- January 22, 2025
In California Wildfires, Climate and Health Collide
- January 09, 2025Source: Physician's Weekly
One in Four Older U.S. Veterans Report Cardiovascular Disease Diagnosis
- October 24, 2024
New Analytics Center for Cardiovascular Medicine
- May 13, 2024Source: CNN
What the Results of Wegovy’s Longest Clinical Trial Yet Show About Weight Loss, Side Effects and Heart Protection
Heart Disease and Stroke
Photo credit: Unsplash
Heart Disease and Stroke are leading causes of death and disability in the United States and worldwide. Numerous primary and secondary faculty used rigorous epidemiologic methods to improve our understanding of heart disease and stroke conducting research both nationally and internationally. For example, in the Department of Chronic Disease Epidemiology, the availability of access to large administrative medical claims databases enables researchers to investigate long term trends, patterns of care, and outcomes among elderly patients with heart disease and stroke.
Our research areas include:
- disease trends
- the role of traditional risk factors
- genetics
- biomarkers
- patterns of care
- biological, social, and environmental factors that influence the presentation and outcomes of young women with heart disease
- effect of community-based characteristics on disease rates and outcomes.
Recent Publications
- Potential spillover investigated by metagenome sequencing in Laikipia, Kenya reveals tick-borne pathogens and a novel bunyavirus.Kamau M, Ergunay K, Bourke BP, Mutura J, Lebunge R, Ochieng G, Gathii K, Waitumbi J, Mutai B, Hassell J, von Fricken ME, Zimmerman D, Murray S, Jiang L, Liao HM, Grieco JP, McDermott EG, Achee NL, Linton YM. One Health. 2025 Dec; 2025 Sep 29. PMID: 41127630.
- Minimalistic transcriptomic signatures permit accurate early prediction of COVID-19 mortality.Narendra R, Lydon EC, Phan HV, Spottiswoode N, Neyton LP, Diray-Arce J, Becker PM, Kim-Schulze S, Hoch A, Pickering H, van Zalm P, Cairns CB, Altman MC, Augustine AD, Bosinger S, Eckalbar W, Guan L, Doni Jayavelu N, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Peters B, Rouphael N, Montgomery RR, Reed E, Schaenman J, Steen H, Levy O, Haller SC, Erle D, Hendrickson CM, Krummel MF, Matthay MA, Woodruff P, Haddad EK, Calfee CS, Langelier CR. JCI Insight. 2025 Nov 10; 2025 Nov 10. PMID: 41212055.
- Phenotypic Selectivity of Artificial Intelligence-Enhanced Electrocardiography in Cardiovascular Diagnosis and Risk Prediction.Croon PM, Dhingra LS, Biswas D, Oikonomou EK, Khera R. Circulation. 2025 Nov 4; 2025 Sep 1. PMID: 40888124.
- Cross-Sectional Association of Ground-Level Ozone and Nitrogen Dioxide With Cardiac Mechanics Using Speckle-Tracking Echocardiography in the Cardiovascular Health Study.Chang AY, Kaufman JD, Shah SJ, Tan AX, Patel RB, Margolis HG, Psaty BM, Gardin JM, Al-Kindi S, Austin TR, Bell ML, Chen K, Odden MC. Echocardiography. 2025 Nov. PMID: 41146536.
- Synergistic toxicity in alcohol-associated liver disease and PFAS exposure.Stem AD, Tieghi RS, Chatzi VL, Kleinstreuer N, Valvi D, Thompson DC, Vasiliou V. Toxicol Sci. 2025 Nov 1. PMID: 40737496.
- Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort.Jayavelu ND, Qi J, Milliren CE, Ozonoff A, Liu S, Levy O, Baden LR, Melamed E, McComsey GA, Cairns CB, Schaenman J, Shaw AC, Hafler DA, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Agudelo Higuita NI, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Geng LN, Sesma AF, Simon V, Krammer F, Bime C, Calfee CS, Bosinger SE, Eckalbar W, Steen H, Maecker HT, Augustine AD, Diray-Arce J, Haddad EK, Sekaly RP, Kraft M, Woodruff PG, Erle DJ, Ehrlich LIR, Montgomery RR, Becker PM, Altman MC, Fourati S. J Allergy Clin Immunol Glob. 2025 Nov; 2025 Jun 12. PMID: 40709330.
- Microbiome signatures of Clostridioides difficile toxin production and toxin gene presence: a shotgun metagenomic approach.Kwon J, Correa MA, Kong Y, Pelletiers W, Wade M, Olson D, Pettigrew MM. mSphere. 2025 Oct 29; 2025 Sep 25. PMID: 40996044.
- TARGET-AI: a foundational approach for the targeted deployment of artificial intelligence electrocardiography in the electronic health record.Oikonomou EK, Batinica B, Dhingra LS, Aminorroaya A, Coppi A, Khera R. medRxiv. 2025 Oct 25; 2025 Oct 25. PMID: 40909833.
- The capsule and genetic background, rather than specific individual loci, strongly influence in vitro pneumococcal growth kinetics.Chaguza C, Arends DW, Lo SW, Putri IH, York A, Lees JA, Wyllie AL, Weinberger DM, Bentley SD, de Jonge MI, Cremers AJH. Elife. 2025 Oct 21; 2025 Oct 21. PMID: 41118311.
- Virulence hierarchies within the Mycobacterium tuberculosis complex.Danchuk SN, Duffy SC, Sullivan J, Beenish Rufai S, McIntosh FA, Lupien A, Harrison LB, Ghasemi Goojani H, Taylor L, Wei Y, Joubert P, Mortensen R, Chen JM, Niroula N, Stevens R, Norleen C, Kapur V, Behr MA. Proc Natl Acad Sci U S A. 2025 Oct 21; 2025 Oct 16. PMID: 41100665.
