Stephanie O'Malley, PhD
Elizabeth Mears and House Jameson Professor of PsychiatryDownloadHi-Res Photo
Cards
Appointments
Psychiatry
Primary
Additional Titles
Deputy Chair, Clinical Research
Contact Info
Psychiatry
Connecticut Mental Health Center - SAC 202, 34 Park Street
New Haven, CT 06508
United States
Appointments
Psychiatry
Primary
Additional Titles
Deputy Chair, Clinical Research
Contact Info
Psychiatry
Connecticut Mental Health Center - SAC 202, 34 Park Street
New Haven, CT 06508
United States
Appointments
Psychiatry
Primary
Additional Titles
Deputy Chair, Clinical Research
Contact Info
Psychiatry
Connecticut Mental Health Center - SAC 202, 34 Park Street
New Haven, CT 06508
United States
About
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Titles
Elizabeth Mears and House Jameson Professor of Psychiatry
Deputy Chair, Clinical Research
Appointments
Psychiatry
ProfessorPrimary
Other Departments & Organizations
- ADVANCE Study
- Call it a Night
- Cancer Prevention and Control
- Center for Nicotine and Tobacco Use Research at Yale (CENTURY)
- Center for the Translational Neuroscience of Alcohol
- Connecticut Mental Health Center
- Division of Addictions
- Division of Substance Abuse
- Division of Women's Behavioral Health Research
- Neuroscience Research Training Program (NRTP)
- Psychiatry
- Psychology Section
- Psychotherapy Development Center
- Smoking Cessation and Alcohol Treatment Research Clinic
- Stress & Addiction Clinical Research Program
- Substance Abuse Research
- Tobacco Research in Youth (TRY)
- Yale Cancer Center
- Yale Medicine
- Yale Tobacco Center of Regulatory Science
- Yale Ventures
Education & Training
- PhD
- Vanderbilt University (1983)
- BS
- Vanderbilt University (1976)
Research
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Overview
Yale Tobacco Center for Regulatory Science
Clinical trials of varenicline for the treatment of alcohol dependence among smokers and of naltrexone for young adult heavy drinkers
Laboratory studies to evaluate medications for substance use disorders
Validation of biomarkers for monitoring drinking in clinical trials
Secondary analyses to identify moderators and predictors of response to treatments for alcohol dependence using tree based and trajectory analyses
Training of clinician and transdisciplinary scientists
Medical Research Interests
Alcoholism; Psychiatry; Psychiatry and Psychology; Risk Reduction Behavior; Smoking; Substance-Related Disorders
ORCID
0000-0002-1976-2369
Research at a Glance
Yale Co-Authors
Frequent collaborators of Stephanie O'Malley's published research.
Research Interests
Research topics Stephanie O'Malley is interested in exploring.
Suchitra Krishnan-Sarin, PhD
Krysten Bold, PhD
Meghan Morean, PhD
Akshika Sharma, PhD
John Krystal, MD
Lisa Fucito, PhD
Publications
2025
A Randomized Trial of Alcohol Telemedicine in Primary Care: Pharmacotherapy and Referral Outcomes
Sterling S, Leibowitz A, Satre D, Cocohoba J, Kline-Simon A, Weisner C, Metz V, Ghadiali M, Corriveau C, O’Malley S, Awsare S, Morris M, Parthasarathy S. A Randomized Trial of Alcohol Telemedicine in Primary Care: Pharmacotherapy and Referral Outcomes. Journal Of General Internal Medicine 2025, 1-10. PMID: 40634649, DOI: 10.1007/s11606-025-09708-y.Peer-Reviewed Original ResearchCitationsAltmetricConceptsReferral to specialty treatmentUnhealthy alcohol usePrimary care physiciansPrimary careAlcohol use disorderSpecialty treatmentUsual careAlcohol usePharmacist-delivered servicesPrimary care-basedAlcohol use disorder medicationsCluster randomized trialYear 2Alcohol use disorder diagnosisRandomized trialsCare-basedCare providersAlcohol use problemsImplementation outcomesIntervention armProvider characteristicsCare physiciansReferral outcomesTelemedicine consultationsReferral facilitationMetabolism in the human brain following oral consumption of a keto-ester for applications in alcohol use disorder (AUD) with 1H-MRSI
