T-Cell Receptor Optimization with Reinforcement Learning and Mutation Polices for Precision Immunotherapy
Chen Z, Min M, Guo H, Cheng C, Clancy T, Ning X. T-Cell Receptor Optimization with Reinforcement Learning and Mutation Polices for Precision Immunotherapy. Lecture Notes In Computer Science 2023, 13976: 174-191. DOI: 10.1007/978-3-031-29119-7_11.Peer-Reviewed Original ResearchT cell receptorReinforcement learningBaseline methodsT cellsT cell receptor recognitionProximal policy optimizationPrecision immunotherapyMutated T-cell receptorImmune responseOptimal T-cell receptorSurface of T cellsDeep autoencoderPolicy optimizationReward functionDevelopment of personalized treatmentsScoring functionVirus-infected cellsHealth status of cellsTCR sequencesMutation policyPersonalized treatmentMotif discoveryStatus of cellsProtein complexesImmunotherapy