2015
Description of a New Galapagos Giant Tortoise Species (Chelonoidis; Testudines: Testudinidae) from Cerro Fatal on Santa Cruz Island
Poulakakis N, Edwards D, Chiari Y, Garrick R, Russello M, Benavides E, Watkins-Colwell G, Glaberman S, Tapia W, Gibbs J, Cayot L, Caccone A. Description of a New Galapagos Giant Tortoise Species (Chelonoidis; Testudines: Testudinidae) from Cerro Fatal on Santa Cruz Island. PLOS ONE 2015, 10: e0138779. PMID: 26488886, PMCID: PMC4619298, DOI: 10.1371/journal.pone.0138779.Peer-Reviewed Original ResearchConceptsMultiple independent evolutionary lineagesGiant tortoise speciesIndependent evolutionary lineagesCompelling genetic evidenceGalapagos tortoisesRank of speciesSanta Cruz IslandGenetic distinctivenessAnalysis of DNAEvolutionary lineagesEvolutionary relationshipsNatural populationsDNA charactersDistinct lineagesIsland of originTaxonomic revisionMorphological charactersMuseum specimensNew speciesGenetic evidenceTortoise speciesLineagesSpeciesTortoisesType specimenHybridization masks speciation in the evolutionary history of the Galápagos marine iguana
MacLeod A, Rodríguez A, Vences M, Orozco-terWengel P, García C, Trillmich F, Gentile G, Caccone A, Quezada G, Steinfartz S. Hybridization masks speciation in the evolutionary history of the Galápagos marine iguana. Proceedings Of The Royal Society B 2015, 282: 20150425. PMID: 26041359, PMCID: PMC4590447, DOI: 10.1098/rspb.2015.0425.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEcuadorGenetic SpeciationHybridization, GeneticIguanasMolecular Sequence DataPhylogenySequence Analysis, DNAConceptsGalápagos marine iguanasEvolutionary historyMarine iguanasIncipient speciationStrong population structureGenome-wide analysisGalápagos land iguanasCommon gene poolDepth genome-wide analysisSpeciation eventsIsland speciationSister lineageEvolutionary potentialFrequent hybridizationExtant populationsLocal adaptationPhylogenetic treeGene poolSister groupPopulation structureVariable markersLand iguanasEvolutionary processesSame islandNearby islands
2012
Genetic isolation within the malaria mosquito Anopheles melas
Deitz K, Athrey G, Reddy M, Overgaard H, Matias A, Jawara M, della Torre A, Petrarca V, Pinto J, Kiszewski A, Kengne P, Costantini C, Caccone A, Slotman M. Genetic isolation within the malaria mosquito Anopheles melas. Molecular Ecology 2012, 21: 4498-4513. PMID: 22882458, PMCID: PMC4067978, DOI: 10.1111/j.1365-294x.2012.05724.x.Peer-Reviewed Original ResearchConceptsMicrosatellite dataIsland populationsGambiae complexMaximum likelihood phylogenetic analysisBp of mtDNALevel of divergenceLast glaciation periodA. gambiae complexMalaria vectorsSalt marsh grassAnopheles gambiae complexAnopheles melasMajor malaria vectorApproximate Bayesian analysisMtDNA divergenceGenetic differentiationGenetic divergenceGenetic isolationMainland populationsPhylogenetic analysisPopulation structureMicrosatellite markersLarval habitatsA. gambiaeGlaciation periodTrypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum Resistance
Symula RE, Beadell JS, Sistrom M, Agbebakun K, Balmer O, Gibson W, Aksoy S, Caccone A. Trypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum Resistance. PLOS Neglected Tropical Diseases 2012, 6: e1728. PMID: 22802982, PMCID: PMC3393672, DOI: 10.1371/journal.pntd.0001728.Peer-Reviewed Original ResearchConceptsTrypanosome lytic factorHuman serum resistanceGroup 2Group 1Serum resistanceHaptoglobin-hemoglobin receptorHuman serumHuman African trypanosomiasisInnate immunityTrypanosoma brucei rhodesienseUnique amino acid substitutionsAltered activityLytic factorCausative agentLytic activityHemoglobin receptorTLF-1African trypanosomiasisBrucei rhodesienseSerumReceptorsAmino acid substitutionsFurther evidenceHpHbRTBR
2011
Unravelling the peculiarities of island life: vicariance, dispersal and the diversification of the extinct and extant giant Galápagos tortoises
