Clinical Trials

Faculty and research staff in the Department of Biostatistics collaborate with clinical researchers across the medical school, Yale New Haven Hospital and the Veterans Administration health system. Biostatisticians comprehensively integrate study design, data management and statistical analysis into Yale’s clinical research to maximize the information gained and disseminated from pivotal medical research. Our department can provide full-service support through faculty investigators, statistical researchers and analysts and data coordinating services provided by the Yale Center for Analytical Sciences and the Collaborative Center for Statistics in Science. Our faculty have expertise in a wide variety of disease areas and topics, including aging, cancer, tobacco use and smoking, mental health and infectious disease.

Faculty of Interest

Heather Allore, PhD
Professor of Medicine (Geriatrics) and of Biostatistics; Leader, Data Management and Statistics Core, Yale Alzheimer's Disease Research Center, Internal Medicine; Associate Director of Gerontologic Biostatistical Methods, Internal Medicine: Geriatrics; Senior Biostatistician and Epidemiologist, Internal Medicine: Rheumatology; Co-Director of Biostatistical Core, Internal Medicine: Geriatrics
Research Interests
Statistics as Topic
Mathematical Concepts
Aging
Biostatistics
Epidemiologic Methods
Geriatrics
Frail Elderly
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Wei Cheng, PhD
Associate Research Scientist in Biostatistics; Yale Cancer Center, Yale School of Medicine
Research Interests
Health Services Research
Network Meta-Analysis
Systematic Review
Evidence-Based Medicine
Electronic Health Records
Clinical Trial
Cohort Studies
Comparative Effectiveness Research
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Elizabeth Claus, PhD, MD
Professor of Biostatistics; Director of Medical Research, School of Public Health
Research Interests
Glioma
Epidemiology
Breast Neoplasms
Central Nervous System Neoplasms
Astrocytoma
Oligodendroglioma
Neurosurgery
Meningioma
Statistics as Topic
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Denise Esserman, PhD
Professor of Biostatistics
Research Interests
Longitudinal Studies
Randomized Controlled Trial
Sampling Studies
Public Health
Biostatistics
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Erich J Greene, PhD
Research Scientist in Biostatistics
Research Interests
Biostatistics
Clinical Trial
Data Interpretation, Statistical
Mathematical Computing
Models, Statistical
Pragmatic Clinical Trial
Statistics
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Ralitza Gueorguieva, PhD
Senior Research Scientist in Biostatistics; Director of Biostatistics in Psychiatry
Research Interests
Biostatistics
Models, Statistical
Psychiatry
Research Design
Risk Assessment
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Raul U. Hernandez-Ramirez, PhD
Research Scientist in Biostatistics (CMIPS); Director, Dissemination and Implementation Science Methods (DISM) Core, Center for Interdisciplinary Research on AIDS; Affiliated Faculty, Yale Institute for Global Health
Research Interests
Environmental Health
Epidemiology
Clinical Trials as Topic
Global Health
Stomach Neoplasms
Translational Research, Biomedical
Nutritional Sciences
HIV
Neoplasms
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Theodore Holford, PhD
Susan Dwight Bliss Professor Emeritus of Biostatistics and Senior Research Scientist in Biostatistics; Affiliated Faculty, Yale Institute for Global Health
Research Interests
Public Health
Statistics
Asthma
Geographic Information Systems
Global Health
Lung Neoplasms
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Yuan Huang, PhD
Assistant Professor of Biostatistics (Biostatistics)
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Fan Li, PhD
Associate Professor of Biostatistics and Associate Professor of Medicine (Cardiovascular Medicine)
Research Interests
Cardiovascular Diseases
Epidemiologic Methods
Longitudinal Studies
Research Design
Selection Bias
Causality
Survival Analysis
Randomized Controlled Trial
Multilevel Analysis
Comparative Effectiveness Research
Propensity Score
Observational Study
Pragmatic Clinical Trial
Machine Learning
Mediation Analysis
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Robert Makuch, PhD
Professor Emeritus of Biostatistics; Affiliated Faculty, Yale Institute for Global Health; Director, Regulatory Affairs Track
Research Interests
Infant, Premature
Biostatistics
Clinical Trials, Phase IV as Topic
Smoking Cessation
Public Health
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Peter Peduzzi, PhD
Professor Emeritus of Biostatistics and Senior Research Scientist of Biostatistics
Research Interests
Clinical Trials as Topic
Biostatistics
Aging
Pragmatic Clinical Trials as Topic
Patient Preference
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Kendra Plourde, PhD
Assistant Professor of Biostatistics
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Donna Spiegelman, ScD
Susan Dwight Bliss Professor of Biostatistics; Director, Center for Methods in Implementation and Prevention Science (CMIPS); Professor of Statistics and Data Science; Professor of Medicine (Cardiovascular Medicine); Assistant Director, Global Oncology, Yale Cancer Center
Research Interests
Biostatistics
Cardiovascular Diseases
Clinical Trial
Epidemiologic Methods
Global Health
Health Plan Implementation
HIV Infections
Implementation Science
Maternal Mortality
Obesity
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Jeffrey Townsend, PhD
Elihu Professor of Biostatistics and Professor of Ecology and Evolutionary Biology; Co-Leader, Genomics, Genetics, & Epigenetics Research Program
Research Interests
Nonlinear Dynamics
Organisms
Mycoses
Molecular Epidemiology
Nature
Neoplasm Metastasis
Neoplasms
Microarray Analysis
Microbiological Phenomena
Models, Genetic
Models, Statistical
Models, Theoretical
Likelihood Functions
Logistic Models
Mathematical Concepts
Sequence Analysis, DNA
Sequence Analysis, Protein
Viruses
Phenomena and Processes
Phylogeny
Polymerase Chain Reaction
Public Health Informatics
Bread
Biological Evolution
Algorithms
Bacteria
Bacterial Infections and Mycoses
Beer
Cell Transformation, Neoplastic
Coccidioidomycosis
Computing Methodologies
Crops, Agricultural
Host-Pathogen Interactions
Fungi
Gene Expression Profiling
Gene Transfer Techniques
Genetic Engineering
Genetic Phenomena
Genetic Speciation
Evolution, Molecular
Wine
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Zuoheng Anita Wang, PhD
Associate Professor of Biostatistics; Associate Professor, Biomedical Informatics & Data Science
Research Interests
Single-Cell Analysis
Psychiatry
Public Health
Informatics
Mental Health
Machine Learning
Longitudinal Studies
Multiomics
Neurosciences
Data Science
Computational Biology
Biostatistics
Electronic Health Records
Genetics
Genomics
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Joshua Warren, PhD
Associate Professor of Biostatistics
Research Interests
Algorithms
Biostatistics
Disorders of Environmental Origin
Eye Diseases
Pregnancy Complications
Probability
Statistical Distributions
Statistics as Topic
Stochastic Processes
Virus Diseases
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Wei Wei, PhD
Assistant Professor of Medicine (Medical Oncology); Interim Director of Biostatistics Shared Resource, Yale Cancer Center
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Heping Zhang, PhD
Susan Dwight Bliss Professor of Biostatistics, Professor in the Child Study Center and Professor of Statistics and Data Science, Professor of Obstetrics, Gynecology, and Reproductive Sciences; Affiliated Faculty, Yale Institute for Global Health
Research Interests
Child Psychiatry
Epidemiology
Infertility
Mental Health
Pregnancy
Psychiatry
Computational Biology
Statistics
Genomics
Biostatistics
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Hongyu Zhao, PhD
Ira V. Hiscock Professor of Biostatistics, Professor of Genetics and Professor of Statistics and Data Science
Research Interests
Genetics
Public Health
Computational Biology
Statistics
Genomics
Proteomics
Biostatistics
Single-Cell Analysis
Microbiota
Wearable Electronic Devices
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Centers and other resources

