2022
Novel Multilocus Sequence Typing and Global Sequence Clustering Schemes for Characterizing the Population Diversity of Streptococcus mitis
Kalizang’oma A, Kwambana-Adams B, Chan J, Viswanath A, Gori A, Richard D, Jolley K, Lees J, Goldblatt D, Beleza S, Bentley S, Heyderman R, Chaguza C. Novel Multilocus Sequence Typing and Global Sequence Clustering Schemes for Characterizing the Population Diversity of Streptococcus mitis. Journal Of Clinical Microbiology 2022, 61: e00802-22. PMID: 36515506, PMCID: PMC9879099, DOI: 10.1128/jcm.00802-22.Peer-Reviewed Original ResearchMeSH KeywordsCluster AnalysisHumansMultilocus Sequence TypingPhylogenyStreptococcusStreptococcus mitisConceptsSequence clustersPathogenic streptococcal speciesMultilocus sequence typing (MLST) schemePopulation diversitySingle-nucleotide polymorphism distancesSequence typesSequence typing schemeUnique sequence typesGenetic diversityPopulation structureBacterial population diversityMolecular typing toolsS. mitisHousekeeping genesSequence fragmentsMLST schemeDiversityOpportunistic pathogenStreptococcus mitisStreptococcal speciesTyping toolSpeciesNew insightsTyping schemeMultilocus sequence typingA new perspective on ancient Mitis group streptococcal genetics
Belman S, Chaguza C, Kumar N, Lo S, Bentley SD. A new perspective on ancient Mitis group streptococcal genetics. Microbial Genomics 2022, 8: 000753. PMID: 35225216, PMCID: PMC8942026, DOI: 10.1099/mgen.0.000753.Peer-Reviewed Original ResearchMeSH KeywordsHumansPneumococcal VaccinesStreptococcusStreptococcus mitisStreptococcus pneumoniaeVirulence FactorsConceptsCommensal speciesVirulence factorsPathogenic speciesSpecific virulence factorsMitis groupHost-microbe interactionsMajor virulence factorInvasive diseaseLeading causeOral cavityVaccine antigensEvolutionary divergenceExtant speciesEvolutionary historyExtant strainsStreptococcus pneumoniaeSuch genesAncient genomesSynthesis genesGene databaseIndividual speciesPolysaccharide capsuleZinc metalloproteasesStable maintenanceObligate bacteria
2021
Streptococcus pneumoniae serotypes that frequently colonise the human nasopharynx are common recipients of penicillin-binding protein gene fragments from Streptococcus mitis
Kalizang'oma A, Chaguza C, Gori A, Davison C, Beleza S, Antonio M, Beall B, Goldblatt D, Kwambana-Adams B, Bentley SD, Heyderman RS. Streptococcus pneumoniae serotypes that frequently colonise the human nasopharynx are common recipients of penicillin-binding protein gene fragments from Streptococcus mitis. Microbial Genomics 2021, 7: 000622. PMID: 34550067, PMCID: PMC8715442, DOI: 10.1099/mgen.0.000622.Peer-Reviewed Original ResearchMeSH KeywordsBacterial ProteinsBeta-Lactam ResistanceDrug Resistance, BacterialGene Transfer, HorizontalGenes, BacterialHumansMicrobial Sensitivity TestsNasopharynxPenicillin-Binding ProteinsPenicillinsPhylogenyPneumococcal InfectionsPneumococcal VaccinesSerogroupStreptococcusStreptococcus mitisStreptococcus oralisStreptococcus pneumoniaeWhole Genome SequencingConceptsMinimum inhibitory concentrationPneumococcal vaccine programsFirst-line treatmentHigh minimum inhibitory concentrationsStreptococcus pneumoniae serotypesPneumococcal population structurePneumococcal serotypes 6ABeta-lactam antibioticsLonger carriage durationBeta-lactam resistanceImportant global pathogenPneumococcal diseaseBacterial pneumoniaPneumococcal serotypesVaccine programSerotypes 6APneumoniae serotypesΒ-lactam susceptibilityPenicillin-binding protein (PBP) genesHuman nasopharynxCarriage durationCommensal streptococciCommon recipientInhibitory concentrationStreptococci