Ruth R Montgomery, PhD
Professor of Medicine and Professor of Epidemiology (Microbial Diseases)DownloadHi-Res Photo
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Additional Titles
Associate Dean for Scientific Affairs, Dept Clinical: Internal Medicine
Administrative Support
Publications Overview
- 164 Publications
- 13,416 Citations
- 110 Yale Co-Authors
Additional Titles
Associate Dean for Scientific Affairs, Dept Clinical: Internal Medicine
Administrative Support
Publications Overview
- 164 Publications
- 13,416 Citations
- 110 Yale Co-Authors
Additional Titles
Associate Dean for Scientific Affairs, Dept Clinical: Internal Medicine
Administrative Support
Publications Overview
- 164 Publications
- 13,416 Citations
- 110 Yale Co-Authors
About
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Titles
Professor of Medicine and Professor of Epidemiology (Microbial Diseases)
Associate Dean for Scientific Affairs, Dept Clinical: Internal Medicine
Biography
Ruth R. Montgomery is a cellular immunologist with particular expertise in use of novel technology for human translational studies. Her research employs systems wide studies to identify individual differences in immune responses that lead to divergent outcomes to infection. Her group focuses on effects of aging on innate immunity and individual variation influencing susceptibility to West Nile, dengue, Zika and COVID-19 viruses, and inflammatory profiling of patients with sickle cell disease. She has overseen studies of immune responsiveness in human cohorts with successful enrollment of >2000 healthy individuals. Dr. Montgomery’s work is notable for her use of primary human cells to demonstrate immune related mechanisms and illuminate potential avenues for therapeutic interventions. She launched the CyTOF facility at Yale in 2013, was co-chair of the University Provost’s ITS Advisory Committee (ITSAC), and serves as Associate Dean for Scientific Affairs.
Last Updated on January 17, 2024.
Appointments
Office of the Dean, School of Medicine
Associate DeanDualRheumatology
ProfessorPrimaryEpidemiology of Microbial Diseases
ProfessorSecondaryPathology
ProfessorSecondary
Other Departments & Organizations
- Cancer Immunology
- Epidemiology of Microbial Diseases
- Human and Translational Immunology Program
- Internal Medicine
- Mobile @ Yale
- Molecular Medicine, Pharmacology, and Physiology
- Office of the Dean, School of Medicine
- Pathology
- Pathology and Molecular Medicine
- Pathology Research
- Program in Translational Biomedicine (PTB)
- Rheumatic Diseases Research Core
- Rheumatology
- Rheumatology, Allergy, & Immunology
- Yale Center for Research on Aging (Y-Age)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Institute for Global Health
- Yale School of Public Health
- Yale-BI Biomedical Data Science Fellowship
Education & Training
- Postdoctoral Fellow
- Yale University (1991)
- PhD
- Rockefeller University (1987)
- BA
- University of Pennsylvania, Biology (1981)
Research
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Overview
Immune profiling; Single cell mass cytometry
Medical Research Interests
Aging; Asthma; COVID-19; Immune System; Immune System Diseases; Immunity, Innate; Macrophages; Neutrophils; Pathology; Public Health; Rheumatology; Virus Diseases; West Nile virus
Public Health Interests
Immunology
ORCID
0000-0002-8661-4454
Research at a Glance
Yale Co-Authors
Frequent collaborators of Ruth R Montgomery's published research.
Publications Timeline
A big-picture view of Ruth R Montgomery's research output by year.
Research Interests
Research topics Ruth R Montgomery is interested in exploring.
