Melinda Irwin, PhD, MPH
Associate Dean of Research and Susan Dwight Bliss Professor of Epidemiology (Chronic Diseases)Cards
Additional Titles
Deputy Director (Public Health), Yale Center for Clinical Investigation
Deputy Director, Yale Cancer Center
Contact Info
Chronic Disease Epidemiology
PO Box 208034, 60 College Street
New Haven, CT 06520-8034
United States
About
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Titles
Associate Dean of Research and Susan Dwight Bliss Professor of Epidemiology (Chronic Diseases)
Deputy Director (Public Health), Yale Center for Clinical Investigation; Deputy Director, Yale Cancer Center
Biography
Melinda L. Irwin, PhD, MPH is the Susan Dwight Bliss Professor of Epidemiology and Associate Dean of Research at the Yale School of Public Health, Deputy Director of the Yale Cancer Center, and Deputy Director (Public Health) in the Yale Center for Clinical Investigation. Nationally, Dr. Irwin co-leads the SWOG Cancer Research Network Cancer Survivorship Committee. In 2018, Dr. Irwin completed the yearlong Hedwig van Ameringen Executive Leadership in Academic Medicine (ELAM) Program. Dr. Irwin’s experience working across departments, schools, and with interdisciplinary groups of investigators has provided her with the skills to train and mentor effectively.
Dr. Irwin is a prominent leader in the field of cancer prevention and survivorship research. Her research over the past 20 years has focused on randomized trials of exercise and weight loss on biological markers, treatment side effects and quality of life in people with diagnosed with cancer. She has received funding from the National Institutes of Health, American Cancer Society, Breast Cancer Research Foundation, American Institute for Cancer Research, Komen for the Cure, and Livestrong Foundation. She is currently leading an NCI-funded clinical trial examining the impact of nutrition and exercise on improving chemotherapy completion rate, endocrine therapy adherence, biomarkers, body composition and quality of life in women beginning chemotherapy for breast cancer, and a also leading a newly funded NCI U01 trial of exercise and nutrition on treatment outcomes in women newly diagnosed with ovarian cancer.
Dr. Irwin is committed to training the next generation of scientists and is currently leading an NCI T32-funded Cancer Prevention and Control Training Program for pre- and post-doctoral fellows and an NCI R25-funded Transdisciplinary Research on Energetics and Cancer (TREC) Training Program for early career investigators. At Yale, Dr. Irwin has advised, mentored and trained over 100 trainees. Her commitment to training the next generation of scientists is evident in the enthusiasm she brings to mentoring. Her vision is to maximize opportunities for early career investigators so they can become leaders in their respective fields and have a maximal impact on the health and well-being of patients and the population.
Appointments
Yale School of Public Health
Associate DeanDualChronic Disease Epidemiology
ProfessorPrimary
Other Departments & Organizations
- Cancer Prevention and Control
- Chronic Disease Epidemiology
- Diabetes Research Center
- Future of Health Innovation Hub
- Irwin Lab (LEAN Study)
- Obesity Research Working Group
- Transdisciplinary Research in Energetics and Cancer Research Education Program
- Yale Cancer Center
- Yale Center for Clinical Investigation (YCCI)
- Yale School of Public Health
- Yale Ventures
Education & Training
- MPH
- University of Washington (2001)
- PhD
- University of South Carolina (1999)
- MS
- University of North Carolina at Chapel Hill (1994)
- BS
- College of William and Mary (1992)
