Qing Lan, MD, PhD
Research & Publications
Biography
Research Summary
We are conducting molecular epidemiologic studies of populations exposed to well-defined classes of chemical compounds that are known or suspected carcinogens, including polycyclic aromatic hydrocarbons (PAHs), benzene, formaldehyde, and trichloroethylene. We use biologic markers to assist in exposure assessment, provide new insights into mechanism of action, and evaluate genetic susceptibility and gene-environment interactions.
Coauthors
Public Health Interests
Biomarkers; Environmental Health
Selected Publications
- High-throughput characterization of functional variants highlights heterogeneity and polygenicity underlying lung cancer susceptibilityLong E, Patel H, Golden A, Antony M, Yin J, Funderburk K, Feng J, Song L, Hoskins J, Amundadottir L, Hung R, Amos C, Shi J, Rothman N, Lan Q, Consortium I, Choi J. High-throughput characterization of functional variants highlights heterogeneity and polygenicity underlying lung cancer susceptibility. American Journal Of Human Genetics 2024 PMID: 38906146, DOI: 10.1016/j.ajhg.2024.05.021.
- Impact of premorbid hypertension and renin-angiotensin-aldosterone system inhibitors on the severity of aneurysmal subarachnoid haemorrhage: a multicentre studyZhong P, Lu Z, Li Z, Li T, Lan Q, Liu J, Chen S, Wang Z, Huang Q. Impact of premorbid hypertension and renin-angiotensin-aldosterone system inhibitors on the severity of aneurysmal subarachnoid haemorrhage: a multicentre study. Stroke And Vascular Neurology 2024, svn-2023-003052. PMID: 38889918, DOI: 10.1136/svn-2023-003052.
- Long-term exposure to particulate matter and all-cause and cause-specific mortality in an analysis of multiple Asian cohortsDownward G, Hystad P, Tasmin S, Abe S, Saito E, Rahman M, Islam M, Gupta P, Sawada N, Malekzadeh R, You S, Ahsan H, Park S, Pednekar M, Tsugane S, Etemadi A, Chen C, Shin A, Chen Y, Boffetta P, Chia K, Matsuo K, Qiao Y, Rothman N, Zheng W, Inoue M, Kang D, Lan Q, Vermeulen R. Long-term exposure to particulate matter and all-cause and cause-specific mortality in an analysis of multiple Asian cohorts. Environment International 2024, 189: 108803. PMID: 38870578, DOI: 10.1016/j.envint.2024.108803.
- Occupational exposure to benzene and mortality risk of lymphohaematopoietic cancers in the Swiss National Cohort.Ge C, Spoerri A, Egger M, Rothman N, Lan Q, Huss A, Vermeulen R. Occupational exposure to benzene and mortality risk of lymphohaematopoietic cancers in the Swiss National Cohort. Scandinavian Journal Of Work, Environment & Health 2024 PMID: 38727681, DOI: 10.5271/sjweh.4164.
- Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, ChinaRahman M, Breeze C, Shu X, Wong J, Blechter B, Cardenas A, Wang X, Ji B, Hu W, Cai Q, Hosgood H, Yang G, Shi J, Long J, Gao Y, Bell D, Zheng W, Rothman N, Lan Q. Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China. Thorax 2024, thorax-2023-220352. PMID: 38702190, DOI: 10.1136/thorax-2023-220352.
- A nested case‐control study of untargeted plasma metabolomics and lung cancer among never‐smoking women within the prospective Shanghai Women's Health StudyRahman M, Shu X, Jones D, Hu W, Ji B, Blechter B, Wong J, Cai Q, Yang G, Gao Y, Zheng W, Rothman N, Walker D, Lan Q. A nested case‐control study of untargeted plasma metabolomics and lung cancer among never‐smoking women within the prospective Shanghai Women's Health Study. International Journal Of Cancer 2024, 155: 508-518. PMID: 38651675, DOI: 10.1002/ijc.34929.
