INTEGRAL‐ILCCO cohort data analysis revealed the association of clonal haematopoiesis with an increased risk of lung cancer
Cheng C, Hong W, Amos C. INTEGRAL‐ILCCO cohort data analysis revealed the association of clonal haematopoiesis with an increased risk of lung cancer. Clinical And Translational Discovery 2024, 4 DOI: 10.1002/ctd2.258.Peer-Reviewed Original ResearchRisk of lung cancerIncreased risk of lung cancerLung cancer riskVariant allele frequencyClonal haematopoiesisCancer riskCH mutationsInternational Lung Cancer ConsortiumLung cancerIncreased riskRisk factorsLung cancer etiologyHighest variant allele frequencyLung cancer casesLung cancer histological subtypesCohort data analysisCancer histological subtypesCancer ConsortiumCancer casesLow variant allele frequencyCancer etiologyDose-response relationshipHigher VAFHistological subtypesLow-VAFLung cancer in ever- and never-smokers: findings from multi-population GWAS studies
Li Y, Xiao X, Li J, Han Y, Cheng C, Fernandes G, Slewitzke S, Rosenberg S, Zhu M, Byun J, Bossé Y, McKay J, Albanes D, Lam S, Tardon A, Chen C, Bojesen S, Landi M, Johansson M, Risch A, Bickeböller H, Wichmann H, Christiani D, Rennert G, Arnold S, Goodman G, Field J, Davies M, Shete S, Le Marchand L, Liu G, Hung R, Andrew A, Kiemeney L, Sun R, Zienolddiny S, Grankvist K, Johansson M, Caporaso N, Cox A, Hong Y, Lazarus P, Schabath M, Aldrich M, Schwartz A, Gorlov I, Purrington K, Yang P, Liu Y, Bailey-Wilson J, Pinney S, Mandal D, Willey J, Gaba C, Brennan P, Xia J, Shen H, Amos C. Lung cancer in ever- and never-smokers: findings from multi-population GWAS studies. Cancer Epidemiology Biomarkers & Prevention 2024, 33: 389-399. PMID: 38180474, PMCID: PMC10905670, DOI: 10.1158/1055-9965.epi-23-0613.Peer-Reviewed Original ResearchConceptsExpression quantitative trait lociLung cancer riskAssociation studiesCis-regulation of gene expressionNever-smokersCancer riskNever-smoker lung cancerQuantitative trait lociComplicated genetic architectureFunctional analysisExcessive DNA damageRisk of variantsLung cancerGenetic epidemiological studiesIndependent lociCis-regulationGenetic architectureGWA studiesTrait lociMultiple lines of evidenceGenetic heterogeneityNever-smoker groupGene expressionLines of evidenceEver-smokers