Research
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Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0001-7571-0304
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Fangyong Li, MS, MPH
Maura Harrigan
Former YSMBrenda Cartmel, PhD
Leah Ferrucci, PhD, MPH
Tara Sanft, MD
Leah Puklin, PhD, MPH
Exercise
Breast Neoplasms
Obesity
Ovarian Neoplasms
Weight Loss
Publications
2026
Motivation to Participate in a Nutrition and Physical Activity Intervention During Chemotherapy for Breast Cancer: A Qualitative Study
Puklin L, Harrigan M, McGowan C, Ferrucci L, Cartmel B, Zupa M, Deyling M, Sanft T, Sharifi M, Irwin M. Motivation to Participate in a Nutrition and Physical Activity Intervention During Chemotherapy for Breast Cancer: A Qualitative Study. Psycho-Oncology 2026, 35: e70472. PMID: 42025931, PMCID: PMC13106104, DOI: 10.1002/pon.70472.Peer-Reviewed Original ResearchFinancial Hardship and Unhealthy Lifestyles: Perspectives and Solutions From Breast Cancer Survivors and Their Care Teams
Pichardo M, Nsubayi C, Ginader A, Peña K, Nguyen T, Irwin M, Sanft T, Molina Y, Fayanju O. Financial Hardship and Unhealthy Lifestyles: Perspectives and Solutions From Breast Cancer Survivors and Their Care Teams. Cancer Control 2026, 33: 10732748261432274. PMID: 41814123, PMCID: PMC12982845, DOI: 10.1177/10732748261432274.Peer-Reviewed Original ResearchAltmetricResearch Priorities and Future Directions in Cardio-Oncology
Mszar R, Ali A, Hull S, Ferrucci L, Baldassarre L, Khera R, Irwin M, Clasen S. Research Priorities and Future Directions in Cardio-Oncology. Current Treatment Options In Oncology 2026, 27: 4. PMID: 41484494, DOI: 10.1007/s11864-025-01366-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2025
Effect of a lifestyle intervention during chemotherapy for breast cancer on quality of life
Puklin L, Li F, Ferrucci L, Cartmel B, Harrigan M, McGowan C, Zupa M, Ligibel J, Sanft T, Irwin M. Effect of a lifestyle intervention during chemotherapy for breast cancer on quality of life. JNCI Cancer Spectrum 2025, 10: pkaf125. PMID: 41452765, PMCID: PMC12803784, DOI: 10.1093/jncics/pkaf125.Peer-Reviewed Original ResearchThis study investigates whether a yearlong nutrition and exercise program during chemotherapy improves quality of life in breast cancer patients, finding no significant benefits compared to usual care.Body mass index and chemotherapy completion among patients with newly diagnosed ovarian cancer
Cao A, Cartmel B, Ratner E, Li F, Schlumbrecht M, Kumar A, Crane T, Esserman D, Irwin M, Ferrucci L. Body mass index and chemotherapy completion among patients with newly diagnosed ovarian cancer. JNCI Cancer Spectrum 2025, 10: pkaf121. PMID: 41442446, PMCID: PMC12854082, DOI: 10.1093/jncics/pkaf121.Peer-Reviewed Original ResearchCitationsAddressing conceptual and design gaps in the oncology nutrition evidence base during chemotherapy: contributions of the Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes Consortium
Compton S, Wopat H, Lopez-Pentecost M, Agurs-Collins T, Brown J, Caan B, Demark-Wahnefried W, Elena J, Ferrucci L, McGowan C, Puklin L, Schmitz K, Thomson C, Robien K, Crane T, Caan B, Anderson S, Bahia H, Castillo A, Feliciano E, Johnson K, Ross M, Weltzein E, Brown J, Compton S, Green T, Nauta P, Yang S, Meyerhardt J, Dieli-Conwright C, Nguyen D, Pena A, Spielmann G, Kim Y, Evans W, Bea J, Blew R, Thomson C, Crane T, Camacho V, Cespedes V, Erlandsen S, Freylersythe S, Hollander K, Lopez-Pentecost M, Penedo F, Rolle L, Rossi P, Schlumbrecht M, Wheeler M, Irwin M, Cao A, Cartmel B, Ferrucci L, Gottlieb L, Harrigan M, Li F, McGowan C, Puklin L, Elena R, Sanft T, Zupa