David Thompson
Associate Professor Adjunct of Epidemiology (Environmental Health)Cards
Contact Info
About
Titles
Associate Professor Adjunct of Epidemiology (Environmental Health)
Appointments
Environmental Health Sciences
Associate Professor AdjunctPrimary
Other Departments & Organizations
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of David Thompson's published research.
Publications Timeline
A big-picture view of David Thompson's research output by year.
Ying Chen, MD, PhD
Georgia Charkoftaki, PharmD, PhD
Rolando Garcia Milian, MLS, AHIP
Emily Davidson
Jaya Prakash Golla, PhD
TuKiet Lam, PhD, BS
94Publications
5,170Citations
Publications
2024
CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study
Wang Y, Charkoftaki G, Orlicky D, Davidson E, Aalizadeh R, Sun N, Ginsberg G, Thompson D, Vasiliou V, Chen Y. CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study. Archives Of Toxicology 2024, 98: 3241-3257. PMID: 39192018, PMCID: PMC11500436, DOI: 10.1007/s00204-024-03811-5.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCYP2E1-null miceLiver toxicityDrinking waterOxidative DNA damageLiver carcinogenAbstract1,4-DioxaneDNA damage repair responseImpaired DNA damage repairWater contaminationOxidative stressElevated oxidative stressEnvironmental pollutionKnockout mouse studiesDamage repair responseCYP2E1-nullMale wildtypeWT miceDNA damageDX exposureRisk assessmentRedox dysregulationCYP2E1 inductionLiver oxidative stressHigh dosesMouse studiesThe European Union Ban on Microplastics Includes Artificial Turf Crumb Rubber Infill: Other Nations Should Follow Suit
Zuccaro P, Thompson D, de Boer J, Llompart M, Watterson A, Bilott R, Birnbaum L, Vasiliou V. The European Union Ban on Microplastics Includes Artificial Turf Crumb Rubber Infill: Other Nations Should Follow Suit. Environmental Science And Technology 2024, 58: 2591-2594. PMID: 38301275, DOI: 10.1021/acs.est.4c00047.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts1,4-Dioxane
Stouffer A, Erickson C, Krick M, Chen Y, Ginsberg G, Loch-Caruso R, Jones R, Madrigal J, Thompson D, Vasliou V. 1,4-Dioxane. 2024, 843-849. DOI: 10.1016/b978-0-12-824315-2.00831-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPersistent environmental contaminationEnvironmental contaminationEnvironmental behaviorEnvironmental releaseChemical intermediatesWater solubilityPotential negative health effectsDioxaneRecent decadesSoilConsumer productsGroundwaterContaminationHealth effectsSolventSolubilityIntermediatesNegative health effectsStabilizerManagementUsesProductsUseToxicityExposure
2023
Multi-omics profiling reveals cellular pathways and functions regulated by ALDH1B1 in colon cancer cells
Wang Y, Popovic Z, Charkoftaki G, Garcia-Milian R, Lam T, Thompson D, Chen Y, Vasiliou V. Multi-omics profiling reveals cellular pathways and functions regulated by ALDH1B1 in colon cancer cells. Chemico-Biological Interactions 2023, 384: 110714. PMID: 37716420, PMCID: PMC10807983, DOI: 10.1016/j.cbi.2023.110714.Peer-Reviewed Original ResearchConceptsColon cancer cellsCellular stress response pathwaysStress response pathwaysMulti-omics analysisCancer cellsSecond messenger signalingMulti-omics profilingNew molecular informationFunctional annotationCellular functionsResponse pathwaysKinase signalingCellular pathwaysColon adenocarcinoma cell lineHuman colon adenocarcinoma cell lineApoptosis signalingEnrichment analysisAldehyde dehydrogenase 1B1Molecular signaturesAdenocarcinoma cell lineMolecular informationSignalingNovel targetProtein expressionCell linesAn AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model