- Microsurgical clipping of multiple intracranial aneurysms via the keyhole approachQian W, Chen Y, Zhu Q, Chen A, Lan Q. Microsurgical clipping of multiple intracranial aneurysms via the keyhole approach. World Neurosurgery 2024 PMID: 38642836, DOI: 10.1016/j.wneu.2024.04.075.
- Nanomodulators targeting endothelial WNT and pericytes to reversibly open the blood–tumor barrier for boosted brain tumor therapyMu R, Sun H, Zeng Y, Tong Y, Tang P, Zhao M, Lv Z, Yu J, Chen Y, Lan Q, Zhen X, Han L. Nanomodulators targeting endothelial WNT and pericytes to reversibly open the blood–tumor barrier for boosted brain tumor therapy. Journal Of Controlled Release 2024, 369: 458-474. PMID: 38575077, DOI: 10.1016/j.jconrel.2024.03.047.
- Abstract LB231: The mutagenic forces shaping the genomic landscape of lung cancer in never smokersDiaz-Gay M, Zhang T, Khandekar A, Otlu B, Nandi S, Steele C, Rothman N, Chanock S, Lan Q, Alexandrov L, Landi M. Abstract LB231: The mutagenic forces shaping the genomic landscape of lung cancer in never smokers. Cancer Research 2024, 84: lb231-lb231. DOI: 10.1158/1538-7445.am2024-lb231.
- The Time-Dependent Association Between Irritable Bowel Syndrome and All-Cause and Cause-Specific Mortality: A Prospective Cohort Study Within the UK Biobank.Li F, Yano Y, Étiévant L, Daniel C, Sharma S, Brown E, Li R, Loftfield E, Lan Q, Sinha R, Moshiree B, Inoue-Choi M, Vogtmann E. The Time-Dependent Association Between Irritable Bowel Syndrome and All-Cause and Cause-Specific Mortality: A Prospective Cohort Study Within the UK Biobank. The American Journal Of Gastroenterology 2024 PMID: 38275237, DOI: 10.14309/ajg.0000000000002675.
- Phenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK BiobankWong J, Blechter B, Hubbard A, Machiela M, Shi J, Gadalla S, Hu W, Rahman M, Rothman N, Lan Q. Phenotypic and genetically predicted leucocyte telomere length and lung cancer risk in the prospective UK Biobank. Thorax 2024, 79: 274-278. PMID: 38238005, PMCID: PMC10923134, DOI: 10.1136/thorax-2023-220076.
- Benzene exposure and risk of lung cancer in the Norwegian Offshore Petroleum Worker cohort: a prospective case-cohort studyBabigumira R, Veierød M, Hosgood H, Samuelsen S, Bråtveit M, Kirkeleit J, Rothman N, Lan Q, Silverman D, Friesen M, Shala N, Grimsrud T, Stenehjem J. Benzene exposure and risk of lung cancer in the Norwegian Offshore Petroleum Worker cohort: a prospective case-cohort study. Occupational And Environmental Medicine 2023, 81: 9-16. PMID: 38154914, DOI: 10.1136/oemed-2023-109139.
- Association between F2-Isoprostane Metabolites and Weight Change in Older Women: A Longitudinal AnalysisZhao Y, Nogueira M, Chen Q, Dai Q, Cai Q, Wen W, Lan Q, Rothman N, Gao Y, Shu X, Zheng W, Milne G, Yang G. Association between F2-Isoprostane Metabolites and Weight Change in Older Women: A Longitudinal Analysis. Gerontology 2023, 70: 134-142. PMID: 37967546, PMCID: PMC10922451, DOI: 10.1159/000534258.
- Efficacy of minimally invasive tubular approaches for management of the lumbar spinal synovial cysts: a meta-analysisChen Y, Yu P, Xu H, Li S, Wang Q, Wu C, Wang J, Ji F, Huang Q, Lan Q. Efficacy of minimally invasive tubular approaches for management of the lumbar spinal synovial cysts: a meta-analysis. European Journal Of Medical Research 2023, 28: 494. PMID: 37941083, PMCID: PMC10631136, DOI: 10.1186/s40001-023-01481-0.
