Richard D'Aquila, MPH
Lecturer in Public Health (Health Policy)Cards
About
Research
Publications
2025
Conversion Therapy Exposure and Elevated Cardiovascular Disease Risk
Gibb J, Schrock J, Smith M, D’Aquila R, McDade T, Mustanski B. Conversion Therapy Exposure and Elevated Cardiovascular Disease Risk. JAMA Network Open 2025, 8: e258745. PMID: 40327341, PMCID: PMC12056572, DOI: 10.1001/jamanetworkopen.2025.8745.Peer-Reviewed Original ResearchConceptsHigh blood pressureSystolic blood pressureDiastolic blood pressureSelf-reported high blood pressureCohort studyCardiovascular health dataCardiovascular health indicatorsSelf-reported hypertensionSGM health disparitiesMental health impactsCardiovascular health consequencesCardiovascular disease riskBlood pressureElevated diastolic blood pressureHealth disparitiesCare approachElevated systolic blood pressureHealth indicatorsMain OutcomesIncreased DBPBehavioral covariatesHealth dataSGM individualsDisease riskHealth consequencesDesign and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity
Sawyer A, Vaca C, Malik N, Clerc I, Craft J, Hudson H, Scholtés G, Schiltz G, Roh M, Song C, D’Aquila R. Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity. Viruses 2025, 17: 514. PMID: 40284957, PMCID: PMC12031279, DOI: 10.3390/v17040514.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusDecreased HIV-1 infectivitySpread of human immunodeficiency virusLevels of A3GHIV-producing cellsHIV-1 infectionA3GDecreased viral infectivityDegradation of A3GDegradation of APOBEC3GResistance-conferring mutationsInfectivity of virionsAnti-HIV therapeuticsViral infectivity factorImmunodeficiency virusCell-intrinsic defenseViral infectionAPOBEC3GCatalytic polypeptide-like 3Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3Infectivity factorInfectionA3G/FVifViral proteinsExplaining Racial and Ethnic Inequities in SARS-CoV-2-Related Outcomes: Results from a Serosurvey in Chicago
Eyo C, Schrock J, Hayford C, Ryan D, Saber R, Benbow N, Newcomb M, Demonbreun A, McNally E, D’Aquila R, McDade T, Mustanski B. Explaining Racial and Ethnic Inequities in SARS-CoV-2-Related Outcomes: Results from a Serosurvey in Chicago. Journal Of Racial And Ethnic Health Disparities 2025, 1-14. PMID: 40063297, DOI: 10.1007/s40615-025-02362-4.Peer-Reviewed Original ResearchEthnic inequalitiesSymptom severityWhite participantsChronic conditionsOccupation typeBlack participantsWhite neighborhoodsCOVID-19 case ratesNeighborhood disadvantageHispanic/Latino neighborhoodsHigher levels of symptom severityHousehold compositionLevels of symptom severityMultiple inequalitiesHealth insurance coverageHigher symptom severityAssociated health outcomesLower symptom severityWhite disparitiesInequalityProximal determinantsSARS-CoV-2-related outcomesNeighborhoodEthnic disparitiesSARS-CoV-2 seropositivity
2024
Childhood Sexual Abuse, Alcohol Problem Scores, and Race Are Associated With Syphilis Incidence in a Prospective Cohort of Young Sexual and Gender Minority Adults Assigned Male at Birth
Hall C, Ryan D, Hayford C, Morgan E, D'Aquila R, Mustanski B. Childhood Sexual Abuse, Alcohol Problem Scores, and Race Are Associated With Syphilis Incidence in a Prospective Cohort of Young Sexual and Gender Minority Adults Assigned Male at Birth. Sexually Transmitted Diseases 2024, 52: 266-271. PMID: 39681071, PMCID: PMC12258698, DOI: 10.1097/olq.0000000000002120.Peer-Reviewed Original ResearchConceptsChildhood sexual abuseSexual abuseSyndemic conditionsAlcohol problemsExperience childhood sexual abuseIndicators of sexual riskUnited StatesGender minoritiesViolence victimizationYoung sexualitiesTransgender womenAlcohol problem scoresComorbid healthBlack identitySexual riskSubstance useSyphilis risk factorsSyndemic frameworkAbuseYoung menMental healthSyphilis ratesGenderSyphilis incidenceRisk factorsHIV, inflammation, and initiation of methamphetamine use in sexual and gender minorities assigned male at birth
Carrico A, Ryan D, Berona J, Dominguez B, Schrock J, McDade T, Newcomb M, D’Aquila R, Mustanski B. HIV, inflammation, and initiation of methamphetamine use in sexual and gender minorities assigned male at birth. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2407046121. PMID: 39348540, PMCID: PMC11474050, DOI: 10.1073/pnas.2407046121.Peer-Reviewed Original ResearchConceptsMethamphetamine useHIV diagnosisRate of incidenceRisk factorsHigh C-reactive proteinC-reactive proteinCox proportional-hazards modelPrevalence of methamphetamine useProportional-hazards modelSGM peopleIdentified risk factorsGender minoritiesInitiation of methamphetamine useHIV seroconversionInflammatory measuresPoisson regression analysisCohort studyHIVMethamphetaminePreventive interventionsBirthInflammationRegression analysisIncidenceDiagnosisHuman induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient
Tatekoshi Y, Chen C, Shapiro J, Chang H, Blancard M, Lyra-Leite D, Burridge P, Feinstein M, D'Aquila R, Hsue P, Ardehali H. Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient. ELife 2024, 13: rp95867. PMID: 39331464, PMCID: PMC11434618, DOI: 10.7554/elife.95867.Peer-Reviewed Original ResearchConceptsHuman induced pluripotent stem cell-derived cardiomyocytesPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesCell-derived cardiomyocytesUptake in vitroHIV viremiaDiastolic dysfunctionHIV patientsCardiomyocyte relaxationSarcoplasmic reticulumSGLT2 inhibitorsHeart failurePotential new interventionsInflammatory cytokinesAnimal modelsHFpEFStudy molecular mechanismsMito-TEMPOCardiomyocytesCytokinesHIVPatientsRelaxation defectsPLWHSerumHuman induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient
Tatekoshi Y, Chen C, Shapiro J, Chang H, Blancard M, Lyra-Leite D, Burridge P, Feinstein M, D'Aquila R, Hsue P, Ardehali H. Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient. ELife 2024, 13 DOI: 10.7554/elife.95867.3.Peer-Reviewed Original ResearchHuman induced pluripotent stem cell-derived cardiomyocytesPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesCell-derived cardiomyocytesUptake in vitroCa 2HIV viremiaDiastolic dysfunctionCardiomyocyte relaxationHIV patientsSarcoplasmic reticulumSGLT2 inhibitorsHeart failurePotential new interventionsInflammatory cytokinesAnimal modelsHFpEFStudy molecular mechanismsMito-TEMPOCardiomyocytesHIVCytokinesRelaxation defectsPatientsPLWHAsymptomatic Rectal Bacterial Pathogens Show Large Prospective Relationships With HIV Incidence in a Cohort of Young Sexual and Gender Minorities: Implications for STI Screening and HIV Prevention
Baiers R, Ryan D, Clifford A, Munson E, D’Aquila R, Newcomb M, Mustanski B. Asymptomatic Rectal Bacterial Pathogens Show Large Prospective Relationships With HIV Incidence in a Cohort of Young Sexual and Gender Minorities: Implications for STI Screening and HIV Prevention. Open Forum Infectious Diseases 2024, 11: ofae444. PMID: 39183815, PMCID: PMC11342390, DOI: 10.1093/ofid/ofae444.Peer-Reviewed Original ResearchHIV seroconversionGeneralized Estimating EquationsChlamydia trachomatisNeisseria gonorrhoeaeHIV infectionPredictors of HIV seroconversionLongitudinal cohort studyPrevent HIV InfectionGender minoritiesSTI screeningRectal NGHIV preventionBiobehavioral interventionsHIV incidenceMultivariate GEE analysisAsymptomatic screeningMethods DataStatistically significant predictorsProspective relationshipHIVChicago metropolitan areaPredictive valueEstimating EquationsGEE analysisStatistically significant pairwise differencesThe Global Impact of Diversifying PrEP Options: Results of an International Discrete Choice Experiment of Existing and Potential PrEP Strategies with Gay and Bisexual Men and Physicians
Rael C, Giguere R, Tfaily E, Sutton S, Horn E, Schieffer R, Hendrix C, D’Aquila R, Hope T. The Global Impact of Diversifying PrEP Options: Results of an International Discrete Choice Experiment of Existing and Potential PrEP Strategies with Gay and Bisexual Men and Physicians. AIDS Research And Human Retroviruses 2024, 40: 591-605. PMID: 38753738, PMCID: PMC11693963, DOI: 10.1089/aid.2023.0120.Peer-Reviewed Original ResearchNorthwestern University resource and education development initiatives to advance collaborative artificial intelligence across the learning health system
Luo Y, Mao C, Sanchez‐Pinto L, Ahmad F, Naidech A, Rasmussen L, Pacheco J, Schneider D, Mithal L, Dresden S, Holmes K, Carson M, Shah S, Khan S, Clare S, Wunderink R, Liu H, Walunas T, Cooper L, Yue F, Wehbe F, Fang D, Liebovitz D, Markl M, Michelson K, McColley S, Green M, Starren J, Ackermann R, D'Aquila R, Adams J, Lloyd‐Jones D, Chisholm R, Kho A. Northwestern University resource and education development initiatives to advance collaborative artificial intelligence across the learning health system. Learning Health Systems 2024, 8: e10417. PMID: 39036530, PMCID: PMC11257059, DOI: 10.1002/lrh2.10417.Peer-Reviewed Original ResearchLearning health systemCollaborative AIMultidisciplinary workforceHealth systemArtificial intelligenceCollaborative artificial intelligenceDevelopment of artificial intelligenceLanguage processing pipelinePeer-reviewed publicationsHealth workforceHealthcare initiativesExtract structural informationAI/machine learningHealth informationHospital administratorsClinical specialtiesHealthcare dataEducational resourcesAI methodsAI scientistsUnmet needsPractical resourcesData modelHealthcareProcessing pipeline
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