Fangbai (Janet) Sun, MPH
BiostatisticianCards
About
Research
Publications
2024
The effect of improved metabolic syndrome parameters on live birth
Spitzer T, Diamond M, Wild R, Legro R, Zhang H, Sun F, Ling S, Santoro N. The effect of improved metabolic syndrome parameters on live birth. Fertility And Sterility 2024, 122: 373-375. PMID: 38641159, DOI: 10.1016/j.fertnstert.2024.04.020.Peer-Reviewed Original ResearchMetabolic syndrome Z-scoreLifestyle interventionLive birthsLive birth rateMetabolic syndrome parametersZ-scoreMetabolic syndromeUnexplained infertilityIntrauterine inseminationOvarian stimulationSyndrome parametersMetabolic parametersObese WomenBirth outcomesLive birth outcomesIntervention phaseImprove metabolic syndromeSecondary analysisFisher's exact testStudy participantsZ-score differenceLifestyle modificationStudent's t-testBirth rateLogistic regression
2023
Moderate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity
Vitek W, Sun F, Cardozo E, Hoeger K, Hansen K, Santoro N, Zhang H, Legro R. Moderate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity. F&S Reports 2023, 4: 308-312. PMID: 37719091, PMCID: PMC10504528, DOI: 10.1016/j.xfre.2023.06.004.Peer-Reviewed Original ResearchLive birth rateSteps/dayPhysical activityInfertility trialsLifestyle modificationUnexplained infertilityObese womenBirth rateClomiphene citrate treatmentUS fertility centersClinical pregnancy rateLifestyle modification programTime of enrollmentModerate physical activityPhysical activity goalsMiscarriage rateFertility centerIntrauterine inseminationFitbit activity trackerPregnancy rateSecondary analysisCitrate treatmentActivity goalsModification programWomenAnti-Müllerian Hormone Level Decline in Patients Undergoing Hysterectomy With and Without Oophorectomy Compared With Natural Menopause
Santoro N, Flyckt R, Davis A, Finkelstein J, Crawford S, Sun F, Derby C, Morrison A, Sluss P, Zhang H. Anti-Müllerian Hormone Level Decline in Patients Undergoing Hysterectomy With and Without Oophorectomy Compared With Natural Menopause. Obstetrics And Gynecology 2023, 141: 331-340. PMID: 36649324, PMCID: PMC9858351, DOI: 10.1097/aog.0000000000005049.Peer-Reviewed Original ResearchConceptsFinal menstrual periodAnti-Müllerian hormone levelsAMH levelsNatural menopauseHormone levelsUndetectable AMH levelsCommunity-based studyOvarian conservationOvarian reserveAMH measurementOvarian failureMenstrual periodSurgery dateHysterectomyLinear mixed modelingMenopauseSurvival analysisPatientsImmediate reductionMixed modelingWomenOvariesSimilar patternRapid declineBSO
2022
Minimal Stimulation Using Gonadotropin-Releasing Hormone Antagonist is Associated with Higher Live Birth Rates: A National Study of 13,050 Cycles
Hurley E, Sun F, Zhang H, Polotsky A, Rios J. Minimal Stimulation Using Gonadotropin-Releasing Hormone Antagonist is Associated with Higher Live Birth Rates: A National Study of 13,050 Cycles. Women's Health Reports 2022, 3: 957-963. PMID: 36479370, PMCID: PMC9712044, DOI: 10.1089/whr.2022.0080.Peer-Reviewed Original ResearchHigher live birth rateLive birth rateGnRH antagonist useAntagonist useMinimal stimulationRank sum testHormone antagonistBirth rateImproved live birth ratesGonadotropin-releasing hormone antagonistCancelation rateCycle cancelation rateGnRH antagonist suppressionMinimal stimulation IVFTotal gonadotropin dosageDiminished ovarian reserveYears of ageWilcoxon rank sum testChi-square testNumber of embryosGonadotropin dosageOvarian reserveGnRH antagonistAntimullerian hormoneOlder womenRELATIONSHIP OF ANTITHYROID ANTIBODIES AND TSH TO INFERTILITY PHENOTYPES AND OUTCOMES
Seungdamrong A, Pal L, Kuokkanen S, Lieman H, Wild R, Sun F, Zhang H, Diamond M, Legro R, Santoro N. RELATIONSHIP OF ANTITHYROID ANTIBODIES AND TSH TO INFERTILITY PHENOTYPES AND OUTCOMES. Fertility And Sterility 2022, 118: e103. DOI: 10.1016/j.fertnstert.2022.08.311.Peer-Reviewed Original ResearchPoor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria
