2024
A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections
Flatby H, Ravi A, Liyanarachi K, Afset J, Rasheed H, Brumpton B, Hveem K, Åsvold B, DeWan A, Solligård E, Damås J, Rogne T. A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections. The Journal Of Infectious Diseases 2024, jiae231. PMID: 38713594, DOI: 10.1093/infdis/jiae231.Peer-Reviewed Original ResearchGenome-wide association studiesMichigan Genomics InitiativeAssociation studiesUpper UTIMendelian randomizationMR analysisUpper urinary tract infectionRisk factorsPotential causal risk factorsCardiometabolic risk factorsModifiable risk factorsSex-stratified analysesCausal risk factorUrinary tract infectionGenome-wideFemale-only analysisGenetic lociPotential causal relationshipGenome InitiativeHealth StudyUK BiobankHLA-DQA2LociTract infectionsSmoking scoreChronic kidney disease and risk of bloodstream infections and sepsis: a 17-year follow-up of the population-based Trøndelag Health Study in Norway
Liyanarachi K, Mohus R, Rogne T, Gustad L, Åsvold B, Romundstad S, Solligård E, Hallan S, Damås J. Chronic kidney disease and risk of bloodstream infections and sepsis: a 17-year follow-up of the population-based Trøndelag Health Study in Norway. Infection 2024, 52: 1983-1993. PMID: 38679665, PMCID: PMC11499395, DOI: 10.1007/s15010-024-02265-2.Peer-Reviewed Original ResearchHazard ratioHazard ratio of deathChronic kidney diseaseCohort studyPopulation-based cohort studyNorwegian HUNT studyAlbumin-creatinine ratioTarget risk factorsAssociation of chronic kidney diseaseLoss of healthProspective cohort studyHUNT StudyHealth StudySystolic blood pressureSmoking statusKidney diseaseHospital admissionMedian follow-up timeGeneral populationRisk of bloodstream infectionImprove preventionFollow-up timeIncreased riskNormal albumin excretionRisk factors
2022
Insomnia symptoms and risk of bloodstream infections: prospective data from the prospective population‐based Nord‐Trøndelag Health Study (HUNT), Norway
Thorkildsen MS, Laugsand LE, Nilsen TIL, Mohus RM, Høvik LH, Rogne T, Solligård E, Damås JK, Gustad LT. Insomnia symptoms and risk of bloodstream infections: prospective data from the prospective population‐based Nord‐Trøndelag Health Study (HUNT), Norway. Journal Of Sleep Research 2022, 32: e13696. PMID: 36068650, PMCID: PMC10078600, DOI: 10.1111/jsr.13696.Peer-Reviewed Original ResearchConceptsFirst-time bloodstream infectionNord-Trøndelag Health StudyHazard ratioBloodstream infectionsInsomnia symptomsProspective dataHealth StudyConfidence intervalsNorwegian Nord-Trøndelag Health StudyRisk of BSIPopulation-based prospective studyPopulation-based Nord-Trøndelag Health StudyFrequent insomnia symptomsNon-restorative sleepRisk of infectionCox regressionProspective studyAbove symptomsImmune functionSymptomsInfectionMortalitySleepRiskParticipantsIncidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study
Liyanarachi KV, Solligård E, Mohus RM, Åsvold BO, Rogne T, Damås JK. Incidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study. PLOS ONE 2022, 17: e0271263. PMID: 35819970, PMCID: PMC9275692, DOI: 10.1371/journal.pone.0271263.Peer-Reviewed Original ResearchConceptsSevere bacterial infectionsPositive blood culturesBacterial infectionsBlood culturesPopulation-based HUNT StudyPositive blood culture rateTrøndelag Health StudyUrinary tract infectionPopulation-based cohortBlood culture rateCommon infectious diseasesInfectious disease burdenRegistry linkageTract infectionsLoss of healthMedian timeHUNT StudyDisease burdenIncidence rateCulture rateGeneral populationHealth StudyHospitalizationImportant causeTotal burden
2021
Risk of lower respiratory tract infections: a genome-wide association study with Mendelian randomization analysis in three independent European populations
Flatby HM, Rasheed H, Ravi A, Thomas LF, Liyanarachi KV, Afset JE, DeWan AT, Brumpton BM, Hveem K, Åsvold BO, Simonsen GS, Furberg AS, Damås JK, Solligård E, Rogne T. Risk of lower respiratory tract infections: a genome-wide association study with Mendelian randomization analysis in three independent European populations. Clinical Microbiology And Infection 2021, 28: 732.e1-732.e7. PMID: 34763054, DOI: 10.1016/j.cmi.2021.11.004.Peer-Reviewed Original ResearchConceptsLower respiratory tract infectionsRespiratory tract infectionsMendelian randomization analysisTract infectionsRisk factorsRisk of LRTICardiometabolic risk factorsSystolic blood pressureTrøndelag Health StudyPrevalence of smokingRandomization analysisBody mass indexCause of morbidityPotential risk factorsBlood pressureMass indexSuch hospitalizationsDisease burdenProtective effectHealth StudyIndependent European populationsLifetime smokingGenome-wide association studiesGenetic susceptibilitySmoking