Charkoftaki G, Aalizadeh R, Santos-Neto A, Tan W, Davidson E, Nikolopoulou V, Wang Y, Thompson B, Furnary T, Chen Y, Wunder E, Coppi A, Schulz W, Iwasaki A, Pierce R, Cruz C, Desir G, Kaminski N, Farhadian S, Veselkov K, Datta R, Campbell M, Thomaidis N, Ko A, Thompson D, Vasiliou V. An AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model. Human Genomics 2023, 17: 80. PMID: 37641126, PMCID: PMC10463861, DOI: 10.1186/s40246-023-00521-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCOVID-19 patientsDisease severityViral outbreaksFuture viral outbreaksLength of hospitalizationIntensive care unitWorse disease prognosisLife-threatening illnessEffective medical interventionsCOVID-19Clinical decision treeGlucuronic acid metabolitesNew potential biomarkersHospitalization lengthCare unitComorbidity dataSerotonin levelsDisease progressionHealthy controlsPatient outcomesDisease prognosisPatient transferPatientsHealthcare resourcesPotential biomarkersAlzheimer’s disease: using gene/protein network machine learning for molecule discovery in olive oil
Rita L, Neumann N, Laponogov I, Gonzalez G, Veselkov D, Pratico D, Aalizadeh R, Thomaidis N, Thompson D, Vasiliou V, Veselkov K. Alzheimer’s disease: using gene/protein network machine learning for molecule discovery in olive oil. Human Genomics 2023, 17: 57. PMID: 37420280, PMCID: PMC10327379, DOI: 10.1186/s40246-023-00503-6.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Assessing extraction-analysis methodology to detect fluorotelomer alcohols (FTOH), a class of perfluoroalkyl and polyfluoroalkyl substances (PFAS), in artificial turf fibers and crumb rubber infill
Zuccaro P, Licato J, Davidson E, Thompson D, Vasiliou V. Assessing extraction-analysis methodology to detect fluorotelomer alcohols (FTOH), a class of perfluoroalkyl and polyfluoroalkyl substances (PFAS), in artificial turf fibers and crumb rubber infill. Case Studies In Chemical And Environmental Engineering 2022, 7: 100280. PMID: 37575658, PMCID: PMC10423336, DOI: 10.1016/j.cscee.2022.100280.Peer-Reviewed Original ResearchCitationsAltmetricUse of clinical chemistry health outcomes and PFAS chain length to predict 28-day rodent oral toxicity
Bellia G, Bilott R, Sun N, Thompson D, Vasiliou V. Use of clinical chemistry health outcomes and PFAS chain length to predict 28-day rodent oral toxicity. Toxicology Mechanisms And Methods 2022, 33: 378-387. PMID: 36446747, PMCID: PMC10625160, DOI: 10.1080/15376516.2022.2150591.Peer-Reviewed Original ResearchCitationsAltmetricProteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cells
Wang Y, Chen Y, Garcia-Milian R, Golla JP, Charkoftaki G, Lam TT, Thompson DC, Vasiliou V. Proteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cells. Chemico-Biological Interactions 2022, 368: 110175. PMID: 36162455, PMCID: PMC9891852, DOI: 10.1016/j.cbi.2022.110175.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCancer stem cellsProteomic profilingOxidative phosphorylationLabel-free quantitative proteomic analysisDNA damage repair pathwaysQuantitative proteomic analysisAldehyde dehydrogenase familyColon cancer stem cellsCOLO320DM cellsStem cellsNucleotide excision repairDamage repair pathwaysIngenuity Pathway AnalysisCell populationsProteomic analysisProteomic datasetsDehydrogenase familyMetabolic switchProteomic studiesRepair pathwaysCellular pathwaysALDH enzymatic activityCellular survivalExcision repairALDH activityArtificial turf and crumb rubber infill: An international policy review concerning the current state of regulations
Zuccaro P, Thompson D, de Boer J, Watterson A, Wang Q, Tang S, Shi X, Llompart M, Ratola N, Vasiliou V. Artificial turf and crumb rubber infill: An international policy review concerning the current state of regulations. Environmental Challenges 2022, 9: 100620. PMID: 36644410, PMCID: PMC9838222, DOI: 10.1016/j.envc.2022.100620.Peer-Reviewed Original ResearchCitationsAltmetricConceptsEuropean UnionOnline archivesPolicy reviewNotable policiesPolicy reportsAgency officialsDirect policyGovernmental policiesMost policiesUnited NationsEnvironmental policyRespective countriesPolicyGovernmental agenciesRegulatory approachesUnited KingdomCountriesUnited StatesUnionHealth researchPublicGrey literatureEnvironmental health risksCountry regulationsSurveillance measures