Baker KC, Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Coward RM, Sun F, Wild R, Masson P, Smith JF, Santoro N, Zhang H, Network R. Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria. F&S Reports 2022, 3: 110-115. PMID: 35789726, PMCID: PMC9250115, DOI: 10.1016/j.xfre.2022.03.003.Peer-Reviewed Original ResearchFertility centerCore laboratoryStrict morphologySecondary cohort analysisPlacebo-controlled trialSame semen sampleMultisite clinical trialLower reference limitSemen samplesInfertility trialsClinical trialsFertility laboratoriesCohort analysisCutoff valueEffect of antioxidantsReference limitsInterobserver agreementCentral laboratoryModerate agreementSemen valuesLack of correlationTrialsGrading criteriaMale fertilityCenter LaboratoryBiomarkers of Stress and Male Fertility
Spitzer TL, Trussell JC, Coward RM, Hansen KR, Barnhart KT, Cedars MI, Diamond MP, Krawetz SA, Sun F, Zhang H, Santoro N, Steiner AZ. Biomarkers of Stress and Male Fertility. Reproductive Sciences 2022, 29: 1262-1270. PMID: 35106743, PMCID: PMC9078052, DOI: 10.1007/s43032-022-00853-x.Peer-Reviewed Original ResearchConceptsLive birth rateSemen parametersSalivary levelsSperm countPregnancy/live birth rateBirth rateTotal motile sperm countMale factor infertilityMotile sperm countDNA fragmentationTotal sperm countSalivary cortisol levelsMale fertilityStress-related biomarkersChi-square testingSalivary alpha-amylaseInfertility trialsCohort studyHighest quintileIntrauterine inseminationPregnancy rateUpper quintileInfertile menPhysiologic measuresBiomarkers of stressA personalized medicine approach to ovulation induction/ovarian stimulation: development of a predictive model and online calculator from level-I evidence
Souter I, Sun F, Zhang H, Diamond MP, Legro RS, Wild RA, Hansen KR, Santoro N, Network F. A personalized medicine approach to ovulation induction/ovarian stimulation: development of a predictive model and online calculator from level-I evidence. Fertility And Sterility 2022, 117: 408-418. PMID: 35125179, PMCID: PMC8985501, DOI: 10.1016/j.fertnstert.2021.10.024.Peer-Reviewed Original ResearchMeSH KeywordsAdultBody Mass IndexClinical Decision-MakingCoitusDecision Support TechniquesFemaleFertilityFertility Agents, FemaleHumansInfertility, FemaleInsemination, ArtificialMaleMaternal AgeOvulation InductionPolycystic Ovary SyndromePrecision MedicinePregnancyPregnancy RateRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsTreatment OutcomeConceptsCumulative pregnancy rateAntimüllerian hormone levelsBody mass indexMultiple pregnanciesPregnancy rateClinical pregnancyOvulation inductionOvarian responseMedication doseMass indexHormone levelsLower body mass indexPregnancy rate/cyclePartner ageHigh antral follicle countLower medication doseMultiple Intrauterine GestationsMultiple pregnancy rateAntral follicle countPolycystic ovary syndromeCharacteristic curveMultivariable regression modelsPersonalized medicine approachGonadotropin useIndividualized chance
2021
INCREASED PHYSICAL ACTIVITY IS NOT DETRIMENTAL TO LIVE BIRTH IN WOMEN WITH OBESITY AND INFERTILITY
Vitek W, Sun F, Cardozo E, Noel M, Hoeger K, Santoro N, Zhang H, Legro R. INCREASED PHYSICAL ACTIVITY IS NOT DETRIMENTAL TO LIVE BIRTH IN WOMEN WITH OBESITY AND INFERTILITY. Fertility And Sterility 2021, 116: e52-e53. DOI: 10.1016/j.fertnstert.2021.07.150.Peer-Reviewed Original ResearchThe relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial
Knudtson JF, Sun F, Coward RM, Hansen KR, Barnhart KT, Smith J, Legro RS, Diamond MP, Krawetz SA, Zhang H, Usadi R, Baker VL, Santoro N, Steiner AZ. The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Journal Of Assisted Reproduction And Genetics 2021, 38: 3005-3013. PMID: 34455507, PMCID: PMC8609082, DOI: 10.1007/s10815-021-02301-2.Peer-Reviewed Original ResearchConceptsPlasma antioxidant levelsLive birthsClinical trialsSemen parametersAntioxidant levelsVitamin ERank sum testSecondary analysisClinical outcomesNormal rangeBaseline plasma valuesVitamin E levelsWilcoxon rank sum testMale fertilityConclusionsAmong menPrimary endpointDNA fragmentationResultsAt baselineSerum levelsFertility centerE levelsMethodsThis studyMale infertilityFertility outcomesPlasma values