Zhangsheng Yu
Professor Adjunct of BiostatisticsCards
About
Research
Publications
2026
Evaluating the Effectiveness of an Enhanced Early Childhood Development Program Integrated Into Primary Health Care in China: Protocol for a Cluster Randomized Controlled Trial
Zhang Y, Dong Y, Wang H, Zhou H, Li G, Dong Z, Jiao J, Wu Y, Qi S, Yu Z, Wei X, Jiang F. Evaluating the Effectiveness of an Enhanced Early Childhood Development Program Integrated Into Primary Health Care in China: Protocol for a Cluster Randomized Controlled Trial. JMIR Research Protocols 2026, 15: e89106. PMID: 42202312, PMCID: PMC13215665, DOI: 10.2196/89106.Peer-Reviewed Original ResearchConceptsPrimary health care systemEarly childhood development servicesHealth care systemEarly childhood developmentEarly childhood development programsUsual careCare systemGroup participantsCluster Randomized Controlled TrialIntervention group participantsPrimary care facilitiesPrimary health careImplementation-related factorsRoutine service deliveryNational scale-upAverage intervention effectControl group participantsInstitutional review boardRandomized controlled superiority trialIntention-to-treat principleService delivery modelsScale-up programsControlled superiority trialChildren Aged 6Incremental cost-effectiveness analysisEmpowering multifaceted analysis of spatial transcriptomics data with RGAST
Gong Y, Yuan X, Yu Z. Empowering multifaceted analysis of spatial transcriptomics data with RGAST. Briefings In Bioinformatics 2026, 27: bbag298. PMID: 42302280, PMCID: PMC13271401, DOI: 10.1093/bib/bbag298.Peer-Reviewed Original ResearchConceptsGraph attention auto-encoderRobust reconstructionAttention auto-encoderAdjusted Rand IndexDownstream tasksAuto-encoderSpatial domain identificationRand indexSecond-best modelComprehensive benchmarkIdentification accuracySuperior performanceLong-range signaling pathwaysDiverse downstream analysesGlobal structureArchitectureMeta-encoder: a unified integration framework for multiple pathological foundation models in cancer detection
Gao R, Yang Z, Yuan X, Wang Y, Xia Y, Zhang Y, Zheng B, Gong Y, Yue Y, Tu Y, Yu Z. Meta-encoder: a unified integration framework for multiple pathological foundation models in cancer detection. Nature Communications 2026 PMID: 41986341, DOI: 10.1038/s41467-026-71558-x.Peer-Reviewed Original ResearchHigh-dimensional tasksComputational pathology tasksCancer detection tasksSingle modelsLack of data sharingCentralized trainingModel architecturePathology tasksBalance of performanceDetection taskData sharingPathological imagesDownstream performanceOptimal balance of performanceSuperior performanceComprehensive representationTaskModel selectionData sourcesExpression predictionFoundation modelIntegrated frameworkOptimal balanceEarly lumbar drainage plus intrathecal urokinase in severe aneurysmal subarachnoid hemorrhage: the LD-ITUK randomized controlled trial protocol
Wu M, Yan T, Hu P, Wang C, Ye M, Yu Z, Wang Y, Mao G, Xiao B, Gong Y, Li J, Zhao R, Yang P, Liu J, Zhu X. Early lumbar drainage plus intrathecal urokinase in severe aneurysmal subarachnoid hemorrhage: the LD-ITUK randomized controlled trial protocol. Trials 2026, 27: 379. PMID: 41968344, PMCID: PMC13182107, DOI: 10.1186/s13063-026-09716-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultCombined Modality TherapyDouble-Blind MethodDrainageEquivalence Trials as TopicFibrinolytic AgentsHumansInjections, SpinalMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicSeverity of Illness IndexSubarachnoid HemorrhageTime FactorsTreatment OutcomeUrokinase-Type Plasminogen ActivatorConceptsSevere aneurysmal subarachnoid hemorrhageAneurysmal subarachnoid hemorrhageLumbar drainageOutcome adjudication committeeSubarachnoid hemorrhageFunctional outcomesSubstantial risk of morbidityPlacebo-controlled superiority trialSubstantial riskLong-term functional outcomeProportion of patientsPresence of subarachnoid bloodRisk of morbidityIntrathecal urokinaseDouble-blindSubarachnoid bloodClot clearanceEmbolization techniquesInvestigator-initiatedSurgical clippingHunt-HessLong-term disabilityRuptured aneurysmsStandard treatmentEligible patientsSurvSTAAR: A Powerful Statistical Framework for Rare Variant Analysis of Time-to-Event Traits in Large-Scale Whole-Genome Sequencing Studies