- Molecular Biomarker Testing Patterns and Turnaround Time in US Patients With Advanced Non-Small Cell Lung Cancer.Wang X, Lee DH, Yang SC, Li Y, Soulos PR, Gross CP, Wang SY, Chiang AC. J Natl Compr Canc Netw. 2025 Oct 10; 2025 Oct 10. PMID: 41072474.
- Prevalence of chronic non-communicable diseases and multimorbidity among adults living in slums in Rio de Janeiro, Brazil: a population-based survey.Echeverría-Guevara A, Luz PM, Pires DC, Jalil EM, Perazzo H, Torres TS, Cardoso SW, Goedert GT, Csillag D, Peixoto EM, de Souza Filho BAB, Costa CAM, Amancio RT, Santos CVBD, Rodrigues NCP, Grinsztejn B, Veloso VG, Struchiner CJ, Coelho LE. Int J Equity Health. 2025 Oct 9; 2025 Oct 9. PMID: 41068736.
- Pixel intensity of wing photos used to infer efficacy of mosquito control interventions against Anopheles gambiae caught during the RIMDAMAL II clinical trial.Pugh G, Sougué E, Burton TA, Yoe R, Gray LI, Hephaestus B, Somé A, Asay B, Parikh S, Somé AF, Dabiré RK, Foy BD. Sci Rep. 2025 Oct 7; 2025 Oct 7. PMID: 41057397.
- Improvement of colony management in insect mass-rearing for sterile insect technique applications.Abd-Alla AMM, Geiger A, Haymer D, Herrero S, Jehle JA, Khamis F, Liedo P, Malacrida AR, Njiokou F, Mastrangelo T, Pagabeleguem S, Ramırez-Santos EM, Ros VID, Segura DF, Tsiamis G, Weiss BL. Insect Sci. 2025 Oct; 2025 Sep 28. PMID: 41017241.
- Diet and Prevention of Cardiovascular Disease and Cancer: JACC: CardioOncology State-of-the-Art Review.Hull SC, Mszar R, Ostfeld RJ, Ferrucci LM, Mucci LA, Giovannucci E, Loeb S. JACC CardioOncol. 2025 Oct; 2025 Aug 29. PMID: 40879583.
- Using the microbiota to study connectivity at human-animal interfaces.Muloi DM, Caron A, Berkley JA, Hassell JM, Brito IL, King K, Moodley A, Fèvre EM. Trends Microbiol. 2025 Oct; 2025 Jun 9. PMID: 40494694.
- Leveraging Alzheimer's Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma.Tolosa-Tort P, DeWan AT. Mol Neurobiol. 2025 Oct; 2025 May 24. PMID: 40411683.
- Artificial Intelligence in the Management of Heart Failure.Cheema B, Hourmozdi J, Kline A, Ahmad F, Khera R. J Card Fail. 2025 Oct; 2025 May 7. PMID: 40345521.
- Relating In Vivo Respiratory Syncytial Virus Infection Kinetics to Host Infectiousness in Different Age Groups.Li K, Bont LJ, Weinberger DM, Pitzer VE. J Infect Dis. 2025 Sep 15. PMID: 40085821.
- How well do disease-specific studies and WHO-CHOICE cost estimates align? Example of estimating cost per episode of diarrhoea and respiratory syncytial virus in 128 low-income and middle-income countries.Li X, Bilcke J, Asare EO, Wenger C, Kwon J, Bont L, Beutels P, Pitzer VE. BMJ Glob Health. 2025 Aug 24; 2025 Aug 24. PMID: 40850784.
- Cancer care interventions for forcibly displaced populations in low- and middle-income countries of the Middle East and North African region affected by humanitarian crises: Protocol for a scoping review.Havlik AL, Ahmed Z, Chadwick PS, Nyhan K, Khoshnood K. PLoS One. 2025; 2025 Aug 18. PMID: 40824891.
- Cross-continental hitchhiking of exotic ticks on human travelers and ensuing public health challenges in the USA.Khalil N, Sandland L, Molaei G. iScience. 2025 Aug 15; 2025 Aug 8. PMID: 40948550.
- Non-communicable disease care for persons living with HIV in Peru: A national physician cross-sectional study.Slotkin R, Granda D, Cabrera D, Benites CM, Garcia PJ, Hsieh E. PLOS Glob Public Health. 2025; 2025 Aug 4. PMID: 40758733.
- Bacterial recolonization of hospital sink biofilms.Healy HG, Pawluk E, Dieter L, Roberts SC, Tanner W, Mathew T, Peaper D, Martinello RA, Peccia J. J Hosp Infect. 2025 Aug; 2025 Jun 2. PMID: 40466811.
- Integrating genomic and spatial analyses to describe tuberculosis transmission: a scoping review.Lan Y, Rancu I, Chitwood MH, Sobkowiak B, Nyhan K, Lin HH, Wu CY, Mathema B, Brown TS, Colijn C, Warren JL, Cohen T. Lancet Microbe. 2025 Aug; 2025 Apr 11. PMID: 40228509.
- Building a growing genomic repository for maternal and fetal health through the PING Consortium.Abdelmalek CM, Singh S, Fasil B, Horvath AR, Mulkey SB, Curé C, Campos M, Cavalcanti DP, Tong VT, Mercado M, Daza M, Benavides MM, Acosta J, Gilboa S, Valencia D, Sancken CL, Newton S, Scalabrin DMF, Mussi-Pinhata MM, Vasconcelos Z, Chakhtoura N, Moye J, Leslie EJ, Bulas D, Vezina G, Marques FJP, Leyser M, Del Campo M, Vilain E, DeBiasi RL, Wang T, Nath A, Haydar T, Muenke M, Mansour TA, du Plessis AJ, Murray JC, Cordero JF, Kousa YA. Pediatr Res. 2025 Aug; 2025 Jan 3. PMID: 39753885.
