Reza Aalizadeh
Associate Research Scientist in EpidemiologyCards
About
Research
Publications
2026
Exploring the chemical profile of Greek honey varieties via liquid chromatography coupled to trapped ion mobility spectrometry and high-resolution mass spectrometry: from metabolomic fingerprint to varietal discrimination
Gialouris P, Nastou E, Preza-Mayo-Kataki D, Aalizadeh R, Dasenaki M, Thomaidis N. Exploring the chemical profile of Greek honey varieties via liquid chromatography coupled to trapped ion mobility spectrometry and high-resolution mass spectrometry: from metabolomic fingerprint to varietal discrimination. Food Chemistry 2026, 147855. DOI: 10.1016/j.foodchem.2026.147855.Peer-Reviewed Original Research
2025
By integrating previously overlooked drivers AI boosts bioaccumulation assessment in fish
Köhler H, Aalizadeh R, Treu G, Gräff T, Peschke K, Prutz I, Thomaidis N, Triebskorn R, von der Ohe P. By integrating previously overlooked drivers AI boosts bioaccumulation assessment in fish. Journal Of Hazardous Materials 2025, 501: 140648. PMID: 41349307, DOI: 10.1016/j.jhazmat.2025.140648.Peer-Reviewed Original ResearchInvestigating the role of biotransformation in the toxicokinetics of ionizable organic compounds, using LC-HRMS: Zebrafish (Danio rerio) embryos exposed to ibuprofen as a case study
Panagopoulou E, Aleiferi E, Damalas D, Tzepkinli V, Kundy L, Schweizer M, Köhler H, Aalizadeh R, von der Ohe P, Triebskorn R, Thomaidis N. Investigating the role of biotransformation in the toxicokinetics of ionizable organic compounds, using LC-HRMS: Zebrafish (Danio rerio) embryos exposed to ibuprofen as a case study. Environment International 2025, 206: 109933. PMID: 41270662, DOI: 10.1016/j.envint.2025.109933.Peer-Reviewed Original ResearchInvestigating the Quantitative Structure–Ionization Efficiency Relationship of Small Molecules and Lipids in the Presence of Ammonium Fluoride in MALDI-TIMS-QTOF Mass Spectrometry Imaging
Nikolopoulou V, Stem A, Vasiliou V, Aalizadeh R. Investigating the Quantitative Structure–Ionization Efficiency Relationship of Small Molecules and Lipids in the Presence of Ammonium Fluoride in MALDI-TIMS-QTOF Mass Spectrometry Imaging. Journal Of The American Society For Mass Spectrometry 2025, 36: 2460-2469. PMID: 41147643, DOI: 10.1021/jasms.5c00211.Peer-Reviewed Original ResearchConceptsIonization efficiencyAmmonium fluoridePresence of ammonium fluorideMass spectrometry imagingSmall moleculesIsotopically labeled metabolitesNegative polarity modeAnalysis of analytesEndogenous compoundsChemical structureIntermediate productsIonizationCompoundsMoleculesRelationship modelFluorideMALDIMetabolitesAnalytesComatrixQuantitationMatrixPolarization modesStructureDihydrochlorideOlive tree at the intersection of environment, public health, and One Health: a sustainable path to global wellbeing
Katsafadou A, Prodromou S, Aalizadeh R, White J, Thomaidis N, Vizirianakis I, Anastas P, Kyriakides T, Pastides H, Piscitelli P, Colao A, Thompson D, Vasiliou V. Olive tree at the intersection of environment, public health, and One Health: a sustainable path to global wellbeing. Frontiers In Public Health 2025, 13: 1658525. PMID: 41048290, PMCID: PMC12491241, DOI: 10.3389/fpubh.2025.1658525.Peer-Reviewed Original ResearchOlive treesEnvironmental impactHuman healthOlive by-productsClimate change mitigationHealth benefitsSustainable agricultural practicesHuman health benefitsMonounsaturated fatty acidsOlive sectorGreenhouse gas emissionsBiodiversity supportEcosystem stewardshipBy-productsFeed additivesOlive oil cultivationAnimal nutritionCarbon sequestrationSoil conservationOlive oil productionSustainable agricultureFood productsLivestock healthAntioxidant propertiesEcological sustainability
2024
From Chemical Similarity to Ionization Efficiency and Beyond: Toward Semi-Quantitative Analysis of Small Molecules and Its Integration in Non-targeted Screening
Nikolopoulou V, Thomaidis N, Aalizadeh R. From Chemical Similarity to Ionization Efficiency and Beyond: Toward Semi-Quantitative Analysis of Small Molecules and Its Integration in Non-targeted Screening. The Handbook Of Environmental Chemistry 2024, 138: 195-232. DOI: 10.1007/698_2024_1188.Peer-Reviewed Original ResearchQuantification Approaches in Non-Target LC/ESI/HRMS Analysis: An Interlaboratory Comparison
