2023
Testing the efficacy of real-time fMRI neurofeedback for training people who smoke daily to upregulate neural responses to nondrug rewards
Chung Y, White R, Geier C, Johnston S, Smyth J, Delgado M, McKee S, Wilson S. Testing the efficacy of real-time fMRI neurofeedback for training people who smoke daily to upregulate neural responses to nondrug rewards. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 440-456. PMID: 36788202, DOI: 10.3758/s13415-023-01070-y.Peer-Reviewed Original ResearchConceptsNondrug rewardsNeurofeedback trainingNeural responsesReal-time fMRI neurofeedback trainingReal-time fMRI neurofeedbackReward-related brain activityReward-related brain areasFMRI neurofeedback trainingTraining runsSingle neurofeedback sessionFMRI neurofeedbackBrain responsesNeurofeedback researchBrain activityBOLD activationNeurofeedback sessionsSuch rewardsStriatal activityNeurofeedbackControl conditionRewardBrain areasMonetary incentivesRecent researchSmoking cessation
2017
Network Analysis of Intrinsic Functional Brain Connectivity in Male and Female Adult Smokers: A Preliminary Study
Maria M, Vanderweyen D, Camp C, Zhu X, McKee SA, Cosgrove KP, Hartwell KJ, Brady KT, Joseph JE. Network Analysis of Intrinsic Functional Brain Connectivity in Male and Female Adult Smokers: A Preliminary Study. Nicotine & Tobacco Research 2017, 20: 810-818. PMID: 29059410, PMCID: PMC5991199, DOI: 10.1093/ntr/ntx206.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetReinforcement, PsychologySex CharacteristicsSmokersSmokingTobacco Use DisorderConceptsFemale smokersMale smokersAdult smokersNicotine dependenceSalience network regionsIntrinsic functional brain connectivityFemale adult smokersHigh nicotine dependenceEffects of nicotineAge-matched controlsGraph theory measuresFunctional brain connectivityIntrinsic functional connectivitySex differencesSmoking interventionsNucleus accumbensRight insulaSmokersBrain network communicationFunctional connectivityBrain connectivityBlood oxygenFunctional magnetic resonance imaging (fMRI) experimentsConnector hubsBrain networksSex disparities in substance abuse research: Evaluating 23 years of structural neuroimaging studies
Lind KE, Gutierrez EJ, Yamamoto DJ, Regner MF, McKee SA, Tanabe J. Sex disparities in substance abuse research: Evaluating 23 years of structural neuroimaging studies. Drug And Alcohol Dependence 2017, 173: 92-98. PMID: 28212516, PMCID: PMC5581940, DOI: 10.1016/j.drugalcdep.2016.12.019.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingFemaleHealthcare DisparitiesHumansMagnetic Resonance ImagingMaleNeuroimagingPatient SelectionResearch DesignSelection BiasSexismSubstance-Related DisordersConceptsSubstance use statusSex differencesBrain imaging researchSex disparitiesBrain imaging studiesStructural brain imaging studiesSubstance use studiesSubstance effectsSex effectsBrain morphometric changesStructural neuroimaging studiesSubstance use disordersUse statusNeuroimaging studiesNumber of participantsSubstance abuse researchBrain morphometryStructural brainGreater biasClinical courseSubstance abuseAnalytic approachBrain structuresProportion of studiesImaging research
2014
A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation
McKee SA, Potenza MN, Kober H, Sofuoglu M, Arnsten A, Picciotto MR, Weinberger AH, Ashare R, Sinha R. A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation. Journal Of Psychopharmacology 2014, 29: 300-311. PMID: 25516371, PMCID: PMC4376109, DOI: 10.1177/0269881114562091.Peer-Reviewed Original ResearchConceptsPlacebo-treated subjectsFunctional magnetic resonance imagingCentral noradrenergic pathwaysPrefrontal cognitive dysfunctionSystolic blood pressureClinical outcome dataAd libitum smokingNovel translational approachStress-induced reinstatementMagnetic resonance imagingNicotine-deprived smokersBlood pressureNoradrenergic pathwaysAgonist guanfacineCognitive dysfunctionTreatment periodTobacco cravingQuit attemptsOutcome dataSmokingComplete abstinenceCortisol levelsTranslational investigationsCigarette useGuanfacineWeak ventral striatal responses to monetary outcomes predict an unwillingness to resist cigarette smoking
Wilson SJ, Delgado MR, McKee SA, Grigson PS, MacLean RR, Nichols TT, Henry SL. Weak ventral striatal responses to monetary outcomes predict an unwillingness to resist cigarette smoking. Cognitive, Affective, & Behavioral Neuroscience 2014, 14: 1196-1207. PMID: 24777394, PMCID: PMC4213351, DOI: 10.3758/s13415-014-0285-8.Peer-Reviewed Original ResearchConceptsNicotine-deprived smokersIndividual differencesNondrug rewardsMonetary outcomesVentral striatumReward-related brain activityMeaningful individual differencesFunctional magnetic resonance imagingReward-motivated behaviorsLarge individual differencesVentral striatal responsePoor smoking cessation outcomesSmoking cessation outcomesNondrug incentivesReward devaluationNeural responsesStriatal responsesNeurobiological mechanismsBrain activityNeurobiological responsesCessation outcomesRewardMonetary reinforcementIndividual variabilityClinical implications
2010
Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers
Cosgrove KP, Esterlis I, McKee S, Bois F, Alagille D, Tamagnan GD, Seibyl JP, Krishnan-Sarin S, Staley JK. Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers. Nicotine & Tobacco Research 2010, 12: 535-539. PMID: 20371741, PMCID: PMC2861889, DOI: 10.1093/ntr/ntq040.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPainReceptors, NicotinicSmokingSubstance Withdrawal SyndromeYoung AdultConceptsPain sensitivityCold pressor taskTobacco smokersNicotinic acetylcholine receptorsPain toleranceAcute withdrawalSmoking abstinenceOccipital cortexAnterior cingulateAcetylcholine receptorsAbstinent tobacco smokersHuman tobacco smokersTobacco smoking abstinenceTomography brain imagingSingle photon emissionIA SPECTIA-85380Smoking withdrawalAntinociceptive effectPainful stimuliAcute abstinencePercent changeSimilar associationSmokersBrain imagingSPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals
Esterlis I, Cosgrove KP, Petrakis IL, McKee SA, Bois F, Krantzler E, Stiklus SM, Perry EB, Tamagnan GD, Seibyl JP, Krystal JH, Staley JK. SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals. Drug And Alcohol Dependence 2010, 108: 146-150. PMID: 20074869, PMCID: PMC2871672, DOI: 10.1016/j.drugalcdep.2009.12.006.Peer-Reviewed Original ResearchConceptsDrinks/occasionNicotinic acetylcholine receptorsControl nonsmokersAcetylcholine receptorsHeavy drinkersHeavy drinkingLast alcoholic beverageHeavy alcohol drinkersHeavy alcoholSingle photon emissionSeverity of drinkingEffect of ageTobacco smokingAlcohol drinkersAlcohol drinkingCommon neural substrateNonsmokersAlcohol consumptionReceptor availabilityLarger studyAlcohol drinksAlcohol use behaviorsAddictive disordersDrinkersNeural substrates