Development of the Nasopharyngeal Microbiota in Infants with Cystic Fibrosis
Prevaes SM, de Winter-de Groot KM, Janssens HM, de Steenhuijsen Piters WA, Tramper-Stranders GA, Wyllie AL, Hasrat R, Tiddens HA, van Westreenen M, van der Ent CK, Sanders EA, Bogaert D. Development of the Nasopharyngeal Microbiota in Infants with Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2016, 193: 504-515. PMID: 26492486, DOI: 10.1164/rccm.201509-1759oc.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBurkholderiaBurkholderia InfectionsCarrier StateCase-Control StudiesCohort StudiesCorynebacteriumCorynebacterium InfectionsCystic FibrosisDNA, BacterialEnterobacteriaceaeEnterobacteriaceae InfectionsFemaleHaemophilus InfectionsHaemophilus influenzaeHumansInfantInfant, NewbornMaleMicrobiotaMoraxellaMoraxellaceae InfectionsNasopharynxProspective StudiesReal-Time Polymerase Chain ReactionRNA, Ribosomal, 16SStaphylococcal InfectionsStaphylococcus aureusStreptococcal InfectionsStreptococcus mitisConceptsHealthy control subjectsControl subjectsMonths of lifeMonths of ageCystic fibrosisAntibiotic useMicrobiota profilesAge-matched healthy control subjectsEarly structural lung diseaseNasopharyngeal microbiota profilesNasopharynx of infantsProspective cohort studyStructural lung diseaseTime of diagnosisMoraxella sppPotential respiratory pathogensRespiratory symptomsAntibiotic therapyCohort studyPulmonary infectionLung diseaseNasopharyngeal microbiotaRespiratory pathogensHaemophilus influenzaeNasopharynx samples