Featured Publications
Pharmacologic and surgical therapies for patients with Meniere’s disease: A systematic review and network meta-analysis
Ahmadzai N, Cheng W, Kilty S, Esmaeilisaraji L, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Hutton B. Pharmacologic and surgical therapies for patients with Meniere’s disease: A systematic review and network meta-analysis. PLOS ONE 2020, 15: e0237523. PMID: 32870918, PMCID: PMC7462264, DOI: 10.1371/journal.pone.0237523.Peer-Reviewed Original ResearchConceptsComplete vertigo controlEndolymphatic sac decompressionRandomized clinical trialsEndolymphatic duct blockageIT steroidsVertigo controlMeniere's diseaseIT gentamicinSurgical interventionSystematic reviewKey patient outcomesHigh cumulative dosageBest treatment optionSensorineural hearing lossEDB groupESD groupAural fullnessIntratympanic gentamicinSteroid injectionVertigo attacksHead trialsHearing preservationSurgical therapyCochrane LibraryCumulative dosage
2019
A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss
Ahmadzai N, Kilty S, Cheng W, Esmaeilisaraji L, Wolfe D, Bonaparte JP, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Moher D, Hutton B. A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss. PLOS ONE 2019, 14: e0221713. PMID: 31498809, PMCID: PMC6733451, DOI: 10.1371/journal.pone.0221713.Peer-Reviewed Original ResearchConceptsIdiopathic sudden sensorineural hearing lossSudden sensorineural hearing lossSensorineural hearing lossPTA improvementSystemic steroidsHearing recoveryHearing lossHigh riskManagement of ISSNHLSystematic reviewPure-tone average improvementSystemic steroid treatmentCause of disabilityExperienced information specialistSelection of treatmentQuality of lifeMajority of casesRemoval of duplicatesIntratympanic steroidsIntravenous steroidsIT steroidsOral steroidsPharmacologic therapySteroid treatmentActive treatment