2023
The potential of saliva as an accessible and sensitive sample type for the detection of respiratory pathogens and host immunity
Laxton C, Peno C, Hahn A, Allicock O, Perniciaro S, Wyllie A. The potential of saliva as an accessible and sensitive sample type for the detection of respiratory pathogens and host immunity. The Lancet Microbe 2023, 4: e837-e850. PMID: 37516121, DOI: 10.1016/s2666-5247(23)00135-0.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Respiratory pathogensPotential of salivaUsefulness of salivaUse of salivaRespiratory specimenRespiratory secretionsDisease burdenImmunological componentsImmunity surveillanceClinical utilityHost immunityClinical useDiagnostic testsNon-invasive natureSalivaCOVID-19 pandemicSample typesMethodological factorsPathogensImmunitySecretion
2020
Serotype Patterns of Pneumococcal Disease in Adults Are Correlated With Carriage Patterns in Older Children
Wyllie AL, Warren JL, Regev-Yochay G, Givon-Lavi N, Dagan R, Weinberger DM. Serotype Patterns of Pneumococcal Disease in Adults Are Correlated With Carriage Patterns in Older Children. Clinical Infectious Diseases 2020, 72: e768-e775. PMID: 32989457, PMCID: PMC8315131, DOI: 10.1093/cid/ciaa1480.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseSerotype-specific invasive pneumococcal diseaseDisease patternsOlder childrenPneumococcal diseasePneumococcal carriageCarriage prevalenceSerotype patternsCause of IPDIPD dataSerotype-specific carriage prevalenceAge groupingsDifferent age groupsComorbidity statusDisease burdenVaccination strategiesAge-related patternsCarriage dataCarriage patternsDifferent age categoriesAge groupsSpecific serotypesYoung adultsAdultsAge categoriesUpper respiratory tract colonization with Streptococcus pneumoniae in adults
Arguedas A, Trzciński K, O’Brien K, Ferreira DM, Wyllie AL, Weinberger D, Danon L, Pelton SI, Azzari C, Hammitt LL, Sá-Leão R, Brandileone MC, Saha S, Suaya J, Isturiz R, Jodar L, Gessner BD. Upper respiratory tract colonization with Streptococcus pneumoniae in adults. Expert Review Of Vaccines 2020, 19: 353-366. PMID: 32237926, DOI: 10.1080/14760584.2020.1750378.Peer-Reviewed Original ResearchConceptsPediatric approachPneumococcal colonizationPneumococcal detectionRespiratory sitesUpper respiratory tract colonizationAdult respiratory tractRespiratory tract colonizationHigh disease burdenPneumococcal carriage studiesRespiratory carriageNasal washesPeer-reviewed journalsRespiratory colonizationCarriage prevalencePneumococcal transmissionTract colonizationDisease burdenRespiratory tractCarriage studiesCurrent evidenceStreptococcus pneumoniaeMolecular diagnostic methodsRoutine cultureAdultsRecent evidence