Heart Disease and Stroke

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Heart Disease and Stroke are leading causes of death and disability in the United States and worldwide. Numerous primary and secondary faculty used rigorous epidemiologic methods to improve our understanding of heart disease and stroke conducting research both nationally and internationally. For example, in the Department of Chronic Disease Epidemiology, the availability of access to large administrative medical claims databases enables researchers to investigate long term trends, patterns of care, and outcomes among elderly patients with heart disease and stroke.

Our research areas include:

disease trends
the role of traditional risk factors
genetics
biomarkers
patterns of care
biological, social, and environmental factors that influence the presentation and outcomes of young women with heart disease
effect of community-based characteristics on disease rates and outcomes.

Recent Publications

Quantifying the community transmission of Mycobacterium tuberculosis in a rapidly growing Chinese city: a nine-year population-based genomic and spatial analysis.Zhu X, Wang Y, Peng L, Lan Y, Mei J, Zhang M, Zheng W, Warren J, Li M, Li N, Li C, Lao Y, Luan J, Chen J, Lu X, Guo Y, Cohen T, Yang C. Emerg Microbes Infect. 2026 Dec; 2026 Jun 26. PMID: 42360842.
Exploring barriers and facilitators for non-communicable disease care for persons living with HIV in Peru through a socioecological framework: HIV physician and coordinator perspectives.Slotkin R, Granda D, Hernandez JM, Cabrera D, Benites CM, Garcia PJ, Hsieh E. PLOS Glob Public Health. 2026; 2026 Sep 25. PMID: 42789601.
Comparing subsampling strategies for efficient pairwise analysis of large pathogen genomic and spatial datasets: An application to Mycobacterium tuberculosis transmission.Lan Y, Wu CY, Lin HH, Cohen T, Warren JL. PLoS Comput Biol. 2026 Sep; 2026 Sep 23. PMID: 42777015.
Advancing the understanding of eosinophilic esophagitis: From pathogenesis to novel therapies.Sharma A, Tiwari A, Deshpande V, Mahesh VA, Kumar H, Shah A, Ray I, Sisodia R, Sonaiya S, Alsakarneh S, Ali H, Dahiya DS. World J Gastrointest Pathophysiol. 2026 Sep 22. PMID: 42780589.
Differences in Ecological Drivers for Leptospira and Hantavirus in an Urban Norway Rat Population.Zeppelini CG, da Paixão Barreto AMB, Santiago DCC, Alves RS, Santo VFE, Rangel CL, de Oliveira RC, de Oliveira D, Carneiro IO, Bazan L, Eyre M, Costa F, Begon M, Khalil H. Ecohealth. 2026 Sep 21; 2026 Sep 21. PMID: 42766255.
Detection of Severe Structural Heart Disease Using an AI-Enhanced Portable 1-Lead ECG: The ACCESS-SHD Study.Aminorroaya A, Shankar SV, Khan M, Carter M, Dhingra LS, Khunte A, Lombo B, McNamara RL, Oikonomou EK, Pedroso AF, Khera R. medRxiv. 2026 Sep 15; 2026 Sep 15. PMID: 42780088.
Constituent-Specific PM(2.5) and Cardiovascular Risk: From Mass to Mixture.Hu Y, Meng X, Chen K. J Am Coll Cardiol. 2026 Sep 1; 2026 Jul 22. PMID: 42484582.
Lineage-specific transmission and spatial clustering of Mycobacterium tuberculosis in Kaohsiung, Taiwan, in 2019-23: a population-based genomic study.Wu CY, Chen YA, Ioerger TR, Lan Y, Bai RY, Li MH, Lee CH, Lin JN, Shin-Jung Lee S, Chien ST, Warren JL, Colijn C, Chang HH, Huang JJ, Cohen T, Lu PL, Lin HH. Lancet Microbe. 2026 Sep; 2026 Jul 2. PMID: 42392122.
Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease.Ain NU, Bar N, Guo L, Klinger K, Gupta P, Rahman AU, Yang R, Deng Y, Neparidze N, Nair S, Mistry PK. Am J Hematol. 2026 Sep; 2026 Jun 17. PMID: 42309787.
Impact of Long-Term Cumulative Exposure to Wildfire Smoke PM(2.5) on Cardiovascular Hospital Admissions Among Older Adults in the United States: A Population-Based Cohort Study.Zhang S, Wang Y, Wei J, Benmarhnia T, Liu Y, Krumholz HM, Lu Y, Chen K. J Am Coll Cardiol. 2026 Sep 1; 2026 Feb 18. PMID: 41706074.
Molecular Surveillance of Dirofilaria immitis in Field-Collected Aedes albopictus from Southeastern Virginia.Karisa J, Mohapatra AR, Sandland L, Abadam C, Akaratovic K, Kiser J, Molaei G. Pathogens. 2026 Aug 28; 2026 Aug 28. PMID: 42796674.
Associations between essential trace elements and Alzheimer's disease and related dementias.Wang X, Albin RL, Giordani B, Mukherjee B, Paulson HL, Bakulski KM. Alzheimers Dement (Amst). 2026 Jul-Sep; 2026 Aug 26. PMID: 42657258.
Associations of smoking and second-hand smoke exposure with obesity and obstructive sleep apnoea risk in Tuvalu.Lin CC, Lin PJ, Hsu YT, Chang CR, Shih CW, Kuo CC, Shiau SC, Lo YH, Elisala N, Elisala J, Tehulu F, López-Gil JF, Lee WY, Hershey MS, Chang SH, Lu JY, Pan CT, Wei CF. J Glob Health. 2026 Aug 21; 2026 Aug 21. PMID: 42626874.