POULAKAKIS N, RUSSELLO M, GEIST D, CACCONE A. Unravelling the peculiarities of island life: vicariance, dispersal and the diversification of the extinct and extant giant Galápagos tortoises. Molecular Ecology 2011, 21: 160-173. PMID: 22098061, DOI: 10.1111/j.1365-294x.2011.05370.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological EvolutionDNA, MitochondrialExtinction, BiologicalGenetic VariationMolecular Sequence DataPhylogenyPhylogeographySequence Analysis, DNATurtlesConceptsGiant Galápagos tortoisesHuman-mediated dispersal eventsVicariant eventsGalápagos tortoisesMainland South AmericaHuman activitiesIndependent evolutionary unitsAvailable geological dataSimple linear trendRecent human activitiesIsland lifeEvolutionary unitsEndangered taxaColonization eventsExtant speciesDispersal eventsEvolutionary historyGeological dataMultiple colonizationsExtinct speciesOcean islandsDNA dataOlder islandsYounger islandsOceanic islandsInfluence of Host Phylogeographic Patterns and Incomplete Lineage Sorting on Within-Species Genetic Variability in Wigglesworthia Species, Obligate Symbionts of Tsetse Flies
Symula RE, Marpuri I, Bjornson RD, Okedi L, Beadell J, Alam U, Aksoy S, Caccone A. Influence of Host Phylogeographic Patterns and Incomplete Lineage Sorting on Within-Species Genetic Variability in Wigglesworthia Species, Obligate Symbionts of Tsetse Flies. Applied And Environmental Microbiology 2011, 77: 8400-8408. PMID: 21948847, PMCID: PMC3233068, DOI: 10.1128/aem.05688-11.Peer-Reviewed Original ResearchConceptsObligate symbiontsHost speciesGenetic variationMultiple host populationsIncongruence length difference testIncomplete lineage sortingHost-symbiont combinationsSingle host speciesPopulation-level processesIncomplete lineageLineage sortingPhylogeographic patternsSouthern lineagesSymbiont lineagesHost mtDNAWigglesworthia glossinidiaMolecular varianceBacterial symbiontsEvolutionary associationEvolutionary historySouthern populationsMitochondrial DNA haplogroupsVariable lociSymbiontsGenetic variabilityPermanent Genetic Resources added to Molecular Ecology Resources Database 1 December 2010–31 January 2011
Consortium M, AGATA K, ALASAAD S, ALMEIDA‐VAL V, ÁLVAREZ‐DIOS J, BARBISAN F, BEADELL JS, BELTRÁN JF, BENÍTEZ M, BINO G, BLEAY C, BLOOR P, BOHLMANN J, BOOTH W, BOSCARI E, CACCONE A, CAMPOS T, CARVALHO BM, CLIMACO GT, CLOBERT J, CONGIU L, COWGER C, DIAS G, DOADRIO I, FARIAS IP, FERRAND N, FREITAS PD, FUSCO G, GALETTI PM, GALLARDO‐ESCÁRATE C, GAUNT MW, OCAMPO ZG, GONÇALVES H, GONZALEZ EG, HAYE P, HONNAY O, HYSENI C, JACQUEMYN H, JOWERS MJ, KAKEZAWA A, KAWAGUCHI E, KEELING CI, KWAN Y, LA SPINA M, LEE W, LEŚNIEWSKA M, LI Y, LIU H, LIU X, LOPES S, MARTÍNEZ P, MEEUS S, MURRAY BW, NUNES AG, OKEDI LM, OUMA JO, PARDO BG, PARKS R, PAULA‐SILVA M, PEDRAZA‐LARA C, PERERA OP, PINO‐QUERIDO A, RICHARD M, ROSSINI BC, SAMARASEKERA NG, SÁNCHEZ A, SANCHEZ JA, dos ANJOS SANTOS C, SHINOHARA W, SORIGUER RC, SOUSA AC, da SILVA SOUSA C, STEVENS VM, TEJEDO M, VALENZUELA‐BUSTAMANTE M, VAN de VLIET MS, VANDEPITTE K, VERA M, WANDELER P, WANG W, WON Y, YAMASHIRO A, YAMASHIRO T, ZHU C. Permanent Genetic Resources added to Molecular Ecology Resources Database 1 December 2010–31 January 2011. Molecular Ecology Resources 2011, 11: 586-589. PMID: 21457476, DOI: 10.1111/j.1755-0998.2011.03004.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDatabases, GeneticFungiMicrosatellite RepeatsMolecular Sequence DataPlantsSequence Analysis, DNAConceptsMolecular Ecology Resources DatabaseJaponica varPermanent Genetic ResourcesBlumeria graminis f.Microsatellite marker lociSalminus hilariiAustropotamobius italicusZootoca viviparaMicrotus cabreraeGraminis f.Salminus franciscanusGenetic resourcesKirengeshoma palmataPacifastacus leniusculusAlytes muletensisPulmonaria officinalisMarker lociDendroctonus ponderosaeChorus giganteusOrconectes virilisGlossina morsitans morsitansSalminus brasiliensisArapaima gigasProcambarus clarkiiMytilus galloprovincialis
