A novel transcriptional risk score for risk prediction of complex human diseases
Shan N, Xie Y, Song S, Jiang W, Wang Z, Hou L. A novel transcriptional risk score for risk prediction of complex human diseases. Genetic Epidemiology 2021, 45: 811-820. PMID: 34245595, PMCID: PMC8604733, DOI: 10.1002/gepi.22424.Peer-Reviewed Original ResearchConceptsTranscriptional risk scoreComplex human diseasesHuman diseasesPolygenetic risk scoresComplex traitsFunctional annotationProteomic dataRNA expression levelsGene expressionEffect size distributionMessenger RNA expression levelsMultiomics datasetsMultiple tissuesLinkage disequilibriumExpression levelsTraitsMultiple diseasesAnnoPredLDpredGreater prediction powerReference datasetPhenotypeAnnotationLarge effectDisequilibrium