Vaccines During Pregnancy
Vaccination during pregnancy helps protect both you and your baby when you are most vulnerable to illness.
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Vaccination during pregnancy is a critical form of lifesaving, preventive care. These vaccinations (also known as prenatal vaccines or maternal immunizations) help protect both you and your baby when you are most vulnerable to illness. Still, many people may have questions about how to keep their growing families healthy. Based on real-world conversations, we’ve answered your most pressing questions below.
Answers written by experts at the Yale School of Public Health: Sydney Perlotto, MPH ’24, Sasha Yeskel, MPH ’27, Olivia Kachingwe, PhD, MPH, and Jason L. Schwartz, PhD; and the National Foundation for Infectious Diseases: Kevin Ault, MD.
Published: May 2026
1. Why are four vaccines recommended during pregnancy?
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Pregnancy impacts the human body in visible and invisible ways, including changes to a person’s immune system, lungs, and heart. These changes can put you at a higher risk for the more severe impacts of certain infectious diseases, even if you are young and healthy. Vaccination against four respiratory diseases (flu, whooping cough, COVID-19, and RSV) is one of the best ways you can protect yourself and your baby during pregnancy, with benefits that last well into the first days and weeks of your newborn’s life.
2. Which vaccines are recommended during pregnancy?
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U.S. medical professionals recommend that you get vaccinated against four respiratory diseases during pregnancy: influenza (flu), pertussis (whooping cough), COVID-19, and RSV. These vaccines are especially important to receive from the fall to early spring, the period when respiratory infections tend to rise.
| Flu vaccine | Tdap vaccine | COVID-19 vaccine | RSV vaccine | |
| Vaccine-preventable disease | Seasonal influenza (flu) | Pertussis (whooping cough) | COVID-19 | Respiratory Syncytial Virus (RSV) |
| Recommended vaccine timing* | Any week of pregnancy | 27 – 36 weeks of pregnancy | Any week of pregnancy | 32 – 36 weeks of pregnancy |
| Vaccine primarily helps protect | You and your newborn | Your newborn | You and your newborn | Your newborn |
| Possible vaccine side effects** | Injection site redness/swelling/soreness, headache, fever, fatigue, nausea, muscle aches | Injection site redness/swelling/pain, headache, fever, fatigue, vomiting, diarrhea, stomachache | Injection site redness/ swelling/pain, headache, fever, tiredness, nausea, muscle pain, or chills | Injection site pain, headache, nausea, muscle pain |
| DISEASE COMPLICATIONS | ||||
| Disease complications for newborns | Life-threatening, risk of hospitalization | Life-threatening, risk of violent coughing fits, strain on lungs and heart, and brain damage from lack of oxygen | Life-threatening, risk of fever, vomiting, diarrhea, trouble breathing, high fevers, and difficulty feeding | Life-threatening, risk of hospitalization, bronchitis, wheezing, difficulty feeding, and trouble breathing |
| Disease complications during pregnancy | Life-threatening, risk of hospitalization and severe pneumonia, strain on heart and lungs, preterm labor, and birth defects | Risk of severe bronchitis (inflammation of airways) | Life-threatening, risk of hospitalization, preeclampsia (dangerously high blood pressure), stillbirth, preterm delivery, and developmental delays | Risk of sinus and lung infections |
*Especially from fall to early spring when respiratory infections tend to rise.
**As with any medicine, talk with your provider to understand the very rare risks for severe allergic reaction, serious injury, or death.
Every pregnancy provides a new opportunity to get vaccinated to protect your baby and boost your own immunity.
Your clinician may also recommend other vaccines before, during, or after pregnancy, depending on your individual medical history and other risk factors. Leading obstetric care professional associations continue to affirm the importance of receiving all recommended vaccines at the appropriate time during pregnancy.
3. How do we know these vaccines are safe for both me and my baby?
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Vaccines are held to extremely high scientific standards, undergoing extensive research, review, and testing before they are approved for use and recommended to the public. Vaccines are continuously monitored for safety to help identify even very rare side effects.
