Melinda Irwin, PhD, MPH
Associate Dean of Research; Interim Department Chair and Susan Dwight Bliss Professor of Epidemiology (Chronic Diseases)Cards
Additional Titles
Deputy Director (Public Health), Yale Center for Clinical Investigation
Deputy Director, Yale Cancer Center
Contact Info
Chronic Disease Epidemiology
PO Box 208034, 60 College Street
New Haven, CT 06520-8034
United States
About
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Titles
Associate Dean of Research; Interim Department Chair and Susan Dwight Bliss Professor of Epidemiology (Chronic Diseases)
Deputy Director (Public Health), Yale Center for Clinical Investigation; Deputy Director, Yale Cancer Center
Biography
Melinda L. Irwin, PhD, MPH is the Susan Dwight Bliss Professor of Epidemiology and Associate Dean of Research at the Yale School of Public Health, Deputy Director of the Yale Cancer Center, and Deputy Director (Public Health) in the Yale Center for Clinical Investigation. Nationally, Dr. Irwin co-leads the SWOG Cancer Research Network Cancer Survivorship Committee. In 2018, Dr. Irwin completed the yearlong Hedwig van Ameringen Executive Leadership in Academic Medicine (ELAM) Program. Dr. Irwin’s experience working across departments, schools, and with interdisciplinary groups of investigators has provided her with the skills to train and mentor effectively.
Dr. Irwin is a prominent leader in the field of cancer prevention and survivorship research. Her research over the past 20 years has focused on randomized trials of exercise and weight loss on biological markers, treatment side effects and quality of life in people with diagnosed with cancer. She has received funding from the National Institutes of Health, American Cancer Society, Breast Cancer Research Foundation, American Institute for Cancer Research, Komen for the Cure, and Livestrong Foundation. She is currently leading an NCI-funded clinical trial examining the impact of nutrition and exercise on improving chemotherapy completion rate, endocrine therapy adherence, biomarkers, body composition and quality of life in women beginning chemotherapy for breast cancer, and a also leading a newly funded NCI U01 trial of exercise and nutrition on treatment outcomes in women newly diagnosed with ovarian cancer.
Dr. Irwin is committed to training the next generation of scientists and is currently leading an NCI T32-funded Cancer Prevention and Control Training Program for pre- and post-doctoral fellows and an NCI R25-funded Transdisciplinary Research on Energetics and Cancer (TREC) Training Program for early career investigators. At Yale, Dr. Irwin has advised, mentored and trained over 100 trainees. Her commitment to training the next generation of scientists is evident in the enthusiasm she brings to mentoring. Her vision is to maximize opportunities for early career investigators so they can become leaders in their respective fields and have a maximal impact on the health and well-being of patients and the population.
