E. Jennifer Edelman, MD, MHS, BS
Professor of Medicine (General Medicine)Cards
About
Research
Publications
2025
Exercise Interventions Among Individuals With Co-occurring HIV And Unhealthy Substance Use: A Systematic Review
Mistler C, Allen W, Grimshaw A, Idiong C, Harsono D, Irwin M, Ash G, Pescatello L, Meyer J, Edelman E. Exercise Interventions Among Individuals With Co-occurring HIV And Unhealthy Substance Use: A Systematic Review. Medicine & Science In Sports & Exercise 2025, 57: 755-755. DOI: 10.1249/01.mss.0001161400.40878.dc.Peer-Reviewed Original ResearchAlcohol interventions for persons with HIV: Meta-analysis of randomized controlled trials using phosphatidylethanol and self-report
Hahn J, Kane J, Fatch R, Espinosa da Silva C, Emenyonu N, Scheffler A, Chirayil P, So-Armah K, Kahler C, Conroy A, Edelman E, Woolf-King S, Parry C, Kiene S, Chamie G, Muyindike W, Adong J, Go V, Cook R, Morojele N, Fiellin D, Santos G, Tahir P, Samet J, Krupitsky E, Allen I. Alcohol interventions for persons with HIV: Meta-analysis of randomized controlled trials using phosphatidylethanol and self-report. Drug And Alcohol Dependence 2025, 276: 112879. PMID: 40992009, DOI: 10.1016/j.drugalcdep.2025.112879.Peer-Reviewed Original ResearchRandomized Controlled TrialsUnhealthy alcohol useAlcohol interventionsSelf-ReportAlcohol useIndividual Participant Data Meta-AnalysisSystematic reviewIntervention RCTsParticipant data meta-analysisPrimary outcomeSelf-reported alcohol useRisk-of-bias assessmentMeta-analysisAlcohol intervention studyCertainty of evidenceData Meta-AnalysisRandom-effects modelMeta-analysis of randomized controlled trialsIPD-MAIntervention efficacyIntervention studiesControlled TrialsEffect sizeModerate riskIntervention253 Implementation Facilitation Improves Readiness for Buprenorphine Initiation in Opioid Use Disorder
Strout T, Dziura J, Barrett T, Cowan E, Hawk K, Herring A, Manteuffel J, McCormack R, Fiellin D, D'Onofrio G, Edelman E. 253 Implementation Facilitation Improves Readiness for Buprenorphine Initiation in Opioid Use Disorder. Annals Of Emergency Medicine 2025, 86: s109. DOI: 10.1016/j.annemergmed.2025.06.269.Peer-Reviewed Original ResearchMicrocosting implementation facilitation for emergency department-initiated buprenorphine for untreated opioid use disorder
Ryan D, Lu T, Edelman E, Hawk K, O'Connor P, Coupet E, Jalali A, Owens P, Fiellin D, D'Onofrio G, Murphy S. Microcosting implementation facilitation for emergency department-initiated buprenorphine for untreated opioid use disorder. The American Journal Of Emergency Medicine 2025, 98: 124-129. PMID: 40865260, DOI: 10.1016/j.ajem.2025.08.002.Peer-Reviewed Original ResearchED-initiated buprenorphineImplementation facilitatorsOpioid use disorderPre-implementationEvidence-based implementation strategiesUse disorderHealth system resourcesEmergency department-initiated buprenorphineMicrocosting analysisUntreated opioid use disorderDrug Abuse Treatment Cost Analysis ProgramPer-patient costsImplementation strategiesBuprenorphine programMicrocostingStudy dataFormative evaluationClinical settingReferralHealthFinancial costsMOUDBuprenorphineQuantitative dataFacilitationHospital-Based Methadone and Buprenorphine Initiation Practices by Addiction Consult Services
Cohen S, Straus E, Fiellin D, Pomeranz J, Suzuki J, Tetrault J, Weimer M, Edelman E, Joudrey P. Hospital-Based Methadone and Buprenorphine Initiation Practices by Addiction Consult Services. JAMA Network Open 2025, 8: e2526077. PMID: 40773194, PMCID: PMC12332638, DOI: 10.1001/jamanetworkopen.2025.26077.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineCross-Sectional StudiesDose-Response Relationship, DrugDrug Administration ScheduleFemaleFentanylHospitals, TeachingHumansMaleMethadoneMiddle AgedNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersPhysician ExecutivesPractice Guidelines as TopicReferral and ConsultationSurveys and QuestionnairesUnited StatesConceptsInitiation of methadoneAddiction consult servicesMethadone initiationBuprenorphine initiationOpioid use disorderHigh dosesLow dosesAddiction medicineLow-dose initiationFull-agonist opioidsUp-titrationCross-sectional survey studyInitiation regimenFentanyl usePrimary outcomeDay 1OpioidBuprenorphineHospital-based practiceUse disorderClinical casesClinical guidelinesMethadoneSynthetic opioidsDoseLong-term, bidirectional associations between depressive symptom severity and opioid use among people with HIV: A prospective cohort study
Macmadu A, Li Y, Bhondoekhan F, Chang C, Bahji A, Crystal S, Gordon K, Kerns R, Vickers-Smith R, Edelman E, Marshall B. Long-term, bidirectional associations between depressive symptom severity and opioid use among people with HIV: A prospective cohort study. Addictive Behaviors Reports 2025, 22: 100619. PMID: 40547483, PMCID: PMC12182372, DOI: 10.1016/j.abrep.2025.100619.Peer-Reviewed Original ResearchDepressive symptom severityVeterans Aging Cohort StudySymptom severityOpioid useCohort studySubstance use disordersPrescription opioid useProspective cohort studyOpioid use disorderAging Cohort StudyMental health servicesDose-response patternGeneralized Estimating Equation modelsVeterans Health Administration sitesUse disorderClinical characteristicsProspective cohortBidirectional associationsFollow-upStudy entryOpioidHarm reduction servicesBidirectional relationshipPLHIVAdministration siteCannabis Use Disorder Among People With and Without HIV.