- Interplay between the gut microbiome and typhoid fever: insights from endemic countries and a controlled human infection model.Ashton PM, Mageiros L, Meiring JE, Chunga-Chirambo A, Khanam F, Dongol S, Banda H, Karkey A, Preciado-Llanes L, Thomaides-Brears H, Gibani M, Rajib NH, Rahman N, Biswas PK, Bhuiyan MAI, Kay S, Auger K, Seret O, Thomson NR, Pollard AJ, Baker S, Basnyat B, Clemens JD, Dolecek C, Dunstan SJ, Dougan G, Heyderman RS, Pitzer VE, Qadri F, Gordon MA, Holt KE, Darton TC. Microbiome. 2025 Jul 22; 2025 Jul 22. PMID: 40696437.
- Integrated Analysis of the 2022 SARS-CoV-2 Omicron Lineage Replacement Dynamics in Connecticut, US.Chen NFG, Pham K, Chaguza C, Lopes R, Klaassen F, Kalinich CC, Yale Sars-CoV-Genomic Surveillance Initiative, Kerantzas N, Pandya S, Ferguson D, Schulz W, Weinberger DM, Pitzer VE, Warren JL, Grubaugh ND, Hahn AM. Viruses. 2025 Jul 21; 2025 Jul 21. PMID: 40733636.
- Association of COVID-19 outcomes with measures of institutional and interpersonal trust: an ecological analysis using national data from 61 countries.Rountree L, Tong G, Bu F, Ranney M, Mukherjee B. Sci Rep. 2025 Jul 21; 2025 Jul 21. PMID: 40691221.
- Development and multinational validation of an ensemble deep learning algorithm for detecting and predicting structural heart disease using noisy single-lead electrocardiograms.Aminorroaya A, Dhingra LS, Pedroso AF, Shankar SV, Coppi A, Khunte A, Foppa M, Brant LCC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. Eur Heart J Digit Health. 2025 Jul; 2025 Apr 10. PMID: 40703117.
- Viral Etiologies of Acute Respiratory Illness in Older Adults and of Congestive Heart Failure and Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization During 2 Prepandemic Respiratory Seasons.Choi C, Ess G, Tippett A, Salazar L, Taylor EG, Ciric C, Reese O, Cheng A, Gibson T, Li W, Hsiao HM, Hellmeister K, Al-Husein Z, Hubler R, Begier E, Liu Q, Uppal S, Kalina WV, Gessner B, Jodar L, Kamidani S, Kao C, Yildirim I, Anderson LJ, Rouphael N, Anderson EJ, Rostad CA. Open Forum Infect Dis. 2025 Jul; 2025 Jun 20. PMID: 40657165.
- Barriers and facilitators to patient utilization of noncommunicable disease services in primary healthcare facilities in Nepal: a qualitative study.Mali S, Rhodes EC, Nakarmi CS, Shrestha S, Dhakal A, Bharati A, Bishwokarma A, Adhikari A, Poudel B, Rai BK, Manandhar S, Kc S, Timalsena D, Silwal S, Dhimal M, Baral PP, Teufel F, Bhattarai S, Spiegelman D, Shrestha A. BMC Health Serv Res. 2025 Jul 1; 2025 Jul 1. PMID: 40598095.
- JACC Data Report: Cardiovascular Disease Mortality Trends in the United States (1999-2023).Yan BW, Arun AS, Curtis LH, Kadakia KT, Lin Z, Lu Y, Wadhera R, Krumholz HM, Dhruva SS. J Am Coll Cardiol. 2025 Jul 1. PMID: 40562514.
- Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis/chronic fatigue syndrome.Bastos VC, Greene KA, Tabachnikova A, Bhattacharjee B, Sjögren P, Bertilson B, Reifert J, Zhang M, Kamath K, Shon J, Gehlhausen JR, Guan L, VanElzakker M, Proal A, Bragée B, Iwasaki A. J Immunol. 2025 Jul 1. PMID: 40373264.
- Integration of Metabolomic and Brain Imaging Data Highlights Pleiotropy Among Posttraumatic Stress Disorder, Glycoprotein Acetyls, and Pallidum Structure.Løkhammer S, Tesfaye M, Cabrera-Mendoza B, Sandås K, Pathak GA, Friligkou E, Le Hellard S, Polimanti R. Biol Psychiatry Glob Open Sci. 2025 Jul; 2025 Mar 17. PMID: 40270839.
- Temporal changes in pneumococcal carriage among childcare-attending children during the COVID-19 pandemic in the Greater New Haven Area, USA.Peno C, Thindwa D, Hislop MS, Yolda-Carr D, Egbewole D, Viswanathan G, Lin TY, Mbodj S, Rayack E, Askari HM, Kazemi Y, Lapidus S, Spatz ES, Zirinsky E, Oliveira CR, Bei AK, Weinberger DM, Wyllie AL. Res Sq. 2025 Jun 23; 2025 Jun 23. PMID: 40678241.
- Respiratory Viral Detection in Children Hospitalized With Pneumonia During Periods of Major Population Disruptions in Nepal, 2014-2018.Shrestha S, Bijukchhe SM, Wahl B, Carter MJ, Kandasamy R, Gurung M, O'Reilly PJ, Voice M, Pokhrel B, Amatya P, Bhandari S, Shrestha S, Kelly S, Kelly DF, Thorson S, Murdoch DR, Fink C, Deloria Knoll M, Pollard AJ. J Pediatric Infect Dis Soc. 2025 Jun 16. PMID: 40495349.
