Research & Publications
Frederick (Rick) L. Altice is a professor of Medicine, Epidemiology and Public Health and is a clinician, clinical epidemiologist, intervention and implementation science researcher at Yale University School of Medicine and School of Public Health. Dr. Altice’s primary research focuses on interventions and implementation science at the interface between infectious diseases and addiction and he has conducted research in several global health settings. He also has a number of projects working in the criminal justice system, including transitional programs addressing infectious diseases, medications for opioid use disorder (methadone, buprenorphine, extended release naltrexone), mental illness, homelessness and social instability. Specific topics include alcohol, opioid, stimulant and nicotine use disorders on HIV treatment outcomes, HIV and addiction treatment, interface with the criminal justice system, and pharmacokinetic drug interactions between treatment for substance use disorders and antiretroviral and tuberculosis therapy. At a basic level, his research focuses on clinical epidemiology, especially in key populations at risk for HIV (e.g., MSM, TGW, PWID, prisoners, sex workers) and development, adaptation and evaluation of of biomedical and behavioral interventions to improve treatment outcomes. His research, however, has evolved and included development and testing of mobile technologies (mHealth) to intervene with key populations to promote health outcomes. His research is especially concentrated in health services research techniques with a focus on implementation science, seeking to introduce and scale-up evidence-based interventions in numerous contexts. A number of implementation science strategies are underway to examine scale-up of medication-assisted therapies to treat opioid use disorder in community, criminal justice and in primary care settings. Most recently, his work has been augmented through use of decision science techniques to understand and promote patient preferences, including the development of informed and shared decision-making aids. His work has emerged primarily with a global health focus with funded research projects internationally in Malaysia, Ukraine, Moldova, Armenia, Kyrgyzstan, Peru, and Indonesia. He has participated in projects through the National Institute on Alcohol Abuse and Alcoholism, the National Institute on Drug Abuse, Centers for Disease Control and Prevention, Substance Abuse and Mental Health Services Agency, Special Projects of National Significance with HRSA, and the Center for Substance Abuse Treatment. He is currently also collaborating on projects with the WHO, UNAIDS, USAID, PEPFAR and UNODC. Current internationally funded projects in dedicated research sites that are being conducted in Malaysia, Ukraine, Moldova, Azerbaijan, Armenia, Kyrgyzstan and Peru. His research and training sites in Malaysia (2005), Peru (2010) and Ukraine (2005) are dedicated training and research sites for the Global Health Equity Scholars Fogarty Training Program and the Doris Duke International Fellowship program. He is currently the director for two International Implementation Science Research and Training Centers with collaborations between Yale University and the University of Malaya and Sichuan University.
Education & Training
- MAYale University, Honorary (2008)
- FellowYale University School of Medicine (1992)
- ResidentYale University School of Medicine (1989)
- MDEmory University (1986)
- MAUniversidad de Santiago de Compostela, Spanish Literature (1982)
- PRIME Studies of Addiction TreatmentSydney, Australia 2020To conduct a preference trial comparing long-acting buprenorphine with sublingual buprenorphine in people with opioid use disorder.
- IMPACT (Integrating Treatment for Addiction, HIV and Tuberculosis in Primary Care Settings)Kyiv, Ukraine 2017A 45 site, cluster randomized controlled trial comparing standard of care (addiction treatment in specialty care settings) versus integrating care into primary care settings, including the assessment of pay-for-performance incentives (P4P). The research uses a facilitation strategy using an ECHO-like platform to teach addiction, HIV and TB care to primary care physicians and uses a Type II Hybrid Implementation Science Trial.
- Studies of Alcohol and Drug Use Among MSM in PeruLima, Peru (2011-2016)Biobehavioral Surveys, RCTs of XR-NTX among HIV+ MSM with alcohol use disorders and RCTs of early vs late initiation of ART among newly seroconverted MSM. This is a Fogarty International Global Health Equity Scholars site.
- HIV, Opioid, Substance abuse, MalaysiaKuala Lumpur, Malaysia 2010Intervention of HIV, Drug Use and the Criminal Justice System in Malaysia
- Opioid Dependence and HIV in MalaysiaKuala Lumpur, Malaysia 2009In 2005, the Malaysian government changed its policies toward substance abuse by implementing syringe exchange programs and methadone maintenance programs. Professor Altice has been a consultant in developing and evaluating the new policies and have since begun several different studies in Malaysia at the interface of substance abuse and infectious diseases, including involvement with the Prison Ministry. Collaboration through the University of Malaysia.
