- June 13, 2024Source: The Guardian
Rare cancers, full-body rashes, death: did fracking make their kids sick?
- May 28, 2024
Dr. Vasilis Vasiliou on Yale Cancer Answers
- May 02, 2024Source: Salud America!
7 Things You Should Know About Brain Tumors
- April 21, 2024Source: The New York Times
We Regulate a Tiny Fraction of the 12,000 ‘Forever Chemicals.’ There’s a Better Way.
Cancer
More people today die from cancer than from almost any other cause in the world. The challenges posed by cancer are immense and top scientists at the Yale School of Public Health are committed to reducing its toll.
The departments of Chronic Disease Epidemiology, Biostatistics and Health Policy and Management are heavily focused on a wide variety of cancer-related research, and the Department of Environmental Health Sciences is renowned for novel approaches to the study of how environmental exposures affect health outcomes. From key partnerships with the Yale Cancer Center to collaborative efforts locally and globally, YSPH scientists are taking significant steps toward preventing and treating a wide range of cancers. Today, research in cancer and other chronic diseases encompasses interdisciplinary teams committed to understanding cancer causation and etiology, prevention, screening and early detection, risk factors, environmental exposures, social determinants of health and survival.
A variety of technologies and approaches are used to detect mechanisms and characteristics of the many different types of cancer, including genomics, metabolomics, social and behavioral effects, evolutionary biology, biostatistical methodology and study design, and outcomes research.
The Yale School of Public Health maintains biospecimens and data from thousands of individuals in more than a dozen studies that can be made applied to future research. It also has partnerships with numerous international cancer researchers, and is the home of leading experts in clinical trial design and data management, and genomic and metabolic centers.
Recent Publications
2024
- A gap analysis of UK biobank publications reveals SNPs associated with intrinsic subtypes of breast cancer.van den Driest L, Kelly P, Marshall A, Johnson CH, Lasky-Su J, Lannigan A, Rattray Z, Rattray NJW. Comput Struct Biotechnol J. 2024 Dec; 2024 May 10. PMID: 38817965.
- Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial.Puklin LS, Ferrucci LM, Harrigan M, McGowan C, Zupa M, Cartmel B, Li FY, Ligibel JA, Spiegelman D, Sharifi M, Sanft T, Irwin ML. Cancer. 2024 Jul 15; 2024 Mar 12. PMID: 38470431.
- Machine learning identifies prognostic subtypes of the tumor microenvironment of NSCLC.Yu D, Kane MJ, Koay EJ, Wistuba II, Hobbs BP. Sci Rep. 2024 Jul 1; 2024 Jul 1. PMID: 38951567.
- Threats to social safety and neuro-inflammatory mechanisms underlying sexual orientation disparities in depression symptom severity: A prospective cohort study of young adults.Bränström R, Hatzenbuehler ML, Lattanner MR, Hollinsaid NL, McDade TW, Pachankis JE. Brain Behav Immun. 2024 Jul; 2024 Mar 27. PMID: 38548185.
- Estimation of multiple networks with common structures in heterogeneous subgroups.Qin X, Hu J, Ma S, Wu M. J Multivar Anal. 2024 Jul; 2024 Feb 13. PMID: 38433779.
- Multiple myeloma incidence and mortality trends in the United States, 1999-2020.Zhu DT, Park A, Lai A, Zhang L, Attar H, Rebbeck TR. Sci Rep. 2024 Jun 24; 2024 Jun 24. PMID: 38914692.
- Folate metabolism and risk of childhood acute lymphoblastic leukemia: a genetic pathway analysis from the Childhood Cancer and Leukemia International Consortium.Metayer C, Spector LG, Scheurer ME, Jeon S, Scott RJ, Takagi M, Clavel J, Manabe A, Ma X, Hailu EM, Lupo PJ, Urayama KY, Bonaventure A, Kato M, Meirhaeghe A, Chiang CWK, Morimoto LM, Wiemels JL. Cancer Epidemiol Biomarkers Prev. 2024 Jun 21; 2024 Jun 21. PMID: 38904462.
- Perioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer: A Nonrandomized Controlled Trial.Cecchini M, Salem RR, Robert M, Czerniak S, Blaha O, Zelterman D, Rajaei M, Townsend JP, Cai G, Chowdhury S, Yugawa D, Tseng R, Mejia Arbelaez C, Jiao J, Shroyer K, Thumar J, Kortmansky J, Zaheer W, Fischbach N, Persico J, Stein S, Khan SA, Cha C, Billingsley KG, Kunstman JW, Johung KL, Wiess C, Muzumdar MD, Spickard E, Aushev VN, Laliotis G, Jurdi A, Liu MC, Escobar-Hoyos L, Lacy J. JAMA Oncol. 2024 Jun 20; 2024 Jun 20. PMID: 38900452.
- Growth characteristics of HCT116 xenografts lacking asparagine synthetase vary according to sex.Aladelokun O, Lu L, Zheng J, Yan H, Jain A, Gibson J, Khan SA, Johnson CH. Hum Genomics. 2024 Jun 17; 2024 Jun 17. PMID: 38886847.
- Rare Drivers at Low Prevalence with High Cancer Effects in T-Cell and B-Cell Pediatric Acute Lymphoblastic Leukemia.Mandell JD, Diviti S, Xu M, Townsend JP. Int J Mol Sci. 2024 Jun 15; 2024 Jun 15. PMID: 38928295.
- Genome-wide analysis to assess if heavy alcohol consumption modifies the association between SNPs and pancreatic cancer risk.Ni Z, Kundu P, McKean DF, Wheeler W, Albanes D, Andreotti G, Antwi SO, Arslan AA, Bamlet WR, Beane Freeman LE, Berndt SI, Bracci PM, Brennan P, Buring JE, Chanock SJ, Gallinger S, Gaziano JM, Giles GG, Giovannucci EL, Goggins MG, Goodman PJ, Haiman CA, Hassan MM, Holly EA, Hung RJ, Katzke V, Kooperberg C, Kraft P, Le Marchand L, Li D, McCullough ML, Milne RL, Moore SC, Neale RE, Oberg AL, Patel AV, Peters U, Rabe KG, Risch HA, Shu XO, Smith Byrne K, Visvanathan K, Wactawski-Wende J, White E, Wolpin BM, Yu H, Zeleniuch-Jacquotte A, Zheng W, Zhong J, Amundadottir LT, Stolzenberg-Solomon RZ, Klein AP. Cancer Epidemiol Biomarkers Prev. 2024 Jun 13; 2024 Jun 13. PMID: 38869494.
- Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions.Dareng EO, Coetzee SG, Tyrer JP, Peng PC, Rosenow W, Chen S, Davis BD, Dezem FS, Seo JH, Nameki R, Reyes AL, Aben KKH, Anton-Culver H, Antonenkova NN, Aravantinos G, Bandera EV, Beane Freeman LE, Beckmann MW, Beeghly-Fadiel A, Benitez J, Bernardini MQ, Bjorge L, Black A, Bogdanova NV, Bolton KL, Brenton JD, Budzilowska A, Butzow R, Cai H, Campbell I, Cannioto R, Chang-Claude J, Chanock SJ, Chen K, Chenevix-Trench G, Chiew YE, Cook LS, DeFazio A, Dennis J, Doherty JA, Dörk T, du Bois A, Dürst M, Eccles DM, Ene G, Fasching PA, Flanagan JM, Fortner RT, Fostira F, Gentry-Maharaj A, Giles GG, Goodman MT, Gronwald J, Haiman CA, Håkansson N, Heitz F, Hildebrandt MAT, Høgdall E, Høgdall CK, Huang RY, Jensen A, Jones ME, Kang