Structural causal influence captures the forces of social inequality in models of infectious disease.Surasinghe S, Manivannan SN, Scarpino SV, Crawford L, Ogbunugafor CB. Biol Lett. 2026 Aug 19. PMID: 42613058.
Commensal bacteria inhibit viral infections via a tryptophan metabolite.Jiang D, Soo N, Tan CY, Dankwa S, Wang HY, Theriot BS, Xue K, Hill D, Ardeshir A, Bain JR, Heston SM, Hurst JH, Siddiqui NY, Van Rompay KKA, Cervantes-Barragan L, Smith JP, Song R, Roper J, Kelly MS, Hudgens MG, De Paris K, Permar SR, Goswami R, Surana NK. Nat Commun. 2026 Aug 13; 2026 Aug 13. PMID: 42722642.
Virus reactivation in acute and long COVID-19.Maguire C, Chen J, Rouphael N, Morse BA, Hoch A, Pickering H, Phan HV, Glascock A, Chu V, Dandekar R, Corry D, Kheradmand F, Baden LR, Sekaly RP, McComsey GA, Haddad EK, Cairns CB, Pulendran B, Fernandez-Sesma A, Simon V, Metcalf JP, Agudelo Higuita NI, Messer WB, Davis MM, Nadeau KC, Kraft M, Bime C, Schaenman J, Erle D, Calfee CS, Atkinson MA, Brakenridge SC, Ehrlich LIR, Montgomery RR, Shaw A, Hough CL, Hafler D, Augustine AD, Becker PM, Peters B, Ozonoff A, Kim-Schulze S, Krammer F, Bosinger SE, Eckalbar W, Altman MC, Wilson M, Guan L, Kleinstein SH, Smolen KK, Reed EF, Levy O, Maecker H, Hunt P, Steen H, Diray-Arce J, Langelier CR, Melamed E. Nature. 2026 Aug; 2026 Aug 5. PMID: 42557313.
Upward Air Temperature Shifts and Acute Cardiovascular Events in Individuals with Atherosclerotic Cardiovascular Disease: A Time-Stratified Case-Crossover Study.Lechner K, Zhang S, Krüger N, Krefting J, Wolf K, Dallavalle M, Dreischulte T, Offenborn F, Starnecker F, von Scheidt M, Chen K, Peters A, Breitner S, Schneider A, Schunkert H. Lancet Reg Health Eur. 2026 Aug; 2026 Jun 4. PMID: 42294354.
Core-sheath coupling controls flagellar curvature and motility in Leptospira.San Martin F, Brady MR, Fule L, Nouchikian L, Rodriguez A, Duchateau M, Mondino S, Larrieux N, Wunder EA Jr, Ko AI, Rey M, Chamot-Rooke J, Duran R, Trajtenberg F, Picardeau M, Sindelar CV, Buschiazzo A. Nat Commun. 2026 Jul 25; 2026 Jul 25. PMID: 42649215.
Central nervous system B cell multiomics reveals a legacy of immune dysregulation in long-term treated HIV infection.Filippidis P, Lu C, Orlinick B, Pang A, Nelson A, Spudich S, Machiavello Roman F, Zigackova D, Singareddy N, Mehta S, Rubin LH, Kleinstein SH, Corley MJ, Farhadian SF. Sci Adv. 2026 Jul 17; 2026 Jul 17. PMID: 42467764.
Primary healthcare system readiness for the prevention and management of non-communicable diseases in Nepal.Nakarmi CS, Bhattarai S, Rhodes EC, Dhimal M, Baral PP, Poudel B, Rai BK, Bishwokarma A, Mali S, Adhikari A, Dhakal A, Bharati A, Manandhar S, Kc S, Silwal S, Adhikari B, Shrestha S, Teufel F, Timalsena D, Acharya Y, Spiegelman D, Shrestha A. Res Sq. 2026 Jul 15; 2026 Jul 15. PMID: 42523475.
Identifying sex-specific genetic effects across 733 traits in UK biobank.Jiang W, Jing Y, Han J, Ye Y, Zhao H. BMC Genomics. 2026 Jul 15; 2026 Jul 15. PMID: 42458269.
Autonomous Agents for Auditable Cardiovascular Artificial Intelligence Development.Dhingra LS, Batinica B, Choi RB, Croon PM, Oikonomou EK, Khera R. medRxiv. 2026 Jul 14; 2026 Jul 14. PMID: 42523449.
The spread of sexually transmissible drug-resistant shigellosis in England: a genomic epidemiology study.Marshall JE, Lefrancq N, Mason LCE, Jawed F, Tam YL, Jenkins C, Salje H, Baker KS. Lancet Infect Dis. 2026 Jul 8; 2026 Jul 8. PMID: 42419333.
Environmental Detection of Pathogenic Leptospira DNA in Agricultural Ecosystems from a Mediterranean-Climate Region of Central Chile.San Martin MF, Quiroga N, Casanovas-Massana A, Botto-Mahan C, Bacigalupo A, Cattan PE, Arroyo P, Contardo J, Salgado R, Yefi-Quinteros E, Correa JP. Pathogens. 2026 Jun 23; 2026 Jun 23. PMID: 42514988.
Establishment of a laboratory mouse model to study Borrelia miyamotoi infection and disease.Bockenstedt LK, Belperron AA, Mao J, Zeiss CJ, Barbour AG, Ledizet M, Krause PJ, Dardick KR. Front Immunol. 2026; 2026 Jun 12. PMID: 42367759.