Erol Fikrig, MD
Albert C Shaw, MD, PhD
Steven Kleinstein, PhD
David A. Hafler, MD, FANA
Xiaomei Wang
Akiko Iwasaki, PhD
164Publications
13,416Citations
West Nile virus
Aging
Immunity, Innate
Macrophages
Neutrophils
COVID-19
Publications
2025
A multi-omics recovery factor predicts long COVID in the IMPACC study
Gabernet G, Maciuch J, Gygi J, Moore J, Hoch A, Syphurs C, Chu T, Jayavelu N, Corry D, Kheradmand F, Baden L, Sekaly R, McComsey G, Haddad E, Cairns C, Rouphael N, Fernandez-Sesma A, Simon V, Metcalf J, Higuita N, Hough C, Messer W, Davis M, Nadeau K, Pulendran B, Kraft M, Bime C, Reed E, Schaenman J, Erle D, Calfee C, Atkinson M, Brakenridge S, Melamed E, Shaw A, Hafler D, Augustine A, Becker P, Ozonoff A, Bosinger S, Eckalbar W, Maecker H, Kim-Schulze S, Steen H, Krammer F, Westendorf K, Network I, Peters B, Fourati S, Altman M, Levy O, Smolen K, Montgomery R, Diray-Arce J, Kleinstein S, Guan L, Ehrlich L. A multi-omics recovery factor predicts long COVID in the IMPACC study. Journal Of Clinical Investigation 2025 PMID: 40924481, DOI: 10.1172/jci193698.Peer-Reviewed Original ResearchAltmetricConceptsSARS-CoV-2 infectionCOVID-19 patientsMulti-OmicsSARS-CoV-2Risk of LCAcute COVID-19 severityImmune profiling dataSubset frequenciesBiomarkers of LCPlasma metabolomeCOVID-19 severityPotential treatment targetPBMC transcriptomesClinical parametersBiological underpinningsStress erythropoiesisCell frequencyInflammatory mediatorsLC biomarkersTherapeutic opportunitiesHospital dischargeAndrogenic steroidsDisease severityTreatment targetPatientsBaseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study
Hou J, Haslund-Gourley B, Diray-Arce J, Hoch A, Rouphael N, Becker P, Augustine A, Ozonoff A, Guan L, Kleinstein S, Peters B, Reed E, Altman M, Langelier C, Maecker H, Kim S, Montgomery R, Krammer F, Wilson M, Eckalbar W, Bosinger S, Levy O, Steen H, Rosen L, Baden L, Melamed E, Ehrlich L, McComsey G, Sekaly R, Schaenman J, Shaw A, Hafler D, Corry D, Kheradmand F, Atkinson M, Brakenridge S, Agudelo Higuita N, Metcalf J, Hough C, Messer W, Pulendran B, Nadeau K, Davis M, Fernandez Sesma A, Simon V, Kraft M, Bime C, Calfee C, Erle D, Impacc Network, Robinson L, Cairns C, Haddad E, Comunale M. Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study. Frontiers In Medicine 2025, 12: 1604388. PMID: 40687705, PMCID: PMC12271175, DOI: 10.3389/fmed.2025.1604388.Peer-Reviewed Original ResearchAltmetricConceptsSequential Organ Failure AssessmentPeripheral blood mononuclear cellsLaboratory biomarkersSequential Organ Failure Assessment scoreAntibody titersNasal viral loadOrgan Failure AssessmentBlood mononuclear cellsSARS-CoV-2 antibody titersSARS-CoV-2 infectionCOVID-19 patientsCOVID-19 cohortMortality prediction modelCOVID-19 severityPatient ageViral loadBlood cytometryImmunophenotypic assessmentMononuclear cellsClinical dataBaseline biomarkersFailure AssessmentBiomarkers of COVID-19Hospitalized patientsIL-6MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury
Pickering H, Alipanah-Lechner N, Chen E, Duchen D, Maecker H, Kim-Schulze S, Montgomery R, Cotsapas C, Steen H, Krammer F, Langelier C, Levy O, Baden L, Melamed E, Ehrlich L, McComsey G, Sekaly R, Cairns C, Haddad E, Shaw A, Hafler D, Corry D, Kheradmand F, Atkinson M, Brakenridge S, Higuita N, Metcalf J, Hough C, Messer W, Pulendran B, Nadeau K, Davis M, Fernandez-Sesma A, Simon V, Kraft M, Bime C, Erle D, Schaenman J, Ozonoff A, Peters B, Kleinstein S, Augustine A, Diray-Arce J, Becker P, Rouphael N, Altman M, Bosinger S, Eckalbar W, Network I, Calfee C, Aguilar O, Reed E, Greenland J, Calabrese D. MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury. JCI Insight 2025, 10: e191951. PMID: 40608426, PMCID: PMC12333951, DOI: 10.1172/jci.insight.191951.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute lung injuryMHC class I polypeptide-related sequence BImmune profileLung injuryMechanical ventilationSARS-CoV-2Variant allelesAcute lung injury severityRisk of mechanical ventilationProfiles of peripheral bloodSoluble inflammatory mediatorsOdds of severe COVID-19Cox proportional hazards modelsSevere COVID-19SARS-CoV-2 infectionProportional hazards modelMultiple immune pathwaysNKG2D-activatingCOVID-19 severityNKG2D ligandsNK cellsViral burdenBronchoalveolar lavagePeripheral bloodHomozygous patientsAirway Immune Signatures in Severe and Fatal Infection with COVID-19
Doni Jayavelu N, Qi J, Fourati S, Kheradmand F, Langelier C, Ehrlich L, Diray-Arce J, Hoch A, Kraft M, Becker P, Altman M, Montgomery R. Airway Immune Signatures in Severe and Fatal Infection with COVID-19. American Journal Of Respiratory Cell And Molecular Biology 2025, 72: 708-712. PMID: 40444914, PMCID: PMC12143404, DOI: 10.1165/rcmb.2024-0462le.Peer-Reviewed Original ResearchAltmetricHigh affinity CD16 polymorphism associated with reduced risk of severe COVID-19
Qualls A, Tsao T, Lui I, Lim S, Su Y, Chen E, Duchen D, Maecker H, Kim-Schulze S, Montgomery R, Krammer F, Langelier C, Levy O, Baden L, Melamed E, Ehrlich L, McComsey G, Sekaly R, Cairns C, Haddad E, Shaw A, Hafler D, Corry D, Kheradmand F, Atkinson M, Brakenridge S, Higuita N, Metcalf J, Hough C, Messer W, Pulendran B, Nadeau K, Davis M, Fernandez-Sesma A, Simon V, Kraft M, Bime C, Calfee C, Erle D, Schaenmann J, Ozonoff A, Peters B, Kleinstein S, Augustine A, Diray-Arce J, Becker P, Rouphael N, Network I, Goldman J, Calabrese D, Heath J, Wells J, Reed E, Lanier L, Pickering H, Aguilar O. High affinity CD16 polymorphism associated with reduced risk of severe COVID-19. JCI Insight 2025, 10: e191314. PMID: 40402577, PMCID: PMC12306582, DOI: 10.1172/jci.insight.191314.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAntibody-dependent cellular cytotoxicitySevere COVID-19Anti-SARS-CoV-2 IgG titersNK cell-mediated immune responsesNK cell-mediated antibody-dependent cellular cytotoxicityHost-directed therapeutic strategiesSevere disease trajectoryCell-mediated immune responsesHospitalized COVID-19 patientsLevels of inflammatory mediatorsNatural killer cellsSevere respiratory complicationsImmunopathogenesis of COVID-19Activating Fc receptorsRisk of ICU admissionRisk of severe COVID-19SARS-CoV-2 infectionCOVID-19 patientsCOVID-19 cohortIn vitro reporter systemKiller cellsRespiratory complicationsCellular cytotoxicityViral loadImmunophenotypic assessment
2024
SenNet recommendations for detecting senescent cells in different tissues
