2022
Comprehensive assessment of neurocognitive function, inflammation markers, and adiposity in treated HIV and control
Mouchati C, Kamari V, Sattar A, Yu J, McComsey G. Comprehensive assessment of neurocognitive function, inflammation markers, and adiposity in treated HIV and control. Medicine 2022, 101: e31125. PMID: 36281153, PMCID: PMC9592384, DOI: 10.1097/md.0000000000031125.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusImmunodeficiency virusNeurocognitive impairmentUndetectable HIV-1 RNA levelsHIV-1 RNA levelsHigh inflammatory markersMarkers of inflammationBody fat compositionVisceral adipose tissueCross-sectional studyBody composition measuresChi-square testHigher total fatInflammatory markersInflammation markersCentral adiposityHIV statusImmune activationInsulin resistanceMean agePLWHHeroin useAdipose tissueDrug AdministrationNeurocognitive functionAmbient air pollution is associated with vascular disease in Ugandan HIV-positive adolescents
Toe S, Nagy M, Albar Z, Yu J, Sattar A, Nazzinda R, Musiime V, Etajak S, Walyawula F, McComsey G, Atuyambe L, Dirajlal-Fargo S. Ambient air pollution is associated with vascular disease in Ugandan HIV-positive adolescents. AIDS 2022, 36: 863-870. PMID: 35131961, PMCID: PMC9081159, DOI: 10.1097/qad.0000000000003186.Peer-Reviewed Original ResearchConceptsIntima-media thicknessVascular diseaseMonocyte activationCarotid intima-media thicknessSubclinical vascular diseaseHIV-positive adolescentsMarkers of inflammationEffects of HIVCross-sectional studyMultivariable quantile regression modelsMultivariable quantile regressionAmbient air pollutionDaily ambient concentrationsDaily PM2.5 exposureExposure of PM2.5Systemic inflammationMedian ageSoluble CD163Atherosclerotic diseasePlasma markersIntestinal permeabilityCardiovascular diseaseGut integrityHIVPM2.5 exposure
2021
Lipidome association with vascular disease and inflammation in HIV+ Ugandan children
Dirajlal-Fargo S, Sattar A, Yu J, Albar Z, Chaves F, Riedl K, Kityo C, Bowman E, McComsey G, Funderburg N. Lipidome association with vascular disease and inflammation in HIV+ Ugandan children. AIDS 2021, 35: 1615-1623. PMID: 33878042, PMCID: PMC8286331, DOI: 10.1097/qad.0000000000002923.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyT cell activationCardiovascular diseaseVascular diseaseCommon carotid artery intimaSubclinical vascular diseaseSerum lipid compositionCarotid artery intimaYears of ageLipid speciesART regimenCVD riskSystemic inflammationHIV infectionMedian ageImmune activationActive infectionPlasma markersSerum lipidomeArtery intimaUgandan childrenCopies/Monocyte activationFree fatty acidsLipid classesDriving Cessation in Old Age: Gender Influences on Mortality
Yu J, Kahana E, Kahana B, Zhang Y. Driving Cessation in Old Age: Gender Influences on Mortality. Journal Of Aging And Health 2021, 33: 447-457. PMID: 33522849, DOI: 10.1177/0898264321991254.Peer-Reviewed Original ResearchConceptsOlder womenOlder menCox proportional hazards regression modelProportional hazards regression modelsCommunity-dwelling older adultsHazards regression modelsRelative riskMortality riskHealth statusOlder ageMortalityCognitive healthOlder adultsPhysical healthProspective panel surveyCessationOverall sampleSocial supportWomenAssociationRegression modelsHealthMenGender differencesRisk
2020
Monocyte activation and gut barrier dysfunction in South African youth on antiretroviral therapy and their associations with endothelial dysfunction.