Appointments
Yale School of Public Health
Associate DeanDualChronic Disease Epidemiology
ProfessorPrimary
Other Departments & Organizations
- All Institutions
- Cancer Prevention and Control
- Chronic Disease Epidemiology
- Diabetes Research Center
- Future of Health Innovation Hub
- Irwin Lab (LEAN Study)
- Obesity Research Working Group
- Transdisciplinary Research in Energetics and Cancer Research Education Program
- Yale Cancer Center
- Yale Center for Clinical Investigation (YCCI)
- Yale School of Public Health
- Yale Ventures
Education & Training
- MPH
- University of Washington (2001)
- PhD
- University of South Carolina (1999)
- MS
- University of North Carolina at Chapel Hill (1994)
- BS
- College of William and Mary (1992)
Research
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Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0001-7571-0304
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Fangyong Li, MS, MPH
Brenda Cartmel, PhD
Leah Ferrucci, PhD, MPH
Tara Sanft, MD
Lingeng Lu, MD, PhD
Leah Puklin, PhD, MPH
Exercise
Breast Neoplasms
Obesity
Ovarian Neoplasms
Weight Loss
Publications
2026
Financial Hardship and Unhealthy Lifestyles: Perspectives and Solutions From Breast Cancer Survivors and Their Care Teams
Pichardo M, Nsubayi C, Ginader A, Peña K, Nguyen T, Irwin M, Sanft T, Molina Y, Fayanju O. Financial Hardship and Unhealthy Lifestyles: Perspectives and Solutions From Breast Cancer Survivors and Their Care Teams. Cancer Control 2026, 33: 10732748261432274. PMID: 41814123, PMCID: PMC12982845, DOI: 10.1177/10732748261432274.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsBreast cancer survivorsSocial ecological modelCancer survivorsFinancial hardshipFinancial navigationHealthy behaviorsLifestyle interventionLatina breast cancer survivorsSocial-ecological model levelClinic-level interventionsHome-based exerciseHealthy lifestyle behaviorsMultidisciplinary survivorship clinicSecondary qualitative analysisBreast cancer diagnosisSingle health systemEmotion-focused copingSemi-structured interviewsCommunity-based solutionsSurvivorship careOncology providersSurvivorship clinicLifestyle behaviorsTransportation vouchersCare teamResearch Priorities and Future Directions in Cardio-Oncology
Mszar R, Ali A, Hull S, Ferrucci L, Baldassarre L, Khera R, Irwin M, Clasen S. Research Priorities and Future Directions in Cardio-Oncology. Current Treatment Options In Oncology 2026, 27: 4. PMID: 41484494, DOI: 10.1007/s11864-025-01366-w.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsIndividual health outcomesCancer survivorsSocial determinantsSocial determinants of healthQuality-of-care metricsCardiovascular diseaseCardio-oncology rehabilitationHealthy lifestyle behaviorsDeterminants of healthCancer risk factorsCardio-OncologyRisk factorsEvidence-based strategiesContemporary clinical guidelinesHealth equityLifestyle behaviorsLong-term cardiac surveillanceHealth outcomesHealth disciplinesCardiac radiation exposureTreatment continuumEvidence gapsImmune checkpoint inhibitorsInnovative clinical trialsClinical guidelines
2025
Effect of a lifestyle intervention during chemotherapy for breast cancer on quality of life
Puklin L, Li F, Ferrucci L, Cartmel B, Harrigan M, McGowan C, Zupa M, Ligibel J, Sanft T, Irwin M. Effect of a lifestyle intervention during chemotherapy for breast cancer on quality of life. JNCI Cancer Spectrum 2025, 10: pkaf125. PMID: 41452765, PMCID: PMC12803784, DOI: 10.1093/jncics/pkaf125.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsQuality of lifePROMIS scoresLifestyle interventionPatient-Reported Outcomes Measurement Information SystemPROMIS Global Health scaleOutcomes Measurement Information SystemStage I-III breast cancerBreast cancerGlobal physical healthI-III breast cancerMeasurement Information SystemGlobal health scaleGlobal mental healthStage I breast cancerCognitive functionTreatment-related declinesPROMIS Cognitive FunctionPsychological Well-BeingExercise interventionExercise componentUsual carePhysical functionHealth ScalePhysical healthMental healthBody mass index and chemotherapy completion among patients with newly diagnosed ovarian cancer
