Daniel Zelterman, PhD
Professor Emeritus of BiostatisticsCards
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Titles
Professor Emeritus of Biostatistics
Biography
Developed discrete distributions in statistics with applications to clustering of family traits. Author of eight books on statistical methods. Plays oboe and bassoon in amateur orchestra groups. Enjoys hiking and backpacking.
Last Updated on April 07, 2025.
Appointments
Biostatistics
EmeritusPrimary
Other Departments & Organizations
- All Institutions
- Biostatistics
- Center for Interdisciplinary Research on AIDS
- SPORE in Lung Cancer
- Yale School of Public Health
- Yale Ventures
- Yale-BI Biomedical Data Science Fellowship
- Yale-UPR Integrated HIV Basic and Clinical Sciences Initiative
Education & Training
- PhD
- Yale University (1983)
Research
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Overview
Medical Research Interests
Acquired Immunodeficiency Syndrome; Biomarkers, Pharmacological; Biostatistics; Computational Biology; Epidemiology; Genetics; Statistics
Public Health Interests
Cancer; Biomarkers; Bioinformatics; Genetics, Genomics, Epigenetics; Modeling; HIV/AIDS
ORCID
0000-0003-0711-8688
Research at a Glance
Yale Co-Authors
Frequent collaborators of Daniel Zelterman's published research.
Publications Timeline
A big-picture view of Daniel Zelterman's research output by year.
Ondrej Blaha, PhD
Wei Wei, PhD
Michael Kane, PhD, MA, MS
Becca Levy, PhD
Amer Zeidan, MBBS, MD
Denise Esserman, PhD
148Publications
3,469Citations
Publications
2026
Change-Point Homogeneity in Piecewise Exponential Survival
Yu C, Wei W, Zelterman D. Change-Point Homogeneity in Piecewise Exponential Survival. Journal Of Statistical Theory And Practice 2026, 20: 32. DOI: 10.1007/s42519-026-00551-w.Peer-Reviewed Original ResearchConceptsChange-pointsIndividual survival timesLikelihood ratio testHazard functionExponential distributionGraphical diagnosticsFailure timeExponential survivalNull hypothesisRatio testDensity functionLow risk of disease progressionSurvival timeRisk of disease progressionLow riskDatabase of womenPiecewiseBreast cancerDisease progressionRenal patientsA joint distribution for indexes of extremes with applications to climate change
Yu C, Kane M, Blaha O, Wei W, Esserman D, Zelterman D. A joint distribution for indexes of extremes with applications to climate change. Statistics And Its Interface 2026, 19: 197-209. DOI: 10.4310/sii.260108021930.Peer-Reviewed Original Research
2025
The Maximum Negative Hypergeometric Distribution
Yu C, Prishwalko K, Blaha O, Kane M, Wei W, Esserman D, Zelterman D. The Maximum Negative Hypergeometric Distribution. Journal Of Statistical Theory And Practice 2025, 19: 88. DOI: 10.1007/s42519-025-00502-x.Peer-Reviewed Original Research
2024
Distributions and Their Approximations for p-Values
Zhou N, Blaha O, Zelterman D. Distributions and Their Approximations for p-Values. 2024, 481-509. DOI: 10.1007/978-3-031-65937-9_16.Peer-Reviewed Original ResearchCitationsConceptsDistribution of p-valuesStudent-t distributionTesting multiple hypothesesT-distributionAlternative distributionsIdentified hypothesisSimulation studySignificant hypothesesDependent samplesApproximationAlternative hypothesisP-valueLack of independenceMultiple hypothesesExamplesIterationMultiplicationDistributionEstimationPerioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer
Cecchini M, Salem R, Robert M, Czerniak S, Blaha O, Zelterman D, Rajaei M, Townsend J, Cai G, Chowdhury S, Yugawa D, Tseng R, Arbelaez C, Jiao J, Shroyer K, Thumar J, Kortmansky J, Zaheer W, Fischbach N, Persico J, Stein S, Khan S, Cha C, Billingsley K, Kunstman J, Johung K, Wiess C, Muzumdar M, Spickard E, Aushev V, Laliotis G, Jurdi A, Liu M, Escobar-Hoyos L, Lacy J. Perioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer. JAMA Oncology 2024, 10: 1027-1035. PMID: 38900452, PMCID: PMC11190830, DOI: 10.1001/jamaoncol.2024.1575.Peer-Reviewed Original ResearchCitationsAltmetricConceptsProgression-free survivalPancreatic ductal adenocarcinomaOverall survivalCtDNA levelsPhase 2 nonrandomized controlled trialAnalysis of circulating tumor DNAMedian progression-free survivalResectable pancreatic ductal adenocarcinomaControlled TrialsAssess surgical candidacyBaseline ctDNA levelModified 5-fluorouracilResectable pancreatic cancerPancreatic protocol computed tomographyAssociated with recurrenceTumor molecular featuresAggressive malignant tumorKaplan-Meier estimatesRandomized clinical trialsStandard of careCtDNA-positivePreoperative cyclesNonrandomized controlled trialsUnresectable diseaseModified FOLFIRINOXA Bayesian platform trial design with hybrid control based on multisource exchangeability modelling