Cui Y, Ma S, Yuan Y, Zhu N, Chen H, Wei T, Li Z, Li X, Yu Z. SurvSTAAR: A Powerful Statistical Framework for Rare Variant Analysis of Time-to-Event Traits in Large-Scale Whole-Genome Sequencing Studies. Journal Of The American Statistical Association 2026, ahead-of-print: 1-12. DOI: 10.1080/01621459.2025.2606388.Peer-Reviewed Original ResearchTime-to-event traitsRare variant analysisWhole-genome sequencingLarge-scale whole-genome sequencing studiesAnalysis of rare genetic variantsWhole-genome sequencing studiesTrait of Alzheimer's diseaseAlzheimer's diseaseVariant association analysisRare genetic variantsAmino acid changesSample relatednessNoncoding variantsWGS dataWGS studiesFunctional annotationNoncoding regionsComplex traitsPopulation structureProtein functionSequencing studiesBinary traitsAssociation analysisAcid changesGenetic mechanismsRetinal structure and microcirculation alterations in dysthyroid optic neuropathy: A comprehensive OCTA study
Tan K, Liu Y, Zhang Y, Chen X, Li J, Wang H, Wu S, Feng M, Xi C, Sun Q, Sun J, Li Y, Yu Z, Zhou H, Fan X. Retinal structure and microcirculation alterations in dysthyroid optic neuropathy: A comprehensive OCTA study. Asia-Pacific Journal Of Ophthalmology 2026, 15: 100303. PMID: 41833634, DOI: 10.1016/j.apjo.2026.100303.Peer-Reviewed Original ResearchDysthyroid optic neuropathyOptical coherence tomography angiographyThyroid eye diseaseArea under the receiver operating characteristic curveWhole retinal layerDiagnostic performanceRetinal VDOptic neuropathyRetinal structureVisual functionVessel densityThyroid eye disease patientsNon-DON patientsVF mean deviationIrreversible visual lossCoherence tomography angiographyReceiver operating characteristic curveVisual evoked potentialsRegions of patientsVisual fieldOperating characteristics curveMacular retinaOCTA parametersVisual acuityVisual lossLeveraging co-attention-based interactions between pathology and radiology for pan-cancer survival prediction
Xia Y, Zhou J, Wang M, Hu T, Zhai W, Zhang Y, Yu Z. Leveraging co-attention-based interactions between pathology and radiology for pan-cancer survival prediction. Computerized Medical Imaging And Graphics 2026, 130: 102744. PMID: 41806501, DOI: 10.1016/j.compmedimag.2026.102744.Peer-Reviewed Original ResearchAssociation Between Renal Dysfunction and Cerebral Small Vessel Disease: A Prospective Cohort Study From the UK Biobank
Sun X, Chen J, Gao Y, Chen Y, Li Y, Pang R, Cai L, Yu Z, Huang D, Li P. Association Between Renal Dysfunction and Cerebral Small Vessel Disease: A Prospective Cohort Study From the UK Biobank. CNS Neuroscience & Therapeutics 2026, 32: e70802. PMID: 41732912, PMCID: PMC12930275, DOI: 10.1002/cns.70802.Peer-Reviewed Original ResearchConceptsRenal dysfunction biomarkersRenal dysfunctionWhite matter hyperintensitiesMagnetic resonance imagingCerebral small vessel diseaseEnlarged Perivascular SpacesCerebral microbleedsEstimated glomerular filtration rateSub-cohortMean diffusivityBrain magnetic resonance imagingFractional anisotropySmall vessel diseaseGlomerular filtration rateFollow-up periodProspective cohort studyBlood urea nitrogenVessel diseaseCerebral small vessel disease burden scoreUK BiobankWhite matter hyperintensityMRI featuresFiltration rateCohort studyFA valuesSafety and feasibility of dual external ventricular and lumbar drainage with rt-PA in intraventricular hemorrhage: A pilot study
Hu P, Wang Y, Du S, Liu L, Yang J, Wu Y, Yan T, Yang X, Xiao B, Ye M, Zhu X, Yu Z, Gong Y, Wu M. Safety and feasibility of dual external ventricular and lumbar drainage with rt-PA in intraventricular hemorrhage: A pilot study. Neurosurgical Review 2026, 49: 217. PMID: 41667715, DOI: 10.1007/s10143-025-04130-8.Peer-Reviewed Original ResearchExternal ventricular drainageIntraventricular hemorrhageLumbar drainageModified Rankin ScaleRt-PAFunctional outcomesIntraventricular hemorrhage clearanceRecombinant tissue plasminogen activatorHistorical matched controlsThree-year mortalityTissue plasminogen activatorPer treatment cyclePilot studyRandomized Controlled TrialsShunt dependencyVentricular drainageCranial CTClot clearanceTreatment detailsHematoma clearanceZero patientsFibrinolytic therapyFollow-upFunctional independenceRankin ScaleSystemic inflammation mediates the link between metabolic syndrome and colorectal cancer risk: insights from a large prospective cohort
Lv W, Wang S, Duan L, Dong Z, Zhu H, Wang G, Yu Z, Xu S. Systemic inflammation mediates the link between metabolic syndrome and colorectal cancer risk: insights from a large prospective cohort. Postgraduate Medical Journal 2026, qgag007. PMID: 41609217, DOI: 10.1093/postmj/qgag007.Peer-Reviewed Original ResearchColorectal cancer riskColorectal cancerHigh risk of colorectal cancerRisk of colorectal cancerColorectal cancer risk predictionMetabolic syndromeMediation analysisSystemic inflammation biomarkersUK Biobank participantsLow-grade inflammationCausal mediation analysisDevelopment of preventive strategiesHigh riskCox proportional hazards modelsInflammation biomarkersMultivariate linear regressionBiobank participantsProportional hazards modelUK BiobankCancer riskCentral obesityInflammation indexSystemic inflammationPrevention strategiesProspective cohort