2021
Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life
Chaguza C, Senghore M, Bojang E, Lo SW, Ebruke C, Gladstone RA, Tientcheu PE, Bancroft RE, Worwui A, Foster-Nyarko E, Ceesay F, Okoi C, McGee L, Klugman KP, Breiman RF, Barer MR, Adegbola RA, Antonio M, Bentley SD, Kwambana-Adams BA. Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life. Frontiers In Pediatrics 2021, 8: 587730. PMID: 33489998, PMCID: PMC7820366, DOI: 10.3389/fped.2020.587730.Peer-Reviewed Original ResearchPneumococcal serotypesPneumococcal conjugate vaccineRural African settingFirst yearColonized infantsPneumococcal acquisitionConjugate vaccineCarriage prevalenceInvasive diseaseNewborn infantsWeek 35Week 1Carriage patternsDisease preventionLatex agglutinationInfantsClinical interventionsMultiple serotypesFirst weekCarriage durationAfrican settingCarriage dynamicsBaseline dataSerotypesLimited data
2015
High multiple carriage and emergence of Streptococcus pneumoniae vaccine serotype variants in Malawian children
Kamng’ona A, Hinds J, Bar-Zeev N, Gould KA, Chaguza C, Msefula C, Cornick JE, Kulohoma BW, Gray K, Bentley SD, French N, Heyderman RS, Everett DB. High multiple carriage and emergence of Streptococcus pneumoniae vaccine serotype variants in Malawian children. BMC Infectious Diseases 2015, 15: 234. PMID: 26088623, PMCID: PMC4474563, DOI: 10.1186/s12879-015-0980-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBacterial CapsulesBacteriological TechniquesChildChild, PreschoolCross ProtectionDNA, BacterialFemaleGenetic VariationHIV InfectionsHumansInfantInfant, NewbornMalawiMaleNasopharynxOligonucleotide Array Sequence AnalysisPhylogenyPneumococcal InfectionsPneumococcal VaccinesSequence Analysis, DNASerogroupStreptococcus pneumoniaeConceptsPneumococcal carriageVaccine typesPneumococcal serotypesMalawian childrenMultiple carriageMultiple serotypesVaccine serotypes 6BInvasive pneumococcal diseaseMultiple pneumococcal serotypesCent of childrenYoung childrenVT serotypesPCV13 introductionPneumococcal diseaseNasopharyngeal samplesPossible genetic alterationsSerotypes 6BMethodsThe studyPneumococcal strainsVaccine escapeKaronga DistrictOlder childrenSterile swabsDistinct serotypesGenetic alterations