Leah Puklin, MPH, BA
About
Research
Publications
2024
Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial
Puklin L, Ferrucci L, Harrigan M, McGowan C, Zupa M, Cartmel B, Li F, Ligibel J, Spiegelman D, Sharifi M, Sanft T, Irwin M. Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial. Cancer 2024, 130: 2440-2452. PMID: 38470431, PMCID: PMC11214600, DOI: 10.1002/cncr.35280.Peer-Reviewed Original ResearchPhysical activityDiet qualityHEI-2015Strength trainingLifestyle behaviorsHealthy Eating Index (HEI)-2015Breast cancerAssociated with baseline fatigueImprove physical activityImprove lifestyle behaviorsHigher HEI-2015Associated with higher oddsExercise interventionUsual careIntervention armIntervention groupBaseline fatigueLifestyle interventionYearlong interventionLower fatigueHigher oddsSecondary analysisLogistic regressionNewly diagnosed patientsStudy arms
2023
Post-diagnosis weight trajectories and mortality among women with breast cancer
Puklin L, Li F, Cartmel B, Zhao J, Sanft T, Lisevick A, Winer E, Lustberg M, Spiegelman D, Sharifi M, Irwin M, Ferrucci L. Post-diagnosis weight trajectories and mortality among women with breast cancer. Npj Breast Cancer 2023, 9: 98. PMID: 38042922, PMCID: PMC10693588, DOI: 10.1038/s41523-023-00603-5.Peer-Reviewed Original ResearchBody mass indexBreast cancer diagnosisWeight changeCause mortalityClinical characteristicsWeight gainWeight lossBreast cancerWeight trajectoriesPost-diagnosis weight changeBreast cancer-specific mortalityCox proportional hazards modelModern treatment eraCancer-specific mortalityCancer diagnosisModerate weight lossModerate weight gainProportional hazards modelAdverse health outcomesElectronic health recordsTreatment eraBaseline characteristicsTumor RegistryMass indexWeight managementRandomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors
Puklin L, Harrigan M, Cartmel B, Sanft T, Gottlieb L, Zhou B, Ferrucci L, Li F, Spiegelman D, Sharifi M, Irwin M. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers 2023, 15: 4719. PMID: 37835412, PMCID: PMC10571774, DOI: 10.3390/cancers15194719.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsLifestyle interventionPhysical activityQuality of lifeBody weightWaitlist groupDiet qualitySelf-reported body weightWeight lossFavorable weight changeHealthy weight lossBody mass indexHealthy body weightGreater weight lossEvidence-based materialsDiverse healthcare settingsIntervention armMass indexClinical practicePositive behavior changeHealthcare settingsSurvivorsWeight changeInterventionRandomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study
Sanft T, Harrigan M, McGowan C, Cartmel B, Zupa M, Li F, Ferrucci L, Puklin L, Cao A, Nguyen T, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Tanasijevic A, Ligibel J, Irwin M. Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study. Journal Of Clinical Oncology 2023, 41: 5285-5295. PMID: 37656930, PMCID: PMC10691793, DOI: 10.1200/jco.23.00871.Peer-Reviewed Original ResearchConceptsRelative dose intensityPathologic complete responseProportion of patientsBreast cancerNeoadjuvant chemotherapyChemotherapy completionComplete responseNutrition interventionsHigher pathologic complete responseHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerChemotherapy dose adjustmentsHome-based exerciseGrowth factor receptor 2Breast cancer outcomesEffects of exerciseFactor receptor 2Electronic medical recordsChi-square testUsual careDose intensityExercise interventionDose adjustmentRandomized trials
2022
Letter to the Editor: Differentiating Between Intentional Versus Unintentional Weight Loss.