- Primary healthcare system readiness for the prevention and management of non-communicable diseases in Nepal: a mixed-methods study.Nakarmi CS, Bhattarai S, Rhodes EC, Dhimal M, Baral PP, Poudel B, Rai BK, Bishwokarma A, Mali S, Adhikari A, Dhakal A, Bharati A, Manandhar S, Kc S, Silwal S, Adhikari B, Shrestha S, Teufel F, Timilsina D, Acharya Y, Spiegelman D, Shrestha A. Res Sq. 2025 Jun 12; 2025 Jun 12. PMID: 40585222.
- Wearable-Echo-FM: An ECG-echo foundation model for single lead electrocardiography.Knight E, Oikonomou EK, Aminorroaya A, Pedroso AF, Khera R. medRxiv. 2025 Jun 12; 2025 Jun 12. PMID: 40585148.
- TITAN-RNA: A hybrid-capture sequencing panel detects known and unknown Flaviviridae for diagnostics and vector surveillance.Murrell CM, Sabaawy A, Wang X, Hashimoto N, Ceres K, Sun Y, Zehr JD, Lehane A, Mader E, Bailey N, Lilly MV, Plimpton L, Reboul G, Brown JJ, Sams K, Singh L, Seiz E, Bourgikos E, Vogels CBF, Ciota AT, Schnurr V, Grenier J, Berthet X, Bento AI, Harrington L, Diuk-Wasser M, Olarte-Castillo X, Goodman LB. bioRxiv. 2025 Jun 8; 2025 Jun 8. PMID: 40501929.
- TICKHUNTER: A Targeted Hybridization-Capture Sequencing Approach for the Detection and Characterization of Tick-borne Pathogens and Blood Meals.Wang X, Brown JJ, Lilly MV, Plimpton L, Murrell CM, Llanos-Soto SG, Zehr JD, Sun Y, Reboul G, Sams K, Sabaawy A, Singh L, Tallmadge RL, Mitchell PK, Anderson RR, Ladd-Wilson SG, Bourgikos E, Vogels CBF, Olarte-Castillo X, Diuk-Wasser M, Goodman LB. bioRxiv. 2025 Jun 6; 2025 Jun 6. PMID: 40501899.
- Shotgun sequencing of airborne eDNA achieves rapid assessment of whole biomes, population genetics and genomic variation.Nousias O, McCauley M, Stammnitz MR, Farrell JA, Koda SA, Summers V, Eastman CB, Duffy FG, Duffy IJ, Whilde J, Duffy DJ. Nat Ecol Evol. 2025 Jun; 2025 Jun 3. PMID: 40461811.
- The validity of test-negative design for assessment of typhoid conjugate vaccine protection: comparison of estimates by different study designs using data from a cluster-randomised controlled trial.Feng S, Zhang Y, Khanam F, Voysey M, Pitzer VE, Qadri F, Clemens JD, Pollard AJ, Liu X. Lancet Glob Health. 2025 Jun; 2025 Apr 16. PMID: 40252689.
- Controversy in Hypertension: Pro-Side of the Argument Using Artificial Intelligence for Hypertension Diagnosis and Management.Armoundas AA, Ahmad FS, Attia ZI, Doudesis D, Khera R, Kyriakoulis KG, Stergiou GS, Tang WHW. Hypertension. 2025 Jun; 2025 Mar 17. PMID: 40091745.
- Structure, conservation and health implications of urban wild meat value chains: A case study of Lagos, Nigeria.Akpan SN, van Hooft P, Happi AN, Buij R, van Langevelde F, Cook EAJ, Hassell JM, Zimmerman DM, Masudi SP, Happi CT, Thomas LF. One Health. 2025 Jun; 2025 Feb 14. PMID: 40040920.
- Temporal Trends of Early COVID-19 Infections in New York City Transit Workers and Residents: March 01, 2020-May 02, 2020.Cziner M, Hawkins D, Rosen J, Hagen D, Merdjanoff A, Vlahov D, Gershon R. J Urban Health. 2025 Jun; 2024 Nov 11. PMID: 39527356.
- Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson's Disease.Zhang L, Yasumizu Y, Deerhake ME, Moon J, Buitrago-Pocasangre N, Russo A, Wang H, Zhu B, Seibyl JP, Reddy V, Wang Q, Spillantini MG, Posner DA, Clatworthy M, Sumida TS, Longbrake EE, Cedarbaum JM, Hafler DA. bioRxiv. 2025 May 21; 2025 May 21. PMID: 40475455.
- Effects of Tirzepatide in Type 2 Diabetes: Individual Variation and Relationship to Cardiometabolic Outcomes.Aminorroaya A, Oikonomou EK, Biswas D, Jastreboff AM, Khera R. J Am Coll Cardiol. 2025 May 20; 2025 Mar 30. PMID: 40368575.
- Minimalistic Transcriptomic Signatures Permit Accurate Early Prediction of COVID-19 Mortality.Narendra R, Lydon EC, Van Phan H, Spottiswoode N, Neyton LP, Diray-Arce J, Becker PM, Kim-Schulze S, Hoch A, Pickering H, van Zalm P, Cairns CB, Altman MC, Augustine AD, Bosinger S, Eckalbar W, Guan L, Jayavelu ND, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Peters B, Rouphael N, Montgomery RR, Reed E, Schaenman J, Steen H, Levy O, Carillo SA, Erle D, Hendrickson CM, Krummel MF, Matthay MA, Woodruff P, Haddad EK, Calfee CS, Langelier CR. medRxiv. 2025 May 19; 2025 May 19. PMID: 40475132.