Haley D, So-Armah K, Justice A, Kidwai-Khan F, Xuan Z, Sayko Adams R, Fox M, Edelman E, Wrona A, Silverberg M, Satre D, Trickey A, Ingle S, McGinnis K. Cannabis Use Disorder Among People With and Without HIV. Journal Of Addiction Medicine 2025 PMID: 40358026, DOI: 10.1097/adm.0000000000001505.Peer-Reviewed Original ResearchCannabis use disorderNon-HispanicHIV statusElectronic health recordsBlack non-HispanicNational US cohortCannabis useUse disorderMultivariate logistic modelHealth recordsCohort of PLWHOlder PLWHPrescription medicationsInternational ClassificationUniversal screeningGeneral populationPLWHDemographic characteristicsPLWOHPotential harmAging populationAge groupsHIVRace/ethnicityTreatment advancesUnhealthy Alcohol Use and HIV Preexposure Prophylaxis—Opportunities for Integrated Care
Oldfield B, Edelman E. Unhealthy Alcohol Use and HIV Preexposure Prophylaxis—Opportunities for Integrated Care. JAMA Network Open 2025, 8: e257301. PMID: 40279131, DOI: 10.1001/jamanetworkopen.2025.7301.Peer-Reviewed Original ResearchPrevalence of Hospitalizations Among a National Sample of U.S. Adults With Substance Use Disorders.
Bernstein E, Calcaterra S, Chopra V, Edelman E, Kruse G. Prevalence of Hospitalizations Among a National Sample of U.S. Adults With Substance Use Disorders. Annals Of Internal Medicine 2025, 178: 900-903. PMID: 40163870, DOI: 10.7326/annals-24-03385.Peer-Reviewed Original ResearchCorrection: Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population
Edelman E, Rojas-Perez O, Nich C, Corvino J, Frankforter T, Gordon D, Jordan A, Paris, Jr M, Weimer M, Yates B, Williams E, Kiluk B. Correction: Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population. Addiction Science & Clinical Practice 2025, 20: 29. PMID: 40128914, PMCID: PMC11931771, DOI: 10.1186/s13722-025-00558-x.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Exemplar Hospital Initiation Trial to Enhance Treatment Engagement (EXHIT ENTRE)
HIC ID2000030586RolePrincipal InvestigatorPrimary Completion Date02/28/2023Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements & Community Involvement
Clinical Care
Overview
E. Jennifer Edelman, MD, MHS, specializes in HIV and addiction medicine. She provides patient care for HIV/AIDS and its associated complications, such as HIV-associated myopathy, dementia, and neurocognitive disorder.
In addition to her clinical work in HIV care, Dr. Edelman’s research examines substance use disorder treatment in HIV clinics, emergency department-initiated buprenorphine programs, and alcohol reduction interventions for people with HIV.
A recipient of the New England Society of General Internal Medicine Award for Excellence in Clinical Investigation and the Society of General Internal Medicine Lawrence Linn Award, her research has been supported by grants from the National Institutes of Health, the National Institute on Alcohol Abuse and Alcoholism, and the National Cancer Institute.
Dr. Edelman is a professor of medicine at Yale School of Medicine.
Clinical Specialties
Internal Medicine; Addiction Medicine; HIV & AIDs Medicine
Fact Sheets
Human Immunodeficiency Virus (HIV)
Learn More on Yale MedicineOpioid Use Disorder
Learn More on Yale MedicineStimulant Use Disorder
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Board Certifications
Addiction Medicine (Internal Medicine)
- Certification Organization
- AB of Addiction Medicine
- Latest Certification Date
- 2024
- Original Certification Date
- 2014
HIV Specialist
- Certification Organization
- American Academy of HIV Medicine
- Latest Certification Date
- 2021
- Original Certification Date
- 2013
Yale Medicine News
News
News
- May 27, 2025
Research Project Studies High Doses of an Opioid Use Disorder Medication Among Veterans
- December 02, 2024
2025 YCCI Funding Opportunities Open for Applications
- October 23, 2024
Penicillin Allergies Among Patients Undergoing Hematopoietic Stem Cell Transplants
- August 05, 2024
Yale partnership seeks to improve HIV prevention and treatment training in Tbilisi, Georgia
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General Internal Medicine
PO Box 208056
New Haven, CT 06520-8025
United States
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