Suryadevara V, Hudgins A, Rajesh A, Pappalardo A, Karpova A, Dey A, Hertzel A, Agudelo A, Rocha A, Soygur B, Schilling B, Carver C, Aguayo-Mazzucato C, Baker D, Bernlohr D, Jurk D, Mangarova D, Quardokus E, Enninga E, Schmidt E, Chen F, Duncan F, Cambuli F, Kaur G, Kuchel G, Lee G, Daldrup-Link H, Martini H, Phatnani H, Al-Naggar I, Rahman I, Nie J, Passos J, Silverstein J, Campisi J, Wang J, Iwasaki K, Barbosa K, Metis K, Nernekli K, Niedernhofer L, Ding L, Wang L, Adams L, Ruiyang L, Doolittle M, Teneche M, Schafer M, Xu M, Hajipour M, Boroumand M, Basisty N, Sloan N, Slavov N, Kuksenko O, Robson P, Gomez P, Vasilikos P, Adams P, Carapeto P, Zhu Q, Ramasamy R, Perez-Lorenzo R, Fan R, Dong R, Montgomery R, Shaikh S, Vickovic S, Yin S, Kang S, Suvakov S, Khosla S, Garovic V, Menon V, Xu Y, Song Y, Suh Y, Dou Z, Neretti N. SenNet recommendations for detecting senescent cells in different tissues. Nature Reviews Molecular Cell Biology 2024, 25: 1001-1023. PMID: 38831121, PMCID: PMC11578798, DOI: 10.1038/s41580-024-00738-8.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSenescent cellsDetect senescent cellsIrreversible cell cycle arrestCellular senescenceCell cycle arrestSenescence markersBiomarker Working GroupCycle arrestCellular senescence markersBiological processesCell biologyPostmitotic cellsSenescent phenotypeCirculating MarkersTissue culture studiesSenescence signatureSenescenceCellsMorphological featuresDetrimental roleTissueMarkersSeasonal investigationIntegrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality
Gygi J, Maguire C, Patel R, Shinde P, Konstorum A, Shannon C, Xu L, Hoch A, Jayavelu N, Haddad E, Network I, Reed E, Kraft M, McComsey G, Metcalf J, Ozonoff A, Esserman D, Cairns C, Rouphael N, Bosinger S, Kim-Schulze S, Krammer F, Rosen L, van Bakel H, Wilson M, Eckalbar W, Maecker H, Langelier C, Steen H, Altman M, Montgomery R, Levy O, Melamed E, Pulendran B, Diray-Arce J, Smolen K, Fragiadakis G, Becker P, Sekaly R, Ehrlich L, Fourati S, Peters B, Kleinstein S, Guan L. Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality. Journal Of Clinical Investigation 2024, 134: e176640. PMID: 38690733, PMCID: PMC11060740, DOI: 10.1172/jci176640.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsClinical outcomesImmune cascadeElevated levels of inflammatory cytokinesDisease severityLevels of inflammatory cytokinesFormation of neutrophil extracellular trapsAcute COVID-19 severityCritically ill patientsNeutrophil extracellular trapsDevelopment of therapiesCOVID-19 cohortCOVID-19 severityViral clearanceImmunosuppressive metabolitesDeep immunophenotypingMultiomic modelIFN-stimulated genesImmunophenotypic assessmentB cellsDisease courseEarly upregulationInflammatory cytokinesDisease progressionIFN inhibitorsExtracellular trapsInnate Immune Mechanisms Associated With Exacerbations on Mepolizumab
Wilson G, Liu Q, Gautam S, Knight J, Shelar A, Stewart E, Visness C, Sanders J, Gill M, Gruchalla R, Liu A, Kattan M, Khurana Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Innate Immune Mechanisms Associated With Exacerbations on Mepolizumab. 2024, a6984-a6984. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6984.Peer-Reviewed Original ResearchHost-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology
Phan H, Tsitsiklis A, Maguire C, Haddad E, Becker P, Kim-Schulze S, Lee B, Chen J, Hoch A, Pickering H, van Zalm P, Altman M, Augustine A, Calfee C, Bosinger S, Cairns C, Eckalbar W, Guan L, Jayavelu N, Kleinstein S, Krammer F, Maecker H, Ozonoff A, Peters B, Rouphael N, Montgomery R, Reed E, Schaenman J, Steen H, Levy O, Diray-Arce J, Langelier C, Erle D, Hendrickson C, Kangelaris K, Nguyen V, Lee D, Chak S, Ghale R, Gonzalez A, Jauregui A, Leroux C, Altamirano L, Rashid A, Willmore A, Woodruff P, Krummel M, Carrillo S, Ward A, Patel R, Wilson M, Dandekar R, Alvarenga B, Rajan J, Schroeder A, Fragiadakis G, Mick E, Guerrero Y, Love C, Maliskova L, Adkisson M, Ehrlich L, Melamed E, Rousseau J, Hurley K, Geltman J, Siles N, Rogers J, Kutzler M, Bernui M, Cusimano G, Connors J, Woloszczuk K, Joyner D, Edwards C, Lin E, Melnyk N, Powell D, Kim J, Goonewardene I, Simmons B, Smith C, Martens M, Croen B, Semenza N, Bell M, Furukawa S, McLin R, Tegos G, Rogowski B, Mege N, Ulring K, Holland S, Rosen L, Lee S, Vaysman T, Fernandez-Sesma A, Simon V, Van Bakel H, Gonzalez-Reiche A, Qi J, Carreño J, Singh G, Raskin A, Tcheou J, Khalil Z, van de Guchte A, Farrugia K, Khan Z, Kelly G, Srivastava K, Eaker L, Bermúdez González M, Mulder L, Beach K, Fatou B, Smolen K, Viode A, van Haren S, Jha M, Kho A, Milliren C, Chang A, McEnaney K, Barton B, Lentucci C, Murphy M, Saluvan M, Shaheen T, Liu S, Syphurs C, Albert M, Hayati A, Bryant R, Abraham J, Salehi-Rad R, Rivera A, Sen S, Elashoff D, Ward D, Presnell S, Kohr B, Arnett A, Boddapati A, Tharp G, Pellegrini K, Johnson B, Panganiban B, Huerta C, Anderson E, Samaha H, Sevransky J, Bristow L, Beagle E, Cowan D, Hamilton S, Hodder T, Esserman D, Brito A, Rothman J, Grubaugh N, Ko A, Hafler D, Shaw A, Gygi J, Pawar S, Konstorum A, Chen E, Cotsapas C, Wang X, Xu L, Dela Cruz C, Iwasaki A, Mohanty S, Nelson A, Zhao Y, Farhadian S, Asashima H, Pulendran B, Nadeau R, Rosenberg-Hasson Y, Leipold M, Sigal N, Rogers A, Fernandez A, Manohar M, Do E, Chang I, Vita R, Westendorf K, Corry D, Kheradmand F, Song L, Nelson E, Baden L, Mendez K, Lasky-Su J, Tong A, Rooks R, Sekaly R, Fourati S, McComsey G, Harris P, Sieg S, Ribeiro S, Overton J, Rahman A, Hutton S, Michelotti G, Wong K, Seyfert-Margolis V, Metcalf J, Agudelo Higuita N, Sinko L, Booth J, Messer W, Hough C, Siegel S, Sullivan P, Lu Z, Kraft M, Bime C, Mosier J, Erickson H, Schunk R, Kimura H, Conway M, Atkinson M, Brakenridge S, Ungaro R, Manning B, Oberhaus J, Guirgis F, Borresen B, Anderson M. Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology. Science Translational Medicine 2024, 16: eadj5154. PMID: 38630846, PMCID: PMC11931290, DOI: 10.1126/scitranslmed.adj5154.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPro-inflammatory genesViral clearanceUpper airwayImmune signaling pathwaysInduction of pro-inflammatory genesBiomarkers of disease severityDelayed viral clearanceImpaired viral clearanceSevere coronavirus disease 2019B cell populationsAge-dependent up-regulationExpression of pro-inflammatory genesHost immune responseSignaling pathwayType I interferon gene expressionCOVID-19 immunopathologyInnate Immune Signaling PathwaysSerum chemokinesAge-dependent impairmentNaive TMulticenter cohortNasal transcriptomeAcute respiratory syndrome coronavirus 2Monocyte populationsSerum protein profilesActivated sputum eosinophils associated with exacerbations in children on mepolizumab