Observational and genetically-informed characterization of Gulf War Illness symptoms in 1990-1991 Gulf War deployed Veterans and non-deployed Gulf War Era Veterans.He J, Pathak GA, Cabrera-Mendoza B, Qiu D, Zawack K, Steele L, Quaden R, Harrington KM, Gifford EJ, Aslan M, Helmer DA, Hauser ER, Polimanti R. Environ Health. 2026 Jun 11; 2026 Jun 11. PMID: 42277823.
Immunomodulation by platelet-derived DKK1: potential for controlling disease and pathology in leishmaniasis and implications for other infectious diseases.Ihedioha OC, McMahon-Pratt D, Bothwell ALM. Front Immunol. 2026; 2026 Jun 2. PMID: 42311685.
Artificial intelligence-enabled electrocardiography to triage echocardiography for structural heart disease diagnosis in a low-resource setting.Pedroso AF, Nascimento BR, Dhingra LS, Shankar SV, Vinhal WC, Reges RBE, Cardoso CS, Sable C, Ribeiro ALP, Khera R. Am J Prev Cardiol. 2026 Jun; 2026 Mar 24. PMID: 42291046.
Long-read nanopore shotgun metagenomic DNA sequencing for river biodiversity, wildlife, pollution, and environmental health monitoring.Nousias O, Duffy FG, Duffy IJ, McCauley M, Whilde J, Duffy DJ. NAR Genom Bioinform. 2026 Jun; 2026 Apr 24. PMID: 42038409.
Failure of endophthalmitis prophylaxis: laboratory model comparing antibiotics and bacterial loads.Moon M, Mathews S, Mahjabin F, Karaiskos K, Libre PE. J Cataract Refract Surg. 2026 Jun 1. PMID: 41642980.
Utilizing virus genomic surveillance to predict vaccine effectiveness.Kwon J, Li K, Warren JL, Pandya S, Hahn AM, Pitzer VE, Weinberger DM, Grubaugh ND. PLoS Comput Biol. 2026 May; 2026 May 26. PMID: 42189851.
Implementation fidelity to the World Health Organization package of essential non-communicable disease interventions (PEN) during scale-up in Nepal's primary healthcare system: a mixed methods study.Teufel F, Nakarmi CS, Mali S, Shrestha S, Acharya Y, Poudel B, Bishwokarma A, Bharati A, Adhikari A, Dhakal A, Rai BK, Manandhar S, Kc S, Timalsena D, Baral PP, Dhimal M, Silwal S, Bhattarai S, Spiegelman D, Rhodes EC, Shrestha A. Implement Sci Commun. 2026 May 7; 2026 May 7. PMID: 42093042.
Understanding the barriers to engagement in a passive tick surveillance program to inform public health strategies in Connecticut.Jones SM, Miranda AM, Bei Y, Oko-Ose O, Khalil N, Wang J, Molaei G. Ticks Tick Borne Dis. 2026 May; 2026 May 11. PMID: 42114248.
Wearable-Echo-FM: an ECG echo foundation model for 1-lead electrocardiography.Knight E, Oikonomou EK, Aminorroaya A, Pedroso AF, Khera R. Eur Heart J Digit Health. 2026 May; 2026 Mar 25. PMID: 42077383.
Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations.Koller D, He J, Løkhammer S, Aranda S, Qiu D, Davtian D, Chen Q, Xu Z, Mao Z, Friligkou E, Karaca S, Cormand B, Flores I, Altmäe S, Mitjans M, Cabrera-Mendoza B, Polimanti R. Nat Genet. 2026 May; 2026 Apr 29. PMID: 42056605.
Activation mechanism of the full-length histidine kinase LvrB from pathogenic Leptospira.Agustoni E, Mechaly A, Dalla Rizza J, Beriashvili D, Pluhackova K, Isaikina P, Trajtenberg F, Müntener T, Wunder EA Jr, Ko AI, Schirmer T, Buschiazzo A, Hiller S. Nat Commun. 2026 Apr 16; 2026 Apr 16. PMID: 41991510.
HHBayes: A Flexible Bayesian Framework for Simulating and Analyzing Household Transmission Dynamics.Li K, Hou Y, Mukherjee B, Pitzer VE, Weinberger DM. medRxiv. 2026 Apr 3; 2026 Apr 3. PMID: 41959791.
e3SIM: Epidemiological-ecological-evolutionary simulation framework for genomic epidemiology.Xu P, Liang S, Hahn A, Zhao V, Lo WT', Haller BC, Sobkowiak B, Chitwood MH, Colijn C, Cohen T, Rhee KY, Messer PW, Wells MT, Clark AG, Kim J. Methods Ecol Evol. 2026 Apr; 2026 Mar 5. PMID: 41953710.
Genomic epidemiology of Mycobacterium tuberculosis in Malawi: using global phylogeography to understand the impact of geographically focused interventions.Beams AB, Song Y, McNichol J, Jones BR, Sobkowiak B, MacPherson P, Nliwasa M, Ndhlovu V, Phiri MD, Cohen T, Colijn C. Microb Genom. 2026 Apr. PMID: 41949012.
Empiric azithromycin alters the upper respiratory microbiome and resistome without anti-inflammatory benefit in COVID-19.Glascock A, Maguire C, Phan HV, Lydon EC, Schaenman J, Calfee CS, Melamed E, Greenland J, Corry DB, Kheradmand F, Baden LR, Sekaly R, McComsey GA, Haddad EK, Cairns CB, Geng LN, Pulendran B, Fernandez-Sesma A, Simon V, Metcalf JP, Agudelo Higuita NI, Messer WB, Davis MM, Nadeau KC, Kraft M, Bime C, Erle DJ, Atkinson MA, Brakenridge SC, Ehrlich LIR, Montgomery RR, Shaw AC, Hough CL, Hafler DA, Augustine AD, Becker PM, Peters B, Ozonoff A, Hoch A, Kim-Schulze S, Krammer F, Bosinger S, Eckalbar W, Altman MC, Wilson M, Guan L, Maecker H, Steen H, Diray-Arce J, Rouphael N, Kleinstein SH, Jayavelu ND, Reed EF, Levy O, Chu VT, Langelier CR. Nat Microbiol. 2026 Apr; 2026 Mar 16. PMID: 41840216.