- Temporal changes in pneumococcal carriage among childcare-attending children during the COVID-19 pandemic in the Greater New Haven Area, USA.Peno C, Thindwa D, Hislop MS, Yolda-Carr D, Egbewole D, Viswanathan G, Lin TY, Mbodj S, Rayack E, Askari HM, Kazemi Y, Lapidus S, Spatz ES, Zirinsky E, Oliveira CR, Bei AK, Weinberger DM, Wyllie AL. medRxiv. 2025 May 16; 2025 May 16. PMID: 40463565.
- Underrepresentation and exclusion of patients with cardiovascular disease in intensive care randomized controlled trials.Ali TN, Grimshaw AA, Thomas A, Solomon MA, Ross JS, Miller PE. Eur Heart J Acute Cardiovasc Care. 2025 May 16. PMID: 39950988.
- Rethinking the Diagnosis and Management of Antibody-Mediated Rejection in Multidisciplinary Transplant Meetings: A Global Survey and Banff Working Group Recommendations.Sapir-Pichhadze R, Askar M, Cooper M, Cornell LD, Cozzi E, Dadhania DM, Diekmann F, de Vries APJ, Schinstock CA, Carroll RP, Abdelrehim A, Gan G, Deng Y, Alasfar S, Bagnasco SM, Batal I, Budde K, Clahsen-van Groningen MC, Kung VL, Lower F, Seija M, Kraus E, Naesens M, Bow LM. Clin Transplant. 2025 May. PMID: 40294134.
- Assessment of health conditions from patient electronic health record portals vs self-reported questionnaires: an analysis of the INSPIRE study.Khera R, Sawano M, Warner F, Coppi A, Pedroso AF, Spatz ES, Yu H, Gottlieb M, Saydah S, Stephens KA, Rising KL, Elmore JG, Hill MJ, Idris AH, Montoy JCC, O'Laughlin KN, Weinstein RA, Venkatesh A. J Am Med Inform Assoc. 2025 May 1. PMID: 40036551.
- Proceedings of the second annual dengue endgame summit: A call to action.Hardy CSC, Bahr LE, Rothman AL, Anderson KB, Barba-Spaeth G, Weiskopf D, Ooi EE, Marques ETA, Bonsignori M, Barrett ADT, Kirkpatrick BD, Castanha PMS, Hamins-Puertolas M, Christofferson RC, Dimopoulos G, Oliveira F, Chiang LW, Ko AI, Gunale B, Kulkarni P, Perkins TA, Dorigatti I, Stewart T, Shaw J, Johansson MA, Thomas SJ, Waickman AT. PLoS Negl Trop Dis. 2025 Apr; 2025 Apr 28. PMID: 40294026.
- Epigenetic Changes in Cerebrospinal Fluid and Blood of People With Neurosyphilis.Mostaghimi D, Mehta S, Yoon J, Kosana P, Marra CM, Corley MJ, Farhadian SF. J Infect Dis. 2025 Apr 15. PMID: 39356164.
- An abundance of aliC and aliD genes were identified in saliva using a novel multiplex qPCR to characterize group II non-encapsulated pneumococci with improved specificity.Laxton CS, Toekiran FL, Lin TY, Lomeda BD, Hislop MS, Keller L, Allicock OM, Wyllie AL. Microbiology (Reading). 2025 Apr. PMID: 40279151.
- The Role of Viral Interference in Shaping RSV Epidemics Following the 2009 H1N1 Influenza Pandemic.Li K, Thindwa D, Weinberger DM, Pitzer VE. Influenza Other Respir Viruses. 2025 Apr. PMID: 40275825.
- Comparative pangenomics of Streptococcus pneumoniae from Malawi: uncovering genetic variability and pathogenicity.Iranzadeh A, Alisoltani A, Kiran AM, Breiman RF, Chaguza C, Peno C, Cornick JE, Everett DB, Mulder N. Microb Genom. 2025 Apr. PMID: 40232949.
- Environmental and Health Care Personnel Sampling and Unobserved Clostridium difficile Transmission in ICU.Keegan LT, Tanner W, Orleans B, Slayton RB, Jernigan JA, McDonald LC, Noble-Wang J, Leecaster M, Haroldsen C, Khader K, Toth DJA, O'Sullivan T, Samore MH, Brazelton W, Rubin M. JAMA Netw Open. 2025 Apr 1; 2025 Apr 1. PMID: 40184069.
- Ensemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images: PRESENT SHD.Dhingra LS, Aminorroaya A, Sangha V, Pedroso AF, Shankar SV, Coppi A, Foppa M, Brant LCC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. J Am Coll Cardiol. 2025 Apr 1. PMID: 40139886.
- Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes.Sierant MC, Jin SC, Bilguvar K, Morton SU, Dong W, Jiang W, Lu Z, Li B, López-Giráldez F, Tikhonova I, Zeng X, Lu Q, Choi J, Zhang J, Nelson-Williams C, Knight JR, Zhao H, Cao J, Mane S, Sedore SC, Gruber PJ, Lek M, Goldmuntz E, Deanfield J, Giardini A, Mital S, Russell M, Gaynor JW, King E, Wagner M, Srivastava D, Shen Y, Bernstein D, Porter GA Jr, Newburger JW, Seidman JG, Roberts AE, Yandell M, Yost HJ, Tristani-Firouzi M, Kim R, Chung WK, Gelb BD, Seidman CE, Brueckner M, Lifton RP. Proc Natl Acad Sci U S A. 2025 Apr; 2025 Mar 24. PMID: 40127276.
- Urology on a changing planet: links between climate change and urological disease.Cole AP, Qian Z, Gupta N, Leapman M, Zurl H, Trinh QD, Sherman JD, Loeb S, Iyer HS. Nat Rev Urol. 2025 Apr; 2025 Jan 28. PMID: 39875561.
- Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans.Hart TM, Cui Y, Telford SR, Marín-López A, Calloway K, Dai Y, Matias J, DePonte K, Jaycox J, DeBlasio M, Hoornstra D, Belperron AA, Cibichakravarthy B, Johnson EE, Alameh MG, Dwivedi G, Hovius JWR, Bockenstedt LK, Weissman D, Ring AM, Fikrig E. Sci Transl Med. 2025 Mar 26; 2025 Mar 26. PMID: 40138454.
- Vaccination for prevention of hearing loss: a scoping review.Johri M, Téhinian S, Pérez Osorio MC, Barış E, Wahl B. Commun Med (Lond). 2025 Mar 24; 2025 Mar 24. PMID: 40128310.
- Harnessing Artificial Intelligence for Innovation in Interventional Cardiovascular Care.Aminorroaya A, Biswas D, Pedroso AF, Khera R. J Soc Cardiovasc Angiogr Interv. 2025 Mar; 2025 Mar 18. PMID: 40230673.
- Understanding the Cardiovascular Impacts of Heatwaves: Moving Beyond Simple Definitions.Chu L, Chen K. J Am Coll Cardiol. 2025 Mar 17; 2025 Mar 17. PMID: 40131260.
- Wild Florida mottled ducks demonstrate strong heterogeneity in their humoral innate immune response.Ayala AJ, Cheng M, Hellinger TA, McBride KM, Webb J, Fanning A, Snyder P, Ferragamo M, Garcia SC, Sterner N, Bischoff KL, Almagro-Moreno S, Ogbunugafor CB. PLoS One. 2025; 2025 Mar 17. PMID: 40096078.
- Recessive genetic contribution to congenital heart disease in 5,424 probands.Dong W, Jin SC, Sierant MC, Lu Z, Li B, Lu Q, Morton SU, Zhang J, López-Giráldez F, Nelson-Williams C, Knight JR, Zhao H, Cao J, Mane S, Gruber PJ, Lek M, Goldmuntz E, Deanfield J, Giardini A, Mital S, Russell M, Gaynor JW, Cnota JF, Wagner M, Srivastava D, Bernstein D, Porter GA Jr, Newburger J, Roberts AE, Yandell M, Yost HJ, Tristani-Firouzi M, Kim R, Seidman J, Chung WK, Gelb BD, Seidman CE, Lifton RP, Brueckner M. Proc Natl Acad Sci U S A. 2025 Mar 11; 2025 Mar 3. PMID: 40030011.
- Expanding artificial intelligence to understudied populations: congenital heart disease as the next frontier.Oikonomou EK, Khera R. Eur Heart J. 2025 Mar 3. PMID: 39523016.
- Long COVID has variable incidence and clinical presentations: our 6-country collaborative study.Szabo S, Muzyka I, Muller V, Szabo AJ, Szijártó A, Gyires K, Doczi T, Janszky J, Stengel A, Göpel S, Trichopoulou A, Diaz R, Camacho N, Malatinszky G, Lambrecht N, Zayachkivska O. Inflammopharmacology. 2025 Mar; 2025 Feb 21. PMID: 39982603.
- The role of viral interference in shaping RSV epidemics following the 2009 H1N1 influenza pandemic.Li K, Thindwa D, Weinberger DM, Pitzer VE. medRxiv. 2025 Feb 19; 2025 Feb 19. PMID: 38464193.
- The Pathogenetic Link Between Ozone Pollution and Cardiovascular Disease.Schneider A, Chen K, Breitner S. J Am Coll Cardiol. 2025 Feb 18; 2025 Jan 22. PMID: 39846937.
- Examining multimorbidity contributors to dementia over time.Klee M, Markwardt S, Elman MR, Han L, Leist AK, Allore H, Quiñones A. Alzheimers Dement. 2025 Feb. PMID: 39988573.
- Detection of Pneumococcal Carriage in Asymptomatic Healthcare Workers.Waghela P, Davis R, Campbell M, Datta R, Hislop MS, Vega NJ, Wurst L, Yolda-Carr D, Couch L, Hernandez M, Grant LR, Alexander-Parrish R, Arguedas A, Gessner BD, Martinello RA, Weinberger DM, Wyllie AL. Open Forum Infect Dis. 2025 Feb; 2025 Jan 15. PMID: 39917332.
- Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes.Awuoche EO, Smallenberger G, Bruzzese DL, Orfano A, Weiss BL, Aksoy S. PLoS Pathog. 2025 Jan; 2025 Jan 31. PMID: 39888974.
- Deep mutational scanning of the Trypanosoma brucei developmental regulator RBP6 reveals an essential disordered region influenced by positive residues.Rojas-Sánchez S, Kolev NG, Tschudi C. Nat Commun. 2025 Jan 30; 2025 Jan 30. PMID: 39885181.
- A new method for detecting mixed Mycobacterium tuberculosis infection and reconstructing constituent strains provides insights into transmission.Sobkowiak B, Cudahy P, Chitwood MH, Clark TG, Colijn C, Grandjean L, Walter KS, Crudu V, Cohen T. Genome Med. 2025 Jan 27; 2025 Jan 27. PMID: 39871355.
- DMEM and EMEM are suitable surrogate media to mimic host environment and expand leptospiral pathogenesis studies using in vitro tools.Garcia LE, Lin Z, Culos S, Catherine Muenker M, Johnson EE, Wang Z, Lopez-Giraldez F, Giraud-Gatineau A, Jackson A, Picardeau M, Goodlett DR, Townsend JP, Pětrošová H, Wunder EA Jr. bioRxiv. 2025 Jan 24; 2025 Jan 24. PMID: 39896660.
