Zeyan Liew, PhD, MPH
Associate Professor of Epidemiology (Environmental Health Sciences)DownloadHi-Res Photo
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Associate Professor of Epidemiology (Environmental Health Sciences)
Biography
Dr. Liew is an environmental and perinatal epidemiologist and a research methodologist. A core focus of his work is understanding how exposures that occur during critical and vulnerable periods of development may shape disease risks and influence health outcomes throughout our life span. Dr. Liew is leading numerous studies with funding from the NIH to evaluate whether fetal exposures to endocrine disrupting compounds and/or neurotoxicants could harm fetal brain development leading to neurological disorders or impaired neuropsychological function in childhood and young adulthood. He is also interested in methodological research, especially the development of novel study designs and analytical techniques that could help us better address biases in observational studies or research using “real-world” data.
Last Updated on April 08, 2025.
Appointments
Environmental Health Sciences
Associate Professor on TermPrimary
Other Departments & Organizations
Education & Training
- Visiting Postdoc
- Aarhus University (2018)
- Visiting Scientist
- Harvard T.H. Chan School of Public Health (2016)
- PhD
- University of California, Los Angeles (UCLA), Epidemiology (2014)
- MPH
- University of California, Los Angeles (UCLA), Environmental Health Sciences (2011)
Research
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Overview
Medical Research Interests
Acetaminophen; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Causality; Cerebral Palsy; Child Development; Endocrine Disruptors; Environmental Pollutants; Epilepsy; Models, Statistical; Pediatric Obesity; Pharmacoepidemiology; Pregnancy
Public Health Interests
Environmental Health; Epidemiology Methods; Global Health; Maternal & Child Health; Child/Adolescent Health; Pharmacoepidemiology; Perinatal/Prenatal Health
ORCID
0000-0002-9424-7869- View Lab Website
The Liew Lab - Environmental and Early Life Epidemiology
Research at a Glance
Yale Co-Authors
Frequent collaborators of Zeyan Liew's published research.
Publications Timeline
A big-picture view of Zeyan Liew's research output by year.
Research Interests
Research topics Zeyan Liew is interested in exploring.
Jingyuan Xiao, MPH, BS, BA
Haoran Zhuo
Joshua Warren, PhD
Nicole Deziel, PhD, MHS
Andrew DeWan, PhD, MPH
Katarzyna Chawarska, PhD
79Publications
1,849Citations
Pregnancy
Environmental Pollutants
Cerebral Palsy
Attention Deficit Disorder with Hyperactivity
Autism Spectrum Disorder
Acetaminophen
Publications
2025
Grandmother's pregnancy complications and autism spectrum disorders in grandchildren, a California multigenerational cohort study
Chow T, Meng Q, Xiao J, O’Sharkey K, Liew Z, Ritz B. Grandmother's pregnancy complications and autism spectrum disorders in grandchildren, a California multigenerational cohort study. JCPP Advances 2025 DOI: 10.1002/jcv2.70047.Peer-Reviewed Original ResearchConceptsHypertensive disordersPregnancy complicationsBirth weightPrevalence of hypertensive disordersOdds ratioPregnancy hypertensive disordersLow birth weightFollow-up timeNormal birth weightASD riskMother-child pairsCalifornia birth cohortCohort studyPregnancyComplicationsInfectionLogistic regressionBirth cohortOffspring autism spectrum disorderSpectrum disorderDisordersBiological underpinningsAutism spectrum disorderMothersOddsSex‐specific pathways from early irritability trajectories to later suicidal ideations and behaviors: Findings from the ABCD study®
Bellaert N, Simeone A, Zhang L, Zhuo H, Orri M, Liew Z, Tseng W. Sex‐specific pathways from early irritability trajectories to later suicidal ideations and behaviors: Findings from the ABCD study®. Journal Of Child Psychology And Psychiatry 2025 PMID: 40908153, DOI: 10.1111/jcpp.70044.Peer-Reviewed Original ResearchConceptsAdolescent Brain Cognitive DevelopmentIrritability trajectoriesSuicidal ideationExternalizing symptomsSex differencesSuicidal behaviorDevelopmental trajectoriesAssociated with adolescent suicidal ideationAssociated with suicidal ideationParent-reported irritabilityAdolescent suicidal ideationPathways to suicide ideationChild Behavior ChecklistGrowth mixture modelingHigh-stable trajectoryChildhood irritabilitySex-specific pathwaysInternalizing symptomsTeacher reportsChild irritabilityBehavior ChecklistIdeationCognitive developmentLow-stableDeclining trajectoryPrenatal exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) and lung function and immune-related outcomes among males in childhood and young adulthood
