What is your current job?
I am a biostatistician at a pharmaceutical company.
Describe your work and why you find it rewarding/challenging.
I have been leading the statistical efforts in the post-market stage of oncology drugs, focusing on activities such as health technology assessment (HTA) submissions, health economics outcome research, and real-world evidence studies. My role involves analyzing data from clinical trials and real-world studies to provide insights into the effectiveness, safety, and quality of life (QoL) of new drugs. This requires me to collaborate closely with market access experts, clinicians, and other professionals to design and implement studies that yield reliable and meaningful results.
For me, one of the most rewarding aspects of my work is the knowledge that the insights we generate can directly impact people's lives. For example, I recently participated in an oral explanation for orphan drug designation for European Medical Agency (EMA) submission. By applying indirect treatment comparison methods, I helped demonstrate the superiority of our drug in QoL outcomes. This answered the question from EMA and contributed to the final approval of the orphan drug status. I felt fulfilled knowing that the approval will help patients access the new drug faster.
The [YSPH Biostatistics] program provided me with a strong foundation in statistical theory and methods, as well as extensive training in the practical application of these methods in the context of health economics and outcome research.
Huangdi (Denise) Yi
However, my work also presents significant challenges. Clinical trials and real-world data can be both complex and difficult, when it comes to accounting for all the variables that may impact a patient's response to treatment. Additionally, we constantly adapt our statistical methods and techniques to ensure we generate the most accurate and useful insights possible. Overcoming these obstacles and generating insights that can improve patients’ lives is what makes my work rewarding.
How did YSPH prepare you for your current work?
YSPH played a critical role in preparing me for my current work as a biostatistician in the pharmaceutical industry. The program provided me with a strong foundation in statistical theory and methods, as well as extensive training in the practical application of these methods in the context of health economics and outcome research.
One of the key strengths of YSPH is its emphasis on interdisciplinary collaboration. Throughout my time at Yale, I had the opportunity to work with professors and post-docs from a wide range of disciplines, including epidemiology, environmental health, and health policy. This gave me a deep appreciation for the complexity and interconnectedness of health issues and helped me develop the communication and collaboration skills that are essential in my current work.
Through a combination of coursework and hands-on research experience, I learned how to apply advanced statistical learning methods to real-world problems in health research. This included working on projects related to clinical trials and observational studies, among others.
Overall, the training that I received at YSPH has been invaluable in preparing me for my current work as a biostatistician in the pharmaceutical industry. The program gave me the technical skills, interdisciplinary perspective, and practical experience that I need to work collaboratively with colleagues from a variety of backgrounds to tackle some of the most pressing health challenges of our time.
Do you have a favorite YSPH experience you can share?
One of the things that I appreciate is the sense of community that is fostered within the Biostatistics PhD program. From the very beginning of the program, students are encouraged to collaborate and build relationships with one another, both in and out of the classroom. There are numerous opportunities for socializing and networking, including seminars, workshops, and social events organized by the Department of Biostatistics and YSPH.
What advice do you have for current/future students?
Get involved in research projects early. One of the best ways to gain practical experience in biostatistics/public health is to participate in research projects. Look for opportunities to work with faculty members, research centers (e.g., YCAS, CORE, VA) to get involved in projects that interest you.
Attend seminars, workshops, and other events. The Department of Biostatistics offers weekly seminars, a lot of workshops, and other events that can help you learn about new methodologies, develop your skills, and network with other students and faculty members. Take advantage of these opportunities to expand your knowledge and meet new people.
Seek out mentorship and guidance. YSPH has an incredibly supportive mentorship program, and there are many alumni and staff who are happy to offer mentorship and guidance. Don't be afraid to ask for advice or help when you need it.
Were there any faculty/staff mentors who influenced your YSPH experience?
First of all, I give my deepest gratitude to my advisor, Dr. Shuangge (Steven) Ma, who not only led me into the world of science but also gave me a lot of valuable advice for my career and life as well. Throughout the years, Dr. Ma provided the best support I could ever ask for. Whenever I got stuck in a project, he was always available and willing to help. I felt very lucky and honored to have Dr. Ma as my advisor at Yale. His confidence in me and high expectations challenged me to improve myself.
I would also like to express my sincere gratitude to Dr. Christian Tschudi and Ms. Melanie Elliot. They were like the dad and mom of all the PhD students at YSPH. I was so grateful that they were always there for me, especially when I was finishing up my PhD and had tons of questions about the procedure.