Global epidemiology of ovarian cancer: patterns, trends, and risk factors.Li R, Zhao A, Liu M, Lu L, Li B, Zeng H. Cancer Biol Med. 2026 Mar 24. PMID: 41877375.
Association of genetic variants in the autophagy gene ATG4B with asthma.Nicholson D, DeWan AT. medRxiv. 2026 Mar 23; 2026 Mar 23. PMID: 41929293.
DMEM and EMEM as alternate growth media for pathogenic Leptospira.Garcia LE, Lin Z, Culos S, Muenker MC, Johnson EE, Wang Z, Lopez-Giraldez F, Giraud-Gatineau A, Jackson AM, Picardeau M, Goodlett DR, Townsend JP, Pětrošová H, Wunder EA Jr. PLoS Negl Trop Dis. 2026 Mar; 2026 Mar 17. PMID: 41843624.
Lipidome changes indicate oxidative stress, inflammation, and specific loss of glycerophosphoserine inflammatory protection in patients with lupus.Koelmel JP, Ramos PS, Costa KA, Godri-Pollitt KJ, Kamen DL, Bowden JA. J Pharm Biomed Anal. 2026 Mar 15; 2025 Dec 3. PMID: 41389493.
A tiled amplicon protocol for culture-free whole-genome sequencing of M. tuberculosis from clinical specimens.Kalinich CC, Gonzalez FL, Osmaston A, Breban MI, Distefano I, Leon C, Coronel J, Tan G, Crudu V, Ciobanu N, Codreanu A, Solano W, Ráez J, Sheen P, Zimic M, Allicock OM, Chaguza C, Wyllie AL, Brandt M, Weinberger DM, Sobkowiak B, Cohen T, Grandjean L, Grubaugh ND, Redmond SN. J Clin Microbiol. 2026 Mar 11; 2026 Feb 9. PMID: 41660836.
Co-production of informal settlement health: a community based participatory research program for building healthy communities in urban informal settlements of Salvador, Brazil.Mogaji H, Alexandra Alzate LY, Figuerêdo LA, Araujo Virgens JH, Aliaga MA, Argibay HD, Salles I, Pereira Moreira A, Lima E Silva TJ, Cristina Dos Santos S, Batista R, Cardoso E, Neves Santos EC, Leal Dos Santos E, Rodrigues Dos Santos E, da Mata Barreto T, Dos Santos Mattos TA, Nery N Jr, Cruz J, Carneiro I, Lustosa R, Dedavid Ferreira VC, Reis M, Ko AI, Costa F, Begon M, Khalil H. Front Public Health. 2026; 2026 Mar 10. PMID: 41883820.
Rare variant analyses provide insights into the genetic architecture of endometriosis.Gui Y, Xie Y, Tong X, Zhao H. Hum Genomics. 2026 Feb 24; 2026 Feb 24. PMID: 41736152.
Unexpected diversification of DENV2 genotype III in Colombia: New Insights and application of the globalized nomenclature.Calvo EP, Madroñero LJ, Hernández LM, Arturo JA, Pinzón H, Delgado FG, Velandia-Romero ML, Hill V, Grubaugh ND, Castellanos JE. PLoS One. 2026; 2026 Feb 24. PMID: 41734239.
Use of Animal-Derived Products for Medicinal and Belief-Based Purposes in Urban Cities of Southwestern Nigeria: A One Health Perspective.Akpan SN, Buij R, van Langevelde F, Thomas LF, Sijuwola AE, Ogunsanya OA, Hooft PV, Adedokun OA, Adeyemo AA, Ayinla AO, Zimmerman DM, Cook EAJ, Masudi SP, Hassell JM, Happi CT, Happi AN. Animals (Basel). 2026 Feb 5; 2026 Feb 5. PMID: 41681482.
Core-sheath coupling controls flagellar curvature and motility in Leptospira.San Martin F, Brady MR, Fule L, Nouchikian L, Rodriguez A, Mondino S, Larrieux N, Wunder EA Jr, Ko AI, Rey M, Chamot-Rooke J, Duran R, Trajtenberg F, Picardeau M, Sindelar CV, Buschiazzo A. bioRxiv. 2026 Feb 3; 2026 Feb 3. PMID: 41676522.
Uncovering the genetic landscape of cholangiocarcinoma and its subtypes via GWAS and integrative analyses.Han Y, Byun J, VanLith CJ, Cooley MA, Shaw VR, Hatia RI, Ahmed FY, Giama NH, Ali HM, Campbell NA, Hassan M, Andersen JB, Ankoma-Sey V, Banales JM, Bujanda L, Bathe OF, Bekaii-Saab TS, Borad MJ, Björkström NK, Chan CHF, Cleary SP, Cornillet M, Folseraas T, Galle PR, Genkinger JM, MacInnis RJ, Gores GJ, Goyal L, Houlston RS, Ilyas SI, Javle M, Johansen JS, Christensen TD, Kamath AS, Kelley RK, Khan SA, Kim RD, Kwee SA, Lamarca A, Lammert F, LaRusso NF, Lindsey S, Macias RIR, Malhi H, Patel TC, Permuth JB, Reeves HL, Rossi S, Sanchez W, Smoot RL, Swerdlow AJ, Tran Cao HS, Valle JW, Weinmann A, Weinmann-Menke J, Wong LL, Zhang X, Zimmer V, Zhu AX, Lazaridis KN, Juran BD, Jalal P, Knox JJ, Hutchinson A, Hicks B, Koshiol JE, Chanock SJ, Hassan MM, Amos CI, McGlynn KA, Roberts LR. Hepatology. 2026 Feb 2; 2026 Feb 2. PMID: 41627892.