- Leptospirosis, melioidosis, and rickettsioses in the vicious circle of neglect.Tshokey T, Ko AI, Currie BJ, Munoz-Zanzi C, Goarant C, Paris DH, Dance DAB, Limmathurotsakul D, Birnie E, Bertherat E, Gongal G, Benschop J, Savelkoel J, Stenos J, Saraswati K, Robinson MT, Day NPJ, Graves SR, Belmain SR, Blacksell SD, Wiersinga WJ. PLoS Negl Trop Dis. 2025 Jan; 2025 Jan 23. PMID: 39847571.
- Estimating the burden of RSV- and influenza-associated hospitalizations, ICU admissions, and deaths across age and socioeconomic groups in New York State, 2005-2019.Xu H, Pitzer VE, Warren JL, Shapiro ED, Weinberger DM. medRxiv. 2025 Jan 12; 2025 Jan 12. PMID: 39830274.
- A framework for ecologically and socially informed risk reduction before and after outbreaks of wildlife-borne zoonoses.Hassell JM, Angwenyi S, VanAcker MC, Adan A, Bargoiyet N, Bundotich G, Edebe J, Fèvre EM, Gichecha P, Kamau J, Lekenit E, Lekopien A, Leseeto JL, Lupempe KG, Mathenge J, Manini D, Muasa B, Muturi M, Ndanyi R, Ndia M, Ndung'u K, Nyaga N, Rono B, Murray S, Worsley-Tonks KEL, Gakuya F, Lekolool I, Kahariri S, Chege S. Lancet Planet Health. 2025 Jan. PMID: 39855232.
- Molecular epidemiology, evolution, and transmission dynamics of raccoon rabies virus in Connecticut.Veytsel G, Desiato J, Chung H, Tan S, Risatti GR, Helal ZH, Jang S, Lee DH, Bahl J. Virus Evol. 2025; 2024 Dec 24. PMID: 39802825.
- Artificial Intelligence-Enhanced Risk Stratification of Cancer Therapeutics-Related Cardiac Dysfunction Using Electrocardiographic Images.Oikonomou EK, Sangha V, Dhingra LS, Aminorroaya A, Coppi A, Krumholz HM, Baldassarre LA, Khera R. Circ Cardiovasc Qual Outcomes. 2025 Jan; 2024 Sep 2. PMID: 39221857.
- An Ensemble Deep Learning Algorithm for Structural Heart Disease Screening Using Electrocardiographic Images: PRESENT SHD.Dhingra LS, Aminorroaya A, Sangha V, Pedroso AF, Shankar SV, Coppi A, Foppa M, Brant LC, Barreto SM, Ribeiro ALP, Krumholz HM, Oikonomou EK, Khera R. medRxiv. 2024 Dec 27; 2024 Dec 27. PMID: 39417095.
- A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose.Rostad CA, Yildirim I, Kao C, Yi J, Kamidani S, Peters E, Stephens K, Gibson T, Hsiao HM, Singh K, Spearman P, McCracken C, Agbakoba V, Tomashek KM, Goll JB, Gelber CE, Johnson RA, Lee S, Maner-Smith K, Bosinger S, Ortlund EA, Chen X, Anderson LJ, Wrammert J, Suthar M, Rouphael N, Anderson EJ. NPJ Vaccines. 2024 Dec 23; 2024 Dec 23. PMID: 39715748.
- Tiled Amplicon Sequencing Enables Culture-free Whole-Genome Sequencing of Pathogenic Bacteria From Clinical Specimens.Kalinich CC, Gonzalez FL, Osmaston A, Breban MI, Distefano I, Leon C, Sheen P, Zimic M, Coronel J, Tan G, Crudu V, Ciobanu N, Codreanu A, Solano W, Ráez J, Allicock OM, Chaguza C, Wyllie AL, Brandt M, Weinberger DM, Sobkowiak B, Cohen T, Grandjean L, Grubaugh ND, Redmond SN. bioRxiv. 2024 Dec 20; 2024 Dec 20. PMID: 39763738.
- A meta-analysis highlights the idiosyncratic nature of tradeoffs in laboratory models of virus evolution.Kabengele K, Turner WC, Turner PE, Ogbunugafor CB. Virus Evol. 2024; 2024 Dec 6. PMID: 39717708.
- Epidemiology and pathogen characteristics of infections following solid organ transplantation.Meng F, Zhu C, Zhu C, Sun J, Chen D, Ding R, Cui L. J Appl Microbiol. 2024 Dec 2. PMID: 39567858.
- A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi-ancestry population from the Million Veteran Program.Kember RL, Rentsch CT, Lynch J, Vujkovic M, Voight B, Justice AC, Assimes TL, Kranzler HR. Alcohol Clin Exp Res (Hoboken). 2024 Dec; 2024 Nov 24. PMID: 39580711.
- Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei.Beaver AK, Keneskhanova Z, Cosentino RO, Weiss BL, Awuoche EO, Smallenberger GM, Buenconsejo GY, Crilly NP, Smith JE, Hakim JMC, Zhang B, Bobb B, Rijo-Ferreira F, Figueiredo LM, Aksoy S, Siegel TN, Mugnier MR. Nature. 2024 Dec; 2024 Oct 30. PMID: 39478231.
- Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19.Maguire C, Chen J, Rouphael N, Pickering H, Phan HV, Glascock A, Chu V, Dandekar R, Corry D, Kheradmand F, Baden LR, Selaky R, McComsey GA, Haddad EK, Cairns CB, Pulendran B, Fernandez-Sesma A, Simon V, Metcalf JP, Higuita NIA, Messer WB, David MM, Nadeau KC, Kraft M, Bime C, Schaenman J, Erle D, Calfee CS, Atkinson MA, Brackenridge SC, Ehrlich LIR, Montgomery RR, Shaw AC, Hough CL, Geng LN, Hafler DA, Augustine AD, Becker PM, Peters B, Ozonoff A, Kim-Schulze SH, Krammer F, Bosinger S, Eckalbar W, Altman MC, Wilson M, Guan L, Kleinstein SH, Smolen KK, Reed EF, Levy O, Maecker H, Hunt P, Steen H, Diray-Arce J, Langelier CR, Melamed E. bioRxiv. 2024 Nov 16; 2024 Nov 16. PMID: 39605478.
- Barriers and Facilitators to Patient Utilization of Non-Communicable Disease Services in Primary Healthcare Facilities in Nepal: A Qualitative Study.Mali S, Rhodes EC, Nakarmi CS, Shrestha S, Dhakal A, Bharati A, Bishwokarma A, Adhikari A, Poudel B, Rai BK, Manandhar S, Kc S, Timalsena D, Silwal S, Dhimal M, Baral PP, Teufel F, Bhattarai S, Spiegelman D, Shrestha A. Res Sq. 2024 Nov 15; 2024 Nov 15. PMID: 39606468.
- Relating in vivo RSV infection kinetics to host infectiousness in different age groups.Li K, Bont LJ, Weinberger DM, Pitzer VE. medRxiv. 2024 Nov 15; 2024 Nov 15. PMID: 39606407.
- Leptospira Leptolysin Contributes to Serum Resistance but Is Not Essential for Acute Infection.Dos Santos Courrol D, Santos CM, Chura-Chambi RM, Morganti L, Avelar KES, de Moraes Maia F, Rodrigues-da-Silva RN, Wunder EA Jr, Barbosa AS. Mol Microbiol. 2024 Nov; 2024 Nov 1. PMID: 39484742.
- Quantifying constraint in the human mitochondrial genome.Lake NJ, Ma K, Liu W, Battle SL, Laricchia KM, Tiao G, Puiu D, Ng KK, Cohen J, Compton AG, Cowie S, Christodoulou J, Thorburn DR, Zhao H, Arking DE, Sunyaev SR, Lek M. Nature. 2024 Nov; 2024 Oct 16. PMID: 39415008.
- Design and implementation of a Type-2 hybrid, prospective randomized trial of opioid agonist therapies integration into primary care clinics in Ukraine.Machavariani E, Dumchev K, Pykalo I, Filippovych M, Ivasiy R, Esserman D, Madden LM, Bromberg DJ, Haddad M, Morozova O, Ahmad B, Gómez DO, Farnum SO, Dvoriak S, Altice FL. Contemp Clin Trials. 2024 Nov; 2024 Sep 14. PMID: 39265780.
- Antecedent and persistent symptoms in COVID-19 and other respiratory illnesses: Insights from prospectively collected data in the BRACE trial.McDonald E, Pittet LF, Barry SE, Bonten M, Campbell J, Croda J, Croda MG, Dalcolmo MP, Davidson A, de Almeida E Val FF, Dos Santos G, Gardiner K, Gell G, Gwee A, Krastev A, Lacerda MVG, Lucas M, Lynn DJ, Manning L, McPhate N, Perrett KP, Post JJ, Prat-Aymerich C, Quinn LE, Richmond PC, Wood NJ, Messina NL, Curtis N. J Infect. 2024 Nov; 2024 Sep 6. PMID: 39245151.
- Interactions between respiratory syncytial virus and Streptococcus pneumoniae in the pathogenesis of childhood respiratory infections: a systematic review.Besteman SB, Bogaert D, Bont L, Mejias A, Ramilo O, Weinberger DM, Dagan R. Lancet Respir Med. 2024 Nov; 2024 Jul 8. PMID: 38991585.
- Single-cell transcriptomic and proteomic analysis of Parkinson's disease brains.Zhu B, Park JM, Coffey SR, Russo A, Hsu IU, Wang J, Su C, Chang R, Lam TT, Gopal PP, Ginsberg SD, Zhao H, Hafler DA, Chandra SS, Zhang L. Sci Transl Med. 2024 Oct 30; 2024 Oct 30. PMID: 39475571.
- Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes.Awuoche E, Smallenberger G, Bruzzese D, Orfano A, Weiss BL, Aksoy S. bioRxiv. 2024 Oct 24; 2024 Oct 24. PMID: 39484388.
for Faculty working in this area.
Centers and other resources
- Becoming Breastfeeding Friendly (BBF): A Guide to Global Scale UpThis evidence-informed initiative is designed to help countries identify the strength of their breastfeeding-friendly environment and to improve breastfeeding policies and programs.
- Center for Neuroepidemiology and Clinical Neurological Research (CNE2)CNE2 is comprised of researchers across Yale schools who have common and complementary research and methodological interests in clinical neurological research.
- Community Alliance for Research and Engagement (CARE)CARE promotes the prevention of chronic diseases by focusing on social, environmental, and behavioral risk factors.
- Samoan Obesity, lifestyle and Genetic Adaptations Study Group (OLAGA)OLAGA study group aims to understand the origins of obesity among Samoans and other Pacific Islanders to develop relevant interventions to reduce obesity and obesity-related conditions.
- Yale Cancer Center (YCC)The Center provides the best approaches for the prevention, detection, diagnosis, and treatment of cancer.
- Yale-Griffin Prevention Research Center (PRC)The PRC works with community partners to develop and implement community-based approaches to prevent and control chronic diseases such as heart disease, diabetes, and cancer.
- Yale Institute for Global Health (YIGH)YIGH serves as the focal point for research, education, and engagement with global partners to improve the health of individuals and populations worldwide.