Cancer Prevention and Control Research Program
Center for Biomedical Data Science
Center for Methods in Implementation and Prevention Science (CMIPS)CMIPS develops and disseminates innovative methodologic approaches to address implementation gaps and improve public health worldwide.
Center for Outcomes Research & Evaluation (CORE)
Center for Perinatal, Pediatric and Environmental Epidemiology (CPPEE)CPPEE aims, through epidemiologic studies, to investigate the impact of environmental, genetic, and clinical factors on pregnancy, birth, and childhood.
Center of Excellence in Regulatory Science and Innovation (CERSI)
Collaboration for Research Integrity and Transparency (CRIT)
Collaborative Center for Statistics in Science (C²S²)C²S² fosters collaborations involving statistical methods and technology in scientific research, for understanding disease etiologies and developing treatment and prevention strategies.
Family Accommodation Obsessive-Compulsive DisorderFAOCD refers to family members' or significant others’ participation in or facilitation of patients’ rituals and/or avoidance.
Hongyu Zhao Lab - Center for Statistical Genomics and Proteomics
Public Health Modeling UnitThis renowned program uses mathematical representations of disease spread, healthcare processes, and human behavior to make better public health decisions and predictions.
Tobacco Center of Regulatory Science
Women's Health Research at Yale
Yale Cancer Center (YCC)The Center provides the best approaches for the prevention, detection, diagnosis, and treatment of cancer.
Yale Center for Analytical Sciences (YCAS)YCAS collaborative team provides expertise in the design, conduct, and analysis of health and health care studies, methodological development, and education and training.
Yale Alzheimer’s Disease Research CenterThe Yale Alzheimer’s Disease Research Center (ADRC) seeks to advance our understanding of Alzheimer’s disease at a cell biological level with the eventual goal of translating laboratory discoveries into novel effective clinical therapies.
Yale Child Study Center
Yale Claude D. Pepper Older Americans Independence Center
Yale COPPER Center: Cancer Outcomes, Public Policy and Effectiveness Research Center
Yale Depression Research Program
Yale Global Mental Health Program
Yale Network for Global Non-communicable Diseases
Yale Stress Center