Rajita Sinha, PhD
Foundations Fund Professor of Psychiatry and Professor in the Child Study Center and of NeuroscienceCards
Appointments
Additional Titles
Deputy Chair of Psychiatry for Psychology, Psychiatry
Director, Yale Interdisciplinary Stress Center
Chief, Psychology Section in Psychiatry
Contact Info
Appointments
Additional Titles
Deputy Chair of Psychiatry for Psychology, Psychiatry
Director, Yale Interdisciplinary Stress Center
Chief, Psychology Section in Psychiatry
Contact Info
Appointments
Additional Titles
Deputy Chair of Psychiatry for Psychology, Psychiatry
Director, Yale Interdisciplinary Stress Center
Chief, Psychology Section in Psychiatry
Contact Info
About
Copy Link
Titles
Foundations Fund Professor of Psychiatry and Professor in the Child Study Center and of Neuroscience
Deputy Chair of Psychiatry for Psychology, Psychiatry; Director, Yale Interdisciplinary Stress Center; Chief, Psychology Section in Psychiatry
Biography
Rajita Sinha, Ph.D. is the Foundations Fund Endowed Professor in Psychiatry, and Professor in Neuroscience and in Child Study at the Yale University School of Medicine. She is a licensed Clinical Psychologist and Clinical Neuroscientist, Deputy Chair of Psychiatry for Psychology and Chief of the Psychology Section in Psychiatry. She is the founding director of the Yale Interdisciplinary Stress Center that focuses on understanding the neurobiology and psychology of stress, trauma and resilient versus vulnerable biobehavioral coping mechanisms that promote neuropsychiatric diseases such as alcohol use disorders, substance use disorders, chronic pain, PTSD and other chronic diseases. She has developed novel stress, pain and craving provocation paradigms to understand mechanisms that drive these states and related pathologies and their impact on clinical addiction outcomes in alcohol use disorder, substance use disorders and related conditions. Her lab also develops and tests novel pharmacologic and integrative behavioral approaches to address chronic stress and addiction relapse risk to improve addiction treatment outcomes. These objectives are being accomplished through a series of NIH funded research projects and she has published widely on these topics. She is the 2020 recipient of the Research Society on Alcoholism's Distinguished Researcher Award, and the 2020 recipient of the James Tharpe Award for outstanding contributions to Addiction Research. She has served on many NIH special emphasis panels, review committees and workshops, presented at numerous national and international conferences, and her work is widely cited.
Appointments
Psychiatry
ProfessorPrimaryNeuroscience
ProfessorSecondary
Other Departments & Organizations
- Center for Brain & Mind Health
- Connecticut Mental Health Center
- Diabetes Research Center
- Division of Addictions
- Division of Substance Abuse
- MR Core
- Neuroscience
- Neuroscience Research Training Program (NRTP)
- Psychiatry
- Psychology Section
- Psychotherapy Development Center
- South Asian Studies
- Stress & Addiction Clinical Research Program
- Yale Center for the Science of Cannabis and Cannabinoids
- Yale Obesity Research Center (Y-Weight)
- Yale Stress Center
- Yale Ventures
- Yale-Drug use, Addiction, and HIV prevention Research Scholars (DAHRS)
Education & Training
- PhD
- Yale University, Psychology/Clinical Respecialization (1992)
- PhD
- Oklahoma University Health Sciences Center (1990)
Research
Copy Link
Overview
Medical Research Interests
ORCID
0000-0003-3012-4349
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Verica Milivojevic, PhD
Dongju Seo, PhD
Nia Fogelman, PhD
Stephanie Wemm, PhD
Chiang-Shan Ray Li, MD, PhD
Elizabeth Goldfarb, PhD
Stress, Psychological
Substance-Related Disorders
Chronic Disease
Neurobiology
Publications
2026
Effects of the Neuroactive Steroid Precursor Pregnenolone on Stress- and Alcohol Cue–Provoked Pain Responses in Individuals With Alcohol Use Disorder
Quinlan R, Gao H, Sinha R, Milivojevic V. Effects of the Neuroactive Steroid Precursor Pregnenolone on Stress- and Alcohol Cue–Provoked Pain Responses in Individuals With Alcohol Use Disorder. Experimental And Clinical Psychopharmacology 2026 PMID: 42258258, PMCID: PMC13251320, DOI: 10.1037/pha0000862.Peer-Reviewed Original ResearchAltmetricAlterations in glucose and insulin resistance following stress and alcohol cues predict alcohol craving in those with AUD and obesity: A preliminary study
Harvanek Z, Milivojevic V, Sinha R. Alterations in glucose and insulin resistance following stress and alcohol cues predict alcohol craving in those with AUD and obesity: A preliminary study. Alcohol Clinical And Experimental Research 2026, 50: e70283. PMID: 42101823, DOI: 10.1111/acer.70283.Peer-Reviewed Original ResearchAltmetricPerceived Social Support Moderates the Response to Stress and Alcohol Cue During Early Abstinence from Alcohol
Goldstein S, Sinha R, Fox H. Perceived Social Support Moderates the Response to Stress and Alcohol Cue During Early Abstinence from Alcohol. Biological Psychiatry Global Open Science 2026, 100762. DOI: 10.1016/j.bpsgos.2026.100762.Peer-Reviewed Original ResearchGender differences in a causal model of risk factors underlying early alcohol sipping
