A Quantitative System for Studying Metastasis Using Transparent Zebrafish
Heilmann S, Ratnakumar K, Langdon E, Kansler E, Kim I, Campbell N, Perry E, McMahon A, Kaufman C, van Rooijen E, Lee W, Iacobuzio-Donahue C, Hynes R, Zon L, Xavier J, White R. A Quantitative System for Studying Metastasis Using Transparent Zebrafish. Cancer Research 2015, 75: 4272-4282. PMID: 26282170, PMCID: PMC4609292, DOI: 10.1158/0008-5472.can-14-3319.Peer-Reviewed Original ResearchConceptsSingle-cell resolutionStable cell linesZebrafish systemTransparent zebrafishMetastasis-initiating cellsHuman cell culture systemsHigh-throughput investigationCell culture systemComputational image analysisMetastatic biologyMetastatic capabilityCell linesMetastatic capacityMelanoma cellsMetastatic processRapid generationCulture systemSuperior imaging toolCellsMitfaZebrafishMetastasis ScoreDegree of pigmentationBiologyProgeny