Trends in Mortality Associated With Ischemic Heart Disease and Screenable Cancers in the United States, 1999 to 2024.Rana JS, Mszar R, Gianos E, Budoff MJ, Nasir K, Ahmed M. JACC Adv. 2026 Feb; 2026 Jan 19. PMID: 41558364.
Estimating the burden of RSV- and influenza-associated ED visits, hospitalizations, ICU admissions, and deaths across age and socioeconomic groups in New York State, 2005-2019.Xu H, Pitzer VE, Warren JL, Shapiro ED, Perniciaro S, Weinberger DM. BMC Infect Dis. 2026 Jan 28; 2026 Jan 28. PMID: 41606523.
Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models.Wang X, He J, Cabrera-Mendoza B, Qiu D, Mao Z, Gu W, Liu Y, Kim J, Polimanti R. BMC Med. 2026 Jan 22; 2026 Jan 22. PMID: 41572266.
Hygiene knowledge and practices in the Lagos wild meat value chain: Cultural influences, regulatory gaps, and infrastructure needs.Akpan SN, Cook EAJ, van Langevelde F, van Hooft P, Zimmerman DM, Buij R, Hassell JM, Masudi SP, Happi CT, Happi AN, Thomas LF. PLOS Glob Public Health. 2026; 2026 Jan 16. PMID: 41544141.
Proceedings of the inaugural symposium on dengue human challenge studies "Challenging the norm: Accelerating dengue countermeasures through human studies".Kalimuddin S, Waickman AT, Avirutnan P, Alam MS, Chiu C, Young BE, Woods CW, Fay PC, Pakir SK, Manski-Nankervis JA, Bolte C, Pengilley A, Cavaleri M, Lim JCW, Thomas SJ, Ko AI, Ooi EE. PLoS Negl Trop Dis. 2026 Jan; 2026 Jan 9. PMID: 41511926.
Primary healthcare system readiness for the prevention and management of non-communicable diseases in Nepal.Nakarmi CS, Bhattarai S, Rhodes EC, Dhimal M, Baral PP, Poudel B, Rai BK, Bishwokarma A, Mali S, Adhikari A, Dhakal A, Bharati A, Manandhar S, K C S, Silwal S, Adhikari B, Shrestha S, Teufel F, Timalsena D, Acharya Y, Spiegelman D, Shrestha A. Discov Public Health. 2026; 2026 Sep 25. PMID: 42800977.
Decontamination approaches and strategies for the prevention of sink drain-related healthcare-associated infections.Tanner WD, Mathew T, Roberts SC, Dieter L, Healy HG, Peaper DR, Peccia J, Martinello RA. Clin Microbiol Rev. 2025 Dec 11; 2025 Nov 21. PMID: 41269016.
Endosymbiont hijacking of acylcarnitines regulates insect vector fecundity by suppressing the viability of stored sperm.Weiss BL, Gstöttenmayer F, Awuoche E, Smallenberger GM, Attardo GM, Scolari F, Koch RT, Bruzzese DJ, Echodu R, Opiro R, Malacrida A, Abd-Alla AMM, Aksoy S. PLoS Genet. 2025 Dec; 2025 Dec 10. PMID: 41370310.
Potential spillover investigated by metagenome sequencing in Laikipia, Kenya reveals tick-borne pathogens and a novel bunyavirus.Kamau M, Ergunay K, Bourke BP, Mutura J, Lebunge R, Ochieng G, Gathii K, Waitumbi J, Mutai B, Hassell J, von Fricken ME, Zimmerman D, Murray S, Jiang L, Liao HM, Grieco JP, McDermott EG, Achee NL, Linton YM. One Health. 2025 Dec; 2025 Sep 29. PMID: 41127630.
The importance of epistasis in the evolution of viral pathogens.Manivannan SN, Diaz Arenas C, Grubaugh ND, Ogbunugafor CB. Virus Evol. 2025; 2025 Nov 24. PMID: 41383811.
Improving newborn screening accuracy through genome sequencing, targeted metabolomics, and machine learning.Xie Y, Peng G, Tikhonova I, Enns G, Zhao H, Cowan T, Scharfe C. BMC Med Genomics. 2025 Nov 19; 2025 Nov 19. PMID: 41257776.
Minimalistic transcriptomic signatures permit accurate early prediction of COVID-19 mortality.Narendra R, Lydon EC, Phan HV, Spottiswoode N, Neyton LP, Diray-Arce J, Becker PM, Kim-Schulze S, Hoch A, Pickering H, van Zalm P, Cairns CB, Altman MC, Augustine AD, Bosinger S, Eckalbar W, Guan L, Doni Jayavelu N, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Peters B, Rouphael N, Montgomery RR, Reed E, Schaenman J, Steen H, Levy O, Haller SC, Erle D, Hendrickson CM, Krummel MF, Matthay MA, Woodruff P, Haddad EK, Calfee CS, Langelier CR. JCI Insight. 2025 Nov 10; 2025 Nov 10. PMID: 41212055.