2010
Genetic Differentiation between Marine Iguanas from Different Breeding Sites on the Island of Santa Fé (Galápagos Archipelago)
Lanterbecq D, Glaberman S, Vitousek M, Steinfartz S, Benavides E, Wikelski M, Caccone A. Genetic Differentiation between Marine Iguanas from Different Breeding Sites on the Island of Santa Fé (Galápagos Archipelago). Journal Of Heredity 2010, 101: 663-675. PMID: 20538757, DOI: 10.1093/jhered/esq067.Peer-Reviewed Original ResearchConceptsMarine iguanasGenetic diversitySex-biased dispersalMitochondrial control regionMitochondrial DNA markersGalápagos marine iguanasSanta FéDifferent breeding sitesSouthern sitesGenetic differentiationEvolutionary signalGenetic structureMicrosatellite lociDNA markersControl regionGenetic variationGenetic patternsBreeding sitesLittle differentiationBase pairsNeighboring islandsIguanasDiversitySampling sitesDifferentiation
2008
Historical DNA analysis reveals living descendants of an extinct species of Galápagos tortoise
Poulakakis N, Glaberman S, Russello M, Beheregaray LB, Ciofi C, Powell JR, Caccone A. Historical DNA analysis reveals living descendants of an extinct species of Galápagos tortoise. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 15464-15469. PMID: 18809928, PMCID: PMC2563078, DOI: 10.1073/pnas.0805340105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA, MitochondrialEcuadorExtinction, BiologicalHumansMolecular Sequence DataPhylogenySequence Analysis, DNASpecies SpecificityTurtlesConceptsMuseum specimensHistorical DNA analysisDiversification of organismsCaptive breeding programsIsland of FloreanaModern DNA techniquesMicrosatellite dataGalápagos tortoisesConservation biologyMitochondrial DNANatural selectionExtinct speciesExtinct taxaBreeding programsGiant tortoisesIntense harvestingGenetic analysisGenetic dataGalápagos ArchipelagoTortoise populationsDNA techniquesHuman exploitationNearby islandsEnough individualsSpeciesCharacterization of a Nonclassical Class I MHC Gene in a Reptile, the Galápagos Marine Iguana (Amblyrhynchus cristatus)
Glaberman S, Du Pasquier L, Caccone A. Characterization of a Nonclassical Class I MHC Gene in a Reptile, the Galápagos Marine Iguana (Amblyrhynchus cristatus). PLOS ONE 2008, 3: e2859. PMID: 18682845, PMCID: PMC2483932, DOI: 10.1371/journal.pone.0002859.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDNA PrimersDNA, ComplementaryExonsGene AmplificationGenes, MHC Class IIguanasMolecular Sequence DataRNASeawaterConceptsGalápagos marine iguanasClass I MHC genesMHC genesMarine iguanasLarge taxonomic gapsClassical class I genesGenomic sequence dataClassical MHC genesMajor histocompatibility complex (MHC) genesPeptide-binding residuesClass I genesMHC evolutionNonclassical genesVertebrate taxaDiverse orderClass I sequencesMHC organizationCytoplasmic domainPhylogenetic analysisGenomic sequencesTaxonomic gapsConserved characterI geneSequence dataI sequencesSpecies-specific evolution of class I MHC genes in iguanas (Order: Squamata; Subfamily: Iguaninae)
Glaberman S, Caccone A. Species-specific evolution of class I MHC genes in iguanas (Order: Squamata; Subfamily: Iguaninae). Immunogenetics 2008, 60: 371-382. PMID: 18488213, DOI: 10.1007/s00251-008-0298-y.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsEvolution, MolecularGenes, MHC Class IGenetic VariationIguanasMolecular Sequence DataPhylogenySpecies SpecificityConceptsMarine iguanasSpecies-specific evolutionGalápagos land iguanasGalápagos marine iguanasDifferent phylogenetic historiesNon-avian reptilesSpecies-specific mannerClass I MHC genesMajor histocompatibility complexConservation geneticsPhylogenetic historySquamate speciesVertebrate taxaDiversified orderGenetic diversityNatural selectionMHC researchDNA dataGenetic basisLand iguanasMultiple lociMHC genesMHC studiesHost resistanceIguanasHistorical analysis of a near disaster: Anopheles gambiae in Brazil.