Maxwell A, Cullen K, Kummerfeld E, Sinha R, Zilverstand A. Gender differences in a causal model of risk factors underlying early alcohol sipping. Child And Adolescent Psychiatry And Mental Health 2026, 20: 68. PMID: 41917987, PMCID: PMC13159307, DOI: 10.1186/s13034-026-01077-6.Peer-Reviewed Original ResearchCitationsMindfulness Intervention for Parent Stress and Childhood Obesity Risk: A Randomized Trial
Fogelman N, Bernstein H, Bautista T, Chaplin T, Silverman W, Jastreboff A, Sinha R. Mindfulness Intervention for Parent Stress and Childhood Obesity Risk: A Randomized Trial. PEDIATRICS 2026, 157: e2025072230. PMID: 41786283, PMCID: PMC12989181, DOI: 10.1542/peds.2025-072230.Peer-Reviewed Original ResearchAltmetricSex-specific neural activation to stress and alcohol cues in high-risk drinkers: links between orbitofrontal circuits, alcohol craving, and future drinking
Freeman C, Radoman M, Martins J, Lacadie C, Seo D, Sinha R. Sex-specific neural activation to stress and alcohol cues in high-risk drinkers: links between orbitofrontal circuits, alcohol craving, and future drinking. Neuropsychopharmacology 2026, 1-9. PMID: 41792252, PMCID: PMC13032816, DOI: 10.1038/s41386-026-02379-1.Peer-Reviewed Original ResearchCitationsAltmetricAssociations Among Stressful Events, Social Support, and Alcohol Use in Women and Men
Hovnanyan A, Sinha R, Fogelman N. Associations Among Stressful Events, Social Support, and Alcohol Use in Women and Men. Behavioral Sciences 2026, 16: 261. PMID: 41750070, PMCID: PMC12938169, DOI: 10.3390/bs16020261.Peer-Reviewed Original ResearchCitationsSafety, tolerability, and drug-drug interactions of NYX-783 and oxycodone in persons using opioids recreationally: Preliminary results from a randomized, double-blind, placebo-controlled phase 1 study
Harvanek Z, Mignosa M, Kitaneh R, Oliva H, Borelli A, Dauginikas E, Fogelman N, Sakmar E, Taylor J, DiLeone R, Sinha R, Angarita G. Safety, tolerability, and drug-drug interactions of NYX-783 and oxycodone in persons using opioids recreationally: Preliminary results from a randomized, double-blind, placebo-controlled phase 1 study. Drug And Alcohol Dependence 2026, 279: 113041. PMID: 41604752, PMCID: PMC12924154, DOI: 10.1016/j.drugalcdep.2026.113041.Peer-Reviewed Original Research
2025
Assessing Autonomic Regulation Under Stress with the Yale Pain Stress Test in Social Drinking and Alcohol Use Disorder
Barreto S, McGowan C, Fogelman N, Sinha R, Wemm S. Assessing Autonomic Regulation Under Stress with the Yale Pain Stress Test in Social Drinking and Alcohol Use Disorder. Behavioral Sciences 2025, 15: 1732. PMID: 41464075, PMCID: PMC12729474, DOI: 10.3390/bs15121732.Peer-Reviewed Original ResearchAltmetricDynamic brain mechanisms supporting salient memories under cortisol
Huang Y, O’Connor D, Harris B, Sinha R, Constable R, Goldfarb E. Dynamic brain mechanisms supporting salient memories under cortisol. Science Advances 2025, 11: eadz4143. PMID: 41370392, PMCID: PMC12693973, DOI: 10.1126/sciadv.adz4143.Peer-Reviewed Original ResearchThis study investigates how cortisol enhances emotional memory by dynamically altering brain networks, strengthening connections for arousal and memory, and prioritizing emotionally salient information.
Clinical Trials
Current Trials
Prazosin for Alcohol Use Disorder
IRB ID2000029805RolePrincipal InvestigatorPrimary Completion Date01/15/2026Recruiting ParticipantsGenderBothAge18 years - 70 yearsCharacterizing Subjective and Physiological Responses to Stress and Pain and Cognitive Learning and Executive Function
IRB ID2000026626RolePrincipal InvestigatorPrimary Completion Date06/30/2023Recruiting ParticipantsGenderBothAge18 years - 50 years
News & Links
Copy Link
Media
- Higher the cumulative stress exposure, greater the reduction in brain volume in specific regions of the medial, anterior and lateral prefrontal cortex, and in the insula and striatum (shown in yellow blobs). These are regions involved in emotion, reward and motivation processing. Ansel et al., Biological Psychiatry 2011.
News
- September 18, 2026
Yale Stress Center Receives Contract to Develop Models to Detect and Treat Stress-Related Behavioral Health Illnesses
- June 30, 2026
Women’s Health Research at Yale and SWHR’s Symposium Highlights the Power of Collaboration to Advance Women’s Health Research
- June 08, 2026
Fehon Awarded 2026 Sidney J. Blatt Faculty Award
- June 05, 2026Source: Drug and Alcohol Dependence
Pilot Trial: Pregnenolone Reduces Provoked Craving and Cocaine Use in Men and Women with Cocaine Use Disorder
Related Links
- AARP Bulletin Today on how stress can impact your health - Published 5/1/2009
- Even in the healthy, stress causes brain to shrink, Yale study shows
- Gender in the mix: Under stress, men crave alcohol more than women do - The Los Angeles Times, Health section (5/19/08)
- Link between stress and alcohol craving in alcoholics struggling to achieve recovery - Neuropsychopharmacology, 6/18/08
- Yale Stress Center
Get In Touch
Copy Link