Cao A, Cartmel B, Ratner E, Li F, Schlumbrecht M, Kumar A, Crane T, Esserman D, Irwin M, Ferrucci L. Body mass index and chemotherapy completion among patients with newly diagnosed ovarian cancer. JNCI Cancer Spectrum 2025, 10: pkaf121. PMID: 41442446, PMCID: PMC12854082, DOI: 10.1093/jncics/pkaf121.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsBody mass indexRelative dose intensityDose intensityOvarian cancerMass indexChemotherapy completionDose modificationRetrospective cohortRetrospective cohort of patientsContemporary treatment eraChemotherapy dose intensityHigher body surface areaHigher Body Mass IndexCohort of patientsBody surface areaBody composition dataAverage RDIDose cappingHigher RDIHematologic toxicityOvarian Cancer StudyAssociated with lower complianceDose reductionTreatment eraChemotherapyExercise Interventions Among Individuals With Co-occurring HIV And Unhealthy Substance Use: A Systematic Review
Mistler C, Allen W, Grimshaw A, Idiong C, Harsono D, Irwin M, Ash G, Pescatello L, Meyer J, Edelman E. Exercise Interventions Among Individuals With Co-occurring HIV And Unhealthy Substance Use: A Systematic Review. Medicine & Science In Sports & Exercise 2025, 57: 755-755. DOI: 10.1249/01.mss.0001161400.40878.dc.Peer-Reviewed Original ResearchAddressing conceptual and design gaps in the oncology nutrition evidence base during chemotherapy: contributions of the Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes Consortium
Compton S, Wopat H, Lopez-Pentecost M, Agurs-Collins T, Brown J, Caan B, Demark-Wahnefried W, Elena J, Ferrucci L, McGowan C, Puklin L, Schmitz K, Thomson C, Robien K, Crane T, Caan B, Anderson S, Bahia H, Castillo A, Feliciano E, Johnson K, Ross M, Weltzein E, Brown J, Compton S, Green T, Nauta P, Yang S, Meyerhardt J, Dieli-Conwright C, Nguyen D, Pena A, Spielmann G, Kim Y, Evans W, Bea J, Blew R, Thomson C, Crane T, Camacho V, Cespedes V, Erlandsen S, Freylersythe S, Hollander K, Lopez-Pentecost M, Penedo F, Rolle L, Rossi P, Schlumbrecht M, Wheeler M, Irwin M, Cao A, Cartmel B, Ferrucci L, Gottlieb L, Harrigan M, Li F, McGowan C, Puklin L, Elena R, Sanft T, Zupa M, Berger N, Cerne S, Mills C, Conochan S, Hundal J, Owusu C, Pink J, Ligibel J, Campbell N, DiGuglielmo K, Kemp W, Maples-Campbell C, Nguyen T, Oppenheim J, Tanasijevic A, Thomson C, Yung A, Basen-Engquist K, Loomba P, Chinchilli V, Schmitz K, Binder J, Doerksen S, Foldi J, Garrett S, Scalise R, Sobolewski M, Scott J, Cercek A, Cai S, Cao S, Furberg H, Harrison J, Jones L, Lee C, Levine R, Michalski M, Moskowitz C, Meara A, Rabazzi J, Stoeckel K, Salz T, Weiser M, Yu A, Demark-Wahnefried W, Robien K, Evans S, DiPietro L, Duong B, Edelstein S, Helmchen L, Le D, McCleary C, Tjaden A, Wopat H, Rabin B, Perna F, Agurs-Collins T, Czajkowski S, Elena J, Nebeling L, Norton W. Addressing conceptual and design gaps in the oncology nutrition evidence base during chemotherapy: contributions of the Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes Consortium. Journal Of The National Cancer Institute 2025, 117: 2441-2451. PMID: 40680173, PMCID: PMC12682377, DOI: 10.1093/jnci/djaf143.Peer-Reviewed Original ResearchAltmetricConceptsNutritional interventionPractice guidelinesNutrition practice guidelinesActive cancer treatmentDevelopment of practice guidelinesScientific rigor of researchNutrition evidence baseNutritional assessment toolCancer continuumScientific rigorCancer preventionTreatment-related outcomesLong-term survivorshipEvidence baseAssessment toolInterventionExerciseRigor of researchConceptual frameworkCancer treatmentResearch ConsortiumNutritionCompletion of chemotherapyGuidelinesCancerExtending Cancer Survival with Exercise — Time for Oncology to Act