D, Karlan BY, Karnezis AN, Kelemen LE, Kennedy CJ, Khusnutdinova EK, Kiemeney LA, Kjaer SK, Kupryjanczyk J, Labrie M, Lambrechts D, Larson MC, Le ND, Lester J, Li L, Lubiński J, Lush M, Marks JR, Matsuo K, May T, McLaughlin JR, McNeish IA, Menon U, Missmer S, Modugno F, Moffitt M, Monteiro AN, Moysich KB, Narod SA, Nguyen-Dumont T, Odunsi K, Olsson H, Onland-Moret NC, Park SK, Pejovic T, Permuth JB, Piskorz A, Prokofyeva D, Riggan MJ, Risch HA, Rodríguez-Antona C, Rossing MA, Sandler DP, Setiawan VW, Shan K, Song H, Southey MC, Steed H, Sutphen R, Swerdlow AJ, Teo SH, Terry KL, Thompson PJ, Vestrheim Thomsen LC, Titus L, Trabert B, Travis R, Tworoger SS, Valen E, Van Nieuwenhuysen E, Edwards DV, Vierkant RA, Webb PM, Weinberg CR, Weise RM, Wentzensen N, White E, Winham SJ, Wolk A, Woo YL, Wu AH, Yan L, Yannoukakos D, Zeinomar N, Zheng W, Ziogas A, Berchuck A, Goode EL, Huntsman DG, Pearce CL, Ramus SJ, Sellers TA, Freedman ML, Lawrenson K, Schildkraut JM, Hazelett D, Plummer JT, Kar S, Jones MR, Pharoah PDP, Gayther SA. Am J Hum Genet. 2024 Jun 6; 2024 May 8. PMID: 38723632.
- Development of a Longitudinal Prostate Cancer Transcriptomic and Clinical Data Linkage.Leapman MS, Ho J, Liu Y, Filson CP, Zhao X, Hakansson A, Proudfoot JA, Davicioni E, Martin DT, An Y, Seibert TM, Lin DW, Spratt DE, Cooperberg MR, Ross AE, Sprenkle PC. JAMA Netw Open. 2024 Jun 3; 2024 Jun 3. PMID: 38874922.
- Hypertension and Risk of Endometrial Cancer: A Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium (E2C2).Habeshian TS, Peeri NC, De Vivo I, Schouten LJ, Shu XO, Cote ML, Bertrand KA, Chen Y, Clarke MA, Clendenen TV, Cook LS, Costas L, Dal Maso L, Freudenheim JL, Friedenreich CM, Gallagher G, Gierach GL, Goodman MT, Jordan SJ, La Vecchia C, Lacey JV, Levi F, Liao LM, Lipworth L, Lu L, Matias-Guiu X, Moysich KB, Mutter GL, Na R, Naduparambil J, Negri E, O'Connell K, O'Mara TA, Onieva Hernández I, Palmer JR, Parazzini F, Patel AV, Penney KL, Prizment AE, Ricceri F, Risch HA, Sacerdote C, Sandin S, Stolzenberg-Solomon RZ, van den Brandt PA, Webb PM, Wentzensen N, Wijayabahu AT, Wilkens LR, Xu W, Yu H, Zeleniuch-Jacquotte A, Zheng W, Du M, Setiawan VW. Cancer Epidemiol Biomarkers Prev. 2024 Jun 3. PMID: 38530242.
- Tobacco smoking, smoking cessation and life expectancy among people with HIV on antiretroviral therapy in South Africa: a simulation modelling study.Thielking AM, Fitzmaurice KP, Sewpaul R, Chrysanthopoulou SA, Dike L, Levy DE, Rigotti NA, Siedner MJ, Wood R, Paltiel AD, Freedberg KA, Hyle EP, Reddy KP. J Int AIDS Soc. 2024 Jun. PMID: 38924347.
