Statistical assessment of biomarker replicability using MAJAR method
Xie Y, Zhai S, Jiang W, Zhao H, Mehrotra D, Shen J. Statistical assessment of biomarker replicability using MAJAR method. Statistical Methods In Medical Research 2023, 32: 1961-1972. PMID: 37519295, DOI: 10.1177/09622802231188519.Peer-Reviewed Original ResearchConceptsBayesian false discovery rateDifferent data generation processesNovel statistical frameworkExtensive simulation studyExpectation-maximization algorithmStatistical frameworkComputational efficiencyGWAS summary statistics dataSimulation studyData generation processStatistical assessmentSimulation resultsStatistical powerFalse discovery rateResponse predictionSummary statistics dataDiscovery rateSample sizeLimited powerOutliersAlgorithmGeneration processRobustnessPowerSmall sample sizeWhole-Exome Sequencing Analyses Support a Role of Vitamin D Metabolism in Ischemic Stroke
Xie Y, Acosta J, Ye Y, Demarais Z, Conlon C, Chen M, Zhao H, Falcone G. Whole-Exome Sequencing Analyses Support a Role of Vitamin D Metabolism in Ischemic Stroke. Stroke 2023, 54: 800-809. PMID: 36762557, PMCID: PMC10467223, DOI: 10.1161/strokeaha.122.040883.Peer-Reviewed Original ResearchMeSH KeywordsExome SequencingGenetic TestingGenome-Wide Association StudyHumansIschemic StrokePhenotypeConceptsGene-based testingRare genetic variationGene-based analysisGenetic variationAssociation studiesGenome-wide association studiesSingle-variant association analysisWide significance levelSusceptibility risk lociWide association studyDeleterious missense variantsMissense rare variantsBonferroni-corrected thresholdWhole-exome sequencing dataRare variantsSingle variant analysisHeritable traitRisk lociExome-wide studySequencing dataExome sequencing analysisAssociation analysisSequencing analysisMissense variantsTraits