- Lung Cancer Risk Prediction Models for Asian Ever-SmokersYang J, Wen W, Zahed H, Zheng W, Lan Q, Abe S, Rahman M, Islam M, Saito E, Gupta P, Tamakoshi A, Koh W, Gao Y, Sakata R, Tsuji I, Malekzadeh R, Sugawara Y, Kim J, Ito H, Nagata C, You S, Park S, Yuan J, Shin M, Kweon S, Yi S, Pednekar M, Kimura T, Cai H, Lu Y, Etemadi A, Kanemura S, Wada K, Chen C, Shin A, Wang R, Ahn Y, Shin M, Ohrr H, Sheikh M, Blechter B, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Rothman N, Inoue M, Kang D, Robbins H, Shu X. Lung Cancer Risk Prediction Models for Asian Ever-Smokers. Journal Of Thoracic Oncology 2023, 19: 451-464. PMID: 37944700, PMCID: PMC11126207, DOI: 10.1016/j.jtho.2023.11.002.
- Incidence of Lung Adenocarcinoma by Age, Sex, and Smoking Status in TaiwanChien L, Jiang H, Tsai F, Chang H, Freedman N, Rothman N, Lan Q, Hsiung C, Chang I. Incidence of Lung Adenocarcinoma by Age, Sex, and Smoking Status in Taiwan. JAMA Network Open 2023, 6: e2340704. PMID: 37910104, PMCID: PMC10620613, DOI: 10.1001/jamanetworkopen.2023.40704.
- Time-dependent association between an RNA oxidation biomarker (8-oxoGuo) and colorectal cancer riskNogueira M, Zhao Y, Milne G, Chen Q, Gao Y, Cai Q, Lan Q, Rothman N, Shu X, Zheng W, Yang G. Time-dependent association between an RNA oxidation biomarker (8-oxoGuo) and colorectal cancer risk. Free Radical Biology And Medicine 2023, 208: s109. DOI: 10.1016/j.freeradbiomed.2023.10.247.
- Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in TaiwanBlechter B, Chien L, Chen T, Chang I, Choudhury P, Hsiao C, Shu X, Wong J, Chen K, Chang G, Tsai Y, Su W, Huang M, Chen Y, Chen C, Hung H, Hu J, Shi J, Zheng W, Rositch A, Chen C, Chatterjee N, Yang P, Rothman N, Hsiung C, Lan Q. Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan. JAMA Network Open 2023, 6: e2339254. PMID: 37955902, PMCID: PMC10644212, DOI: 10.1001/jamanetworkopen.2023.39254.
- The association between inflammatory bowel disease and all-cause and cause-specific mortality in the UK BiobankLi F, Ramirez Y, Yano Y, Daniel C, Sharma S, Brown E, Li R, Moshiree B, Loftfield E, Lan Q, Sinha R, Inoue-Choi M, Vogtmann E. The association between inflammatory bowel disease and all-cause and cause-specific mortality in the UK Biobank. Annals Of Epidemiology 2023, 88: 15-22. PMID: 38013230, PMCID: PMC10842122, DOI: 10.1016/j.annepidem.2023.10.008.
- Exposure to hydrocarbons and risk of bladder cancer in petroleum workersShala N, Stenehjem J, Babigumira R, Liu F, Berge L, Silverman D, Friesen M, Rothman N, Lan Q, Hosgood H, Samuelsen S, Bråtveit M, Kirkeleit J, Andreassen B, Veierød M, Grimsrud T. Exposure to hydrocarbons and risk of bladder cancer in petroleum workers. ISEE Conference Abstracts 2023, 2023 DOI: 10.1289/isee.2023.op-158.
- Molecular study on differentiation-associated genes involved in both malignant progression of glioma and differentiation of human fetal neural stem cellsDong J, Wu Y, Huang Q, Wang F, Wang A, Lan Q. Molecular study on differentiation-associated genes involved in both malignant progression of glioma and differentiation of human fetal neural stem cells. Cancer Biology & Medicine 2006, 3: 386-391. DOI: 10.1007/s11805-006-0126-9.