Puklin L, Irwin ML, Sanft T, Ferrucci LM. Letter to the Editor: Differentiating Between Intentional Versus Unintentional Weight Loss. Journal Of The National Comprehensive Cancer Network 2022, 20: xliv. PMID: 34991074, DOI: 10.6004/jnccn.2021.7052.Peer-Reviewed Original Research
2021
Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors
Puklin L, Cartmel B, Harrigan M, Lu L, Li FY, Sanft T, Irwin ML. Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors. Npj Breast Cancer 2021, 7: 49. PMID: 33976224, PMCID: PMC8113314, DOI: 10.1038/s41523-021-00260-6.Peer-Reviewed Original ResearchBreast cancer survivorsBody mass indexCancer survivorsGhrelin levelsLifestyle interventionUsual careWeight lossPg/Higher ghrelin levelsWeight loss interventionLean body massSix-month changesGreater weight lossWeight regainLoss interventionStudy armsMass indexWeight maintenanceBlood biomarkersHormone ghrelinBlood samplesGhrelinBody compositionBody weightBaseline associationsBridging The Gap: Qualitative Interviews With Pediatric Non-Physician Healthcare Team Members Regarding Roles During Communication Of Difficult News To Patients And Families
Murtha T, Eldred H, Puklin L, Schapiro B, Keene D. Bridging The Gap: Qualitative Interviews With Pediatric Non-Physician Healthcare Team Members Regarding Roles During Communication Of Difficult News To Patients And Families. Pediatrics 2021, 147: 459-460. DOI: 10.1542/peds.147.3ma5.459.Peer-Reviewed Original Research
2020
The Impact of Suboptimal Diet on Type 2 Diabetes at Global, Regional, National, and Sub-National Levels: A Comparative Risk Assessment Analysis
O’Hearn M, Singh G, Cudhea F, Miller V, Zhang J, Shi P, Reedy J, Puklin L, Micha R, Mozaffarian D. The Impact of Suboptimal Diet on Type 2 Diabetes at Global, Regional, National, and Sub-National Levels: A Comparative Risk Assessment Analysis. Current Developments In Nutrition 2020, 4: nzaa053_082. PMCID: PMC7257637, DOI: 10.1093/cdn/nzaa053_082.Peer-Reviewed Original ResearchSugar-sweetened beveragesPopulation attributable fractionGlobal Dietary DatabaseSuboptimal dietT2D incidenceIntake of sugar-sweetened beveragesType 2 diabetesMeta-analyses of prospective cohort studiesLow intake of whole grainsWhole grainsGlobal Burden of Disease StudyBurden of type 2 diabetesEtiologic effectsBurden of Disease StudyIntake of whole grainsComparative risk assessment frameworkBurden of T2DPublic health interventionsHigh-income countriesProspective cohort studyUnprocessed red meatAttributable fractionAttributable burdenHealth interventionsT2D casesDiet Quality and Mortality, Stunting and Wasting in Children Aged 6–59 Months: An Ecological Analysis from the Global Dietary Database
Miller V, Webb P, Cudhea F, Zhang J, Shi P, Reedy J, Puklin L, Micha R, Coates J, Mozaffarian D. Diet Quality and Mortality, Stunting and Wasting in Children Aged 6–59 Months: An Ecological Analysis from the Global Dietary Database. Current Developments In Nutrition 2020, 4: nzaa061_082. PMCID: PMC7259310, DOI: 10.1093/cdn/nzaa061_082.Peer-Reviewed Original ResearchDisability-adjusted life yearsGlobal Dietary DatabaseDASH scoreIncreased risk of overweight/obesityDietary databaseGlobal Burden of Disease StudyBurden of Disease StudyAssociated with overweight/obesityRisk of overweight/obesityChild minimum dietary diversityAged 6Burden of malnutritionCross-sectional associationsMinimum dietary diversityPoisson regression modelsWorld Bank’s World Development IndicatorsChild growth outcomesChildren aged 6Risk of deathDiet qualityNational intakeDietary dataWorld Development IndicatorsOverweight/obesityCountry-level dataGlobal Plant-Based Food Intakes by Country Wealth and Socioeconomic Status: Findings from the Global Dietary Database
Karageorgou D, Cudhea F, Reedy J, Puklin L, Miller V, Zhang J, Shi P, Castor L, Coates J, Webb P, Mozaffarian D, Micha R. Global Plant-Based Food Intakes by Country Wealth and Socioeconomic Status: Findings from the Global Dietary Database. Current Developments In Nutrition 2020, 4: nzaa053_055. PMCID: PMC7257989, DOI: 10.1093/cdn/nzaa053_055.Peer-Reviewed Original ResearchLower-middle income countriesUpper-middle income countriesGlobal Dietary DatabasePopulation socioeconomic statusSocioeconomic statusHigher incomeIntake of non-starchy vegetablesIncome countriesDietary databaseHigher vegetable consumptionIndividual-level intakesIntake of fruitsNon-starchy vegetablesUrban-rural residenceVegetable consumptionFruit intakeEstimated mean intakeLower educationPlant-based foodsGrain intakePF intakeRural residentsCharacterize inequitiesSubnational surveysMean intake