Deus Thindwa, PhD
Postdoctoral AssociateAbout
Research
Publications
2025
The Complex Landscape of Updated Pneumococcal Conjugate Vaccines
Thindwa D, Shapiro E, Weinberger D. The Complex Landscape of Updated Pneumococcal Conjugate Vaccines. Open Forum Infectious Diseases 2025, 12: ofaf050. PMID: 39968305, PMCID: PMC11834978, DOI: 10.1093/ofid/ofaf050.Peer-Reviewed Original Research
2024
Estimating pneumococcal carriage dynamics in adults living with HIV in a mature infant pneumococcal conjugate vaccine programme in Malawi, a modelling study
Phiri J, Sibale L, Mlongoti L, Mitole N, Kusakala A, Khwiya M, Kayembe T, Lisimba E, Kapwata P, Malisita K, Chaguza C, Ferreira D, Thindwa D, Jambo K. Estimating pneumococcal carriage dynamics in adults living with HIV in a mature infant pneumococcal conjugate vaccine programme in Malawi, a modelling study. BMC Medicine 2024, 22: 419. PMID: 39334289, PMCID: PMC11438070, DOI: 10.1186/s12916-024-03631-5.Peer-Reviewed Original ResearchConceptsNon-PCV13 serotypesAntiretroviral therapyPneumococcal carriage prevalencePneumococcal carriageCarriage prevalenceHIV- adultsStudy groupCarriage acquisitionDetect pneumococcal carriageAntiretroviral therapy durationHuman immunodeficiency virusSocial economic statusPneumococcal conjugate vaccination programmeMultivariate longitudinal analysesPCV13 serotypesProlonged carriageImmunodeficiency virusMedian ageHIV individualsNasopharyngeal clearancePneumococcal serotypesALWHIVLatex agglutinationCulture microbiologyPoint prevalenceModelling Salmonella Typhi in high-density urban Blantyre neighbourhood, Malawi, using point pattern methods.
Khaki JJ, Meiring JE, Thindwa D, Henrion MYR, Jere TM, Msuku H, STRATAA Consortium, Heyderman RS, Gordon MA, Giorgi E. Modelling Salmonella Typhi in high-density urban Blantyre neighbourhood, Malawi, using point pattern methods. Sci Rep 2024, 14: 17164. PMID: 39060281, DOI: 10.1038/s41598-024-66436-9.Peer-Reviewed Original ResearchPathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study
Dyson Z, Ashton P, Khanam F, Chirambo A, Shakya M, Meiring J, Tonks S, Karkey A, Msefula C, Clemens J, Dunstan S, Baker S, Dougan G, Pitzer V, Basnyat, Qadri F, Heyderman R, Gordon M, Pollard A, Holt K, Group S, Banda H, Biswas P, Bhuiyan A, Blohmke C, Darton T, Dolecek C, Dongol S, Mujadidi Y, Hill J, Hoang N, Jere T, Mbewe M, Msuku H, Nga T, Nkhata R, Rahman S, Rahman N, Saad N, Tan T, Thindwa D, Voysey M, Wachepa R. Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study. The Lancet Microbe 2024, 5: 100841. PMID: 38996496, PMCID: PMC11300424, DOI: 10.1016/s2666-5247(24)00047-8.Peer-Reviewed Original ResearchParatyphi ASerovars TyphiPathogenic variantsAntimicrobial resistanceSalmonella enterica serovar TyphiEnteric feverAncestral state reconstructionS paratyphi ADeterminants of antimicrobial resistanceSingle-nucleotide variantsAntimicrobial resistance determinantsQuinolone-resistance mutationsAntimicrobial resistance transmissionCore genomePhylogenomic analysisAzithromycin resistance mutationsPhylogenetic analysisGenomic dataPopulation structurePathogen diversityS typhiTransmission of resistant strainsGenomic epidemiologyAntimicrobial resistant infectionsAge groupsGlobal patterns of rebound to normal RSV dynamics following COVID-19 suppression
Thindwa D, Li K, Cooper-Wootton D, Zheng Z, Pitzer V, Weinberger D. Global patterns of rebound to normal RSV dynamics following COVID-19 suppression. BMC Infectious Diseases 2024, 24: 635. PMID: 38918718, PMCID: PMC11201371, DOI: 10.1186/s12879-024-09509-4.Peer-Reviewed Original ResearchWorkshop on the design and use of clinical trials with multiple endpoints, with a focus on prevention of RSV
O. Prunas, J. Willemsen, J.L. Warren, L. et al.Peer-Reviewed Case Reports and Technical NotesEvaluating the relationship between ciprofloxacin prescription and non-susceptibility in Salmonella Typhi in Blantyre, Malawi: an observational study.