Irwin M. Extending Cancer Survival with Exercise — Time for Oncology to Act. The New England Journal Of Medicine 2025, 393: 82-84. PMID: 40601943, DOI: 10.1056/nejme2506363.Peer-Reviewed Original ResearchCitationsAltmetricAccelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers
Abraham S, Parekh J, Lee S, Afrin H, Rozenblit M, Blenman K, Perry R, Ferrucci L, Liu J, Irwin M, Lustberg M. Accelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers. Cancer Medicine 2025, 14: e70929. PMID: 40322791, PMCID: PMC12051034, DOI: 10.1002/cam4.70929.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBiological age of patientsLeukocyte telomere lengthInterleukin-6Treatment-related toxicityAge of patientsTherapy-induced toxicityExpression of p16INK4aPredictors of toxicityStatus of biomarkersMarkers of cellular senescenceRadiation therapyBiological ageCancer patientsCancer therapyFunctional reserveAging biomarkersPhysiological reserveCancer treatmentCancerConfirmatory studiesTherapyClinical practiceFunctional capacityPatientsFunctional statusExercise Interventions Conducted Among Individuals with Co-occurring HIV and Unhealthy Substance Use: A Systematic Review
Mistler C, Allen W, Grimshaw A, Idiong C, Harsono D, Irwin M, Ash G, S. Pescatello L, Meyer J, Jennifer Edelman E. Exercise Interventions Conducted Among Individuals with Co-occurring HIV and Unhealthy Substance Use: A Systematic Review. AIDS And Behavior 2025, 29: 2783-2796. PMID: 40289036, PMCID: PMC12353901, DOI: 10.1007/s10461-025-04735-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnhealthy substance useExercise interventionRandomized Controlled TrialsSubstance useCochrane data collection formsEvidence-based exercise interventionsCo-occurring risk factorsSystematic reviewPositive associations with outcomesHome-based trainingCo-occurring HIVRisk factorsLow risk of biasFull-text reviewData collection formRisk of biasQuasi-experimental designAerobic/resistance trainingTai ChiPhysical inactivityPhysical activityCognitive behavioral therapyImprove HIVHealth outcomesBehavioral counseling
2024
Correction: Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study
Bade B, Gan G, Li F, Lu L, Tanoue L, Silvestri G, Irwin M. Correction: Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study. BMC Cancer 2024, 24: 1409. PMID: 39548453, PMCID: PMC11566398, DOI: 10.1186/s12885-024-13183-9.Peer-Reviewed Original ResearchCitationsAltmetric
Clinical Trials
Current Trials
Trial of Exercise and Lifestyle (TEAL) for Women with Ovarian and Endometrial Cancer
IRB ID2000032524RolePrincipal InvestigatorPrimary Completion Date06/30/2027Recruiting Participants
Academic Achievements & Community Involvement
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News & Links
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Media
Smilow Shares: Breast Cancer Awareness Month: Screening, Genetics, and Prevention
October 2, 2025
Presentations by: Parisa Lotfi, MD, Tracy Battaglia, MD, MPH, and Melinda Irwin, PhD, MPH
News
- January 30, 2026Source: Prevention
Scientists find taking this many steps a day lowers your cancer risk
- January 27, 2026
Epidemiologist Dr. Magdalena Cerdá joins YSPH as Chair of the Department of Chronic Disease Epidemiology
- October 28, 2025Source: Oprah Daily
Dr. Melinda Irwin discusses the association between excess weight and breast cancer
- July 22, 2025Source: The Washington Post
The surprisingly simple treatment that could transform cancer care
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Contacts
Chronic Disease Epidemiology
PO Box 208034, 60 College Street
New Haven, CT 06520-8034
United States
Locations
60 College Street
Academic Office
Ste 428
New Haven, CT 06510
Events
Everyone Dr. Fred Cohen - Morag Grassie, PhD - Melinda Irwin, PhD, MPH
Everyone Melinda Irwin, PhD, MPH