, bpad024, https://doi.org/10.1093/biomethods/bpad024Peer-Reviewed Original Research
2021
MCVIS: A New Framework for Collinearity Discovery, Diagnostic, and Visualization
Chen Lin, Kevin Wang & Samuel Mueller (2021) MCVIS: A New Framework for Collinearity Discovery, Diagnostic, and Visualization, Journal of Computational and Graphical Statistics, 30:1, 125-132, DOI: 10.1080/10618600.2020.1779729Peer-Reviewed Original Research