Ashton PM, Chunga Chirambo A, Meiring JE, Patel PD, Mbewe M, Silungwe N, Chizani K, Banda H, Heyderman RS, Dyson ZA, MacPherson P, Henrion MYR, STRATAA Study Group, Holt KE, Gordon MA. Evaluating the relationship between ciprofloxacin prescription and non-susceptibility in Salmonella Typhi in Blantyre, Malawi: an observational study. Lancet Microbe 2024, 5: e226-e234. PMID: 38387472, DOI: 10.1016/S2666-5247(23)00327-0.Peer-Reviewed Original Research
2023
Cost-effectiveness analysis of typhoid conjugate vaccines in an outbreak setting: a modeling study
Phillips M, Antillon M, Bilcke J, Bar-Zeev N, Limani F, Debellut F, Pecenka C, Neuzil K, Gordon M, Thindwa D, Paltiel A, Yaesoubi R, Pitzer V. Cost-effectiveness analysis of typhoid conjugate vaccines in an outbreak setting: a modeling study. BMC Infectious Diseases 2023, 23: 143. PMID: 36890448, PMCID: PMC9993384, DOI: 10.1186/s12879-023-08105-2.Peer-Reviewed Original ResearchConceptsTyphoid Conjugate VaccineRoutine vaccinationReactive vaccinationVaccination strategiesOutbreak settingsMultidrug-resistant Salmonella typhiQueen Elizabeth Central HospitalTyphoid fever epidemicYears of ageMonths of ageCost-effectiveness analysisWorld Health OrganizationConjugate vaccineCentral HospitalRoutine immunizationVaccine deploymentPreventive vaccinationVaccinationTyphoid feverCost-effective strategyAge 15Health OrganizationFever epidemicAntimicrobial resistanceOutbreak definitionsOptimal age targeting for pneumococcal vaccination in older adults; a modelling study.
Thindwa D, Clifford S, Kleynhans J, von Gottberg A, Walaza S, Meiring S, Swarthout TD, Miller E, McIntyre P, Andrews N, Amin-Chowdhury Z, Fry N, Jambo KC, French N, Almeida SCG, Ladhani SN, Heyderman RS, Cohen C, de Cunto Brandileone MC, Flasche S. Optimal age targeting for pneumococcal vaccination in older adults; a modelling study. Nat Commun 2023, 14: 888. PMID: 36797259, DOI: 10.1038/s41467-023-36624-8.Peer-Reviewed Original ResearchUnmasking Pneumococcal Carriage in a High Human Immunodeficiency Virus (HIV) Prevalence Population in two Community Cohorts in South Africa, 2016-2018: The PHIRST Study.
Carrim M, Tempia S, Thindwa D, Martinson NA, Kahn K, Flasche S, Hellferscee O, Treurnicht FK, McMorrow ML, Moyes J, Mkhencele T, Mathunjwa A, Kleynhans J, Lebina L, Mothlaoleng K, Wafawanaka F, Gómez-Olivé FX, Cohen C, von Gottberg A, Wolter N, PHIRST group. Unmasking Pneumococcal Carriage in a High Human Immunodeficiency Virus (HIV) Prevalence Population in two Community Cohorts in South Africa, 2016-2018: The PHIRST Study. Clin Infect Dis 2023, 76: e710-e717. PMID: 35717655, DOI: 10.1093/cid/ciac499.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Get In Touch
Contacts
Locations
350 George Street
Academic Office
New Haven, CT 06511