Dirajlal-Fargo S, Yu J, Albar Z, Sattar A, Mahtab S, Jao J, Myer L, Zar H, McComsey G. Monocyte activation and gut barrier dysfunction in South African youth on antiretroviral therapy and their associations with endothelial dysfunction. AIDS 2020, 34: 1615-1623. PMID: 32769763, PMCID: PMC9390079, DOI: 10.1097/qad.0000000000002615.Peer-Reviewed Original ResearchConceptsReactive hyperemic indexGut barrier dysfunctionPoorer endothelial functionEndothelial dysfunctionMonocyte activationHIV- youthEndothelial functionBarrier dysfunctionAntiretroviral therapyLDL cholesterolLong-term clinical significanceCape Town Adolescent Antiretroviral CohortAntiretroviral therapy durationYears of ageViral suppressionHyperemic indexSystemic inflammationTherapy durationHIV- participantsMedian ageSpearman correlation coefficientViral loadSerum biomarkersSoluble CD14YLPHIVProductive Activity Patterns and Functional Health: A Comparison of Urban and Rural Chinese Older Adults
Yu J, Yang Y, Kahana E. Productive Activity Patterns and Functional Health: A Comparison of Urban and Rural Chinese Older Adults. The International Journal Of Aging And Human Development 2020, 91: 538-562. PMID: 31955589, DOI: 10.1177/0091415019900168.Peer-Reviewed Original ResearchConceptsFunctional health trajectoriesChinese older adultsOlder adultsLatent class analysisHealth trajectoriesFunctional health declineRetirement Longitudinal StudyActivity patternsFunctional healthRural residenceChina HealthHealth consequencesRural differencesHealth declineAdultsLongitudinal studyMultilevel regression analysisRegression analysisAssociationComparison of UrbanClass analysisHealthNonengagers
2019
Brief Report: Zinc Supplementation and Inflammation in Treated HIV.
Dirajlal-Fargo S, Yu J, Kulkarni M, Sattar A, Funderburg N, Barkoukis H, Mccomsey G. Brief Report: Zinc Supplementation and Inflammation in Treated HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: 275-280. PMID: 31609926, PMCID: PMC6812547, DOI: 10.1097/qai.0000000000002129.Peer-Reviewed Original ResearchConceptsZinc supplementationZinc levelsDouble-arm studyHigh-dose armLow-dose armMedian zinc levelStable antiretroviral therapyMarkers of inflammationYears old peopleTreated HIVAntiretroviral therapyHIV infectionMedian ageClinical comorbiditiesBiomarker levelsMonocyte activationLarge effect sizesHIVInflammationPilot studyPhase ISupplementationDlElemental zincAfrican AmericansDepressive symptoms among elderly men and women who transition to widowhood: comparisons with long term married and long term widowed over a 10-year period
Yu J, Kahana E, Kahana B, Han C. Depressive symptoms among elderly men and women who transition to widowhood: comparisons with long term married and long term widowed over a 10-year period. Journal Of Women & Aging 2019, 33: 231-246. PMID: 31671028, DOI: 10.1080/08952841.2019.1685855.Peer-Reviewed Original Research
2018
Whose advocacy counts in shaping elderly patients’ satisfaction with physicians’ care and communication?
Kahana B, Yu J, Kahana E, Langendoerfer K. Whose advocacy counts in shaping elderly patients’ satisfaction with physicians’ care and communication? Clinical Interventions In Aging 2018, 13: 1161-1168. PMID: 29983551, PMCID: PMC6025777, DOI: 10.2147/cia.s165086.Peer-Reviewed Original ResearchConceptsPatient satisfactionElderly patientsOlder adultsPhysician advocacyPhysician emotional supportAfrican American patientsSignificant predictorsEmotional supportPhysician-patient relationshipPatient ageWhite patientsLatino patientsPatients' perceptionsPhysician communicationCare satisfactionHealth characteristicsFunctional limitationsPatientsPatient advocatesMedical careLimited evidencePhysiciansPhysician ReadinessRegression analysisAdults