2021
Optimal Biomechanical Parameters for Measuring Sclerotic Chronic Graft-Versus-Host Disease
Baker L, Chen F, Cronin A, Chen H, Vain A, Jagasia M, Tkaczyk E. Optimal Biomechanical Parameters for Measuring Sclerotic Chronic Graft-Versus-Host Disease. JID Innovations 2021, 1: 100037. PMID: 34790906, PMCID: PMC8594905, DOI: 10.1016/j.xjidi.2021.100037.Peer-Reviewed Original ResearchCGVHD patientsBiomechanical parametersChronic Graft-VersusSclerotic chronic graftHost disease patientsBackward stepwise selectionChronic graftGraft-VersusSclerotic cGvHDHost diseaseUnivariable analysisTransplant controlsDisease patientsAnatomic sitesPatientsDisease severityLogistic regressionSclerotic diseaseBiomechanical studyDiscriminatory abilityLASSO regressionCharacteristic curveMyotonometerStepwise selectionDisease
2020
18323 Diagnostic potential of five different biomechanical parameters to detect sclerotic cutaneous graft-versus-host disease
Ssempijja Y, Chen F, Wang L, Vain A, Jagasia M, Tkaczyk E. 18323 Diagnostic potential of five different biomechanical parameters to detect sclerotic cutaneous graft-versus-host disease. Journal Of The American Academy Of Dermatology 2020, 83: ab98. DOI: 10.1016/j.jaad.2020.06.478.Peer-Reviewed Original ResearchCutaneous graftHost diseaseBiomechanical parametersDiagnostic potentialDifferent biomechanical parameters
2019
Diagnostic Potential of Five Different Biomechanical Parameters to Detect Sclerotic Cutaneous Graft-Versus-Host Disease
Chen F, Wang L, Ssempijja Y, Vain A, Jagasia M, Tkaczyk E. Diagnostic Potential of Five Different Biomechanical Parameters to Detect Sclerotic Cutaneous Graft-Versus-Host Disease. Blood 2019, 134: 2002. DOI: 10.1182/blood-2019-129381.Peer-Reviewed Original ResearchCGVHD patientsBMT controlsCross-sectional studyHost diseaseSkin sclerosisSkin scoreBiomechanical parametersSclerotic patientsCutaneous Graft-VersusPost-BMT patientsMechanical stress relaxation timeHigh diagnostic yieldProspective longitudinal studyChronic graftGraft-VersusGVHD patientsSkin involvementUnaffected skinUnivariate analysisHealthy controlsMultivariate predictive modelClinician assessmentDiagnostic yieldTreatment responseResponse assessment
2018
Reproducibility of the durometer and myoton devices for skin stiffness measurement in healthy subjects
Dellalana L, Chen F, Vain A, Gandelman J, Põldemaa M, Chen H, Tkaczyk E. Reproducibility of the durometer and myoton devices for skin stiffness measurement in healthy subjects. Skin Research And Technology 2018, 25: 289-293. PMID: 30414198, PMCID: PMC6546306, DOI: 10.1111/srt.12646.Peer-Reviewed Original ResearchConceptsInterobserver intraclass correlation coefficientOverall stiffnessIntraclass correlation coefficientHealthy subjectsMinimal detectable changeSkin stiffness measurementsDisease progressionMyotonClinical assessmentTreatment efficacyDorsal forearmUpper armVolar forearmIndustrial devicesMeasure of reproducibilityBiomechanical parametersStiffness measurementSingle observerStiffness parametersSkin stiffnessDetectable changeFurther investigationForearmStiffnessCoefficient of variation