Hull S, Ferguson K, London S, Hougaard K, Lindh C, Petersen K, Flachs E, Wise L, Wilcox A, Liew Z, Ramlau-Hansen C, Toft G, Bonde J, Tøttenborg S. Prenatal exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) and lung function and immune-related outcomes among males in childhood and young adulthood. Environmental Research 2025, 286: 122746. PMID: 40907682, PMCID: PMC12451454, DOI: 10.1016/j.envres.2025.122746.Peer-Reviewed Original ResearchAltmetricConceptsForced Vital CapacityPhthalate metabolitesImmune-related outcomesPolyfluoroalkyl substancesPrenatal exposureSingle-pollutant analysesOdds ratioPFAS mixtureHay feverPrenatal PFAS exposureYoung adulthoodLower FEV1Associated with lower oddsYears of ageImmune system developmentCurrent hay feverAssociated with lower FEV1 anPregnancy plasmaImmune maturationCohort of malesLung developmentSex-specific effectsExposure to per-Young adult malesQuantile g-computation modelsMaternal Residential Mobility Between Births: A California Statewide Study
Bellia G, Zhuo H, Ning X, Liew Z. Maternal Residential Mobility Between Births: A California Statewide Study. Paediatric And Perinatal Epidemiology 2025 PMID: 40698650, DOI: 10.1111/ppe.70055.Peer-Reviewed Original ResearchConceptsPrenatal careMaternal mobilitySocial Vulnerability IndexPerinatal epidemiological studiesNon-Hispanic black raceRisk ratioMaternal residential addressSibling pairsSibling comparison analysisYoung maternal ageLower educational attainmentTime-varying confoundersGeneralisability of findingsMaternal sociodemographicsResidential addressesSociodemographic subgroupsResidential mobilityPaediatric healthBirth outcomesEpidemiological researchNulliparous statusZip codesSibling cohortEducation levelMaternal agePaternal and maternal exposures to per- and polyfluoroalkyl substances (PFAS) and birth outcomes: a multi-country cohort study
Guo P, Luo J, Zhang J, Bonde J, Struciński P, Ohniev V, Arah O, Deziel N, Warren J, Toft G, Liew Z. Paternal and maternal exposures to per- and polyfluoroalkyl substances (PFAS) and birth outcomes: a multi-country cohort study. Environmental Health 2025, 24: 48. PMID: 40652244, PMCID: PMC12255010, DOI: 10.1186/s12940-025-01199-y.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsShort birth lengthAdverse birth outcomesBirth outcomesBirth lengthMulti-country cohort studyAntenatal care visitsAssociated with lower offspring birth weightParent-specific effectsPFAS exposureMaternal exposureBirth weightQuantile g-computationOffspring birth weightPrenatal PFAS exposureCare visitsResultsNo associationEffects of PFAS exposureG-computationLow birth weightCohort studyINUENDO cohortEffect sizeMedical recordsMethodsThis studyPaternal exposureThe Nationwide Impact of Guidelines for Prophylactic Aspirin Treatment for Preeclampsia
Vendelbo J, Thunbo M, Henriksen T, Liew Z, Larsen A, Pedersen L. The Nationwide Impact of Guidelines for Prophylactic Aspirin Treatment for Preeclampsia. Paediatric And Perinatal Epidemiology 2025 PMID: 40620204, DOI: 10.1111/ppe.70046.Peer-Reviewed Original ResearchAltmetricConceptsHigh-risk pregnanciesPostpartum haemorrhageAspirin useNeonatal intracranial haemorrhageGuideline changesRisk of preeclampsiaPlacental abruptionAspirin treatmentIntracranial haemorrhageRisk of placental abruptionImpact of guidelinesInterrupted time series analysisPreterm deliverySevere preeclampsiaIntroduction of national guidelinesNationwide Danish registriesProportion of preeclampsiaRisk of confoundingRate of preterm deliveryHigher risk of preeclampsiaEarly aspirin treatmentProportion of outcomesPreterm delivery rateRedeemed prescriptionsTreatment of preeclampsiaAge, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study