Wilson G, Knight J, Liu Q, Shelar A, Stewart E, Wang X, Yan X, Sanders J, Visness C, Gill M, Gruchalla R, Liu A, Kattan M, Khurana Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Activated sputum eosinophils associated with exacerbations in children on mepolizumab. Journal Of Allergy And Clinical Immunology 2024, 154: 297-307.e13. PMID: 38485057, PMCID: PMC11305967, DOI: 10.1016/j.jaci.2024.01.031.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAirway eosinophilsSputum eosinophilsPatients treated with mepolizumabPlacebo-controlled clinical trialAnti-IL-5 treatmentEffect of mepolizumabEosinophil subpopulationsSevere eosinophilic asthmaAnti-interleukin-5Expression of CD62LFrequency of exacerbationsEosinophilic asthmaActivation markersSputum samplesUnsupervised cluster analysisMepolizumabTreatment armsReduce exacerbationsCD62LClinical trialsExacerbationMass cytometryEosinophilsExacerbation riskIntracellular markers
Clinical Trials
Current Trials
Immune Response Analysis in Lymph Node Tissue
HIC ID2000032631RoleSub InvestigatorPrimary Completion Date04/30/2027Recruiting ParticipantsEffects of circadian regulation and sleep on immune responses
HIC ID2000027037RoleSub InvestigatorPrimary Completion Date02/28/2025Recruiting ParticipantsGenderBothAge21+ yearsImpact of HIV Infection on Immunologic, Transcriptomic, and Metabolomic Signatures
HIC ID1608018239RoleSub InvestigatorPrimary Completion Date09/01/2021Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements & Community Involvement
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Activities
activity Immunity & Ageing
02/01/2019 - PresentJournal ServiceAssociate EditorDetailsBoard memberactivity Coalition for Epidemic Preparedness Innovations (CEPI)
02/15/2019 - PresentProfessional OrganizationsCommittee MemberDetailsSystems Immunology Task Forceactivity Phenomics
11/01/2020 - PresentJournal ServiceEditorial Board Memberactivity CIVICs NIAID Collaborative Influenza Vaccine Innovation Centers (CIVICs) Program
08/01/2020 - 01/01/2025Advisory BoardsExpert Panel MemberDetailsCIVICs NIAID Collaborative Influenza Vaccine Innovation Centers (CIVICs) Programactivity Society of Leukocyte Biology
2018 - 2021Professional OrganizationsCouncil MemberDetailsCouncil Member
Honors
honor Fellow
03/27/2025National AwardAAAS American Association for the Advancement of ScienceDetailsUnited Stateshonor Member
07/01/2020Regional AwardConnecticut Academy of Science and EngineeringDetailsUnited States
News & Links
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Media
- An in-depth single cell analysis identifies multiple distinct subtypes of airway immune cells and provides insights of cellular function relevant for pathogenesis of asthma. J Leuk Biol. 2020;108:1555-64.
- 360 cell type/functional marker combinations were rank-ordered by P value comparing virus-induced changes with dengue (top panel) or Zika (bottom panel). Enrichment scores for innate cell types showed striking differences between naive and recall responses. PLoS Negl Trop Dis. 2020;14:e0008112.
- Increase in diversity of NK cell receptors following infection with virus. Sci Trans Med 7:297ra115. PMCID:PMC4547537
- Ixodes tick, vector of Lyme disease
News
- March 27, 2025Source: Yale News
Eight Yale Faculty Members Named AAAS Fellows
- November 20, 2024
How Does Aging Affect Innate Immunity?
- May 01, 2024
COVID-19: New ‘Omics’ Models Show Why Some People Are at Greater Risk of Severe Disease, Death
- March 19, 2024
Why Do Some People Experience Asthma Symptoms Despite Treatment?
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Mailing Address
Rheumatology
300 Cedar St
New Haven, CT 06520
United States
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