Recessive genomic and phenotypic variation in consanguineous families with cerebral palsy.Bisarad P, Wang YC, Skidmore PT, Galaz-Montoya CI, Lewis SA, Alhaddad B, Kong N, Julian D, Magee H, Kruer TN, Xie Y, Zheng W, Li B, Rajabpour FV, Liu J, Revanur A, Bakur K, Firouzabadi SG, Sharbatkhori S, Tafakhori A, Taghiabadi E, Nezaminargabad E, Vosoogh S, Jamshidi J, Arefnia S, Hosseini SA, Khajehmirzaei A, Jamali F, Ahmadifard A, Khodadadi H, Daneshmand P, Bohlega S, Maddirevula S, Nadeef SS, Hashem MO, Salih MA, Mohmed IN, Sticht H, Morias SP, Damásio J, Santos M, Loureiro JL, Rodrigues R, Stevanin G, Benkirane M, Dauriat B, Head N, Baptista J, Shahhosseini S, Mohammad F, Zhao H, Padilla-Lopez S, Alkuraya F, Bakhtiari S, Kruer MC, Jin SC, Darvish H. medRxiv. 2025 Nov 6; 2025 Nov 6. PMID: 41282771.
Reliability of Artificial Intelligence-enhanced Electrocardiography.Dhingra LS, Croon PM, Batinica B, Aminorroaya A, Pedroso AF, Oikonomou EK, Khera R. medRxiv. 2025 Nov 6; 2025 Nov 6. PMID: 41282699.
Phenotypic Selectivity of Artificial Intelligence-Enhanced Electrocardiography in Cardiovascular Diagnosis and Risk Prediction.Croon PM, Dhingra LS, Biswas D, Oikonomou EK, Khera R. Circulation. 2025 Nov 4; 2025 Sep 1. PMID: 40888124.
Leveraging Systems-of-Systems Analysis to Strengthen Epidemic Intelligence for Preparedness and Response.Drake JM, Bahl J, Cacciatore MA, Ghadami A, Graeden E, Han BA, Nowak G, Marty É, Robertson H, Rohani P, Sarkar S, Stott GL, Winter AK, Epureanu BI. Health Secur. 2025 Nov-Dec. PMID: 41370647.
Cross-Sectional Association of Ground-Level Ozone and Nitrogen Dioxide With Cardiac Mechanics Using Speckle-Tracking Echocardiography in the Cardiovascular Health Study.Chang AY, Kaufman JD, Shah SJ, Tan AX, Patel RB, Margolis HG, Psaty BM, Gardin JM, Al-Kindi S, Austin TR, Bell ML, Chen K, Odden MC. Echocardiography. 2025 Nov. PMID: 41146536.
Synergistic toxicity in alcohol-associated liver disease and PFAS exposure.Stem AD, Tieghi RS, Chatzi VL, Kleinstreuer N, Valvi D, Thompson DC, Vasiliou V. Toxicol Sci. 2025 Nov 1. PMID: 40737496.
Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort.Jayavelu ND, Qi J, Milliren CE, Ozonoff A, Liu S, Levy O, Baden LR, Melamed E, McComsey GA, Cairns CB, Schaenman J, Shaw AC, Hafler DA, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Agudelo Higuita NI, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Geng LN, Sesma AF, Simon V, Krammer F, Bime C, Calfee CS, Bosinger SE, Eckalbar W, Steen H, Maecker HT, Augustine AD, Diray-Arce J, Haddad EK, Sekaly RP, Kraft M, Woodruff PG, Erle DJ, Ehrlich LIR, Montgomery RR, Becker PM, Altman MC, Fourati S. J Allergy Clin Immunol Glob. 2025 Nov; 2025 Jun 12. PMID: 40709330.
Microbiome signatures of Clostridioides difficile toxin production and toxin gene presence: a shotgun metagenomic approach.Kwon J, Correa MA, Kong Y, Pelletiers W, Wade M, Olson D, Pettigrew MM. mSphere. 2025 Oct 29; 2025 Sep 25. PMID: 40996044.
TARGET-AI: a foundational approach for the targeted deployment of artificial intelligence electrocardiography in the electronic health record.Oikonomou EK, Batinica B, Dhingra LS, Aminorroaya A, Coppi A, Khera R. medRxiv. 2025 Oct 25; 2025 Oct 25. PMID: 40909833.
The capsule and genetic background, rather than specific individual loci, strongly influence in vitro pneumococcal growth kinetics.Chaguza C, Arends DW, Lo SW, Putri IH, York A, Lees JA, Wyllie AL, Weinberger DM, Bentley SD, de Jonge MI, Cremers AJH. Elife. 2025 Oct 21; 2025 Oct 21. PMID: 41118311.
Virulence hierarchies within the Mycobacterium tuberculosis complex.Danchuk SN, Duffy SC, Sullivan J, Beenish Rufai S, McIntosh FA, Lupien A, Harrison LB, Ghasemi Goojani H, Taylor L, Wei Y, Joubert P, Mortensen R, Chen JM, Niroula N, Stevens R, Norleen C, Kapur V, Behr MA. Proc Natl Acad Sci U S A. 2025 Oct 21; 2025 Oct 16. PMID: 41100665.
Molecular Biomarker Testing Patterns and Turnaround Time in US Patients With Advanced Non-Small Cell Lung Cancer.Wang X, Lee DH, Yang SC, Li Y, Soulos PR, Gross CP, Wang SY, Chiang AC. J Natl Compr Canc Netw. 2025 Oct 10; 2025 Oct 10. PMID: 41072474.
Prevalence of chronic non-communicable diseases and multimorbidity among adults living in slums in Rio de Janeiro, Brazil: a population-based survey.Echeverría-Guevara A, Luz PM, Pires DC, Jalil EM, Perazzo H, Torres TS, Cardoso SW, Goedert GT, Csillag D, Peixoto EM, de Souza Filho BAB, Costa CAM, Amancio RT, Santos CVBD, Rodrigues NCP, Grinsztejn B, Veloso VG, Struchiner CJ, Coelho LE. Int J Equity Health. 2025 Oct 9; 2025 Oct 9. PMID: 41068736.