Malm L, Liigand J, Aalizadeh R, Alygizakis N, Ng K, Fro̷kjær E, Nanusha M, Hansen M, Plassmann M, Bieber S, Letzel T, Balest L, Abis P, Mazzetti M, Kasprzyk-Hordern B, Ceolotto N, Kumari S, Hann S, Kochmann S, Steininger-Mairinger T, Soulier C, Mascolo G, Murgolo S, Garcia-Vara M, de Alda M, Hollender J, Arturi K, Coppola G, Peruzzo M, Joerss H, van der Neut-Marchand C, Pieke E, Gago-Ferrero P, Gil-Solsona R, Licul-Kucera V, Roscioli C, Valsecchi S, Luckute A, Christensen J, Tisler S, Vughs D, Meekel N, Andújar B, Aurich D, Schymanski E, Frigerio G, Macherius A, Kunkel U, Bader T, Rostkowski P, Gundersen H, Valdecanas B, Davis W, Schulze B, Kaserzon S, Pijnappels M, Esperanza M, Fildier A, Vulliet E, Wiest L, Covaci A, Schönleben A, Belova L, Celma A, Bijlsma L, Caupos E, Mebold E, Le Roux J, Troia E, de Rijke E, Helmus R, Leroy G, Haelewyck N, Chrastina D, Verwoert M, Thomaidis N, Kruve A. Quantification Approaches in Non-Target LC/ESI/HRMS Analysis: An Interlaboratory Comparison. Analytical Chemistry 2024, 96: 16215-16226. PMID: 39353203, PMCID: PMC11483430, DOI: 10.1021/acs.analchem.4c02902.Peer-Reviewed Original ResearchNontarget screeningIonization efficiencyIonization efficiencies of compoundsElectrospray ionization high-resolution mass spectrometryHigh-resolution mass spectrometryNontargeted screening methodEfficiency of compoundsChemical coverageHPLC-grade waterAuthentic standardsMass spectrometryWater matricesSpiked concentrationsNORMAN networkQuantification approachCompoundsDiverse data setsIonizationStandard quantificationConcentration levelsLC/ESI/HRMSESI/HRMSGrade waterQuantificationEnvironmental contaminationCYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study
Wang Y, Charkoftaki G, Orlicky D, Davidson E, Aalizadeh R, Sun N, Ginsberg G, Thompson D, Vasiliou V, Chen Y. CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study. Archives Of Toxicology 2024, 98: 3241-3257. PMID: 39192018, PMCID: PMC11500436, DOI: 10.1007/s00204-024-03811-5.Peer-Reviewed Original ResearchCYP2E1-null miceLiver toxicityDrinking waterOxidative DNA damageLiver carcinogenAbstract1,4-DioxaneDNA damage repair responseImpaired DNA damage repairWater contaminationOxidative stressElevated oxidative stressEnvironmental pollutionKnockout mouse studiesDamage repair responseCYP2E1-nullMale wildtypeWT miceDNA damageDX exposureRisk assessmentRedox dysregulationCYP2E1 inductionLiver oxidative stressHigh dosesMouse studiesBeyond target chemicals: updating the NORMAN prioritisation scheme to support the EU chemicals strategy with semi-quantitative suspect/non-target screening data
Dulio V, Alygizakis N, Ng K, Schymanski E, Andres S, Vorkamp K, Hollender J, Finckh S, Aalizadeh R, Ahrens L, Bouhoulle E, Čirka Ľ, Derksen A, Deviller G, Duffek A, Esperanza M, Fischer S, Fu Q, Gago-Ferrero P, Haglund P, Junghans M, Kools S, Koschorreck J, Lopez B, Lopez de Alda M, Mascolo G, Miège C, Osté L, O’Toole S, Rostkowski P, Schulze T, Sims K, Six L, Slobodnik J, Staub P, Stroomberg G, Thomaidis N, Togola A, Tomasi G, von der Ohe P. Beyond target chemicals: updating the NORMAN prioritisation scheme to support the EU chemicals strategy with semi-quantitative suspect/non-target screening data. Environmental Sciences Europe 2024, 36: 113. DOI: 10.1186/s12302-024-00936-3.Peer-Reviewed Original ResearchSuspect screeningTarget chemicalsEcotoxicological effects dataMonitoring dataPrioritisation schemeMedium priorityRetrospective suspect screeningEffluent wastewater samplesScreening workflowEnvironmental compartmentsChemical pollutantsMonitoring programmesMarine environmentEnvironmental managementWastewater samplesOccurrence levelsPhysico-chemical dataMitigation actionsTargeted monitoringTargeted analysisRiver BasinWastewater monitoring dataPollutionRelevant chemicalsSemi-quantitative data
2023
Comprehensive profiling and semi-quantification of exogenous chemicals in human urine using HRMS-based strategies
Gutiérrez-Martín D, Restrepo-Montes E, Golovko O, López-Serna R, Aalizadeh R, Thomaidis N, Marquès M, Gago-Ferrero P, Gil-Solsona R. Comprehensive profiling and semi-quantification of exogenous chemicals in human urine using HRMS-based strategies. Analytical And Bioanalytical Chemistry 2023, 415: 7297-7313. PMID: 37946034, PMCID: PMC10684428, DOI: 10.1007/s00216-023-04998-9.Peer-Reviewed Original ResearchConceptsHigh-resolution mass spectrometryTriple quadrupole instrumentNon-target strategiesHuman urine samplesQuadrupole instrumentExtraction recoveryUrine samplesMatrix effectsHuman urineDeconjugation stepDetection limitMass spectrometryChemical interactionTargeted analysisHuman biomonitoringSample treatment protocolsChemical classesPlastic additivesChemicalPersonal care productsMultiple exposure pathwaysSemi-quantificationChemical analysisComprehensive profileExogenous chemicals
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Locations
Yale School of Public Health (LEPH)
Lab
60 College Street, Fl 5
New Haven, CT 06510