- Infectious Diseases and AddictionKuala Lumpur, Malaysia 2005Funded Research Activities with Centre of Excellence in Research on AIDS (CERiA). Projects are extensive and include epidemiological studies with vulnerable populations including prisoners, female sex workers, men who have sex with men and people who inject drugs. Current studies also include those involving HIV, TB, substance abuse and intervention research. This is a Fogarty International Global Health Equity Scholars site.
- HIV/AIDS, Tuberculosis and AddictionUkraine 2005Technical Assistance and Research, Developed integrated health care delivery system, Rolled out buprenorphine and methadone
- Opioid Dependence and HIV in UkraineUkraine 2005Since 2005, Professor Altice have trained the physicians on treatment of opioid dependence, HIV and tuberculosis. Specifically, in collaboration with his Ukrainian colleagues, They introduced the first pilot buprenorphine treatment programs in the country. They are now participating in the establishment and expansion of methadone maintenance treatment and how integrated health services can be developed that target substance abuse, HIV and tuberculosis. Currently, there are two NIH funded research projects. One is to expand medication assisted therapies in Ukraine, while the other is to introduce and expand evidence-based intervention for prisoners in Ukraine and Central Asia. This is a Fogarty International Global Health Equity Scholars site.
- HIV, Tuberculosis and Drug Dependence In IranTehran, Iran (2001-2009)This involves three projects: 1. HIV and TB Coinfection Among Drug Users in Iran 2. Treatment for Opioid Dependence Among Individuals with HIV or TB 3. Prisoners and Methadone Maintenance.
Honors & Recognition
|Most Influential Paper on Addictions - 2016 (Lancet)||European Monitoring Centre for Drugs and Drug Addiction||2017|
|Appointed as Academic Icon Professor of Medicine, Centre for Excellence in Research in AIDS (CERiA) at University of Malaya||Infectious Diseases Unit, Department of Medicine, Faculty of Medicine, University of Malaya||2009|
|Board of Permanent Officers||Yale University School of Medicine||2009|
|National Hope is a Vaccine" Award Recipient||GAIA, Global Alliance to Immunize against AIDS||2008|
|Dean's Advisory Committee on LGBTQI Issues, Yale University School of Medicine||Advisor||2017 - Present|
|World Health Organization Guidelines Committee for Treatment of HIV and Tuberculosis Among Drug Users.||2009 - Present|
|Symposium Chair, International AIDS Society Conference, 2009, Cape Town, South Africa||2009 - Present|
|American Board of Correctional Medicine||2009 - Present|
|Board of Permanent Officers, Yale Univ. School of Medicine||2009 - Present|
|Yale School of Medicine M.D. Thesis Mentor Council. Office of Student Research.||2008 - 2009|
|Correctional Academic Liaison Meeting (CALM), CT. Department of Corrections.||2008 - Present|
|Addiction, Journal of General Internal Medicine, International Journal of Prison Health Care||2008 - Present|
|The Open Public Health Journal, Open Infectious Diseases Journal, International Journal of Prisoner Health||2008 - Present|
|Executive Board, Liberty Community Services, Inc. New Haven CT.||2008 - Present|
|Research Director, AIDS Project Hartford||2007 - Present|
|Clinical Core Committee, Center for Interdisciplinary Research on AIDS (CIRA)||2007 - Present|
|Scientific Advisory Board, Center for Drug Abuse and AIDS Research (CDAAR) P30 grant at Tufts University, School of Medicine.||2007 - Present|
|Clinical Infectious Diseases, Drug and Alcohol Dependence, Journal of Substance Abuse Treatment||2005 - Present|
|American Society of Addiction Medicine||2005 - Present|
|AAHIVM-American Academy of HIV Medicine||2004 - Present|
|AIDS Reader, Annals of Internal Medicine, JAIDS, JAMA||2003 - Present|
|Advisory Committee, Connecticut AIDS Drug Assistance Program (CADAP)||2002 - Present|
|NIDA K Training & Career Development Subcommittee, National Institute on Drug Abuse Initial Review Group||2001 - Present|
|American Correctional Association||2001 - Present|
|Society for Correctional Physicians||1997 - Present|
|Morse College, Yale University||1995 - Present|
|Yale University School of Medicine||Student Mentor||1995 - Present|
|International AIDS Society||1994 - Present|
|American College of Physicians||1993 - Present|
|Infectious Disease Society of America||1993 - Present|
|American Public Health Association||1992 - Present|