Pixel intensity of wing photos used to infer efficacy of mosquito control interventions against Anopheles gambiae caught during the RIMDAMAL II clinical trial.Pugh G, Sougué E, Burton TA, Yoe R, Gray LI, Hephaestus B, Somé A, Asay B, Parikh S, Somé AF, Dabiré RK, Foy BD. Sci Rep. 2025 Oct 7; 2025 Oct 7. PMID: 41057397.
Population-Specific Transcriptomic Shifts Underlie Secondary Metabolic Diversification in Aspergillus flavus and the Domestication of Aspergillus oryzae.Drott MT, Wang YW, Hatmaker EA, Mercado-Soto NM, Elmore JM, Luciano-Rosaro D, Yu JH, Rokas A, Gibbons JG, Huttenlocher A, Yang K, Keller NP. bioRxiv. 2025 Oct 3; 2025 Oct 3. PMID: 41256382.
Improvement of colony management in insect mass-rearing for sterile insect technique applications.Abd-Alla AMM, Geiger A, Haymer D, Herrero S, Jehle JA, Khamis F, Liedo P, Malacrida AR, Njiokou F, Mastrangelo T, Pagabeleguem S, Ramırez-Santos EM, Ros VID, Segura DF, Tsiamis G, Weiss BL. Insect Sci. 2025 Oct; 2025 Sep 28. PMID: 41017241.
Diet and Prevention of Cardiovascular Disease and Cancer: JACC: CardioOncology State-of-the-Art Review.Hull SC, Mszar R, Ostfeld RJ, Ferrucci LM, Mucci LA, Giovannucci E, Loeb S. JACC CardioOncol. 2025 Oct; 2025 Aug 29. PMID: 40879583.
Using the microbiota to study connectivity at human-animal interfaces.Muloi DM, Caron A, Berkley JA, Hassell JM, Brito IL, King K, Moodley A, Fèvre EM. Trends Microbiol. 2025 Oct; 2025 Jun 9. PMID: 40494694.
Leveraging Alzheimer's Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma.Tolosa-Tort P, DeWan AT. Mol Neurobiol. 2025 Oct; 2025 May 24. PMID: 40411683.
Artificial Intelligence in the Management of Heart Failure.Cheema B, Hourmozdi J, Kline A, Ahmad F, Khera R. J Card Fail. 2025 Oct; 2025 May 7. PMID: 40345521.
Relating In Vivo Respiratory Syncytial Virus Infection Kinetics to Host Infectiousness in Different Age Groups.Li K, Bont LJ, Weinberger DM, Pitzer VE. J Infect Dis. 2025 Sep 15. PMID: 40085821.
How well do disease-specific studies and WHO-CHOICE cost estimates align? Example of estimating cost per episode of diarrhoea and respiratory syncytial virus in 128 low-income and middle-income countries.Li X, Bilcke J, Asare EO, Wenger C, Kwon J, Bont L, Beutels P, Pitzer VE. BMJ Glob Health. 2025 Aug 24; 2025 Aug 24. PMID: 40850784.
Cancer care interventions for forcibly displaced populations in low- and middle-income countries of the Middle East and North African region affected by humanitarian crises: Protocol for a scoping review.Havlik AL, Ahmed Z, Chadwick PS, Nyhan K, Khoshnood K. PLoS One. 2025; 2025 Aug 18. PMID: 40824891.
Cross-continental hitchhiking of exotic ticks on human travelers and ensuing public health challenges in the USA.Khalil N, Sandland L, Molaei G. iScience. 2025 Aug 15; 2025 Aug 8. PMID: 40948550.
Non-communicable disease care for persons living with HIV in Peru: A national physician cross-sectional study.Slotkin R, Granda D, Cabrera D, Benites CM, Garcia PJ, Hsieh E. PLOS Glob Public Health. 2025; 2025 Aug 4. PMID: 40758733.
Bacterial recolonization of hospital sink biofilms.Healy HG, Pawluk E, Dieter L, Roberts SC, Tanner W, Mathew T, Peaper D, Martinello RA, Peccia J. J Hosp Infect. 2025 Aug; 2025 Jun 2. PMID: 40466811.
Integrating genomic and spatial analyses to describe tuberculosis transmission: a scoping review.Lan Y, Rancu I, Chitwood MH, Sobkowiak B, Nyhan K, Lin HH, Wu CY, Mathema B, Brown TS, Colijn C, Warren JL, Cohen T. Lancet Microbe. 2025 Aug; 2025 Apr 11. PMID: 40228509.
Building a growing genomic repository for maternal and fetal health through the PING Consortium.Abdelmalek CM, Singh S, Fasil B, Horvath AR, Mulkey SB, Curé C, Campos M, Cavalcanti DP, Tong VT, Mercado M, Daza M, Benavides MM, Acosta J, Gilboa S, Valencia D, Sancken CL, Newton S, Scalabrin DMF, Mussi-Pinhata MM, Vasconcelos Z, Chakhtoura N, Moye J, Leslie EJ, Bulas D, Vezina G, Marques FJP, Leyser M, Del Campo M, Vilain E, DeBiasi RL, Wang T, Nath A, Haydar T, Muenke M, Mansour TA, du Plessis AJ, Murray JC, Cordero JF, Kousa YA. Pediatr Res. 2025 Aug; 2025 Jan 3. PMID: 39753885.