M, Berger N, Cerne S, Mills C, Conochan S, Hundal J, Owusu C, Pink J, Ligibel J, Campbell N, DiGuglielmo K, Kemp W, Maples-Campbell C, Nguyen T, Oppenheim J, Tanasijevic A, Thomson C, Yung A, Basen-Engquist K, Loomba P, Chinchilli V, Schmitz K, Binder J, Doerksen S, Foldi J, Garrett S, Scalise R, Sobolewski M, Scott J, Cercek A, Cai S, Cao S, Furberg H, Harrison J, Jones L, Lee C, Levine R, Michalski M, Moskowitz C, Meara A, Rabazzi J, Stoeckel K, Salz T, Weiser M, Yu A, Demark-Wahnefried W, Robien K, Evans S, DiPietro L, Duong B, Edelstein S, Helmchen L, Le D, McCleary C, Tjaden A, Wopat H, Rabin B, Perna F, Agurs-Collins T, Czajkowski S, Elena J, Nebeling L, Norton W. Addressing conceptual and design gaps in the oncology nutrition evidence base during chemotherapy: contributions of the Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes Consortium. Journal Of The National Cancer Institute 2025, 117: 2441-2451. PMID: 40680173, PMCID: PMC12682377, DOI: 10.1093/jnci/djaf143.Peer-Reviewed Original ResearchAltmetricExtending Cancer Survival with Exercise — Time for Oncology to Act
Irwin M. Extending Cancer Survival with Exercise — Time for Oncology to Act. The New England Journal Of Medicine 2025, 393: 82-84. PMID: 40601943, DOI: 10.1056/nejme2506363.Commentaries, Editorials and LettersCitationsAltmetricAccelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers
Abraham S, Parekh J, Lee S, Afrin H, Rozenblit M, Blenman K, Perry R, Ferrucci L, Liu J, Irwin M, Lustberg M. Accelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers. Cancer Medicine 2025, 14: e70929. PMID: 40322791, PMCID: PMC12051034, DOI: 10.1002/cam4.70929.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricExercise Interventions Conducted Among Individuals with Co-occurring HIV and Unhealthy Substance Use: A Systematic Review
Mistler C, Allen W, Grimshaw A, Idiong C, Harsono D, Irwin M, Ash G, S. Pescatello L, Meyer J, Jennifer Edelman E. Exercise Interventions Conducted Among Individuals with Co-occurring HIV and Unhealthy Substance Use: A Systematic Review. AIDS And Behavior 2025, 29: 2783-2796. PMID: 40289036, PMCID: PMC12353901, DOI: 10.1007/s10461-025-04735-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2024
Correction: Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study
Bade B, Gan G, Li F, Lu L, Tanoue L, Silvestri G, Irwin M. Correction: Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study. BMC Cancer 2024, 24: 1409. PMID: 39548453, PMCID: PMC11566398, DOI: 10.1186/s12885-024-13183-9.Commentaries, Editorials and LettersCitationsAltmetric
Clinical Trials
Current Trials
Trial of Exercise and Lifestyle (TEAL) for Women with Ovarian and Endometrial Cancer
IRB ID2000032524RolePrincipal InvestigatorPrimary Completion Date06/30/2027Recruiting Participants
News & Links
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Media
Smilow Shares: Breast Cancer Awareness Month: Screening, Genetics, and Prevention
October 2, 2025
Presentations by: Parisa Lotfi, MD, Tracy Battaglia, MD, MPH, and Melinda Irwin, PhD, MPH
News
- May 20, 2026
Celebrating the Class of 2026: ‘Go forward with hope and courage’
- May 14, 2026
To Fight Cancer, Try Adding Exercise
- January 30, 2026Source: Prevention
Scientists find taking this many steps a day lowers your cancer risk
- January 27, 2026
Epidemiologist Dr. Magdalena Cerdá joins YSPH as Chair of the Department of Chronic Disease Epidemiology
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Contacts
Chronic Disease Epidemiology
PO Box 208034, 60 College Street
New Haven, CT 06520-8034
United States
Locations
60 College Street
Academic Office
Ste 428
New Haven, CT 06510