Parmakelis A, Russello MA, Caccone A, Marcondes CB, Costa J, Forattini OP, Sallum MA, Wilkerson RC, Powell JR. Historical analysis of a near disaster: Anopheles gambiae in Brazil. American Journal Of Tropical Medicine And Hygiene 2008, 78: 176-8. PMID: 18187802, DOI: 10.4269/ajtmh.2008.78.176.Peer-Reviewed Original ResearchConceptsHuman-mediated range expansionIntrinsic historical interestAnopheles gambiaeDisease vectorsHistorical DNA analysisHuman-mediated dispersalInsect disease vectorsMuseum collectionsHistorical analysisNear disasterHistorical interestAnopheles gambiae complexHistorical informationTime of invasionIntercontinental introductionSpecies complexSpecies identityRange expansionMuseum specimensGambiae complexGambiaeSpeciesAnopheles arabiensisIdentityDNA analysis
2007
Independent evolutionary origins of landlocked alewife populations and rapid parallel evolution of phenotypic traits
PALKOVACS E, DION K, POST D, CACCONE A. Independent evolutionary origins of landlocked alewife populations and rapid parallel evolution of phenotypic traits. Molecular Ecology 2007, 17: 582-597. PMID: 18179439, DOI: 10.1111/j.1365-294x.2007.03593.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConnecticutDNA, MitochondrialEvolution, MolecularFishesGeographyMicrosatellite RepeatsMolecular Sequence DataSequence Analysis, DNAConceptsLandlocked populationsAnadromous populationsAlewife populationSmaller adult body sizeRapid parallel evolutionLife history divergenceFreshwater ancestorsIndependent evolutionary originsDivergence time estimatesLife-history variantsGill raker spacingMicrosatellite mutation ratesMtDNA control regionAdult body sizeRate of evolutionSmall prey itemsAnadromous ancestorsForaging traitsPopulation divergenceAllele frequency dataDivergence timesEvolutionary ratesMicrosatellite dataAnadromous formEvolutionary origin
2006
A Bayesian approach on molecules and behavior: reconsidering phylogenetic and evolutionary patterns of the Salamandridae with emphasis on Triturus newts
Steinfartz S, Vicario S, Arntzen J, Caccone A. A Bayesian approach on molecules and behavior: reconsidering phylogenetic and evolutionary patterns of the Salamandridae with emphasis on Triturus newts. Journal Of Experimental Zoology Part B Molecular And Developmental Evolution 2006, 308B: 139-162. PMID: 16969762, DOI: 10.1002/jez.b.21119.Peer-Reviewed Original ResearchConceptsCourtship traitsSpecies of TriturusDNA sequence dataLast common ancestorTrue salamandersSalamandrid speciesMitochondrial genesMolecular phylogenyTriturus newtsGenus TriturusSpecies assemblagesPhylogenetic positionCommon ancestorEuropean newtsFamily SalamandridaeEvolutionary patternsT. vittatusMorphological charactersSequence dataLife historySalamandridaeT. alpestrisTemporal divergenceNewtsTriturusAn analysis of species boundaries and biogeographic patterns in a cryptic species complex: The rotifer—Brachionus plicatilis
Suatoni E, Vicario S, Rice S, Snell T, Caccone A. An analysis of species boundaries and biogeographic patterns in a cryptic species complex: The rotifer—Brachionus plicatilis. Molecular Phylogenetics And Evolution 2006, 41: 86-98. PMID: 16815046, DOI: 10.1016/j.ympev.2006.04.025.Peer-Reviewed Original ResearchConceptsCryptic species complexSpecies conceptSpecies boundariesCryptic complexesSpecies complexRotifer Brachionus plicatilisGenealogical species conceptMolecular sequence divergenceBiological species conceptEvidence of isolationMultiple species conceptsDifferent species conceptsLarge geographic scalesReproductive isolationMolecular phylogeneticsSpecies hypothesesBiogeographic patternsPhylogenetic dataSequence divergencePassive dispersalLarge vertebratesMarine invertebratesPhylogenetic studiesReproductive successCosmopolitan speciesAncient DNA forces reconsideration of evolutionary history of Mediterranean pygmy elephantids