- 'It Just Makes Sense to Me': A qualitative study exploring patient decision-making and experiences with prostate MRI during active surveillance for prostate cancer.Sutherland R, Gross CP, Ma X, Jeong F, Seibert TM, Cooperberg MR, Catalona WJ, Ellis SD, Loeb S, Schulman-Green D, Leapman MS. BJUI Compass. 2024 Jun; 2024 Apr 2. PMID: 38873351.
- Novel non-invasive molecular signatures for oral cavity cancer, by whole transcriptome and small non-coding RNA sequencing analyses: Predicted association with PI3K/AKT/mTOR pathway.Vageli DP, Doukas PG, Townsend JP, Pickering C, Judson BL. Cancer Med. 2024 Jun. PMID: 38819439.
- Characterization of time toxicity in older patients with metastatic breast cancer.Atre SY, Soulos PR, Kuderer NM, Gross CP, Baum LVM, Dinan MA, Lustberg MB. Breast Cancer Res Treat. 2024 May 31; 2024 May 31. PMID: 38816556.
- Synergistic Immunoregulation: harnessing CircRNAs and PiRNAs to Amplify PD-1/PD-L1 Inhibition Therapy.Han R, Rao X, Zhou H, Lu L. Int J Nanomedicine. 2024; 2024 May 28. PMID: 38828205.
- ACO leakage among gynecologic cancer patients: Incidence, predictors, and impact on annual Medicare expenditure.Osazuwa-Peters OL, Greiner MA, Kaufman BG, Zambrano Guevara LM, Dinan M, Havrilesky L, Moss HA. Gynecol Oncol. 2024 May 23; 2024 May 23. PMID: 38788516.
- Partial Hepatectomy and Ablation for Survival of Early-Stage Hepatocellular Carcinoma Patients: A Bayesian Emulation Analysis.Wang J, Im Y, Wang R, Ma S. Life (Basel). 2024 May 22; 2024 May 22. PMID: 38929645.
- Information-incorporated sparse hierarchical cancer heterogeneity analysis.Han W, Zhang S, Ma S, Ren M. Stat Med. 2024 May 20; 2024 Mar 30. PMID: 38553996.
- Artificial intelligence assisted diagnosis of early tc markers and its application.Zhang L, Wong C, Li Y, Huang T, Wang J, Lin C. Discov Oncol. 2024 May 18; 2024 May 18. PMID: 38761260.
- The protective effect of dietary folate intake on gastric cancer is modified by alcohol consumption: A pooled analysis of the StoP Consortium.Gonzalez-Palacios S, Compañ-Gabucio LM, Torres-Collado L, Oncina-Canovas A, García-de-la-Hera M, Collatuzzo G, Negri E, Pelucchi C, Rota M, López-Carrillo L, Lunet N, Morais S, Ward MH, Martin V, Lozano-Lorca M, Malekzadeh R, Pakseresht M, Hernández-Ramírez RU, Bonzi R, Patel L, López-Cervantes M, Rabkin CS, Tsugane S, Hidaka A, Trichopoulou A, Karakatsani A, Camargo MC, Curado MP, Zhang ZF, La Vecchia C, Boffetta P, Vioque J. Int J Cancer. 2024 May 16; 2024 May 16. PMID: 38757245.
- The effect of a fermented soy beverage among patients with localized prostate cancer prior to radical prostatectomy.Lokeshwar SD, Ali A, Weiss TR, Reynolds J, Shuch BM, Ferencz T, Kyriakides TC, Mehal WZ, Brito J, Renzulli J, Leapman MS. BMC Urol. 2024 May 3; 2024 May 3. PMID: 38702664.
Centers and other resources
- Yale Cancer Center (YCC)The Center provides the best approaches for the prevention, detection, diagnosis, and treatment of cancer.
- Yale Center for Analytical Sciences (YCAS)YCAS collaborative team provides expertise in the design, conduct, and analysis of health and health care studies, methodological development, and education and training.
- Yale-Griffin Prevention Research Center (PRC)The PRC works with community partners to develop and implement community-based approaches to prevent and control chronic diseases such as heart disease, diabetes, and cancer.