Virk M, Kitaneh R, Mignosa M, McIntyre S, Nixon T, DeMartini K, O’Malley S, Krystal J, De Feyter H, Angarita G, Mason G, de Graaf R, Kumaragamage C. Metabolism in the human brain following oral consumption of a keto-ester for applications in alcohol use disorder (AUD) with 1H-MRSI. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/0612.Peer-Reviewed Original ResearchAcute Alcohol‐Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography
Raval N, Smart K, Angarita G, Miller R, Huang Y, Krystal J, Carson R, Cosgrove K, O'Malley S, Hillmer A. Acute Alcohol‐Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography. Addiction Biology 2025, 30: e70031. PMID: 40309934, PMCID: PMC12044519, DOI: 10.1111/adb.70031.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsBlood alcohol levelsAlcohol challengeEffects of acute alcohol consumptionPeak blood alcohol levelsLaboratory alcohol challengeNon-displaceable binding potentialMetabotropic glutamate receptor 5Acute alcohol challengeGlutamate releaseAlcohol-induced changesGlutamate receptor 5Alcohol consumptionAcute alcohol consumptionMGluR5 availabilityPET scansSocial drinkersEthanol doseAlcohol effectsBrain regionsAcute alcoholBinding potentialCortical regionsClinically relevant dosesDrinking occasionsAlcohol levels598. Impact of the mGluR5 Antagonist, Mavoglurant, on P300 Response in an Auditory Oddball Task in in Individuals With a Positive or Negative Family History of Alcoholism
Richardson A, Stone A, Pearlson G, Krystal J, DeMartini K, O'Malley S, Mubeen M, Pancholi K. 598. Impact of the mGluR5 Antagonist, Mavoglurant, on P300 Response in an Auditory Oddball Task in in Individuals With a Positive or Negative Family History of Alcoholism. Biological Psychiatry 2025, 97: s345. DOI: 10.1016/j.biopsych.2025.02.837.Peer-Reviewed Original ResearchExamining E-cigarette Flavor Use and Preference by Menthol Cigarette Status and Quit Duration Among U.S. Adults Using E-cigarettes in a Smoking Cessation Attempt
Joseph M, Morean M, Wu R, Krishnan-Sarin S, O’Malley S, Bold K. Examining E-cigarette Flavor Use and Preference by Menthol Cigarette Status and Quit Duration Among U.S. Adults Using E-cigarettes in a Smoking Cessation Attempt. Nicotine & Tobacco Research 2025, 27: 1657-1661. PMID: 40056399, PMCID: PMC12370470, DOI: 10.1093/ntr/ntaf059.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSmoking menthol cigarettesSmoking cessation attemptsE-cigarettesE-cigarette flavorsMenthol cigarettesNon-menthol cigarettesQuit smokingCessation attemptsCross-sectional survey dataReduce cigarette useE-cigarette flavor preferenceDuration of abstinenceDuration of smoking abstinenceUS adultsCigarette typesQuit durationSmoking mentholSmoking abstinenceSurvey dataCigarette useGeneralized linear modelSmokingCigaretteNon-mentholAdultsT49 Effects of Nicotine Flux and Form on Speed and Total Amount of Arterial Blood Nicotine Delivery during Acute E-Cigarette Vaping
Baldassarri S, McKinney E, Mysirlidis S, Sharma M, Blohowiak R, Joseph P, Eid T, Nadim H, Hanna E, Karaoghlanian N, Adeniji A, Shihadeh A, Eissenberg T, Krishnan-Sarin S, O'Malley S, El-Hellani A, Talih S. T49 Effects of Nicotine Flux and Form on Speed and Total Amount of Arterial Blood Nicotine Delivery during Acute E-Cigarette Vaping. Drug And Alcohol Dependence 2025, 267: 111817. DOI: 10.1016/j.drugalcdep.2024.111817.Peer-Reviewed Original ResearchEvading Menthol Bans through Chemistry: The tobacco industry illustrates why we need to overhaul the way we regulate chemicals.
