2024
Enhancing prognostic power in multiple myeloma using a plasma cell signature derived from single-cell RNA sequencing
Li J, Arsang-Jang S, Cheng Y, Sun F, D’Souza A, Dhakal B, Hari P, Huang Q, Auer P, Li Y, Urrutia R, Zhan F, Shaughnessy J, Janz S, Dong J, Cheng C. Enhancing prognostic power in multiple myeloma using a plasma cell signature derived from single-cell RNA sequencing. Blood Cancer Journal 2024, 14: 38. PMID: 38443358, PMCID: PMC10915134, DOI: 10.1038/s41408-024-01024-8.Peer-Reviewed Original ResearchConceptsInternational Staging SystemPlasma cell malignancyMultiple myelomaCell malignancySpectrum of plasma cell dyscrasiasPlasma cell gene signaturePresence of cytogenetic abnormalitiesRevised ISSHeterogeneous plasma cell malignancyTumor immune microenvironmentPlasma cell dyscrasiaRefining risk stratificationPlasma cell signatureTherapeutic approach to MMShorter overall survivalCytogenetic abnormalitiesOverall survivalR-ISSTP53 mutationsImmune microenvironmentPrognostic effectClinical outcomesStaging systemRisk stratificationPrognostic power
2023
Prognostic landscape of mitochondrial genome in myelodysplastic syndrome after stem-cell transplantation
Dong J, Buradagunta C, Zhang T, Spellman S, Bolon Y, DeZern A, Gadalla S, Deeg H, Nazha A, Cutler C, Cheng C, Urrutia R, Auer P, Saber W. Prognostic landscape of mitochondrial genome in myelodysplastic syndrome after stem-cell transplantation. Journal Of Hematology & Oncology 2023, 16: 21. PMID: 36899395, PMCID: PMC9999628, DOI: 10.1186/s13045-023-01418-4.Peer-Reviewed Original ResearchConceptsWhole-genome sequencingTransplant-related mortalityRelapse-free survivalMtDNA mutationsAllo-HCTImpact of mtDNA mutationsWhole-genome sequencing effortsOverall survivalTransplant outcomesCenter for International Blood and Marrow Transplant ResearchPrognostic performance of modelsAllogeneic hematopoietic cell transplantationPotential pathogenic variantsAllo-HCT outcomesInternational Prognostic ScorePredictors of OSStandard clinical parametersStem-cell transplantationHematopoietic cell transplantationMarrow Transplant ResearchAssociated with inferior transplant outcomesMitochondrial genomeMtDNA genesMtDNA variantsInferior transplant outcomes