Chow T, Meng Q, Xiao J, O'Sharkey K, Liew Z, Ritz B. Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study. Autism Research 2025, 18: 1664-1673. PMID: 40542519, PMCID: PMC12384740, DOI: 10.1002/aur.70074.Peer-Reviewed Original ResearchConceptsOdds ratioOlder grandparentsBirth cohort studyMother-child pairsHispanic grandmothersASD riskCohort studyInfluence of ageInverse associationWhite raceInvestigate associationsGrandparent ageYounger ageLogistic regressionOlder ageAutism spectrum disorderSpectrum disorderRace/ethnicityAgeOddsRiskMaternal grandparentsGrandparentsDisordersGrandmothersRevisiting representativeness
Lu H, Zivich P, Rudolph J, Liew Z, Mukherjee B, Li F. Revisiting representativeness. International Journal Of Epidemiology 2025, 54: dyaf109. PMID: 40587415, PMCID: PMC12208074, DOI: 10.1093/ije/dyaf109.Peer-Reviewed Original ResearchExploring the link between grandmaternal air pollution exposure and Grandchild’s ASD risk: A multigenerational population-based study in California
O'Sharkey K, Chow T, Mitra S, Thompson L, Su J, Cockburn M, Liew Z, Ritz B. Exploring the link between grandmaternal air pollution exposure and Grandchild’s ASD risk: A multigenerational population-based study in California. Environment International 2025, 200: 109526. PMID: 40378475, DOI: 10.1016/j.envint.2025.109526.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAir pollutionLand-use regression modelsExposure to air pollutionAP exposureAir pollution exposureMaternal pregnancy exposuresPopulation-based cohortPopulation-based studyMultigenerational exposurePollution exposureLand-useIncreased ASD riskPregnancy exposurePollutionASD riskInfluence ASD riskMaternal pregnancyExposure levelsInfant exposureLogistic regressionMaternal exposureRisk factorsRegression modelsIncreased prevalenceEnvironmental factorsA sibling study of the prenatal and perinatal risks for cerebral palsy
Zhuo H, Rogne T, Liew Z. A sibling study of the prenatal and perinatal risks for cerebral palsy. Pediatric Research 2025, 1-8. PMID: 40316681, DOI: 10.1038/s41390-025-04055-4.Peer-Reviewed Original ResearchAltmetricConceptsSibling comparison designCerebral palsyLow Apgar scoreMaternal pregnancy complicationsSibling designPerinatal factorsAssociated with CPApgar scoreComparison designPregnancy complicationsOdds ratioPreterm birthAttenuated to nullConfidence intervalsPre-pregnancy overweightLifestyle-related factorsCP riskSibling comparison studiesSibling-comparison designGestational ageMaternal cigarette smokingSingleton birthsCP etiologyInterpretation of findingsPre-pregnancy
Academic Achievements & Community Involvement
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Activities
activity Society for Epidemiologic Research (SER)
2013 - PresentProfessional OrganizationsMemberactivity International Society for Environmental Epidemiology (ISEE)
2013 - PresentProfessional OrganizationsMemberactivity Society for Pediatric and Perinatal Epidemiologic Research
2015 - PresentProfessional OrganizationsMemberactivity American Academy for Cerebral Palsy and Developmental Medicine
2020 - PresentProfessional OrganizationsMemberactivity International Society for Autism Research
2016 - 2019Professional OrganizationsMember
Honors
honor Early Career Investigator Research Award
05/22/2024Yale University AwardYale School of Public Healthhonor NIH Research Project Grant Program (R01)
05/15/2024National AwardNational Institute of Environmental Health Scienceshonor Pilot Grant in Climate Change and Health
05/01/2024Yale University AwardYale Center on Climate Change and Healthhonor NIH Research Project Grant Program (R01)
09/15/2023National AwardEunice Kennedy Shriver National Institute of Child Health and Human Developmenthonor Planetary Solutions Project seed grant
06/01/2023Yale University AwardYALE PLANETARY SOLUTIONS PROJECT
News & Links
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News
- September 23, 2025
What the research says about autism and acetaminophen use during pregnancy
- September 05, 2025Source: The Washington Post
Some suggest Tylenol is linked to autism. Here’s what to know.
- July 21, 2025
New YSPH Pilot Grants Support Innovative Interdisciplinary Research
- May 27, 2025Source: Yale News
Yale Planetary Solutions Announces a New ‘Constellation’ of Grants
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Yale Center for Perinatal, Pediatric and Environmental Epidemiology (CPPEE)
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1 Church Street
New Haven, CT 06510