Trajectories of Purpose in Life Across Diagnosis of Alzheimer's Disease or Related Dementias in Older Adulthood.Mroz EL, Collette T, Keefe K, Gil H, Monin J, Sharma S. J Aging Health. 2025 Aug; 2024 May 30. PMID: 38816276.
Interplay between the gut microbiome and typhoid fever: insights from endemic countries and a controlled human infection model.Ashton PM, Mageiros L, Meiring JE, Chunga-Chirambo A, Khanam F, Dongol S, Banda H, Karkey A, Preciado-Llanes L, Thomaides-Brears H, Gibani M, Rajib NH, Rahman N, Biswas PK, Bhuiyan MAI, Kay S, Auger K, Seret O, Thomson NR, Pollard AJ, Baker S, Basnyat B, Clemens JD, Dolecek C, Dunstan SJ, Dougan G, Heyderman RS, Pitzer VE, Qadri F, Gordon MA, Holt KE, Darton TC. Microbiome. 2025 Jul 22; 2025 Jul 22. PMID: 40696437.
Integrated Analysis of the 2022 SARS-CoV-2 Omicron Lineage Replacement Dynamics in Connecticut, US.Chen NFG, Pham K, Chaguza C, Lopes R, Klaassen F, Kalinich CC, Yale Sars-CoV-Genomic Surveillance Initiative, Kerantzas N, Pandya S, Ferguson D, Schulz W, Weinberger DM, Pitzer VE, Warren JL, Grubaugh ND, Hahn AM. Viruses. 2025 Jul 21; 2025 Jul 21. PMID: 40733636.
Association of COVID-19 outcomes with measures of institutional and interpersonal trust: an ecological analysis using national data from 61 countries.Rountree L, Tong G, Bu F, Ranney M, Mukherjee B. Sci Rep. 2025 Jul 21; 2025 Jul 21. PMID: 40691221.
Development and multinational validation of an ensemble deep learning algorithm for detecting and predicting structural heart disease using noisy single-lead electrocardiograms.Aminorroaya A, Dhingra LS, Pedroso AF, Shankar SV, Coppi A, Khunte A, Foppa M, Brant LCC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. Eur Heart J Digit Health. 2025 Jul; 2025 Apr 10. PMID: 40703117.
Viral Etiologies of Acute Respiratory Illness in Older Adults and of Congestive Heart Failure and Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization During 2 Prepandemic Respiratory Seasons.Choi C, Ess G, Tippett A, Salazar L, Taylor EG, Ciric C, Reese O, Cheng A, Gibson T, Li W, Hsiao HM, Hellmeister K, Al-Husein Z, Hubler R, Begier E, Liu Q, Uppal S, Kalina WV, Gessner B, Jodar L, Kamidani S, Kao C, Yildirim I, Anderson LJ, Rouphael N, Anderson EJ, Rostad CA. Open Forum Infect Dis. 2025 Jul; 2025 Jun 20. PMID: 40657165.
Barriers and facilitators to patient utilization of noncommunicable disease services in primary healthcare facilities in Nepal: a qualitative study.Mali S, Rhodes EC, Nakarmi CS, Shrestha S, Dhakal A, Bharati A, Bishwokarma A, Adhikari A, Poudel B, Rai BK, Manandhar S, Kc S, Timalsena D, Silwal S, Dhimal M, Baral PP, Teufel F, Bhattarai S, Spiegelman D, Shrestha A. BMC Health Serv Res. 2025 Jul 1; 2025 Jul 1. PMID: 40598095.
JACC Data Report: Cardiovascular Disease Mortality Trends in the United States (1999-2023).Yan BW, Arun AS, Curtis LH, Kadakia KT, Lin Z, Lu Y, Wadhera R, Krumholz HM, Dhruva SS. J Am Coll Cardiol. 2025 Jul 1. PMID: 40562514.
Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis/chronic fatigue syndrome.Bastos VC, Greene KA, Tabachnikova A, Bhattacharjee B, Sjögren P, Bertilson B, Reifert J, Zhang M, Kamath K, Shon J, Gehlhausen JR, Guan L, VanElzakker M, Proal A, Bragée B, Iwasaki A. J Immunol. 2025 Jul 1. PMID: 40373264.

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Becoming Breastfeeding Friendly (BBF): A Guide to Global Scale UpThis evidence-informed initiative is designed to help countries identify the strength of their breastfeeding-friendly environment and to improve breastfeeding policies and programs.
Center for Neuroepidemiology and Clinical Neurological Research (CNE2)CNE2 is comprised of researchers across Yale schools who have common and complementary research and methodological interests in clinical neurological research.
Center for Outcomes and Research (CORE)
Community Alliance for Research and Engagement (CARE)CARE promotes the prevention of chronic diseases by focusing on social, environmental, and behavioral risk factors.
Olive Oil and Health
Samoan Obesity, lifestyle and Genetic Adaptations Study Group (OLAGA)OLAGA study group aims to understand the origins of obesity among Samoans and other Pacific Islanders to develop relevant interventions to reduce obesity and obesity-related conditions.
Transdisciplinary Research in Energetics and Cancer Research Education Program (TREC-REP)
Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO)
Yale Cancer Center (YCC)The Center provides the best approaches for the prevention, detection, diagnosis, and treatment of cancer.
Yale-Griffin Prevention Research Center (PRC)The PRC works with community partners to develop and implement community-based approaches to prevent and control chronic diseases such as heart disease, diabetes, and cancer.
Yale Institute for Global Health (YIGH)YIGH serves as the focal point for research, education, and engagement with global partners to improve the health of individuals and populations worldwide.
Yale Network for Global Non-communicable Diseases
Tobacco Center of Regulatory Science

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