2023
Statistical assessment of biomarker replicability using MAJAR method
Xie Y, Zhai S, Jiang W, Zhao H, Mehrotra D, Shen J. Statistical assessment of biomarker replicability using MAJAR method. Statistical Methods In Medical Research 2023, 32: 1961-1972. PMID: 37519295, DOI: 10.1177/09622802231188519.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremBiomarkersGenome-Wide Association StudyHumansPhenotypePolymorphism, Single NucleotideRandomized Controlled Trials as TopicConceptsBayesian false discovery rateDifferent data generation processesNovel statistical frameworkExtensive simulation studyExpectation-maximization algorithmStatistical frameworkComputational efficiencyGWAS summary statistics dataSimulation studyData generation processStatistical assessmentSimulation resultsStatistical powerFalse discovery rateResponse predictionSummary statistics dataDiscovery rateSample sizeLimited powerOutliersAlgorithmGeneration processRobustnessPowerSmall sample size
2021
A novel transcriptional risk score for risk prediction of complex human diseases
Shan N, Xie Y, Song S, Jiang W, Wang Z, Hou L. A novel transcriptional risk score for risk prediction of complex human diseases. Genetic Epidemiology 2021, 45: 811-820. PMID: 34245595, PMCID: PMC8604733, DOI: 10.1002/gepi.22424.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes Mellitus, Type 2HumansModels, GeneticPolymorphism, Single NucleotideProteomicsRisk FactorsConceptsTranscriptional risk scoreComplex human diseasesHuman diseasesPolygenetic risk scoresComplex traitsFunctional annotationProteomic dataRNA expression levelsGene expressionEffect size distributionMessenger RNA expression levelsMultiomics datasetsMultiple tissuesLinkage disequilibriumExpression levelsTraitsMultiple diseasesAnnoPredLDpredGreater prediction powerReference datasetPhenotypeAnnotationLarge effectDisequilibrium