2009
Inhibition of Neutrophil Function by Two Tick Salivary Proteins
Guo X, Booth CJ, Paley MA, Wang X, DePonte K, Fikrig E, Narasimhan S, Montgomery RR. Inhibition of Neutrophil Function by Two Tick Salivary Proteins. Infection And Immunity 2009, 77: 2320-2329. PMID: 19332533, PMCID: PMC2687334, DOI: 10.1128/iai.01507-08.Peer-Reviewed Original ResearchConceptsPolymorphonuclear leukocytesPMN functionNumber of PMNPMN integrinsPMN adherenceNeutrophil functionSpirochete burdenTick salivary proteinsTick salivaLyme diseaseTick attachmentSalivary glandsBorrelia burgdorferiTick feedingCausative agentReduced levelsInhibitory proteinSalivaBlood mealAntihemostatic activityInfectionInhibitionSalivary proteinsHematophagous arthropodsTick Ixodes scapularis
1986
Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein.
Montgomery RR, Nathan CF, Cohn ZA. Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 6631-6635. PMID: 3018740, PMCID: PMC386558, DOI: 10.1073/pnas.83.17.6631.Peer-Reviewed Original ResearchConceptsLow-density lipoproteinDensity lipoproteinHuman monocytesModification of LDLUntreated low-density lipoproteinOxidation of LDLThiobarbituric acidAortic endothelial cell linePhorbol myristate acetateEndothelial cell lineReactive oxygen intermediatesCell line monolayersRespiratory burstMyristate acetateMacrophagesMouse macrophagesReagent H2O2Cell linesOxygen intermediatesMonocytesLipoproteinTBA reactivityHuman plasmaMaximal oxidation