Wei W, Blaha O, Esserman D, Zelterman D, Kane M, Liu R, Lin J. A Bayesian platform trial design with hybrid control based on multisource exchangeability modelling. Statistics In Medicine 2024, 43: 2439-2451. PMID: 38594809, PMCID: PMC11325877, DOI: 10.1002/sim.10077.Peer-Reviewed Original ResearchCitations
2023
Laparotomy versus Peritoneal Drainage for Necrotizing Enterocolitis and Perforation
Moss R, Dimmitt R, Barnhart D, Zelterman D, Silverman B. Laparotomy versus Peritoneal Drainage for Necrotizing Enterocolitis and Perforation. 2023, 51-53. DOI: 10.1201/b23252-18.Peer-Reviewed Original ResearchConceptsNecrotising enterocolitisPremature infantsPeritoneal drainagePrimary peritoneal drainageMulticentre randomized trialNeonatal centrePreterm infantsNeonatal surgeryNecrotizing enterocolitisSurgical managementBowel resectionOptimal treatmentPaediatric surgeryRandomized trialsSurgical trialsEnterocolitisInfantsLaparotomySurgeryMortalityMorbidityTrialsStatistically evaluate differencesPretermResectionAKT/mTOR signaling modulates resistance to endocrine therapy and CDK4/6 inhibition in metastatic breast cancers
Abu-Khalaf M, Alex Hodge K, Hatzis C, Baldelli E, El Gazzah E, Valdes F, Sikov W, Mita M, Denduluri N, Murphy R, Zelterman D, Liotta L, Dunetz B, Dunetz R, Petricoin E, Pierobon M. AKT/mTOR signaling modulates resistance to endocrine therapy and CDK4/6 inhibition in metastatic breast cancers. Npj Precision Oncology 2023, 7: 18. PMID: 36797347, PMCID: PMC9935518, DOI: 10.1038/s41698-023-00360-5.Peer-Reviewed Original ResearchCitationsAltmetricConceptsEndocrine therapyProgressive diseaseCDK4/6 inhibitionImmune cellsTumor epitheliumOpen-label multicenter clinical trialMetastatic breast cancer patientsPI3K/AKT/mTOR activationFirst-line treatmentMetastatic breast cancerBreast cancer patientsAkt/mTOR activationMulticenter clinical trialAkt/mTORMBC patientsCancer patientsPredictive markerClinical trialsDisease progressionBreast cancerTreatment selectionTissue biopsiesPatientsNumber of FDAMTOR activationImplicit and Explicit Dehumanization of Older Family Members: Novel Determinants of Elder Abuse Proclivity
Chang E, Monin J, Isenberg N, Zelterman D, Levy B. Implicit and Explicit Dehumanization of Older Family Members: Novel Determinants of Elder Abuse Proclivity. Stigma And Health 2023, 8: 40-48. PMID: 37092028, PMCID: PMC10120856, DOI: 10.1037/sah0000370.Peer-Reviewed Original ResearchCitationsAltmetricConceptsExplicit dehumanizationElder abuseSelf-reported factorsOlder personsPsychological factorsOlder family membersCare-recipient healthDehumanizationFamily caregiversCurrent studyCaregiver burdenAbuseMost researchCaregiversProclivityWeb-based surveyRelevant covariatesPersonsCaregiver-based interventionsFamily membersVictimsHealthInterventionRelianceNovel determinant
2022
Regression methods for the appearances of extremes in climate data
Yu C, Blaha O, Kane M, Wei W, Esserman D, Zelterman D. Regression methods for the appearances of extremes in climate data. Environmetrics 2022, 33 DOI: 10.1002/env.2764.Peer-Reviewed Original ResearchCitationsConcepts
Academic Achievements & Community Involvement
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News & Links
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Media
- In the French countryside
- Following a recent orchestra concert
- Blazing the Appalachian Trail in the Green Mountains of Vermont
News
- June 20, 2024
Chemotherapy Before Surgery Benefits Some Patients With Pancreatic Cancer
- December 12, 2022
4 longtime biostatistics professors look back on their years at YSPH
- June 30, 2020
Senior YSPH Professors Retiring
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Emeritus Faculty
PO Box 1115
W Townshend, VT 05359
United States