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Ying Chen, MD, PhD

Research Scientist in Epidemiology (Environmental Health Sciences)

Contact Information

Ying Chen, MD, PhD

Lab Location

Mailing Address

  • Environmental Health Sciences

    60 College St, LEPH 521

    New Haven, CT 06520

    United States

Extensive Research Description

Dr. Chen’s research focuses on understanding the mechanistic functions of redox homeostasis and antioxidant deficiencies in human diseases associated with environmental and dietary stress. Reduced GSH is the most abundant thiol antioxidant that combats excessive oxidants generated during cellular metabolism or in response to environmental assaults. GSH deficiency has been associated with numerous pathological conditions in human. Dr. Chen’s research work involves the use of unique redox animal models and system biology approach to elucidate the molecular mechanisms underlying liver diseases and neurological disorders. 

Specific research projects include:

  • Redox-mediated mechanisms in protection against alcohol-associated fatty liver disease
  • The mechanistic role of oxidative stress in water contaminant 1,4-dioxane-induced liver cytotoxicity and genotoxicity
  • The functional interplay between two  antioxidants (glutathione and ascorbate) in the central nervous system


Research Interests

Digestive System Diseases; Disorders of Environmental Origin; Nervous System Diseases; Nutritional and Metabolic Diseases

Public Health Interests

Cancer; Environmental Health; Genetics, Genomics, Epigenetics; Metabolomics

Selected Publications