2020
Dolosigranulum pigrum Cooperation and Competition in Human Nasal Microbiota
Brugger SD, Eslami SM, Pettigrew MM, Escapa IF, Henke MT, Kong Y, Lemon KP. Dolosigranulum pigrum Cooperation and Competition in Human Nasal Microbiota. MSphere 2020, 5: 10.1128/msphere.00852-20. PMID: 32907957, PMCID: PMC7485692, DOI: 10.1128/msphere.00852-20.Peer-Reviewed Original ResearchConceptsMicrobe-microbe interactionsHuman nasal microbiotaGenomic analysisPhenotypic interactionsBiosynthetic gene clusterSmall genomesNasal microbiotaGene clusterAccessory genomeKey nutrientsNew insightsGenomic capacityBacterial residentsPathogenic speciesNasal microbiota compositionBeneficial bacteriumFunctional assaysDiverse repertoireHuman hostGenomeSpeciesAcid productionMicrobiotaNasal bacteriaBacteria
2014
Dynamic Changes in the Streptococcus pneumoniae Transcriptome during Transition from Biofilm Formation to Invasive Disease upon Influenza A Virus Infection
Pettigrew MM, Marks LR, Kong Y, Gent JF, Roche-Hakansson H, Hakansson AP. Dynamic Changes in the Streptococcus pneumoniae Transcriptome during Transition from Biofilm Formation to Invasive Disease upon Influenza A Virus Infection. Infection And Immunity 2014, 82: 4607-4619. PMID: 25135685, PMCID: PMC4249342, DOI: 10.1128/iai.02225-14.Peer-Reviewed Original ResearchConceptsWhole transcriptome shotgun sequencingPneumococcal transcriptomeTransparent colony phenotypeVirus infectionTranscriptional differencesShotgun sequencingUpregulated genesFebrile range temperaturesColony phenotypeInfluenza A Virus InfectionNutrient availabilityTranscriptomeS. pneumoniae pathogenesisA virus infectionProduction of bacteriocinsHost immune responsePlanktonic cellsBiofilm formationGenesPlanktonic bacteriaBiofilm bacteriaExtracellular ATPCarbohydrate metabolismBacteriaEnzymatic assay