A novel transcriptional risk score for risk prediction of complex human diseases
Shan N, Xie Y, Song S, Jiang W, Wang Z, Hou L. A novel transcriptional risk score for risk prediction of complex human diseases. Genetic Epidemiology 2021, 45: 811-820. PMID: 34245595, PMCID: PMC8604733, DOI: 10.1002/gepi.22424.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes Mellitus, Type 2HumansModels, GeneticPolymorphism, Single NucleotideProteomicsRisk FactorsConceptsTranscriptional risk scoreComplex human diseasesHuman diseasesPolygenetic risk scoresComplex traitsFunctional annotationProteomic dataRNA expression levelsGene expressionEffect size distributionMessenger RNA expression levelsMultiomics datasetsMultiple tissuesLinkage disequilibriumExpression levelsTraitsMultiple diseasesAnnoPredLDpredGreater prediction powerReference datasetPhenotypeAnnotationLarge effectDisequilibrium