Qing Lan, MD, PhD
Professor Adjunct of Epidemiology (Environmental Health)About
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Titles
Professor Adjunct of Epidemiology (Environmental Health)
Professor Adjunct, Environmental Health Sciences
Biography
Dr. Qing Lan a world leader in environmental and occupational exposures, human health studies and gene environment interaction. Her research focuses on molecular epidemiologic studies of populations exposed to several classes of chemical compounds that are known or suspected occupational and environmental carcinogens. She is one of YSPH’s main collaborators at NCI studying environmental exposures, genetic susceptibility for NHL and multiple myeloma, indoor air pollution and gene polymorphisms for lung cancer risk in Xuanwei, China. She has mentored several YSPH PhD candidates.
Dr. Lan received her M.D. at Weifang Medical University and her Ph.D. in molecular epidemiology at the Chinese Academy of Preventive Medicine in Beijing, as part of a joint training program with the United States Environmental Protection Agency and University of North Carolina at Chapel Hill, and received her MPH at Johns Hopkins University.
Appointments
Environmental Health Sciences
Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- PhD
- Chinese Academy of Preventive Medicine (2001)
- MD
- Weifang Medical College (1985)
Research
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Overview
Public Health Interests
ORCID
0000-0002-8468-4942
Research at a Glance
Yale Co-Authors
Publications Timeline
Melissa Friesen
Huey Cai
Publications
2025
Benzene Metabolism Is Dominated by a High-Affinity Pathway at Ambient Exposures with Implications for Cancer Risks
Thomas R, Kim S, Lan Q, Vermeulen R, Zhang L, Rothman N, Smith M, Rappaport S. Benzene Metabolism Is Dominated by a High-Affinity Pathway at Ambient Exposures with Implications for Cancer Risks. International Journal Of Molecular Sciences 2025, 26: 8550. PMID: 40943470, PMCID: PMC12428784, DOI: 10.3390/ijms26178550.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsHigh-affinity pathwayMichaelis-Menten-like modelLow-affinity pathwayMetabolic pathwaysToxic benzene metabolitesInitial metabolismPathwayNonsmoking malesComplex metabolismMetabolismLow affinityHigher affinitySmoking malesCancer riskLung metabolismAir concentrationsMetabolic rateTwo-pathway modelBlood cancerLiver metabolismBioactivation of benzeneAmbient benzene concentrationsLung adenomasLung-cancer incidenceNever smokersPre-diagnostic serum concentrations of free light chains and risk of non-Hodgkin lymphoma in a population-based prospective study
Hu W, Landgren O, Bassig B, Purdue M, Engels E, Lan Q, Rothman N. Pre-diagnostic serum concentrations of free light chains and risk of non-Hodgkin lymphoma in a population-based prospective study. Leukemia & Lymphoma 2025, ahead-of-print: 1-8. PMID: 40671387, DOI: 10.1080/10428194.2025.2524505.Peer-Reviewed Original ResearchConceptsSerum free light chainsNon-Hodgkin's lymphomaMonoclonal B-cell lymphocytosisFree light chainsFollicular lymphomaElevated serum free light chainsAIDS-related non-Hodgkin's lymphomaRisk of non-Hodgkin lymphomaPost-transplant lymphoproliferative disorderSmall lymphocytic lymphomaIncident NHL casesB-cell lymphocytosisAssociated with increased riskChronic lymphocytic leukemiaFollow-up timePopulation-based prospective studyPre-diagnostic samplesLight chainProspective ProstateLymphocytic lymphomaNHL casesLymphoproliferative disordersMonoclonal patternNHL riskLymphocytic leukemiaEvaluation of pressure-induced pain in patients with disorders of consciousness based on functional near infrared spectroscopy
Zhang T, Wang N, Chai X, He Q, Cao T, Yuan L, Lan Q, Yang Y, Zhao J. Evaluation of pressure-induced pain in patients with disorders of consciousness based on functional near infrared spectroscopy. Frontiers In Neurology 2025, 16: 1542691. PMID: 40260139, PMCID: PMC12009939, DOI: 10.3389/fneur.2025.1542691.Peer-Reviewed Original ResearchAltmetricConceptsDorsolateral prefrontal cortexPrimary somatosensory cortexFunctional connectivitySomatosensory association cortexPainful stimulationPain-induced brain activationDisorders of consciousnessPain-related brain areasPrimary motor cortexTemporal gyrusPressure pain stimulationFrontopolar areaBrain activityHemodynamic responsePressure-induced painNear-infrared spectroscopyEnhanced functional connectivityProcessing pain informationTarget brain regionsNo significant changesPain informationPain processingBrain hemodynamic responsesPrefrontal cortexPatientsBenzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohort
Babigumira R, Veierød M, Larsen I, Berge L, Shala N, Marjerrison N, Samuelsen S, Bråtveit M, Kirkeleit J, Nordby K, Hosgood H, Demers P, Vermeulen R, Kromhout H, Engel L, Nilsen T, Silverman D, Friesen M, Rothman N, Lan Q, Grimsrud T, Stenehjem J. Benzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohort. Environmental Research 2025, 276: 121407. PMID: 40118315, DOI: 10.1016/j.envres.2025.121407.Peer-Reviewed Original ResearchAltmetricConceptsRisk of colorectal cancerOffshore petroleum workersJob-exposure matrixHazard ratioColorectal cancerAnatomic subsiteColorectal cancer riskConfidence intervalsColorectal cancer casesEstimate hazard ratiosCase-cohort analysisPetroleum workersWork historyExposure-response associationsPositive exposure-response associationsBody mass indexRight-sided colon cancerPublic health implicationsPhysical activityBenzene exposureMeat intakeAlcohol intakeQuartile 4Mass indexCase cohortHSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism
Imani P, Grigoryan H, Dudoit S, Shu X, Wong J, Zhang L, Zhang J, Hu W, Cai Q, Gao Y, Blechter B, Rahman M, Zheng W, Rothman N, Lan Q, Rappaport S. HSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism. Antioxidants 2025, 14: 335. PMID: 40227422, PMCID: PMC11939640, DOI: 10.3390/antiox14030335.Peer-Reviewed Original ResearchCitationsConceptsPolycyclic aromatic hydrocarbonsNever-smokersAir pollutionLung cancerOne-carbon metabolismAirborne fine particulate matterLung adenocarcinomaUrinary polycyclic aromatic hydrocarbonsFine particulate matterShanghai Women's Health StudyWomen's Health StudySmoking-related cancersReactive oxygen speciesIncidence of lung adenocarcinomaAromatic hydrocarbonsLung cancer casesParticulate matterEast Asian womenHealth StudyCancer casesAsian womenDietary factorsPollutionHuman serum albuminHigher incidenceSex Differences in Anti–Epstein-Barr Virus Antibody Responses
Jackson S, Francis J, Pfeiffer R, Proietti C, Coghill A, Yu K, Sarathkumara Y, Hsu W, Argirion I, Wang C, Chen C, Rothman N, Lan Q, Hildesheim A, Doolan D, Liu Z. Sex Differences in Anti–Epstein-Barr Virus Antibody Responses. The Journal Of Infectious Diseases 2025, jiaf067. PMID: 39932888, PMCID: PMC12372535, DOI: 10.1093/infdis/jiaf067.Peer-Reviewed Original ResearchCitationsOverview of historical occupational exposure to trichloroethylene in China
Nie J, Ge C, Rothman N, Hu W, Vermeulen R, Lan Q, Peters S. Overview of historical occupational exposure to trichloroethylene in China. Annals Of Work Exposures And Health 2025, 69: 251-260. PMID: 39851217, PMCID: PMC11911510, DOI: 10.1093/annweh/wxae103.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsSensitivity to Environmental Stress and Adversity and Lung Cancer
Chen Y, Lan Q, Yu J, Godbole D, Byun J, Amos C, Zhang H. Sensitivity to Environmental Stress and Adversity and Lung Cancer. JAMA Network Open 2025, 8: e2457079. PMID: 39878978, PMCID: PMC11780474, DOI: 10.1001/jamanetworkopen.2024.57079.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLung cancer riskAssociated with lung cancer riskInternational Lung Cancer ConsortiumIndividuals of European ancestryCancer riskGenetic association studiesMendelian randomizationCross-ancestryCancer ConsortiumAssociation studiesInfluence lung cancer riskIncreased risk of lung cancerEuropean ancestryRisk of lung cancerGenome-Wide Meta-AnalysisIncreased riskGenome-wide association studiesLung cancer casesIndividuals of African ancestryIndividuals of East Asian ancestryEast Asian ancestryUK BiobankPsychosocial factorsMain OutcomesCancer cases
2024
The need for a cancer exposome atlas: a scoping review
Young A, Mullins C, Sehgal N, Vermeulen R, Kolijn P, Vlaanderen J, Rahman M, Birmann B, Barupal D, Lan Q, Rothman N, Walker D. The need for a cancer exposome atlas: a scoping review. JNCI Cancer Spectrum 2024, 9: pkae122. PMID: 39700422, PMCID: PMC11729703, DOI: 10.1093/jncics/pkae122.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCancer riskGenetic susceptibility to cancerStudy design limitationsSusceptibility to cancerCancer heritabilitySocial determinantsCancer epidemiologyExposome approachProspective associationsExternal risk factorsCancer casesPrimary preventionUnmet opportunitiesCancer researchChemical exposure profilesEnvironmental exposuresRisk factorsExposomeEvaluate progressCancer typesCancerRiskExposure profilesEnvironmental influencesLifestyleIntegrated surgical intervention for intradural extramedullary hemangioblastoma of the cervical spine: a case report and literature review
Wang Y, Zhu Q, Chen A, Dai C, Xu L, Sheng M, Huang Q, Lan Q, Mu Q, Li R. Integrated surgical intervention for intradural extramedullary hemangioblastoma of the cervical spine: a case report and literature review. Frontiers In Oncology 2024, 14: 1387005. PMID: 39600635, PMCID: PMC11588709, DOI: 10.3389/fonc.2024.1387005.Peer-Reviewed Original ResearchAltmetricConceptsIntradural extramedullary hemangioblastomaVon Hippel-Lindau syndromeExtramedullary hemangioblastomaHippel-Lindau syndromeComplete resectionC6-C7 vertebral levelsIncreased risk of recurrenceIntraoperative bleeding riskElevated risk of bleedingComplete tumor resectionSpinal cord tumorsRisk of recurrenceRisk of bleedingSatisfactory postoperative recoveryUpregulation of CD31Hybrid operating roomInjection of embolic agentsPyramidal tract signsMuscle strengthExtramedullary regionOcclusion of blood vesselsCombined surgeryFenestration surgerySpinal hemangioblastomasSpinal tumors
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