Poulakakis N, Parmakelis A, Lymberakis P, Mylonas M, Zouros E, Reese D, Glaberman S, Caccone A. Ancient DNA forces reconsideration of evolutionary history of Mediterranean pygmy elephantids. Biology Letters 2006, 2: 451-454. PMID: 17148428, PMCID: PMC1686204, DOI: 10.1098/rsbl.2006.0467.Peer-Reviewed Original ResearchConceptsEvolutionary historyDNA sequencesAncient DNA studiesDNA fragmentsMultiple displacement amplification (MDA) methodPygmy mammothsIndependent historyShort DNA sequencesB-DNA fragmentEastern MediterraneanMediterranean islandsPhylogenetic analysisMolecular dataMainland samplesCretan sampleDNA studiesHistoryElephantidsDiagnostic sitesElephasPrevailing viewIslandsMammothsMammuthusSequenceMolecular phylogeny and historical biogeography of the land snail genus Solatopupa (Pulmonata) in the peri-Tyrrhenian area
Ketmaier V, Giusti F, Caccone A. Molecular phylogeny and historical biogeography of the land snail genus Solatopupa (Pulmonata) in the peri-Tyrrhenian area. Molecular Phylogenetics And Evolution 2006, 39: 439-451. PMID: 16442313, DOI: 10.1016/j.ympev.2005.12.008.Peer-Reviewed Original ResearchConceptsMolecular clock estimatesClock estimatesPeri-Tyrrhenian areaSardinia-Corsica microplateMain cladogenetic eventsNuclear genesVicariant processesCladogenetic eventsHistorical biogeographyMolecular phylogenyPhylogenetic resultsPhylogenetic relationshipsEvolutionary historyPhylogenetic hypothesisSister taxaInsular rangeGenetic relationshipsCalcareous substratesCorsica-Sardinia microplateMiddle–late PlioceneGenusSpeciesItalian peninsulaMiddle MioceneElba Island
2005
Short report: Phylogenetic relationships of the anthropophilic Plasmodium falciparum malaria vectors in Africa.
Marshall J, Powell J, Caccone A. Short report: Phylogenetic relationships of the anthropophilic Plasmodium falciparum malaria vectors in Africa. American Journal Of Tropical Medicine And Hygiene 2005, 73: 749-52. PMID: 16222020, DOI: 10.4269/ajtmh.2005.73.749.Peer-Reviewed Original ResearchConceptsNumber of speciesMalaria vectorsAfrican mosquito vectorsMosquito vectorsNuclear genesParaphyletic relationshipSubgenus CelliaPhylogenetic relationshipsPhylogenetic analysisAdditional speciesStatistical supportSpeciesPlasmodium falciparumP. falciparumCausative agentCelliaFalciparumGenesHistorical associationVectorBayesian methodsA rapid loss of stripes: the evolutionary history of the extinct quagga
Leonard J, Rohland N, Glaberman S, Fleischer R, Caccone A, Hofreiter M. A rapid loss of stripes: the evolutionary history of the extinct quagga. Biology Letters 2005, 1: 291-295. PMID: 17148190, PMCID: PMC1617154, DOI: 10.1098/rsbl.2005.0323.Peer-Reviewed Original ResearchConceptsEvolutionary historyDNA sequencesShort mitochondrial DNA sequencesMitochondrial DNA sequencesPlains zebraLittle genetic diversityPleistocene climate changePhylogeographic patternsGenetic diversityHolarctic faunaExtinct quaggaFirst extinct speciesAncient DNAExtinct speciesMuseum skinsGenetic informationQuaggaZebraDNARapid lossGlacial MaximumSequenceClimate changeFaunaSpecies
2004
Variation in an intron sequence of the voltage‐gated sodium channel gene correlates with genetic differentiation between Anopheles gambiae s.s. molecular forms
Gentile G, Santolamazza F, Fanello C, Petrarca V, Caccone A, Della Torre A. Variation in an intron sequence of the voltage‐gated sodium channel gene correlates with genetic differentiation between Anopheles gambiae s.s. molecular forms. Insect Molecular Biology 2004, 13: 371-377. PMID: 15271209, DOI: 10.1111/j.0962-1075.2004.00494.x.Peer-Reviewed Original ResearchConceptsVoltage-gated sodium channel geneSodium channel geneGenetic differentiationGenetic variationChannel genesPossible selective sweepMajor haplotypesSingle mutational stepAnopheles gambiae MRDNA sitesGene flowSelective sweepsMutational stepsTaxonomic statusIntron sequencesGambiae MMolecular formsIntron ISingle localityIntronic regionsAnopheles gambiae s.Additional haplotypesGambiae s.HaplotypesGenes