Zimmerman J, Erythropel H, Muellers T, Petrovic P, O'Malley S, Krishnan-Sarin S, Jabba S, Jordt S, Anastas P. Evading Menthol Bans through Chemistry: The tobacco industry illustrates why we need to overhaul the way we regulate chemicals. Scientific American 2025, 332: 71. PMID: 39688992, PMCID: PMC12208286, DOI: 10.1038/scientificamerican012025-7utzdfyksaqx7txbhvuhtg.Peer-Reviewed Original ResearchConcepts
2024
Natural language processing in mixed-methods evaluation of a digital sleep-alcohol intervention for young adults
Griffith F, Ash G, Augustine M, Latimer L, Verne N, Redeker N, O’Malley S, DeMartini K, Fucito L. Natural language processing in mixed-methods evaluation of a digital sleep-alcohol intervention for young adults. Npj Digital Medicine 2024, 7: 342. PMID: 39613828, PMCID: PMC11606959, DOI: 10.1038/s41746-024-01321-3.Peer-Reviewed Original ResearchCitationsConceptsYoung adultsLanguage processingEvaluating young adultsControl participantsHeavy drinkingSleep factorsImprove sleepNatural language processingPersonalized feedbackParticipation motivationParticipantsSleepAdultsMixed-methods evaluationControl interventionsInterventionConvergent mixed methodsMotivationIncreased awarenessAlcoholUnderstanding Use of E-cigarettes for Smoking Cessation Among a Sample of U.S. Adults
Sharma A, Morean M, Krishnan-Sarin S, O’Malley S, Bold K. Understanding Use of E-cigarettes for Smoking Cessation Among a Sample of U.S. Adults. Nicotine & Tobacco Research 2024, 27: 926-931. PMID: 39475073, PMCID: PMC12012231, DOI: 10.1093/ntr/ntae251.Peer-Reviewed Original ResearchCitationsAltmetricConceptsQuit smokingNicotine replacement treatmentSmoking cessation aidE-cigarettesSmoking cessationCessation aidsSmoking cigarettesCessation attemptsSample of US adultsMajority of participantsSmoking cessation attemptsE-cigarette useComponents of e-cigarettesTime of surveyCessation supportUS adultsRegular cigarette smokingSmoking abstinenceRelapse rateNicotine patchSmokingReplacement treatmentNicotine-freeCigarette smokingOnline surveyA Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder
Kiluk B, Benitez B, DeVito E, Frankforter T, LaPaglia D, O’Malley S, Nich C. A Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder. JAMA Network Open 2024, 7: e2435205. PMID: 39325452, PMCID: PMC11428014, DOI: 10.1001/jamanetworkopen.2024.35205.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCognitive behavioral therapyDigital cognitive behavioral therapyAlcohol use disorderAlcohol useCBT programUse disorderCognitive behavioral therapy programCurrent alcohol use disorderTreatment-seeking adultsBehavioral therapy programEvidence-based treatmentsBaseline to 6-month follow-upRates of alcohol useReducing alcohol useTreatment periodRandomized clinical trialsBehavioral therapyOutpatient substancePercentage of daysOutpatient treatmentIntention-to-treat analysisIndividual counselingStudy periodFollow-upIntention-to-treat
Clinical Trials
Current Trials
Brief training for 18-26 year olds: Regulation of alcohol craving
HIC ID2000029394RoleSub InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge18 years - 26 yearsVarenicline for treatment of e-cigarette dependence
HIC ID2000032740RoleSub InvestigatorPrimary Completion Date09/30/2023Recruiting ParticipantsGenderBothAge18+ yearsThe interaction of flavor with nicotine form in adult smokers
HIC ID2000025687RoleSub InvestigatorPrimary Completion Date05/31/2022Recruiting ParticipantsGenderBothAge21+ years
Academic Achievements & Community Involvement
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Activities
activity Alcoholism:Clinical and Experimental Research
2011 - PresentProfessional OrganizationsMemberDetailsSenior Advisory Boardactivity American College of Neuropsychopharmacology/American Society of Clinical Psychopharmacology
2008 - PresentProfessional OrganizationsMemberDetailsWorking group on alcohol medication trial designactivity Psychiatry Investigation
2004 - PresentProfessional OrganizationsMemberDetailsEditorial Boardactivity JAMA Psychiatry
2015 - PresentProfessional OrganizationsMemberDetailsEditorial Boardactivity NIDA
2015 - PresentCommitteesMemberDetailsData Safety Monitoring Board, Clinical Trials Network
Honors
honor Thwarp Award
11/01/2018National AwardFirst Tennessee Bank, Trustee under Will of James H. ThwarpDetailsUnited Stateshonor Distinguished Researcher Award
06/15/2018National AwardResearch Society on AlcoholismDetailsUnited Stateshonor Sidney J. Blatt Award
06/01/2015Yale School of Medicine AwardPsychology Section, Department of PsychiatryDetailsUnited Stateshonor Elected Member
04/01/2014Regional AwardConnecticut Academy of Science and Engineering (CASE)DetailsUnited Stateshonor Presidential Citation for Leadership and Research in the Field of Addictions
04/01/2014National AwardAmerican Psychological AssociationDetailsUnited States
News & Links
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News
- July 18, 2025Source: Yale News
For Young Adults, Improved Sleep Is Incentive to Drink Less
- June 26, 2025Source: Tobacco Control
Effects of Oral Nicotine Pouches on Cigarette Smoking Behavior and Tobacco Harm Exposure: A Randomised Pilot Trial in Adults
- December 03, 2024Source: Nature Digital Medicine
Natural Language Processing in Mixed-Methods Evaluation of a Digital Sleep-Alcohol Intervention For Young Adults
- September 26, 2024
Yale Study: Digital Cognitive Behavioral Therapy Program Found More Effective Than Clinician-Delivered Therapy at Reducing Alcohol Use in a Clinical Trial
Get In Touch
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Contacts
Mailing Address
Psychiatry
Connecticut Mental Health Center - SAC 202, 34 Park Street
New Haven, CT 06508
United States