Pregnant people may have unique safety or side effect concerns about vaccines and other medications because they are concerned not just about themselves, but also their future child. Vaccines recommended during pregnancy must have met three required criteria:
- The infectious disease is determined to pose a significant risk to the life or health of the pregnant person, fetus, or newborn.
- The likelihood of infection, complications, and even death is high in the absence of vaccines.
- The vaccine targeting the disease is both safe and effective when delivered to pregnant people.
Mild discomfort like a sore arm or feeling tired after vaccination is a sign that your immune system is working to build protection. Severe complications from respiratory diseases far outweigh any temporary vaccine side effects.
Hundreds of millions of pregnant people around the world have received vaccines for decades, with families and experts working together to make safety the top priority.
4. Why are certain prenatal vaccines recommended during different trimesters? Does the timing and spacing of these vaccines matter?
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Vaccination schedules are made to give you and your baby the best protection possible.
Vaccination schedules are designed to give you and your baby the best protection possible. The Tdap and RSV vaccines are specifically recommended later in pregnancy to ensure that immunity passes to the baby, since whooping cough and RSV are particularly deadly to newborns. The flu and COVID-19 vaccines are recommended earlier to help prevent severe complications or death during pregnancy. The four vaccines can be administered together in one trip to the doctor’s office or pharmacy, or they can be received separately based on your preferences.
5. The last time I got vaccinated, I still got sick. Why should I get vaccinated now that I’m pregnant?
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Human bodies and infectious diseases are complex, so many vaccines cannot guarantee 100% protection. This doesn’t mean that vaccines aren’t important and lifesaving: they can make symptoms of illness milder, lower or eliminate the risk of serious harm for you and your baby, and protect other family members.
Vaccination is preventative, meaning its benefits are often invisible. It can help you avoid illness — or keep you and your baby from becoming seriously sick — without you ever realizing it.
6. My clinician recommended that family members and the other people I regularly see also get vaccinated before the baby is born. Why?
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Cocooning is a great way to take some of the pressure off your loved one who’s already physically and emotionally carrying a lot — including your new family member.
Your clinician is talking about cocooning. Think of cocooning like an invisible bubble of protection. When someone is more vulnerable to infectious diseases (like newborns and during pregnancy), everyone in close contact can get vaccinated to help strengthen this protective bubble. Having partners, grandparents, siblings, babysitters, friends, and others up to date on their immunizations makes them less likely to spread respiratory illnesses to mom and baby.
7. In addition to vaccination, what other steps can help protect me and my baby from infectious diseases?
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Layering different protective measures such as handwashing with soap, wearing quality masks, using HEPA air filters, implementing a “no kissing baby” rule, and limiting contact with ill individuals, alongside vaccination further increases protection against respiratory diseases.
8. I still need more information to feel confident about prenatal vaccines. Where can I go for more information?
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If you still have questions about getting vaccinated while pregnant, talking to a health care professional is the best way to ensure the conversation addresses your specific needs and concerns. Your obstetrician, pediatrician, primary care provider, nurse-midwife, or local pharmacist can give you evidence-based advice or direct you to additional resources.
Respected medical organizations like the American College of Obstetricians & Gynecologists (ACOG) regularly publish the latest facts about vaccines, and many health education organizations collect and amplify people’s stories. When sourced from trusted messengers, both additional evidence and personal stories can help us feel more informed and confident about vaccination during pregnancy.
Funding Acknowledgement: Perlotto’s and Yeskel’s work on this information sheet was supported by the Maurice R. Hilleman Early-Stage Career Investigator Award, sponsored by the National Foundation for Infectious Diseases (NFID). The 2025 award is funded in part by an unrestricted educational grant from Merck & Co., Inc. The authors’ work and decisions are made independent of outside influence and guided by a steadfast commitment to evidence-based, accessible information for families. None of the prenatal vaccines discussed are manufactured by Merck & Co., Inc.